LOCUS       NM_001044308            9833 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Mus musculus calcium channel, voltage-dependent, alpha 1I subunit
            (Cacna1i), mRNA.
ACCESSION   NM_001044308 XM_139476 XM_985985
VERSION     NM_001044308.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9833)
  AUTHORS   Huikang,W., Shiya,C., Di,P., Kiani,F.A., Hao,L., Sha,N., Xuan,L.,
            Abouelfetouh,M.M., Ahmed,Z., Mingxing,D. and Yi,D.
  TITLE     Elucidation of Dexmedetomidine-Induced Analgesic Tolerance
            Mechanisms in Neuropathic Pain With Modulation of SGK1, NR2A, and
            NR2B Expression via the Spinal SGK1/NF-kappaB Signalling Pathway
  JOURNAL   J Cell Mol Med 29 (6), e70372 (2025)
   PUBMED   40099662
REFERENCE   2  (bases 1 to 9833)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 9833)
  AUTHORS   Arulkandarajah,K.H., Osterstock,G., Lafont,A., Le Corronc,H.,
            Escalas,N., Corsini,S., Le Bras,B., Chenane,L., Boeri,J.,
            Czarnecki,A., Mouffle,C., Bullier,E., Hong,E., Soula,C.,
            Legendre,P. and Mangin,J.M.
  TITLE     Neuroepithelial progenitors generate and propagate non-neuronal
            action potentials across the spinal cord
  JOURNAL   Curr Biol 31 (20), 4584-4595 (2021)
   PUBMED   34478646
REFERENCE   4  (bases 1 to 9833)
  AUTHORS   Ratkai,A., Tarnok,K., Aouad,H.E., Micska,B., Schlett,K. and
            Szucs,A.
  TITLE     Homeostatic plasticity and burst activity are mediated by
            hyperpolarization-activated cation currents and T-type calcium
            channels in neuronal cultures
  JOURNAL   Sci Rep 11 (1), 3236 (2021)
   PUBMED   33547341
  REMARK    GeneRIF: Homeostatic plasticity and burst activity are mediated by
            hyperpolarization-activated cation currents and T-type calcium
            channels in neuronal cultures.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9833)
  AUTHORS   Feseha,S., Timic Stamenic,T., Wallace,D., Tamag,C., Yang,L.,
            Pan,J.Q. and Todorovic,S.M.
  TITLE     Global genetic deletion of CaV3.3 channels facilitates anaesthetic
            induction and enhances isoflurane-sparing effects of T-type calcium
            channel blockers
  JOURNAL   Sci Rep 10 (1), 21510 (2020)
   PUBMED   33299036
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9833)
  AUTHORS   Porter,G.A. Jr., Makuck,R.F. and Rivkees,S.A.
  TITLE     Intracellular calcium plays an essential role in cardiac
            development
  JOURNAL   Dev Dyn 227 (2), 280-290 (2003)
   PUBMED   12761855
REFERENCE   7  (bases 1 to 9833)
  AUTHORS   Yunker,A.M., Sharp,A.H., Sundarraj,S., Ranganathan,V.,
            Copeland,T.D. and McEnery,M.W.
  TITLE     Immunological characterization of T-type voltage-dependent calcium
            channel CaV3.1 (alpha 1G) and CaV3.3 (alpha 1I) isoforms reveal
            differences in their localization, expression, and neural
            development
  JOURNAL   Neuroscience 117 (2), 321-335 (2003)
   PUBMED   12614673
  REMARK    GeneRIF: Expression of T-type calcium channels increases during
            perinatal development in various brain regions and in the spinal
            cord.
            Erratum:[Neuroscience. 2006 Oct 13;142(2):607]
REFERENCE   8  (bases 1 to 9833)
  AUTHORS   Son,W.Y., Han,C.T., Lee,J.H., Jung,K.Y., Lee,H.M. and Choo,Y.K.
  TITLE     Developmental expression patterns of alpha1H T-type Ca2+ channels
            during spermatogenesis and organogenesis in mice
  JOURNAL   Dev Growth Differ 44 (3), 181-190 (2002)
   PUBMED   12060068
REFERENCE   9  (bases 1 to 9833)
  AUTHORS   Berthier,C., Monteil,A., Lory,P. and Strube,C.
