LOCUS       NM_009785               3710 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus calcium channel, voltage-dependent, alpha2/delta
            subunit 3 (Cacna2d3), mRNA.
ACCESSION   NM_009785
VERSION     NM_009785.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3710)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   2  (bases 1 to 3710)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3710)
  AUTHORS   Shao,W., Zheng,H., Zhu,J., Li,W., Li,Y., Hu,W., Zhang,J., Jing,L.,
            Wang,K. and Jiang,X.
  TITLE     Deletions of Cacna2d3 in parvalbumin-expressing neurons leads to
            autistic-like phenotypes in mice
  JOURNAL   Neurochem Int 169, 105569 (2023)
   PUBMED   37419212
  REMARK    GeneRIF: Deletions of Cacna2d3 in parvalbumin-expressing neurons
            leads to autistic-like phenotypes in mice.
REFERENCE   4  (bases 1 to 3710)
  AUTHORS   Wadle,S.L., Schmitt,T.T.X., Engel,J., Kurt,S. and Hirtz,J.J.
  TITLE     Altered population activity and local tuning heterogeneity in
            auditory cortex of Cacna2d3-deficient mice
  JOURNAL   Biol Chem 404 (6), 607-617 (2022)
   PUBMED   36342370
  REMARK    GeneRIF: Altered population activity and local tuning heterogeneity
            in auditory cortex of Cacna2d3-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3710)
  AUTHORS   Ablinger,C., Eibl,C., Geisler,S.M., Campiglio,M., Stephens,G.J.,
            Missler,M. and Obermair,G.J.
  TITLE     alpha2delta-4 and Cachd1 Proteins Are Regulators of Presynaptic
            Functions
  JOURNAL   Int J Mol Sci 23 (17), 9885 (2022)
   PUBMED   36077281
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3710)
  AUTHORS   Schilling,K. and Oberdick,J.
  TITLE     The treasury of the commons: making use of public gene expression
            resources to better characterize the molecular diversity of
            inhibitory interneurons in the cerebellar cortex
  JOURNAL   Cerebellum 8 (4), 477-489 (2009)
   PUBMED   19554387
REFERENCE   7  (bases 1 to 3710)
  AUTHORS   Shibasaki,M., Kurokawa,K. and Ohkuma,S.
  TITLE     Role of alpha2/delta subunit in the development of morphine-induced
            rewarding effect and behavioral sensitization
  JOURNAL   Neuroscience 163 (3), 731-734 (2009)
   PUBMED   19596051
REFERENCE   8  (bases 1 to 3710)
  AUTHORS   Harrell,M.D., Harbi,S., Hoffman,J.F., Zavadil,J. and Coetzee,W.A.
  TITLE     Large-scale analysis of ion channel gene expression in the mouse
            heart during perinatal development
  JOURNAL   Physiol Genomics 28 (3), 273-283 (2007)
   PUBMED   16985003
REFERENCE   9  (bases 1 to 3710)
  AUTHORS   Ding,S., Wu,X., Li,G., Han,M., Zhuang,Y. and Xu,T.
  TITLE     Efficient transposition of the piggyBac (PB) transposon in
            mammalian cells and mice
  JOURNAL   Cell 122 (3), 473-483 (2005)
   PUBMED   16096065
REFERENCE   10 (bases 1 to 3710)
  AUTHORS   Klugbauer,N., Lacinova,L., Marais,E., Hobom,M. and Hofmann,F.
