LOCUS       NM_001282977            3520 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus calcium channel, voltage-dependent, beta 1 subunit
            (Cacnb1), transcript variant 5, mRNA.
ACCESSION   NM_001282977
VERSION     NM_001282977.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3520)
  AUTHORS   Montanes-Agudo,P., Aufiero,S., Schepers,E.N., van der Made,I.,
            Cocera-Ortega,L., Ernault,A.C., Richard,S., Kuster,D.W.D.,
            Christoffels,V.M., Pinto,Y.M. and Creemers,E.E.
  TITLE     The RNA-binding protein QKI governs a muscle-specific alternative
            splicing program that shapes the contractile function of
            cardiomyocytes
  JOURNAL   Cardiovasc Res 119 (5), 1161-1174 (2023)
   PUBMED   36627242
REFERENCE   2  (bases 1 to 3520)
  AUTHORS   Chen,X., Liu,Y., Xu,C., Ba,L., Liu,Z., Li,X., Huang,J., Simpson,E.,
            Gao,H., Cao,D., Sheng,W., Qi,H., Ji,H., Sanderson,M., Cai,C.L.,
            Li,X., Yang,L., Na,J., Yamamura,K., Liu,Y., Huang,G., Shou,W. and
            Sun,N.
  TITLE     QKI is a critical pre-mRNA alternative splicing regulator of
            cardiac myofibrillogenesis and contractile function
  JOURNAL   Nat Commun 12 (1), 89 (2021)
   PUBMED   33397958
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3520)
  AUTHORS   Fecher-Trost,C., Lux,F., Busch,K.M., Raza,A., Winter,M.,
            Hielscher,F., Belkacemi,T., van der Eerden,B., Boehm,U.,
            Freichel,M. and Weissgerber,P.
  TITLE     Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is
            Involved In Offspring Bone Development
  JOURNAL   J Bone Miner Res 34 (4), 699-710 (2019)
   PUBMED   30786075
REFERENCE   4  (bases 1 to 3520)
  AUTHORS   Liu,Y., Sugiura,Y., Chen,F., Lee,K.F., Ye,Q. and Lin,W.
  TITLE     Blocking skeletal muscle DHPRs/Ryr1 prevents neuromuscular synapse
            loss in mutant mice deficient in type III Neuregulin 1 (CRD-Nrg1)
  JOURNAL   PLoS Genet 15 (3), e1007857 (2019)
   PUBMED   30870432
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3520)
  AUTHORS   Kaplan,M.M., Sultana,N., Benedetti,A., Obermair,G.J., Linde,N.F.,
            Papadopoulos,S., Dayal,A., Grabner,M. and Flucher,B.E.
  TITLE     Calcium Influx and Release Cooperatively Regulate AChR Patterning
            and Motor Axon Outgrowth during Neuromuscular Junction Formation
  JOURNAL   Cell Rep 23 (13), 3891-3904 (2018)
   PUBMED   29949772
REFERENCE   6  (bases 1 to 3520)
  AUTHORS   Gregg,R.G., Messing,A., Strube,C., Beurg,M., Moss,R., Behan,M.,
            Sukhareva,M., Haynes,S., Powell,J.A., Coronado,R. and Powers,P.A.
  TITLE     Absence of the beta subunit (cchb1) of the skeletal muscle
            dihydropyridine receptor alters expression of the alpha 1 subunit
            and eliminates excitation-contraction coupling
  JOURNAL   Proc Natl Acad Sci U S A 93 (24), 13961-13966 (1996)
   PUBMED   8943043
REFERENCE   7  (bases 1 to 3520)
  AUTHORS   Mock,B.A., Krall,M.M., Byrd,L.G., Chin,H., Barton,C.H., Charles,I.,
            Liew,F.Y. and Blackwell,J.
  TITLE     The inducible form of nitric oxide synthase (NOS2) isolated from
            murine macrophages maps near the nude mutation on mouse chromosome
            11
  JOURNAL   Eur J Immunogenet 21 (4), 231-238 (1994)
   PUBMED   9098436
REFERENCE   8  (bases 1 to 3520)
  AUTHORS   Perez-Reyes,E., Castellano,A., Kim,H.S., Bertrand,P., Baggstrom,E.,
            Lacerda,A.E., Wei,X.Y. and Birnbaumer,L.
