LOCUS       NM_023116               4924 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Mus musculus calcium channel, voltage-dependent, beta 2 subunit
            (Cacnb2), transcript variant 1, mRNA.
ACCESSION   NM_023116
VERSION     NM_023116.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4924)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4924)
  AUTHORS   Seitter,H., Obkircher,J., Grabher,P., Hartl,J., Zanetti,L.,
            Lux,U.T., Fotakis,G., Fernandez-Quintero,M.L., Kaserer,T. and
            Koschak,A.
  TITLE     A novel calcium channel Cavbeta2 splice variant with unique
            properties predominates in the retina
  JOURNAL   J Biol Chem 299 (4), 102972 (2023)
   PUBMED   36738788
  REMARK    GeneRIF: A novel calcium channel Cavbeta2 splice variant with
            unique properties predominates in the retina.
REFERENCE   3  (bases 1 to 4924)
  AUTHORS   Westhoff,M. and Dixon,R.E.
  TITLE     Mechanisms and Regulation of Cardiac CaV1.2 Trafficking
  JOURNAL   Int J Mol Sci 22 (11), 5927 (2021)
   PUBMED   34072954
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4924)
  AUTHORS   Murakami,M., Xu,F., Ohba,T., Kobayashi,T., Inoue,Y., Murakami,A.M.,
            Miyoshi,I., Ono,K. and Tohse,N.
  TITLE     Requirement of the Ca2+ channel beta2 subunit for sympathetic PKA
            phosphorylation
  JOURNAL   J Pharmacol Sci 145 (3), 253-261 (2021)
   PUBMED   33602505
  REMARK    GeneRIF: Requirement of the Ca(2+) channel beta2 subunit for
            sympathetic PKA phosphorylation.
REFERENCE   5  (bases 1 to 4924)
  AUTHORS   Moreau,J.L.M., Kesteven,S., Martin,E.M.M.A., Lau,K.S., Yam,M.X.,
            O'Reilly,V.C., Del Monte-Nieto,G., Baldini,A., Feneley,M.P.,
            Moon,A.M., Harvey,R.P., Sparrow,D.B., Chapman,G. and Dunwoodie,S.L.
  TITLE     Gene-environment interaction impacts on heart development and
            embryo survival
  JOURNAL   Development 146 (4) (2019)
   PUBMED   30787001
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4924)
  AUTHORS   Lee,C.G., Morse,H.C. 3rd, Kay,B.K. and Kozak,C.A.
  TITLE     Genetic mapping of eight SH3 domain genes on seven mouse
            chromosomes
  JOURNAL   Mamm Genome 10 (4), 402-404 (1999)
   PUBMED   10087302
REFERENCE   7  (bases 1 to 4924)
  AUTHORS   Taviaux,S., Williams,M.E., Harpold,M.M., Nargeot,J. and Lory,P.
  TITLE     Assignment of human genes for beta 2 and beta 4 subunits of
            voltage-dependent Ca2+ channels to chromosomes 10p12 and 2q22-q23
  JOURNAL   Hum Genet 100 (2), 151-154 (1997)
   PUBMED   9254841
REFERENCE   8  (bases 1 to 4924)
  AUTHORS   Girard,L., Hanna,Z., Beaulieu,N., Hoemann,C.D., Simard,C.,
            Kozak,C.A. and Jolicoeur,P.
  TITLE     Frequent provirus insertional mutagenesis of Notch1 in thymomas of
            MMTVD/myc transgenic mice suggests a collaboration of c-myc and
            Notch1 for oncogenesis
  JOURNAL   Genes Dev 10 (15), 1930-1944 (1996)
   PUBMED   8756350
REFERENCE   9  (bases 1 to 4924)
  AUTHORS   Chin,H., Kwon,O.J., Jung,H.H., Kim,D.S. and Kozak,C.A.
