LOCUS       NM_001174049            5512 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus calcium channel, voltage-dependent, alpha 2/delta
            subunit 2 (Cacna2d2), transcript variant 4, mRNA.
ACCESSION   NM_001174049
VERSION     NM_001174049.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5512)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5512)
  AUTHORS   Sun,T., Grassam-Rowe,A., Pu,Z., Li,Y., Ren,H., An,Y., Guo,X.,
            Hu,W., Liu,Y., Zheng,Y., Liu,Z., Kou,K., Ou,X., Chen,T., Fan,X.,
            Liu,Y., Tu,S., He,Y., Ren,Y., Chen,A., Shang,Z., Xia,Z.,
            Miquerol,L., Smart,N., Zhang,H., Tan,X., Shou,W. and Lei,M.
  TITLE     Dbh+ catecholaminergic cardiomyocytes contribute to the structure
            and function of the cardiac conduction system in murine heart
  JOURNAL   Nat Commun 14 (1), 7801 (2023)
   PUBMED   38016975
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5512)
  AUTHORS   Moreau,M.X., Saillour,Y., Elorriaga,V., Bouloudi,B., Delberghe,E.,
            Deutsch Guerrero,T., Ochandorena-Saa,A., Maeso-Alonso,L.,
            Marques,M.M., Marin,M.C., Spassky,N., Pierani,A. and Causeret,F.
  TITLE     Repurposing of the multiciliation gene regulatory network in fate
            specification of Cajal-Retzius neurons
  JOURNAL   Dev Cell 58 (15), 1365-1382 (2023)
   PUBMED   37321213
REFERENCE   4  (bases 1 to 5512)
  AUTHORS   Beeson,K.A., Westbrook,G.L. and Schnell,E.
  TITLE     alpha2delta-2 is required for depolarization-induced suppression of
            excitation in Purkinje cells
  JOURNAL   J Physiol 600 (1), 111-122 (2022)
   PUBMED   34783012
  REMARK    GeneRIF: alpha2delta-2 is required for depolarization-induced
            suppression of excitation in Purkinje cells.
REFERENCE   5  (bases 1 to 5512)
  AUTHORS   Yogosawa,S., Ohkido,M., Horii,T., Okazaki,Y., Nakayama,J.,
            Yoshida,S., Toyokuni,S., Hatada,I., Morimoto,M. and Yoshida,K.
  TITLE     Mice lacking DYRK2 exhibit congenital malformations with lung
            hypoplasia and altered Foxf1 expression gradient
  JOURNAL   Commun Biol 4 (1), 1204 (2021)
   PUBMED   34671097
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5512)
  AUTHORS   Doolittle,D.P. and Schweikart,K.M.
  TITLE     Myelin deficient, a new neurological mutant in the mouse
  JOURNAL   J Hered 68 (5), 331-332 (1977)
   PUBMED   599283
REFERENCE   7  (bases 1 to 5512)
  AUTHORS   Dung,H.C.
  TITLE     Evidence of prolactin cell deficiency in connection with low
            reproductive efficiency of female 'torpid' mice
  JOURNAL   J Reprod Fertil 45 (1), 91-99 (1975)
   PUBMED   1195260
REFERENCE   8  (bases 1 to 5512)
  AUTHORS   Murad,S. and Kishimoto,Y.
  TITLE     Alpha hydroxylation of lignoceric acid to cerebronic acid during
            brain development. Diminished hydroxylase activity in
            myelin-deficient mouse mutants
  JOURNAL   J Biol Chem 250 (15), 5841-5846 (1975)
   PUBMED   1150661
REFERENCE   9  (bases 1 to 5512)
  AUTHORS   Meier,H. and McPike,A.D.
  TITLE     Ducky, a neurological mutation in mice characterized by deficiency
            of cerebrosides
  JOURNAL   Exp Med Surg 28 (3), 256-269 (1970)
   PUBMED   4111750
REFERENCE   10 (bases 1 to 5512)
  AUTHORS   Meier,H.
  TITLE     The neuropathology of ducky, a neurological mutation of the mouse.
            A pathological and preliminary histochemical study
  JOURNAL   Acta Neuropathol 11 (1), 15-28 (1968)
   PUBMED   4177347
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731803.16 and AL672219.7.