  TITLE     Cloning and expression of a cardiac/brain beta subunit of the
            L-type calcium channel
  JOURNAL   J Biol Chem 267 (3), 1792-1797 (1992)
   PUBMED   1370480
REFERENCE   9  (bases 1 to 3520)
  AUTHORS   Pragnell,M., Sakamoto,J., Jay,S.D. and Campbell,K.P.
  TITLE     Cloning and tissue-specific expression of the brain calcium channel
            beta-subunit
  JOURNAL   FEBS Lett 291 (2), 253-258 (1991)
   PUBMED   1657644
REFERENCE   10 (bases 1 to 3520)
  AUTHORS   Ruth,P., Rohrkasten,A., Biel,M., Bosse,E., Regulla,S., Meyer,H.E.,
            Flockerzi,V. and Hofmann,F.
  TITLE     Primary structure of the beta subunit of the DHP-sensitive calcium
            channel from skeletal muscle
  JOURNAL   Science 245 (4922), 1115-1118 (1989)
   PUBMED   2549640
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591209.17.
            
            On Nov 14, 2022 this sequence version replaced NM_001282977.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB685743.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-289               AL591209.17        103063-103351       c
            290-376             AL591209.17        100401-100487       c
            377-496             AL591209.17        97444-97563         c
            497-619             AL591209.17        93533-93655         c
            620-756             AL591209.17        92906-93042         c
            757-833             AL591209.17        92587-92663         c
            834-988             AL591209.17        92064-92218         c
            989-1069            AL591209.17        91017-91097         c
            1070-1128           AL591209.17        90579-90637         c
            1129-1238           AL591209.17        90290-90399         c
            1239-1390           AL591209.17        90002-90153         c
            1391-1486           AL591209.17        86409-86504         c
            1487-1672           AL591209.17        85850-86035         c
            1673-3520           AL591209.17        82236-84083         c
FEATURES             Location/Qualifiers
     source          1..3520
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 61.5 cM"
     gene            1..3520
                     /gene="Cacnb1"
                     /gene_synonym="CAB1; Cchb1; Cchlb1"
                     /note="calcium channel, voltage-dependent, beta 1 subunit"
                     /db_xref="GeneID:12295"
                     /db_xref="MGI:MGI:102522"
     exon            1..289
                     /gene="Cacnb1"
                     /gene_synonym="CAB1; Cchb1; Cchlb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..2134
                     /gene="Cacnb1"
                     /gene_synonym="CAB1; Cchb1; Cchlb1"
                     /note="isoform E is encoded by transcript variant 5;
                     voltage-dependent L-type calcium channel subunit beta-1;
                     voltage-dependent calcium channel beta1 subunit; calcium
                     channel voltage-dependent subunit beta 1"
                     /codon_start=1
                     /product="voltage-dependent L-type calcium channel subunit
                     beta-1 isoform E"
                     /protein_id="NP_001269906.1"
                     /db_xref="GeneID:12295"
                     /db_xref="MGI:MGI:102522"
                     /translation="MVQKSGMSRGPYPPSQEIPMEVFDPSPQGKYSKRKGRFKRSDGS
                     TSSDTTSNSFVRQGSAESYTSRPSDSDVSLEEDREALRKEAERQALAQLEKAKTKPVA
                     FAVRTNVGYNPSPGDEVPVQGVAITFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIP
                     SPVKLDSLRLLQEQTLRQNRLSSSKSGDNSSSSLGDVVTGTRRPTPPASGNEMTNFAF
                     ELDPLELEEEEAELGEHGGSAKTSVSSVTTPPPHGKRIPFFKKTEHVPPYDVVPSMRP