  TITLE     Alpha(1H) mRNA in single skeletal muscle fibres accounts for T-type
            calcium current transient expression during fetal development in
            mice
  JOURNAL   J Physiol 539 (Pt 3), 681-691 (2002)
   PUBMED   11897840
REFERENCE   10 (bases 1 to 9833)
  AUTHORS   Cribbs,L.L., Martin,B.L., Schroder,E.A., Keller,B.B., Delisle,B.P.
            and Satin,J.
  TITLE     Identification of the t-type calcium channel (Ca(v)3.1d) in
            developing mouse heart
  JOURNAL   Circ Res 88 (4), 403-407 (2001)
   PUBMED   11230107
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147585.1, AC155313.2 and CJ259561.1.
            
            On Sep 7, 2007 this sequence version replaced NM_001044308.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript that matched the
            reference genome was available for the full length of the gene. The
            extent of this transcript is supported by transcript alignments and
            orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147585.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2037              AK147585.1         1-2037
            2038-2038           AC155313.2         40142-40142         c
            2039-2617           AK147585.1         2039-2617
            2618-2655           AC155313.2         32368-32405         c
            2656-9781           AK147585.1         2656-9781
            9782-9833           CJ259561.1         409-460
FEATURES             Location/Qualifiers
     source          1..9833
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.85 cM"
     gene            1..9833
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /note="calcium channel, voltage-dependent, alpha 1I
                     subunit"
                     /db_xref="GeneID:239556"
                     /db_xref="MGI:MGI:2178051"
     exon            1..540
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            541..791
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             562..7161
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /note="low voltage-activated T-type calcium channel
                     alpha-1 subunit (CACNA1I); low-voltage-activated calcium
                     channel alpha13.3"
                     /codon_start=1
                     /product="voltage-dependent T-type calcium channel subunit
                     alpha-1I"
                     /protein_id="NP_001037773.2"
                     /db_xref="CCDS:CCDS49670.1"
                     /db_xref="GeneID:239556"
                     /db_xref="MGI:MGI:2178051"
                     /translation="MADSNLPPSSSAAPDPEPGITEQPGPRSPPPSPPGLEEPLDGTN
                     PDVPHPDLAPVAFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDD
                     MECLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGM
                     VEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVF
                     FIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIM
                     GCHEIPPLKEQGRECCLSKDDMYDFGAGRQDLNASGLCVNWNRYYNVCRTGNANPHKG
                     AINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCL
                     VVIATQFSETKQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHILRKAKRR
                     ALGLYQALQNRRQATGPGTPAPAKPGPHAKEPSHCKLCPRHSPLDTTPHTLVQPISAI
                     LASDPSSCPRCQHEAGRRPSGLGSTDSGQEGSGSGGSAEAEANGDGPQSSEDGVSSGL
                     GKEEEQEDGAARLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPE
                     ELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQAD
                     GGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH
                     IFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTTPWASL
                     YFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNLEELDKLPEGLDSS
                     RDLKLCPIPMTPNGHLDPSLPLGGHLGPAGAMGAAPRLSLQPDPVLVALESRKSSVMS
                     LGRMSYDQRSLSSSRSSYYGPWGRSGTWASRRSSWNSLKHKPPSAEHESLLSGERGGS
                     CVRACEGAREDAPPRAAPLHAPHTHHAHHGPHLAHRHRHHRRTLSLDTRDSVDLAELV
                     PVVGAHSRAAWRAAGQAPGHEDCNGRMPNIAKDVFTKMDDRRDRGEDEEEIDYTLCFR
                     VRKMIDVYKPDWCEVREDWSVYLFSPENKFRILCQTIIAHKLFDYVVLAFIFLNCITI
                     ALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDG
                     FLVFVSIIDIVVSVASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSL
                     KPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCVAANYRWVHHKY
                     NFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVS
                     FFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCPTR
                     LLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAV
                     LKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIA
                     RVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENP
                     CEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLY
                     FVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAEIELEMAHGLGPGPGPCPC
                     PCPCPCPCPCPGPRMPTSSPGAPGRGSGGAGVGGDTESHLCRHCYSPAQETLWLDSVS
                     LIIKDSLEGELTIIDNLSGSIFHHYSSPAGCDKCHHDKQEVQLAETEAFSLNSDRSSS
                     VLLGDDLSLEDPTACPQGPKESKGELEPPEPMQAGDLDECFFPFAGEPVSAGPESLLC
                     EMGAIPFNPVQSWLKHESNQAPPSPFSPDGSSPLLQMPAEFFHPAVSASQKGQEPGMS
                     SGTLPKIALQGSWASLRSPSVNCTLLRQATVSDTSLDASPSSSAGSLQTTLEDSLTLS
                     DSPRRALGPPVQVPGPRASLSPATRRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGC
                     TYHDSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSLFCLPPTLPPPGLTPARKFSS
                     TSSLAAGPGRPGATVSVRGLARSPSWAADRSKDPPGQAQLASGFGSSAPEPQPPPGES
                     TDAASKRKR"
     exon            792..903
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1037
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1135
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1295
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1611
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1704
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..2017
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2427
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2579
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2765
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..2883
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2884..3039
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            3040..3133
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            3134..3336
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            3337..3810
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            3811..3911
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            3912..4035
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            4036..4104
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            4105..4289