  TITLE     Molecular diversity of the calcium channel alpha2delta subunit
  JOURNAL   J Neurosci 19 (2), 684-691 (1999)
   PUBMED   9880589
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ010949.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ010949.1, MK327280.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3710
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 16.8 cM"
     gene            1..3710
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /note="calcium channel, voltage-dependent, alpha2/delta
                     subunit 3"
                     /db_xref="GeneID:12294"
                     /db_xref="MGI:MGI:1338890"
     exon            1..219
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..3373
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /note="voltage-dependent calcium channel subunit
                     alpha-2/delta-3; voltage-gated calcium channel subunit
                     alpha-2/delta-3; alpha 2 delta-3; voltage-dependent
                     calcium channel alpha2/delta-3 transcript"
                     /codon_start=1
                     /product="voltage-dependent calcium channel subunit
                     alpha-2/delta-3 precursor"
                     /protein_id="NP_033915.1"
                     /db_xref="GeneID:12294"
                     /db_xref="MGI:MGI:1338890"
                     /translation="MAGPGSLCCASRGASALLATALLYAALGDVVRSEQQIPLSVVKL
                     WASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKKLAKIMEEMFHKK
                     SEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHF
                     NNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAK
                     GFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGLRLTIAK
                     QTVSSILDTLGDDDFFNIITYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKG
                     IGMLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRI
                     FTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQEHDV
                     VWTEAYIDSTLPQAQKLADDQGLVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKE
                     LLKTIPKYKLGIHGYAFAITNNGYILTHPELRPLYEEGKKRRKPNYSSVDLSEVEWED
                     RDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYYTDIKGTPFSLGVALSRGH
                     GKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEP
                     LLQCDKELIQEVLFDAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLF
                     VGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIAGSFVYSIPFSTGTVNKSNVV
                     TASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVNC
                     YLIDNNGFILVSEDYTQTGDFFGEVEGAVMNKLLTMGSFKRITLYDYQAMCRANKESS
                     DSAHGLLDPYKAFLSAAKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTLEPCDTE
                     YPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPI
                     EIRYNESLKCERLKAQKIRRRPESCHGFHPEENARECGGASSLQAQAALLLLPLVSSL
                     FSR"
     exon            220..301
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            302..418
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            419..478
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            479..641
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            642..773
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            774..834
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            835..985
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1060
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1150
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1264
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1343
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1477
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1495
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1567
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1648
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1723
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1807
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1879
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..1941
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2009
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2055
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2153
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2247
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2343
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            2344..2465
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..2546
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2608
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            2609..2653
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..2716
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..2787
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            2788..2863
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            2864..2916
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            2917..2972
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3084
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            3085..3197