  TITLE     Genetic mapping of the mouse genes encoding the voltage-sensitive
            calcium channel subunits
  JOURNAL   Genomics 28 (3), 592-595 (1995)
   PUBMED   7490102
REFERENCE   10 (bases 1 to 4924)
  AUTHORS   Massa,E., Kelly,K.M., Yule,D.I., MacDonald,R.L. and Uhler,M.D.
  TITLE     Comparison of fura-2 imaging and electrophysiological analysis of
            murine calcium channel alpha 1 subunits coexpressed with novel beta
            2 subunit isoforms
  JOURNAL   Mol Pharmacol 47 (4), 707-716 (1995)
   PUBMED   7723731
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL935312.10 and AL928632.13.
            
            On May 10, 2022 this sequence version replaced NM_023116.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034054.1, BC109156.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-329               AL935312.10        73241-73569
            330-422             AL935312.10        83275-83367
            423-542             AL928632.13        42219-42338
            543-665             AL928632.13        126215-126337
            666-802             AL928632.13        128104-128240
            803-879             AL928632.13        131355-131431
            880-1013            AL928632.13        135391-135524
            1014-1094           AL928632.13        139011-139091
            1095-1153           AL928632.13        139511-139569
            1154-1263           AL928632.13        142579-142688
            1264-1415           AL928632.13        148755-148906
            1416-1511           AL928632.13        150237-150332
            1512-1700           AL928632.13        151700-151888
            1701-4924           AL928632.13        153037-156260
FEATURES             Location/Qualifiers
     source          1..4924
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 10.7 cM"
     gene            1..4924
                     /gene="Cacnb2"
                     /gene_synonym="CAB2; Cavbeta2; Cchb2"
                     /note="calcium channel, voltage-dependent, beta 2 subunit"
                     /db_xref="GeneID:12296"
                     /db_xref="MGI:MGI:894644"
     exon            1..329
                     /gene="Cacnb2"
                     /gene_synonym="CAB2; Cavbeta2; Cchb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..2189
                     /gene="Cacnb2"
                     /gene_synonym="CAB2; Cavbeta2; Cchb2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     voltage-dependent L-type calcium channel subunit beta-2;
                     calcium channel voltage-dependent beta 2 subunit isoform
                     N4b; calcium channel voltage-dependent beta 2 subunit
                     isoform N4a"
                     /codon_start=1
                     /product="voltage-dependent L-type calcium channel subunit
                     beta-2 isoform 1"
                     /protein_id="NP_075605.1"
                     /db_xref="CCDS:CCDS15702.1"
                     /db_xref="GeneID:12296"
                     /db_xref="MGI:MGI:894644"
                     /translation="MVQSDTSKSPPVAAVAQESQMELLESAAPAGALGAQSYGKGARR
                     KNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQ
                     LEKAKTKPVAFAVRTNVRYSAAQEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLV
                     KEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPS