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            4290..4416
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            4417..4542
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            4543..4632
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            4633..4825
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            4826..4977
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            4978..5087
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            5088..5221
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            5222..5292
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            5293..5371
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            5372..5493
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            5494..5886
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            5887..6033
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            6034..6156
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            6157..6322
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            6323..6519
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            6520..9794
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9764..9769
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /note="hexamer: AATAAA"
     polyA_site      9783
                     /gene="Cacna1i"
                     /gene_synonym="Ca(V)3.3"
                     /note="major polyA site"
ORIGIN      
        1 ggtgtcagta taaggacggc ttttcctcgc acgcggcgcg gctcggtctc gccgccgccg
       61 cacgtccccg caccgcctgg cgctccggct cctccgcagc ccccgtcgcg cgcagcccct
      121 ttgcgcctcg agtccgggcc gggggcgcca ggggcgccga agccggggac ccgggtgacc
      181 cgaccccgcg ctccgccgcg cctgccgccc cgcacctgcc ctgccgcggc cccgcgcccc
      241 cgcccccggc ccggagcgcc gcgcgcccgc cgcccgccgc gcgctccaac tccgcgcggt
      301 ccgccgctcg tccgcgccac ccgccccgag ccgcggcgac ccgcccgcca tggcccgcgc
      361 ccccgggccc gccaccctgc gtgcgccgcc cccctcgccc cgggggcgca gctgatcccg
      421 gaatctgagg cgtggggccg gcggggcgcg gggtccctct ccacgccggc ttcggggaca
      481 cgcgtcaccc ccgcatctct gcccgggacg accccgctgc ccagccacgt ccatgccaag
      541 ggctccctgc tccacgctga catggctgac agcaacttac caccctcatc ttcagcagcc
      601 ccggaccctg agccgggaat cactgagcag ccggggcccc ggagtccccc tccatcccct
      661 ccaggcctgg aggagccatt ggatggaacc aaccctgacg tcccgcatcc agacctggca
      721 cccgttgcct tcttctgcct gcgccagacc acgagcccac ggaactggtg catcaagatg
      781 gtatgtaacc cgtggttcga gtgtgtgagc atgctggtca tcctgctgaa ctgtgtgacc
      841 ctgggcatgt accagccatg tgacgatatg gagtgcctct cagaccgctg caagatcctg
      901 caggtctttg atgacttcat cttcatcttc ttcgccatgg agatggtgct taagatggtg
      961 gccctgggca tttttggcaa gaagtgctac ctcggggaca catggaaccg cttggacttc
     1021 ttcattgtca tggcagggat ggtcgagtac tctctggacc tacagaacat caacctgtca
     1081 gccatccgca ctgtgcgtgt cctgaggcct ctcaaagcca tcaaccgtgt tcccagcatg
     1141 cggattctgg tgaacctgct gctggacacg ctgcccatgc tgggaaacgt gctcctgctc
     1201 tgtttcttcg tcttcttcat ctttggcatc atcggcgtgc agctctgggc aggcctgctg
     1261 cggaaccgct gcttcctgga ggagaacttc accatacaag gggatgtggc cctgccccct
     1321 tactaccaac cagaagagga cgacgagatg cccttcatct gctccctgtc gggggacaat
     1381 ggcattatgg gctgtcacga gatccctcca ctcaaggagc agggccgaga gtgctgcctg
     1441 tccaaagatg acatgtacga cttcggggcg ggacgccaag acctcaacgc cagcggcctc
     1501 tgcgtcaact ggaaccgcta ctacaacgtc tgccgcacgg gcaacgccaa ccctcacaag