            
            [WARNING] On Aug 8, 2024 this sequence was replaced by
            NM_001174049.2.
            
            Transcript Variant: This variant (4) lacks an alternate in-frame
            exon and uses an alternate in-frame splice site, compared to
            variant 1. The resulting isoform (4) lacks two internal segments,
            compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158058.1, MK327277.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849390, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-404               AL731803.16        14881-15284
            405-486             AL731803.16        41054-41135
            487-603             AL672219.7         38702-38818
            604-663             AL672219.7         70609-70668
            664-708             AL672219.7         79097-79141
            709-850             AL672219.7         82344-82485
            851-982             AL672219.7         85150-85281
            983-1040            AL672219.7         85452-85509
            1041-1091           AL672219.7         86203-86253
            1092-1191           AL672219.7         86382-86481
            1192-1350           AL672219.7         86622-86780
            1351-1458           AL672219.7         86984-87091
            1459-1537           AL672219.7         87194-87272
            1538-1587           AL672219.7         87781-87830
            1588-1677           AL672219.7         88009-88098
            1678-1749           AL672219.7         88300-88371
            1750-1824           AL672219.7         88568-88642
            1825-1899           AL672219.7         90244-90318
            1900-1971           AL672219.7         90400-90471
            1972-2043           AL672219.7         90562-90633
            2044-2105           AL672219.7         90740-90801
            2106-2182           AL672219.7         91342-91418
            2183-2243           AL672219.7         95272-95332
            2244-2341           AL672219.7         97244-97341
            2342-2432           AL672219.7         97547-97637
            2433-2495           AL672219.7         97761-97823
            2496-2599           AL672219.7         97980-98083
            2600-2698           AL672219.7         98306-98404
            2699-2787           AL672219.7         98493-98581
            2788-2835           AL672219.7         98762-98809
            2836-2907           AL672219.7         99050-99121
            2908-3060           AL672219.7         99212-99364
            3061-3113           AL672219.7         99492-99544
            3114-3169           AL672219.7         99634-99689
            3170-3296           AL672219.7         99837-99963
            3297-3406           AL672219.7         100086-100195
            3407-3489           AL672219.7         100303-100385
            3490-5512           AL672219.7         100470-102492
FEATURES             Location/Qualifiers
     source          1..5512
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 58.02 cM"
     gene            1..5512
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /note="calcium channel, voltage-dependent, alpha 2/delta
                     subunit 2"
                     /db_xref="GeneID:56808"
                     /db_xref="MGI:MGI:1929813"
     exon            1..404
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..3633
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 4; alpha 2 delta calcium channel subunit;
                     voltage-dependent calcium channel subunit alpha-2/delta-2;
                     protein ducky; voltage-gated calcium channel subunit
                     alpha-2/delta-2; voltage-dependent calcium channel
                     alpha2/delta-2"
                     /codon_start=1