                     SAIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPS
                     MRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSK
                     HAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYV
                     KISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPQESFDVILDENQLEDACEHL
                     ADYLEAYWKATHPPSGNLPNPLLSRTLASSTLPLSPTLASNSQGSQGDQRPDRSAPRS
                     ASQAEEEPCLEPVKKSQHRSSSATHQNHRSGTGRGLSRQETFDSETQESRDSAYVEPK
                     EDYSHEHVDRYVPHREHNHREETHSSNGHRHRESRHRSRDMGRDQDHNECIKQRSRHK
                     SKDRYCDKEGEVISKRRNEAGEWNRDVYIRQ"
     exon            330..422
                     /gene="Cacnb2"
                     /gene_synonym="CAB2; Cavbeta2; Cchb2"
                     /inference="alignment:Splign:2.1.0"
     exon            423..542
                     /gene="Cacnb2"
                     /gene_synonym="CAB2; Cavbeta2; Cchb2"
                     /inference="alignment:Splign:2.1.0"
     exon            543..665
                     /gene="Cacnb2"
                     /gene_synonym="CAB2; Cavbeta2; Cchb2"
                     /inference="alignment:Splign:2.1.0"
     exon            666..802
                     /gene="Cacnb2"
                     /gene_synonym="CAB2; Cavbeta2; Cchb2"
                     /inference="alignment:Splign:2.1.0"
     exon            803..879
                     /gene="Cacnb2"
                     /gene_synonym="CAB2; Cavbeta2; Cchb2"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1013
                     /gene="Cacnb2"
                     /gene_synonym="CAB2; Cavbeta2; Cchb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1094
                     /gene="Cacnb2"
                     /gene_synonym="CAB2; Cavbeta2; Cchb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1153
                     /gene="Cacnb2"
                     /gene_synonym="CAB2; Cavbeta2; Cchb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1263
                     /gene="Cacnb2"
                     /gene_synonym="CAB2; Cavbeta2; Cchb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1415
                     /gene="Cacnb2"
                     /gene_synonym="CAB2; Cavbeta2; Cchb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1511
                     /gene="Cacnb2"
                     /gene_synonym="CAB2; Cavbeta2; Cchb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1700
                     /gene="Cacnb2"
                     /gene_synonym="CAB2; Cavbeta2; Cchb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..4924
                     /gene="Cacnb2"
                     /gene_synonym="CAB2; Cavbeta2; Cchb2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3024..3029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cacnb2"
                     /gene_synonym="CAB2; Cavbeta2; Cchb2"
                     /note="hexamer: CATAAA"
     polyA_site      3049
                     /gene="Cacnb2"
                     /gene_synonym="CAB2; Cavbeta2; Cchb2"
     regulatory      3519..3524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cacnb2"
                     /gene_synonym="CAB2; Cavbeta2; Cchb2"
                     /note="hexamer: AATAAA"
     polyA_site      3556
                     /gene="Cacnb2"
                     /gene_synonym="CAB2; Cavbeta2; Cchb2"
                     /note="major polyA site"
     regulatory      3998..4003