     1561 ggcgccatca actttgacaa cattggctat gcctggatcg tgatctttca ggtgatcact
     1621 ctggaaggct gggtggagat catgtactac gtgatggatg cacattcttt ctacaacttc
     1681 atctacttca tcctgctcat catagtgggc tccttcttca tgatcaacct gtgcctcgtt
     1741 gtcatagcga cccagttctc tgagaccaag caacgggagc accggctgat gctggagcaa
     1801 cgccagcgct acctgtcctc cagcacggtg gccagttacg ccgagcccgg cgactgctat
     1861 gaggagatct tccaatatgt ctgtcacatc cttcgcaagg ccaagcgccg tgctctaggc
     1921 ctctaccagg ccctgcagaa ccggcgccag gccacgggcc ccgggacacc agcccctgcc
     1981 aagcctgggc cccatgccaa ggagcccagc cactgcaagc tgtgcccacg acacagtccc
     2041 ctggacacca ctccccacac actggtgcag cccatctctg ccattctggc ctccgatccc
     2101 agcagctgcc ctcgctgcca gcacgaggca ggcaggcggc cctctggcct gggcagcact
     2161 gactcgggcc aggaaggctc aggttctggc ggttctgcag aggctgaagc caatggcgat
     2221 ggaccccaaa gcagtgagga tggggtctcc tcaggtttgg ggaaggagga ggaacaggag
     2281 gacggggcag cccgactgtg tggggatgtg tggcgagaga cacgggccaa gctgcggggc
     2341 attgtggaca gcaagtactt caacagaggc atcatgatgg ctattctggt taacactgtc
     2401 agcatgggca tcgagcacca tgaacagcca gaggaactga ccaacatcct ggagatctgc
     2461 aacgtggtct tcaccagcat gtttgccctg gagatgattc tgaagctggc tgcctttggg
     2521 ctctttgact acctgcggaa cccttacaac atcttcgaca gcatcattgt catcatcagc
     2581 atctgggaaa tcgtggggca ggctgacggc ggcctgtccg tgctgcgcac cttccggctg
     2641 ctgcgggtgc tgaagctggt gcgcttcatg ccggcgctgc ggcgccagct cgtggtgctc
     2701 atgaagacca tggacaacgt ggccaccttc tgcatgctgc tcatgctctt cattttcatc
     2761 ttcagcatcc ttgggatgca tatctttggc tgcaaattca gcctccgcac ggacactgga
     2821 gacacagtcc ctgacaggaa gaacttcgat tccttactgt gggccatcgt caccgtgttt
     2881 cagatcctca ctcaggagga ctggaacgtt gtcctgtaca atggcatggc ctccaccacc
     2941 ccctgggcct ccctctattt tgttgccctc atgacctttg gcaactatgt tctcttcaat
     3001 ctcctggtgg ctatcctggt cgagggcttc caggctgagg gtgatgctaa tcgctcctac
     3061 tcagacgagg accagagctc atccaacttg gaggagcttg ataagctccc agagggcctg
     3121 gacagcagca gagatctcaa gctctgccca atacccatga cacccaatgg acacctggac
     3181 cctagtctcc ctctgggtgg acatctgggt cctgctggtg ccatgggtgc tgccccccgc
     3241 ctctcactgc agccagaccc agtgctggtg gccctagaat cccggaaaag cagtgtcatg
     3301 tcactgggca ggatgagcta tgatcagcga tctttgtcca gctcccggag ctcctactat
     3361 gggccctggg gccgcagcgg gacctgggcc agccgccgct ccagctggaa cagcctgaaa
     3421 cacaagccac cctcagctga gcacgagtcc ctgctctccg gggagcgtgg tggtagttgc
     3481 gtcagggcct gtgaaggcgc ccgggaggat gcgccacctc gcgctgcacc cctgcatgcc
     3541 ccgcacaccc accacgcgca tcatggaccc cacttggcac accgtcaccg ccaccaccgt
     3601 cggacactgt cccttgatac cagggactct gttgacctgg cagagctggt gcccgtggtg
     3661 ggtgcccact cgcgggccgc ttggagggcg gcaggccagg cccctgggca cgaggactgc
     3721 aatggcagaa tgcccaacat agccaaggat gtcttcacca agatggacga ccgccgcgac
     3781 cgtggggagg acgaggagga gatcgactac accctgtgtt tccgcgtccg caagatgatt
     3841 gatgtgtaca agcctgactg gtgcgaagtc cgcgaggact ggtcggtcta cctcttctcc
     3901 cctgagaaca agttccggat cctgtgtcag accattattg ctcacaagct ttttgactac
     3961 gtggtcttgg ccttcatctt cctcaactgt atcaccattg ctctggagag gccccagatc
     4021 gaagctggta gcactgagcg catcttcctc acggtgtcta actacatctt cacagccatc
     4081 tttgtgggcg agatgacact gaaggtggtc tctttgggcc tatacttcgg tgagcaagca
     4141 tacttgcgta gcagctggaa cgtcctggat ggtttcctgg tctttgtgtc tatcatcgat
     4201 atcgtggtat ccgtggcctc tgcaggggga gccaagatcc tgggggtcct ccgggtcctg
     4261 cggctcctgc gtaccttacg tcctttgagg gtcatcagcc gggcccctgg gctgaagctg