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            3198..3280
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     exon            3281..3695
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3673..3678
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /note="hexamer: AATAAA"
     polyA_site      3695
                     /gene="Cacna2d3"
                     /gene_synonym="alapha2delta3; Cacnad3"
                     /note="major polyA site"
ORIGIN      
        1 gcgcggcgga gcaggcagcc cagcgcgctc gcccaccgcc cgcccggcgc agctctccgc
       61 ggccgctcca gtcgccgccg ccgccgccgc cgccaggatg gccgggccgg gctcgctgtg
      121 ctgcgcgtcc cggggggcct cggcgctcct agccaccgcg cttctctacg ccgctctggg
      181 ggacgtggtg cgctccgagc agcagatccc gctctccgta gtgaagctgt gggcctccgc
      241 ttttggtggg gagataaaat ccatcgctgc caagtactcg ggctcccagc ttctgcaaaa
      301 gaaatacaaa gagtatgaga aggacgttgc cattgaagaa atcgacggtc tccaactggt
      361 gaagaagttg gctaaaatca tggaggagat gttccacaag aagtccgagg cagtgaggcg
      421 tcttgtggag gctgcagagg aggcacacct gaaacatgaa tttgatgctg acttgcagta
      481 tgaatacttc aatgctgtgc tgatcaacga gagggacaaa gacgggaact ttttggaatt
      541 gggaaaggaa ttcatcttag cccccaatga ccattttaat aatttgcctg tgaacatcag
      601 tctgagtgat gtgcaagtgc caacgaacat gtacaacaaa gatcctgcca ttgtcaatgg
      661 agtgtattgg tctgaatctc taaacaaagt ttttgtggat aactttgatc gggatccgtc
      721 tctcatatgg cagtactttg gaagtgcaaa gggctttttc agacagtacc cagggattaa
      781 atgggaacca gatgagaatg gagtcattgc ctttgactgc aggaacagaa aatggtacat
      841 ccaggcagcg acttctccaa aggatgttgt cattttggtg gacgtcagtg ggagcatgaa
      901 aggactccgc ttgaccatcg ccaagcaaac agtgtcctca atactggata ctctgggtga
      961 tgatgacttc ttcaacatca tcacgtataa cgaagagctt cactatgtgg aaccttgtct
     1021 gaacggaaca ctggttcaag ctgacaggac caacaaggag cacttcaggg agcatttgga
     1081 caaacttttt gccaaaggga ttggaatgct ggatatcgca ctgaacgagg ccttcaacat
     1141 actgagcgat ttcaaccaca ctggacaagg aagcatttgc agccaggcca tcatgctcat
     1201 aactgatggg gcagtggaca cctatgatac catctttgca aaatataatt ggccagaccg
     1261 aaaggttcga atctttactt acctcattgg acgggaggct gcttttgccg acaatctcaa
     1321 gtggatggct tgtgctaaca aaggattttt cacccagatc tccaccttgg ctgatgtgca
     1381 ggaaaatgtc atggaatacc tccatgtgct tagccgacct aaagtcattg accaggagca
     1441 tgatgtggtg tggaccgaag cgtacattga cagcaccctc cctcaggctc aaaagcttgc
     1501 tgatgatcag ggcctcgtct tgatgaccac ggtggccatg cctgtgttta gtaagcagaa
     1561 cgaaactagg tcaaagggca ttcttctggg tgtggttggc acagatgtcc cagttaaaga
     1621 gcttctgaag accatcccca aatacaagtt aggaattcat ggttacgcct tcgccatcac
     1681 gaataatgga tatatcctga cgcacccgga gctcaggcca ctgtatgaag aaggaaaaaa
     1741 acggaggaaa cccaactaca gtagtgtgga tctctctgaa gtcgagtggg aagaccggga
     1801 tgatgtgtta cgaaatgcca tggtaaatcg gaagactggg aaattctcca tggaagtgaa
     1861 gaagaccgtg gacaaaggga aacgggtttt ggtgatgacc aatgactact actatacaga
     1921 catcaagggt actcctttca gtttaggtgt ggcgctctcc aggggccatg ggaaatactt
     1981 cttccgaggg aatgtaacca ttgaagaagg cctccatgac ttagaacatc ctgacgtgtc
     2041 cttggcagat gaatggtcct actgcaacac tgacctgcac ccagagcacc gccatctatc
     2101 tcaactggaa gccattaagc tctacctcaa aggcaaggag cctctgcttc aatgtgacaa
     2161 agaattgatt caagaagtcc tttttgatgc tgtggtgagc gcccctattg aagcctattg
     2221 gacgagcctg gccctcaaca aatctgagaa ttctgacaag ggtgtagagg tcgccttcct
     2281 cggcactcgc acaggcctct caagaatcaa cctgtttgtg ggggccgaac aactcaccaa
     2341 tcaggacttt ctgaaggctg gagacaaaga gaacattttt aatgccgatc atttccctct
     2401 ctggtacaga agagctgccg agcagatcgc aggaagcttt gtctattcca tccccttcag
     2461 cacaggaaca gtcaacaaaa gcaatgtggt gacagcaagt acctccatcc agctcctgga
     2521 tgagcggaaa tctcccgtgg tggcagctgt aggcattcag atgaaacttg aattcttcca
     2581 aaggaagttc tggactgcca gcagacagtg tgcctccctg gatggcaaat gctccataag
     2641 ctgcgatgac gagactgtga actgttacct tatagacaat aacggattca ttctggtgtc
     2701 tgaagactac acacagactg gagatttttt tggtgaggtg gaaggagctg tcatgaacaa
     2761 gttgttaaca atgggttcct ttaaaagaat aaccttgtac gactaccaag ccatgtgtag
     2821 agccaacaag gagagcagtg acagtgccca tggacttctg gacccctata aggcctttct
     2881 ctctgcagcc aagtggataa tgacggaact tgtcttgttc ctggtggagt ttaacctgtg
     2941 cagttggtgg cactccgaca tgacagctaa agcccagaaa ctgaaacaga ccctggaacc
     3001 ttgtgatact gaatacccag cctttgtttc tgaacgcacc atcaaggaga ccacagggaa
     3061 cattgcttgc gaagactgct ccaagtcctt cgtcatccag caaatcccga gtagcaatct
     3121 gttcatggtg gtggtggaca gtagctgtct ctgtgagtcc gtggctccta taaccatggc
     3181 acccattgaa atcaggtata atgaatccct taagtgtgaa cggttaaagg ctcagaagat
     3241 cagacgacgt ccagaatcct gccacggctt ccatcctgag gagaatgcaa gagagtgtgg
     3301 gggtgcatcg agtcttcagg cccaggcggc cttgctgctg ctgcccctgg tttcgagtct
     3361 cttctcaagg tgacactaac taatgggatg ttcttttggc atgctataaa tcatggataa
     3421 actgtgaacc caactatggt gcgacatagg agacataagc atagcccagc catcagcatc
     3481 tcatgatttt aaactgtgcg tgatagaaac tctaacaggt acattgacaa aaagttatct
     3541 ttttactttg ccagtcatgc aaatgtgaat ttgccacatg atcacccttc atcagaaatg
     3601 gggctgtact gggtaggcag tgtccttctg cttgaaaacc atggaaacca atttaaaact
     3661 gtgtactttt taaataaagt atattaaaat cataaaaaaa aaaaaaaaaa
//