                     IILVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKHII
                     IERSNTRSSLAEVQSEIERIFELARTLQLVALDADTINHPAQLSKTSLAPIIVYIKIT
                     SPKVLQRLIKSRGKSQSKHLNVQIAASEKLAQCPPEMFDIILDENQLEDACEHLAEYL
                     EAYWKATHPPSSTPPNPLLNRTMATAALAASPAPVSNLQGPYLASGDQPLDRATGEHA
                     SVHEYPGELGQPPGLYPSNHPPGRAGTLRALSRQDTFDADTPGSRNSAYTEPGDSCVD
                     METDPSEGPGPGDPAGGGTPPARQGSWEDEEDYEEEMTDNRNRGRNKARYCAEGGGPV
                     LGRNKNELEGWGQGVYIR"
     exon            290..376
                     /gene="Cacnb1"
                     /gene_synonym="CAB1; Cchb1; Cchlb1"
                     /inference="alignment:Splign:2.1.0"
     exon            377..496
                     /gene="Cacnb1"
                     /gene_synonym="CAB1; Cchb1; Cchlb1"
                     /inference="alignment:Splign:2.1.0"
     exon            497..619
                     /gene="Cacnb1"
                     /gene_synonym="CAB1; Cchb1; Cchlb1"
                     /inference="alignment:Splign:2.1.0"
     exon            620..756
                     /gene="Cacnb1"
                     /gene_synonym="CAB1; Cchb1; Cchlb1"
                     /inference="alignment:Splign:2.1.0"
     exon            757..833
                     /gene="Cacnb1"
                     /gene_synonym="CAB1; Cchb1; Cchlb1"
                     /inference="alignment:Splign:2.1.0"
     exon            834..988
                     /gene="Cacnb1"
                     /gene_synonym="CAB1; Cchb1; Cchlb1"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1069
                     /gene="Cacnb1"
                     /gene_synonym="CAB1; Cchb1; Cchlb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1128
                     /gene="Cacnb1"
                     /gene_synonym="CAB1; Cchb1; Cchlb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1238
                     /gene="Cacnb1"
                     /gene_synonym="CAB1; Cchb1; Cchlb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1390
                     /gene="Cacnb1"
                     /gene_synonym="CAB1; Cchb1; Cchlb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1486
                     /gene="Cacnb1"
                     /gene_synonym="CAB1; Cchb1; Cchlb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1672
                     /gene="Cacnb1"
                     /gene_synonym="CAB1; Cchb1; Cchlb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..3520
                     /gene="Cacnb1"
                     /gene_synonym="CAB1; Cchb1; Cchlb1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3490..3495
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cacnb1"
                     /gene_synonym="CAB1; Cchb1; Cchlb1"
                     /note="hexamer: TATAAA"
     polyA_site      3520
                     /gene="Cacnb1"
                     /gene_synonym="CAB1; Cchb1; Cchlb1"
                     /note="major polyA site"
ORIGIN      
        1 ggcgacggcg gcagcggccg cagagagcac agcgcgagcc gggagggcaa gcaaggcggc
       61 gagcgtgcag ccggaggtcc agctgggaga ctgcacccgg tgctggctgc gcgacgccgc
      121 gctgctctgg gctcggacgg cctctcccat gcgctgagag cgcccggctg ggctgggagg
      181 gcggccggac cggaggatcc tctccatggt ccagaagagc ggcatgtccc ggggccctta
      241 cccaccttcc caagagatcc ctatggaggt cttcgacccc agcccacagg gcaagtacag
      301 caagaggaaa gggcggttca aaaggtcaga cgggagtacg tcctcggata caacatccaa
      361 cagcttcgtc cgccagggct cagcagagtc ctacacgagc cgaccatcag actctgatgt
      421 gtctctggag gaggaccggg aagccttaag gaaggaggca gagcgccagg ccttagccca
      481 gctcgagaaa gccaagacca aaccagtggc ttttgctgtt cggacaaatg ttggctacaa
      541 tccgtctcca ggggatgagg tgcctgtaca gggagtggcc atcacctttg agcccaagga