     4321 gtggtagaga cgctcatctc ctccctcaag cccattggaa acattgtcct catctgctgc
     4381 gccttcttca tcatcttcgg tatcctgggg gtgcagcttt tcaaaggcaa gttctatcac
     4441 tgtctgggag tggacacccg aaacatcacc aaccgatcag actgtgtggc cgccaactac
     4501 cgctgggtgc atcacaaata caactttgat aacctgggcc aggctttgat gtccctcttt
     4561 gtcttggcct ccaaggatgg ctgggtgaac atcatgtata atggattgga tgctgttgct
     4621 gtggaccagc agccggtgac aaaccacaac ccctggatgc tgctgtactt catctccttc
     4681 ctgctcatcg tcagcttctt cgtgctcaac atgttcgtgg gagtggtcgt ggagaacttc
     4741 cacaagtgcc ggcagcatca ggaggctgag gaggcacggc ggcgtgagga gaaacggcta
     4801 cggcgcctgg aaaagaagcg ccgtaaggct cagaggctgc cctactatgc cacctactgt
     4861 cccacaagac tgctcatcca ctccatgtgc actagccact acctggacat cttcatcacc
     4921 ttcatcatct gcctcaacgt ggtcaccatg tccctggagc actacaacca gcctacatcc
     4981 ctagagacag ccctcaagta ctgcaactac atgttcacca ctgtctttgt gctggaggct
     5041 gtgctgaagc tggtggcgtt tggcctgagg cgtttcttca aggaccgatg gaaccagctg
     5101 gacttggcca ttgtgctgct gtctgtcatg ggcatcacac tggaggagat tgagatcaat
     5161 gcggccctgc ccatcaaccc caccatcatc cgtatcatgc gtgttctgcg tattgcccgg
     5221 gtgttgaagc tgttgaagat ggccacagga atgcgggccc tgctggacac agtggtacag
     5281 gctctgcccc aggtgggcaa cctgggcctc ctcttcatgc tgctcttctt catctacgcc
     5341 gctctgggag tggagctctt cggaaagctg gtctgcaatg acgagaaccc gtgtgagggc
     5401 atgagccggc acgccacctt cgagaacttc ggcatggcct tcctcacact cttccaggtc
     5461 tccacaggcg ataactggaa tgggattatg aaggacactc tgcgagactg cacccacgac
     5521 gagcgcagct gcctgagcag cctgcagttt gtgtcgcctc tctactttgt gagcttcgta
     5581 ctcacagcgc agtttgtgct catcaacgtg gtggtggccg tgctgatgaa acatctggat
     5641 gacagcaaca aggaggccca ggaggatgca gagatggatg ctgagatcga gctggagatg
     5701 gcccatggcc taggccccgg gcccggcccc tgtccctgtc cctgtccctg cccctgcccc
     5761 tgtccctgtc ctggcccgag gatgcccacc agttcaccgg gggctccagg ccgaggatca
     5821 ggaggggcag gcgttggagg cgacactgag agccacctgt gccggcactg ctattctcca
     5881 gcccaggaga ccctgtggct ggacagcgtc tctttaatca tcaaggactc cttggagggg
     5941 gagctgacca tcattgacaa cctgtctggc tccatcttcc accactactc ctcacctgcc
     6001 ggctgtgaca agtgtcacca tgacaagcaa gaggtgcagc tggctgagac agaggccttc
     6061 tccctgaact cagacaggtc ctcgtccgtc ctgctggggg atgacctgag tcttgaggac
     6121 cccacggcct gcccgcaggg ccccaaggag agcaagggtg agctagagcc tccggagccc
     6181 atgcaggctg gagacctgga tgaatgcttc ttcccctttg ccggtgagcc agtgtctgca
     6241 ggcccagaga gcctgctgtg cgagatgggg gccattccat tcaaccccgt ccagtcctgg
     6301 ctcaaacatg agagcaacca agcaccccca agccctttct ccccggatgg ttccagccct
     6361 ctgctgcaga tgcctgctga gttcttccac cctgctgtgt ctgccagcca gaaggggcag
     6421 gaaccgggca tgagttcagg gaccctgccc aagattgcac ttcaggggtc ctgggcatcc
     6481 ctgaggtcac cgagtgtcaa ctgcaccctc ttgcgccagg ctactgtgag tgacacgtct
     6541 ttggatgcca gccctagcag ctcagcgggc agcctgcaga ccacactgga ggacagtctg
     6601 accctgagtg acagtcctcg gcgtgccctg ggaccaccag tccaggtgcc agggccacgg
     6661 gctagcctgt cacctgccac ccggcgccgc ctcagcctgc gggggcgtgg cctgtttagt
     6721 ctgcgtgggc tgcgggccca tcagcgtagc cacagcagcg gtggctccac cagccctggc
     6781 tgcacttacc acgactccat ggacccctct gatgaggagg gccgcggggg cgcaggtggt
     6841 gggggcgcgg gcagtgagca ctccgagacc ctcagcagcc tgtcactcac atctctcttc
     6901 tgcctaccac ccacgctgcc accacccggt ctcaccccag ccaggaagtt cagcagtacc
     6961 agcagcctgg ctgctggacc tggccgtcct ggcgccactg tctcggtccg cggcctggcc
     7021 aggagtccct catgggctgc agaccgcagc aaggacccac caggccaggc acagctggcc