                     /product="voltage-dependent calcium channel subunit
                     alpha-2/delta-2 isoform 4 precursor"
                     /protein_id="NP_001167520.1"
                     /db_xref="GeneID:56808"
                     /db_xref="MGI:MGI:1929813"
                     /translation="MAVPARTCGASWPGPVRTARPWPGRGPRPCPDPRGPASGPARPL
                     LLLLPPLLLLPLLTAPGASAYSFPQQHTMQHWARRLEQEIDGVMRIFGGVQQLREIYK
                     DNRNLFEVQENEPQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEE
                     DIMYYDAKADAELDDPESEDMERGSKTSALRLDFIEDPNFKNKVNYSYTAVQIPTDIY
                     KGSTVILNELNWTEALENVFIENRRQDPTLLWQVFGSATGVTRYYPATPWRAPKKIDL
                     YDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVAS
                     FNEKAQPVSCFTHLVQANVRNKKVFKEAVQGMVAKGTTGYKAGFEYAFDQLQNSNITR
                     ANCNKMIMMFTDGGEDRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACTNKG
                     YYFEIPSIGAIRINTQEYLDVLGRPMVLAGKDAKQVQWTNVYEDALGLGLVVTGTLPV
                     FNLTQDGPGEKKNQLILGVMGIDVALNDIKRLTPNYTLGANGYVFAIDLNGYVLLHPN
                     LKPQTTNFREPVTLDFLDAELEDENKEEIRRSMIDGDKGHKQIRTLVKSLDERYIDEV
                     IRNYTWVPIRSTNYSLGLVLPPYSTYYLQANLSDQILQVKYFEFLLPSSFESEGHVFI
                     APREYCKDLNASDNNTEFLKNFIELMEKVTPDSKQCNNFLLHNLILDTGITQQLVERV
                     WRDQDLNTYSLLAVFAATDGGITRVFPNKAAEDWTENPEPFNASFYRRSLDNHGYIFK
                     PPHQDSLLRPLELENDTVGVLVSTAVELSLGRRTLRPAVVGVKLDLEAWAEKFKVLAS
                     NRTHQDQPQKCGPSSHCEMDCEVNNEDLLCVLIDDGGFLVLSNQNHQWDQVGRFFSEV
                     DANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPTIADFLNLAWWTSA
                     AAWSLFQQLLYGLIYHSWFQADPAEAEGSPETRESSCVMKQTQYYFGSVNASYNAIID
                     CGNCSRLFHAQRLTNTNLLFVVAEKPLCSQCEAGRLLQKETHSDGPEQCELVQRPRYR
                     RGPHICFDYNATEDTSDCGRGASFPPSLGVLVSLQLLLLLGLPPRPQPQVHSFAASRH
                     L"
     exon            405..486
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            487..603
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            604..663
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            664..708
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            709..850
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            851..982
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1040
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1091
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1191
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1350
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1458
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1537
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1587
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1677
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1749
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1824
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1899
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..1971
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2043
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2105
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2182
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2243
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2341
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..2432
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2495
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2599
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..2698
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            2699..2787
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            2788..2835
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            2836..2907