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cacnb2"
                     /gene_synonym="CAB2; Cavbeta2; Cchb2"
                     /note="hexamer: AATAAA"
     polyA_site      4020
                     /gene="Cacnb2"
                     /gene_synonym="CAB2; Cavbeta2; Cchb2"
     regulatory      4899..4904
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cacnb2"
                     /gene_synonym="CAB2; Cavbeta2; Cchb2"
                     /note="hexamer: AATAAA"
     polyA_site      4924
                     /gene="Cacnb2"
                     /gene_synonym="CAB2; Cavbeta2; Cchb2"
ORIGIN      
        1 agtcccagcc tccgccgctc gcgggcccag aagctccaaa gaactggcgc ccctcgcccc
       61 ggccacccag cctcgtgcct gcgccaccgc ctagtctagg ctttgcaaca tgcttcagcg
      121 gcgtcgcgcg cactgagagc ctccgatcct ggggcgaaga ggagcggggg acccgggtcg
      181 tggaggaggg gacccgcagc cttggagtcg actttttgcc gatggtccaa agcgacacgt
      241 ccaagtcgcc tcccgtagcg gcggtggcgc aggagagcca gatggagctg ctggagagcg
      301 cggctcccgc gggggcgctc ggagcacagt cctatggaaa aggagccagg aggaaaaata
      361 gatttaaagg ctcggatgga agcacatcgt cagacactac ctcaaacagt tttgtccgcc
      421 agggttcggc agactcctac accagccgcc catccgattc agatgtgtct ttggaagagg
      481 accgggaggc agtacgtaga gaagctgagc ggcaggcaca ggcacagttg gaaaaagcaa
      541 agacaaaacc tgttgcattt gcagttcgga ccaatgtcag atacagcgca gcccaggagg
      601 atgacgttcc ggtgcctggc atggccatct ccttcgaggc caaagatttt ctgcatgtta
      661 aagaaaaatt taataatgac tggtggatag gacggctggt taaagaaggc tgtgaaatcg
      721 gatttattcc aagcccagtc aaactagaga acatgaggct acagcacgaa cagagagcca
      781 agcaagggaa attctattcc agtaaatcag gagggaattc atcatccagt ttgggtgaca
      841 tagtgcccag ttccagaaaa tcgacaccgc cgtcatctgc tatagacata gatgctactg
      901 gcttagatgc agaagagaat gatattccag caaaccaccg ctcccctaag cccagtgcaa
      961 acagtgtaac atcaccccac tccaaagaga aaagaatgcc cttctttaag aagacagagc
     1021 acactcctcc ttatgatgtg gtaccttcca tgcgaccagt ggtgctggtg ggcccgtctc
     1081 tgaaggggta tgaggtcaca gatatgatgc aaaaagcact gtttgatttt ctaaaacaca
     1141 gatttgaagg gcggatatcc atcacaagag tcactgctga catctccctt gccaaacgct
     1201 cagtattaaa caatcccagt aagcatgcaa tcatagaaag atccaacaca aggtccagct
     1261 tagcggaagt tcagagtgaa attgaaagga tttttgaact tgcaagaaca ctgcaattgg
     1321 tagtccttga cgcggataca attaatcacc cagctcaact cagtaagacc tctttggccc
     1381 ctatcatagt gtacgtaaag atttcttctc ccaaggtttt acaaaggttg ataaaatctc
     1441 gagggaaatc tcaagcaaaa cacctcaatg tccagatggt agcagctgat aaactggccc
     1501 aatgtcctcc gcaggaatca tttgatgtga tcttggatga gaaccagctg gaggacgctt
     1561 gtgagcatct tgccgactat ctggaggcat actggaaggc cacccaccct cccagcggta
     1621 acctccccaa ccctctgctt agccggactt tagcctcctc aactttacct ctgagcccca
     1681 ccctcgcctc taattcacag ggttctcaag gtgatcaaag gcctgatcgc tctgctcccc
     1741 ggtctgcttc ccaagctgaa gaagaacctt gcctagaacc cgtcaaaaaa tcccaacacc
     1801 gttcctcctc agccacacac caaaaccacc gcagcgggac aggtcgaggc ctctctaggc
     1861 aagagacgtt tgactctgaa acccaagaga gccgagactc tgcctacgtg gagccaaagg
     1921 aagattattc acatgaacat gtggaccggt atgtcccaca ccgcgagcat aaccacagag
     1981 aggagaccca cagcagcaat ggccacagac acagggagtc tcgccaccgc tctagggaca
     2041 tgggtcgaga ccaggaccac aatgagtgca tcaaacaacg aagccggcat aaatctaagg
     2101 atcgctactg tgacaaggag ggggaagtaa tatccaagag aaggaatgag gctggcgagt
     2161 ggaacaggga tgtatacatc cgccaatgac cgtgcgtgtc cctaccccca agtctttgtg