     7081 tccggcttcg gctcctcagc acccgagcca cagccacctc ccggggagtc aacggatgcg
     7141 gcgagcaaaa ggaagagatg aggggccgca ggggctgtgg ggggacctgc tacccgctgt
     7201 cctcccgcct gccccatctt gccttctttt aacctcagga gccagggagc agacagcaat
     7261 actttgccca cacctgggag tggcataggg gccagccagc gccaggccac cgggcaggcg
     7321 actgagaggg tctgggttag ccaaggctca gatgcgcccc gtctgaggcc cttccagtgc
     7381 atatgcagat atatacatat atatatagag acagacatat atttatttat tttttttact
     7441 gagagcttat gaattccaga acgtgctaaa gttgagggtg caggccaggg cctagacagg
     7501 ggtctcgtct gttggtttag cacacaggcc ttcacagcag agatgctcct actagggcat
     7561 cagtggctgt agttttaggg gtctccccga gttgagagca gcttgggaga gcgttcgggg
     7621 cccaggagac agaagagaag caattcaggg tgcacttttt ttcccttttc aagaagagac
     7681 cctactaagt tccccaaccc ctaccccaca catcagggta tatcagtctt gtccctctga
     7741 ctattgtggt gttgtgaagt cttttgtaga cactcttgac acaaactttc ttagccggct
     7801 agatgttctc tttagaaaaa cctggcgggg ggggggggag ggttagtcat atttcttaga
     7861 gcagggttgg gggacagagc aggaggctca gggtgcagtt ttgactttcg tgaacacttt
     7921 gggggacagt tcacaccccc tgaaggcagc aaacaattca tgaagggggg acaggtgaag
     7981 ggagtcagca gtacttactt ggttcacacg gatgccctgt tactggtact gtcgggtaca
     8041 caggaacttt ctgtcctgat ccactctgaa ggcctcatac ttcagctttc ctggggatta
     8101 tggtcactca ccctgagcaa ccctatcctc gccccagggg tgtttggggt aacaaatcta
     8161 aagtgggctc tgaacaccca cccaaaccct ggctccagcc tttccccacc cccgacactc
     8221 ttagcctcct cggactcatg cttacccctg agtatgtctc gctgtctcaa gctgtgggct
     8281 gggtctcgct atggtcctgc ttcctgaatt agttcaggac aggtagcttt atctgagctc
     8341 taaagtggat gggtttaaac tcagctgaaa gagtgtggcc gcctgctact gctggcctgc
     8401 tgttgttcag gggcagtatc atggggtgct tgcccgtatt accaagggtc accttggacc
     8461 ctgcgaagaa catgggtgtc tcatctctgc tcctgagtcc caagttctca gaagtggcct
     8521 tctagccagg ctagtgggca gcagctgcat ttgtgtttgt agactctgag gtgttcctgt
     8581 ccatcgctgg gatcctgggg tcagggcttt gtgaggaagt ggggaatatt gaaggatgct
     8641 gcctgtaaag cccttcttag aggtgaggag tgggacagta gttgttagac ccactttaca
     8701 catgggtaaa ctgaggttct cggtaacaga agcagccatt ttaccctggc agtaaagagc
     8761 ccgggtcacc tgtgaggggg tcctggcctg agcatctggc ctgtgctttt cagaggtggt
     8821 ggttgatagc atccagcacc ctctgctttc tgggtccagt caggcagtta tctcagcctt
     8881 cagggggccc ctgtatgatt atgctgctct ccacagccag cgtttctccc tatcagggct
     8941 ctgaggctgg ggagggatgt tcaggcatcc ataattctac actgtgtcct cagagcaagc
     9001 agacatgttg aagggtgttc tagggggtgg ggatgaagga agctctgagc tcctggtaag
     9061 atgagctata aagggccagg gttgggcaag tgttctgttc cttctttgac gctgtagctt
     9121 ggggctgtgg cctgtccatc atcaaagcac aaatgtctcc aatccacatg ggcctgtcta
     9181 tgaggagaat ggggacctcc gtaccaatgc tctaaccaat gcccatgtgc ctgactgtgt
     9241 ggcttggagg ctggagggta ccacaacatc tgtagagaag ggtctggagc tagttgggcc
     9301 tgccctggct tattcctgtc ttcggctctg gtcctggctt tccctcagag gaggatgaac
     9361 gaatcatgag cagtacttac ctgtctgctt gtccctaata tttctttggg agctcctagc
     9421 tcccagggtc acctccaggc ccttttgctg ctctgcggaa gggcttgggg tcttagaagc
     9481 cgctgtttag cccagacaca tttttttccc ttttggtctt tgtgcaataa tcaacgtccc
     9541 tggcagagcc agggctgaac tggggcctgg gaggaggcag aggccgcctt gtccagcaag
     9601 tccctagccc ggctctgctg ctgtgactct aacttccggt cactgtacag tttctacagt
     9661 gtgaacgaac ttccctccta gttgctgaag gcgctggtcc ctgctggccc agatggcccg
     9721 ggcatagaga aaccaagccg caccgccagc cagcgttgtt ttgaataaaa ccccagaaac
     9781 gtgtttaggc ctttaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