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            2908..3060
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            3061..3113
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            3114..3169
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            3170..3296
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            3297..3406
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            3407..3489
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
     exon            3490..5512
                     /gene="Cacna2d2"
                     /gene_synonym="a2d2; Cacna2d; du; mKIAA0558; td; torpid"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagcgcggc ggggagatcg ctgcgcgcag cccgcagagg cgctgcggcc agtgcagccc
       61 cggaggcccc gcgcggagaa ggaggtggag aagaggccgg ctttccgccc gccgcccgcg
      121 cccccccacc tccatcccgc cgccgccgtc ccccctccct ccccgcggcg ccgcatcttg
      181 aatggaaaca tggcggtgcc ggctcggacc tgcggcgctt cttggcccgg cccggtgcgg
      241 accgctcgcc cctggcccgg tcgcggcccc cggccctgcc ctgacccccg gggcccagcg
      301 tccgggcccg cacgcccgct cttgctcttg ctgccgcctc tgttgctttt accgctgctc
      361 accgcccccg gcgcctctgc ctacagcttc ccccagcagc acacgatgca gcactgggcc
      421 cggcgcctgg agcaggagat tgacggtgtg atgcggattt ttggaggcgt gcagcagctc
      481 cgagagatct acaaggacaa tcggaacctg tttgaagtgc aggagaatga accacagaaa
      541 ttggtggaga aagtggcagg ggacatcgag agcctgctgg acaggaaggt ccaggccctg
      601 aagagactgg ctgacgctgc agagaatttc cagaaagccc atcgctggca ggacaacatc
      661 aaggaggaag acatcatgta ctacgatgcc aaggctgacg ccgagctgga tgaccctgag
      721 agtgaagata tggagagggg atccaagacc agcgccttaa ggctggactt catcgaggac
      781 ccaaacttca agaacaaagt caactattca tacacggctg tgcagatccc cacagacatc
      841 tacaaaggct ctaccgtcat cctcaatgag cttaactgga cagaggccct ggagaacgtc
      901 ttcattgaga accgtaggca agaccctaca ctgttgtggc aagtctttgg cagtgccacg
      961 ggagtcactc gctattaccc agccacacca tggcgagccc ccaagaagat tgacctgtac
     1021 gatgtcagaa gacgaccctg gtatatacag ggggcctcat cacccaagga catggtcatc
     1081 attgtggatg tgagtggcag cgtgagcggc ctgactctga agctgatgaa gacgtccgtc
     1141 tgtgagatgc tagacacgct ctctgatgat gactatgtga acgtggcctc attcaacgag
     1201 aaggcgcagc ctgtgtcttg cttcacacac ctggtgcagg ccaatgtgcg taacaagaag
     1261 gtgttcaagg aagctgtgca gggcatggtg gccaagggca ccacaggcta caaggccggc
     1321 tttgagtatg cctttgacca gctacagaat tccaacatca cgcgggctaa ctgcaataag
     1381 atgatcatga tgttcacgga tgggggtgag gatcgcgtgc aggatgtctt cgaaaagtac
     1441 aattggccca atcggacggt acgtgtgttc acgttctccg taggacagca taactatgat
     1501 gtcacaccct tgcagtggat ggcctgtact aacaaaggtt actattttga gatcccttcc
     1561 atcggagcca tccgcatcaa cacacaggaa tacctggatg tgctgggtag gcccatggta
     1621 ctggcaggca aggacgccaa gcaagtgcaa tggacaaacg tgtatgaaga tgcactgggg
     1681 ctggggttgg tggtaacagg aactctccct gttttcaacc tgacacagga tggccctggg
     1741 gaaaagaaga accagttaat cctgggtgtc atgggcatcg atgtggcctt gaatgacatc
     1801 aaaaggctga ctcccaacta cacactcggc gccaatggct atgtgttcgc catcgacctg
     1861 aacggctacg tgttgctaca tcccaatctc aagccccaga ctaccaactt ccgggagcct
     1921 gtgaccttgg acttcctgga cgcagagctg gaagatgaga acaaggagga gatccgtcgc
     1981 agcatgattg acggcgacaa aggccacaag cagatcagaa ccttggtcaa atccctggat
     2041 gagaggtaca tagacgaagt gattcggaac tacacctggg tgcctataag gagtaccaac
     2101 tacagcctgg ggctggtgct cccaccctac agcacctact acctccaagc caacctcagc
     2161 gaccagatcc tgcaggtcaa gtattttgag ttcctgcttc ccagcagctt tgagtctgaa
     2221 ggacacgttt tcattgctcc gagagagtat tgcaaggact tgaacgcctc ggacaacaac
     2281 accgagttcc tgaagaactt catcgagctc atggagaaag tgactccgga ctccaagcag
     2341 tgtaataact tccttcttca taacttgatt ctggacacgg gcattacaca gcagttagtg
     2401 gaacgtgtgt ggcgggacca agatctcaac acgtacagcc tgctagccgt atttgctgcc
     2461 actgatggtg gcatcacacg tgtcttcccg aacaaggcag ccgaagactg gacagaaaac