      601 cttcctacac atcaaggaga agtacaataa tgactggtgg attgggcggc tggtgaagga
      661 aggctgcgag gttggcttca tccccagccc ggtcaaactg gacagccttc gtctgctgca
      721 ggaacagacc ctgcgccaga accgcctcag ctccagcaag tcaggtgaca actccagttc
      781 cagtctggga gatgtggtga ctggcacccg ccgccccaca ccccctgcca gtggtaatga
      841 aatgactaac tttgcctttg agctagaccc cctagagtta gaggaggagg aggcagagct
      901 aggggagcac ggcggctcag ccaagactag cgtgagcagt gtcaccacgc cgccacccca
      961 cggcaagcgc atccccttct ttaagaagac agagcacgtg cccccctatg acgtggtgcc
     1021 ttccatgagg cccatcatcc tggtgggacc gtcgctcaag ggctatgagg tgacagacat
     1081 gatgcagaaa gcgttgtttg acttcctcaa gcatcggttt gatggcagga tttccatcac
     1141 ccgggtaaca gctgacattt ccctggccaa acgctccgtc ctcaacaacc ccagcaaaca
     1201 catcatcatt gagcgctcca acacgcgttc cagcctggct gaggtacaga gtgaaattga
     1261 gaggatcttc gagctggccc ggaccttgca gctggtcgcc ttggacgctg acaccatcaa
     1321 ccacccagcc cagctctcta aaacgtcgct ggcccccatc attgtttaca tcaagatcac
     1381 atctcccaag gtactgcaga ggctcatcaa atcccgaggg aagtctcaat ccaaacacct
     1441 caatgtccaa atagcagcct cggagaagct ggcacagtgt ccccccgaaa tgtttgacat
     1501 aatcctggac gagaaccaat tggaagatgc ctgcgagcac ctggctgagt acttggaagc
     1561 ctactggaag gccacacatc cgcctagcag cacgccaccc aatccgctgc tgaaccgcac
     1621 catggctacc gcagctctgg ctgccagccc tgcccccgtc tccaacctcc agggacccta
     1681 ccttgcttcc ggggaccagc cgctggaccg ggccactggg gaacatgcca gtgtgcacga
     1741 gtaccccggg gaactgggcc agcccccagg cctttacccc agcaaccacc cacctggccg
     1801 ggcaggcacc ctgcgggcgc tatcccgcca agacaccttt gatgctgaca cccccggcag
     1861 ccgaaattct gcctacacgg agccgggaga ctcgtgtgtg gacatggaga cagacccctc
     1921 agagggccca gggcctggag accctgcagg gggaggcaca ccaccagccc ggcagggctc
     1981 ctgggaagac gaggaagact atgaggagga gatgaccgac aacaggaacc ggggccggaa
     2041 taaggcccgc tactgtgcgg agggtggtgg gccggttctg gggcgcaata agaatgagct
     2101 ggagggctgg ggacaaggcg tctacatccg ctgagaggca agggcagttc tgggagagga
     2161 aaggctctga gctcggggag gggaagggag ggcagagggg cacaccaccc aagatgtgtc
     2221 ttgcctccag ggggcgctgt gtccctcgtt ttcagatgcc tttgcttaaa gcttggggtt
     2281 tctttggtgg taattatccc agctcttggg aggtccttaa tccccagctg taggtttttc
     2341 cctaaactgc tgtaggtgga tgggggaatg cctactttct gaagtgcccc ctttccccat
     2401 ctttgggggc tctctccctc ccagagaaaa ggtgcacttc ctcaactctt tctactcggg
     2461 gctgtaagcg aaggtcttaa tcggggtggg ggtgggggct tcttctacca acacaggggt
     2521 acttgggaaa ggttgggtgc ttttcctgaa gagagcccgc tgaatcttcc ccaatccccc
     2581 agacccggga tcccccacca tgtccatccc ataacataac agtttcctag cagcattctc
     2641 tggtgggtga aaggcacggc ttggaaaccc ttggggagca gagctgggtg caggctgctg
     2701 ggcatcagtg cgcgctctct gccctccatg gtcatagcaa gaaagcaggt cctagaacct
     2761 tgaggagtga gcaactcaag atgctgcccc cctccctcca ccccttgcct cccccaggaa
     2821 tgagctttgt ctacagcata ccctgcctgc tgccatcagg agagaggggc cctctgcatc
     2881 tgagccccac atctccgtgc cacctgggtg tggagaccat gaatactttg tggtccacct
     2941 cattctaaac caaaaaaact gctccttcac cgtcaccctg aggccccagg ggacaggctc
     3001 tatgtgttgg tacccgtgag gtgaccacca tccaggggct tcctaaggac cttgggtctc
     3061 ccctaggggt cttggttgct gctgcttctc tgtatttgcc tcttgtgacc ctgtccttcc
     3121 ccagtgtcca ctttccccaa gagaggccat ggtagcccct ctcccctggg gttcccttag
     3181 cctcagcatc cctaagagtc cagcagccct gccccctccc cagcatcaca gctggtccag
     3241 agagagccga ttgtgccaac gaggactggg ccctgcccag ctgcccacct cagggatggg
     3301 cacctcacgc ctgtctcgcc acctcctgtg ccaatgttgc cccaccctcc tggggggtgg
     3361 ggtgcagctt ccactaacag gttagaagat agcactgccc aacctttcgc tccctgcccc
     3421 ggtctactgt cctgtgccca tctgtctgtc tgtctgtctg tactcctcta ggagagatat
     3481 tttgccacat ataaaaccgc agttctgtcc tttgcggcca
//