     2221 tatcatcctt aagcaaaatc tttgggggtt acattgcaac catatgtgat ttgtcttgtc
     2281 tattttgtat tgctgttgct ccaatagcaa tggcatgcaa tcaagtatta ctatacattc
     2341 ttttgtaagt accacagaaa ttggcctagt acagctgcag actatatcct gaacaattca
     2401 aaagctgttt gggtagctgc catctcaaca gagtggctcc agaaacgtag ttactatatc
     2461 cagtgagcca gatgcagcgc agataacaag tgggatttct ccgtattttc aatacccaga
     2521 tacctgacct gtcattcttt catggaccac tgtttcttgc ttgtacctct ggctgactaa
     2581 atttggggat agattcagtc ttgccttaca caaaggggat tataaagtta gaatctattt
     2641 tctatgtact agtactgtgt actgtgtaga cagtttgtaa atgttatttc tgcaaacacc
     2701 ttattataat tatatatgta tatataatta tatatacgta tatataatta tatatacata
     2761 tatatatata tatatatata tatatatata tatatatata tcagtttgat cacacaattt
     2821 tagggtctta atgccaagtc agcaggtttg ctttatgaat cacagggact agaaatgccc
     2881 acattcagga aatttctaat attgtctaga taactctccc tattctaaga gagagactgt
     2941 acatactgta aatacgtgtg attgcttgac ttgaggcttg atttatgaat gtaatcccat
     3001 ccttgtaagt ttttcatttt aaccataaat tatggtaaat gtaaccaaac tccagaggtt
     3061 tttctactcc atacagtcca cactgattgt gacaaacaca ttcttagcag ctagtgtctg
     3121 ttatagtcac cgcactggag tatccaagcg gagcccacca tgtgcacatg cgcgtgtgag
     3181 tgagtgagtg tgtgagcggc tgagatgaag tggaactcgg aagacgaatg cggaaagcag
     3241 aggctgctgg ctgagagttc ggcccacctg gctctgtact taactgtgtt gtatgttgct
     3301 ttcaaaccca ctgagcagcc agggaatgtg aggaagcttg ctgccaaagg aacgaaggaa
     3361 gcactcggct gctgacgcct agcttttgcc cctgaagaga gcaaacatgg gcatcttgta
     3421 ctgtgagtgt tccactggaa atggacaatc tttgtgtgtc agagtatttt gttttagtaa
     3481 gaaatgttta cacagcttgt gcaattattt cgtagggaaa taaattttta taactcgtcc
     3541 cactttcctt tctaaacgtg cctcttgctc ctgttgttta tcctcagcca cccactcttc
     3601 ctcccccagc accaacctga gcagccacac tgtctgtcag aatctagaag tgcttcttat
     3661 aaccaaagtt cctgctcaag cttcagaagt tatcagggca aaatggaatg acttgaagca
     3721 aaaaagttga aacactctct tacaggacac atctctgaag gagaacctag aagacacttt
     3781 cttcttgcct caatttgcct gtgttaagaa gcttagacta tacaatagcc aagactatac
     3841 agtctctctc tctctctctc aagagtccag tgctaatgga tggataggta agactgtatt
     3901 agccgcaaga gcccctagca ttcgaagtct ttcacaggca aacgtctgcc tgtgattacc
     3961 caaccagatt ggtatattac taacaaatca tggttacaat aaatatattt ttgttttgtt
     4021 tcctggttat ttcatattct tctgaaatac tcgtaggcat ttatgtaaag cagttttaca
     4081 tttactactt tatcctatac ccaagaaaac tcgagcgttt aaaacaggaa ttgcatatat
     4141 attttaccag tggttttacc tgcttagaga atgaaaattt tccttagaat cagcactgta
     4201 cttatagaat ttatacacta tacacagtaa tttcagaccc aaatttagaa agcactcatc
     4261 agagactctg agcagtgatc tattcccttc ctctgtgtgt gtgtgtgtgt gtgtgtttca
     4321 tccagaggaa tggctgagac attcagcctc atgatggtgt ttctcatacc tgcagtaacc
     4381 atgcatccct ttcataaact agttctaatg ttgtccatcc atctgcttac tgtgcgcatg
     4441 tgtgtgcaca tcactgcatc cctccactct gctgaagggt cttatacagg gcacctctgt
     4501 gtgaaagcac acactggggc tccatcagca gtgtgtgctt gacctctcaa ctgactacta
     4561 ggatgtaaca ctgctcttta cacagcaaaa gtttaatctt aaccaactcc gtggtagaat
     4621 cctgattttt ttttttctgt agtcaagcca ggaaatgctg gggatgtagt taatagtgtt
     4681 atacttctgt gtcagccact tcagttttcc ctgtgctttc taaactgctc acttactgtt
     4741 accaaaaaaa ggtgctgcta aaagtaggtt gtcttcagtc atcctgtacc acagacaata
     4801 ccacatttga acatgtctgc tctgcctccc tgttcgacac tcactgtcac gacactgaac
     4861 tgtttgatga acttggttta aagtaattca tggaaacaaa taaagagctg gcttctgcac
     4921 tgtt
//