     2521 cctgaaccct tcaatgccag cttctaccgt cgcagcctgg ataaccatgg ttatatcttc
     2581 aagcccccac accaggactc cctgttaaga ccactggagc tggagaatga cacagtaggt
     2641 gtcctcgtca gcacagctgt ggagctcagt ctaggtcgtc gcacactgag gccagcagtg
     2701 gtgggtgtca aactggacct agaggcttgg gctgaaaagt tcaaggtgct ggccagcaac
     2761 cgtacccatc aggaccaacc tcagaagtgc ggccccagca gccactgtga gatggactgc
     2821 gaggttaaca acgaggatct actctgtgtc ctcattgatg acggagggtt cctggtgctg
     2881 tcaaaccaga accatcagtg ggaccaggtt ggcagattct tcagtgaggt ggatgccaac
     2941 ctgatgctgg cactgtacaa taactccttc tacacccgaa aggaatccta tgactatcag
     3001 gcagcctgtg cccctcagcc tcctgggaac ctgggtgctg caccccgggg tgtctttgtg
     3061 cccaccattg cagatttcct taacttggcc tggtggacct ctgctgccgc ctggtcctta
     3121 ttccagcagc tactctatgg tctcatctat cacagctggt tccaggcaga cccggcagaa
     3181 gctgagggca gccccgagac gcgcgagagc agctgcgtca tgaaacagac ccagtactac
     3241 ttcggctcgg tgaacgcatc ctataatgcc atcattgact gcggaaactg cagcaggctg
     3301 ttccatgcgc agagactgac caacaccaat ctcctgttcg tggtggccga gaagccgctg
     3361 tgcagccagt gcgaggcggg ccggctgctg cagaaggaga cacactcgga cggcccggag
     3421 cagtgtgagc tggtgcagag accgagatac cgaagaggtc cgcacatctg ttttgactac
     3481 aatgcgacgg aagatacctc agactgtggc cgcggagcct ccttccctcc gtcgctgggc
     3541 gtcttggttt ccttgcagct tttgctcctc ctgggcctgc cacctcggcc gcagcctcaa
     3601 gtccactcct tcgctgcctc tcgccacctc tgagcgaccc acacacacac atcatacccc
     3661 cgccttggcc tcctagcctt tcgctcaccc tcccattcca cattccccaa tctagagcct
     3721 tggccactct ctcctgaagg acctgggtcc cttcccccgg agcctgtgcc ttggggcagg
     3781 ggaaccccaa agtaaggtgc catggtgttt ggcactcaag atttagctca cccttgaact
     3841 gtccaagtgc ccgcagtccc tagactcatc cccgtgggct aggacaggag gccactagta
     3901 ctgatgccaa accaggcctc caccgaccca cctgcctgga gatttcctct atgtaggcaa
     3961 ccctgccact gctgggcacc tctaactggc cctttggccc cacccaagcc caaacttacc
     4021 ttctctgggg gaaaaaaaag gaaagatggt aatagtgaga gattcggggg gcaccccctc
     4081 cccattggtt tctggccctt tcaggctaca accccccagc cttgcaggtg tcagaacagt
     4141 ctcacaatga catcagttta gacacatgcc atatacactt ggatctctga gagcagaaac
     4201 ccaactctca ctagacatac ctgtgatgga acacacaaac agacacgcac catggggggt
     4261 ggcccacaaa gccttacaca aggcgagatg tcaatgaagg ggttggcctg tgtgttccat
     4321 ctctgctcac ctctgcctct actctgagat gcagcctggc tgatcctccc atctctaaaa
     4381 ctgaatgtca aaccgtgcca aatgctgggg ggggggggag acctctctgt ttcaccccta
     4441 gccaccagtg tccccaagtg cccctcaccc tgccaggtgc tcattgtaac catcgttcac
     4501 cagtgtccgg cccctagtag gaccacacat cactgcctga actcctttgg cagaagaacc
     4561 ccaccagaca ttgagacatt gtattttgcc ttagcaggga tgagttggtc tctcctggct
     4621 gggccatccc atccccaatc tggttcttgc acactcaggc ctaattccct ctgcacacac
     4681 acacacacac acacacacac acacacacac acacacacac agtccctgcc cctaggaggc
     4741 caaattaccc ctcccttgct gaacacacac ttgcaccatg cacatgtcta accaaccgta
     4801 ctgcacacac agaggctgga cctgggacac atctctttac acctttcatt ctgtcatttc
     4861 tcccaaaggc atcgtaactt gggggccagg aggggactga ggggcagggg ggaggggtgt
     4921 agctgtgagg ctcagatgga ctgggaggag gggggagggt gatacattaa ttaatggctt
     4981 cgttaattaa tgtcatgttg cttgttgctt tctcagtgtg tgtatggtcc atgcccagtg
     5041 ctggtgacag ggtgggtatc catgatgtgt gcccagcctg gatgtcagct gtgtcctgtg
     5101 ggggcgtgtg tgtaactgta gtgtagtcag gtgctcaacg gagaatataa acaaaaaaaa
     5161 aagaaacaaa cgtatacaga aaaataaata tatattttaa gtttaaagac aaatgaaacc
     5221 agacaaaaca atccccatca ggtagttgtc caacccccag ctgggttcaa ccctctcatt
     5281 acccacctga cctagctgtc cccttactgt gggctggggg acttgggggc catttccttt
     5341 gccctttttt tttgttgtta ttctattttg tacagacaag ttgggaaaac aacagcgaca
     5401 aaaaaaagtc gagaaacttt gtaaaatatt gtgtgtgtga ttccttgtaa aatattttca
     5461 aatggtttat tacagaagat cagttattaa ataatgttca tattttcact tc
//
