LOCUS       NM_021415               8240 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus calcium channel, voltage-dependent, T type, alpha 1H
            subunit (Cacna1h), transcript variant 1, mRNA.
ACCESSION   NM_021415
VERSION     NM_021415.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8240)
  AUTHORS   Li,X., Hu,C., Luo,S., Dai,F., Li,C., Zhou,W., Wang,J., Chen,H.,
            Wang,Z., Long,T., Jiang,L. and Tang,C.
  TITLE     Cav3.2 deletion attenuates nonalcoholic fatty liver disease in mice
  JOURNAL   Gene 929, 148812 (2024)
   PUBMED   39116959
  REMARK    GeneRIF: Cav3.2 deletion attenuates nonalcoholic fatty liver
            disease in mice.
REFERENCE   2  (bases 1 to 8240)
  AUTHORS   Zheng,Q., Li,X., Xu,X., Tang,X., Hammad,B., Xing,J. and Zhang,D.
  TITLE     The mmu_circ_003062, hsa_circ_0075663/miR-490-3p/CACNA1H axis
            mediates apoptosis in renal tubular cells in association with
            endoplasmic reticulum stress following ischemic acute kidney injury
  JOURNAL   Int Immunopharmacol 132, 111956 (2024)
   PUBMED   38554447
  REMARK    GeneRIF: The mmu_circ_003062, hsa_circ_0075663/miR-490-3p/CACNA1H
            axis mediates apoptosis in renal tubular cells in association with
            endoplasmic reticulum stress following ischemic acute kidney
            injury.
REFERENCE   3  (bases 1 to 8240)
  AUTHORS   Ahn,J.W., Kim,S.E., Kim,D.Y., Jeong,I., Kim,S., Chung,S. and
            Lee,S.E.
  TITLE     Cav3.2 T-Type Calcium Channel Mediates Acute Itch and Contributes
            to Chronic Itch and Inflammation in Experimental Atopic Dermatitis
  JOURNAL   J Invest Dermatol 144 (3), 612-620 (2024)
   PUBMED   37863387
REFERENCE   4  (bases 1 to 8240)
  AUTHORS   Nakagawa,M., Takahashi,K., Nishizawa,Y. and Ohta,T.
  TITLE     Involvement of interaction of Cav3.2 and nociceptive TRPA1 in
            pathological pain transmission
  JOURNAL   Biomed Res 45 (1), 45-55 (2024)
   PUBMED   38325845
  REMARK    GeneRIF: Involvement of interaction of Cav3.2 and nociceptive TRPA1
            in pathological pain transmission.
REFERENCE   5  (bases 1 to 8240)
  AUTHORS   Bernheim,S., Borgel,A., Le Garrec,J.F., Perthame,E., Desgrange,A.,
            Michel,C., Guillemot,L., Sart,S., Baroud,C.N., Krezel,W.,
            Raimondi,F., Bonnet,D., Zaffran,S., Houyel,L. and Meilhac,S.M.
  TITLE     Identification of Greb1l as a genetic determinant of crisscross
            heart in mice showing torsion of the heart tube by shortage of
            progenitor cells
  JOURNAL   Dev Cell 58 (21), 2217-2234 (2023)
   PUBMED   37852253
REFERENCE   6  (bases 1 to 8240)
  AUTHORS   Son,W.Y., Han,C.T., Lee,J.H., Jung,K.Y., Lee,H.M. and Choo,Y.K.
  TITLE     Developmental expression patterns of alpha1H T-type Ca2+ channels
            during spermatogenesis and organogenesis in mice
  JOURNAL   Dev Growth Differ 44 (3), 181-190 (2002)
   PUBMED   12060068
REFERENCE   7  (bases 1 to 8240)
  AUTHORS   Berthier,C., Monteil,A., Lory,P. and Strube,C.
  TITLE     Alpha(1H) mRNA in single skeletal muscle fibres accounts for T-type
            calcium current transient expression during fetal development in
            mice
  JOURNAL   J Physiol 539 (Pt 3), 681-691 (2002)
   PUBMED   11897840
REFERENCE   8  (bases 1 to 8240)
  AUTHORS   Cribbs,L.L., Martin,B.L., Schroder,E.A., Keller,B.B., Delisle,B.P.
            and Satin,J.
  TITLE     Identification of the t-type calcium channel (Ca(v)3.1d) in
            developing mouse heart
  JOURNAL   Circ Res 88 (4), 403-407 (2001)
   PUBMED   11230107
REFERENCE   9  (bases 1 to 8240)
  AUTHORS   Cribbs,L.L., Lee,J.H., Yang,J., Satin,J., Zhang,Y., Daud,A.,
            Barclay,J., Williamson,M.P., Fox,M., Rees,M. and Perez-Reyes,E.
  TITLE     Cloning and characterization of alpha1H from human heart, a member
            of the T-type Ca2+ channel gene family
  JOURNAL   Circ Res 83 (1), 103-109 (1998)
   PUBMED   9670923
REFERENCE   10 (bases 1 to 8240)
  AUTHORS   Miesenbock,G., De Angelis,D.A. and Rothman,J.E.
  TITLE     Visualizing secretion and synaptic transmission with pH-sensitive
            green fluorescent proteins
  JOURNAL   Nature 394 (6689), 192-195 (1998)
   PUBMED   9671304
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK147242.1, AK135951.1,
            AC122454.4 and AI834839.1.
            
            On Jul 29, 2009 this sequence version replaced NM_021415.3.
            
            Summary: Voltage-dependent Ca(2+) channels mediate the entry of
            Ca(2+) ions into excitable cells and are involved in a variety of
            Ca(2+)-dependent processes, including muscle contraction, hormone
            or neurotransmitter release, and gene expression. The protein
            encoded by this gene is an integral membrane protein that belongs
            to the calcium channel alpha-1 subunits family. Two transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138026.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4253              AK147242.1         2-4254
            4254-7291           AK135951.1         1-3038
            7292-7937           AK147242.1         7240-7885
            7938-7938           AC122454.4         161855-161855       c
            7939-8227           AK147242.1         7887-8175
            8228-8240           AI834839.1         1-13                c
FEATURES             Location/Qualifiers
     source          1..8240
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.53 cM"
     gene            1..8240
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /note="calcium channel, voltage-dependent, T type, alpha
                     1H subunit"
                     /db_xref="GeneID:58226"
                     /db_xref="MGI:MGI:1928842"
     exon            1..314
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            315..631
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     CDS             333..7412
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /note="isoform 1 is encoded by transcript variant 1;
                     calcium channel alpha13.2 subunit; voltage-dependent
                     T-type calcium channel subunit alpha-1H;
                     low-voltage-activated calcium channel alpha13.2 subunit;
                     voltage-gated calcium channel subunit alpha Cav3.2; T-type
                     Cav3.2"
                     /codon_start=1
                     /product="voltage-dependent T-type calcium channel subunit
                     alpha-1H isoform 1"
                     /protein_id="NP_067390.4"
                     /db_xref="CCDS:CCDS37501.1"
                     /db_xref="GeneID:58226"
                     /db_xref="MGI:MGI:1928842"
                     /translation="MTEGTLAADEVRVPLGASPSAPAAPVRASPASPGVPGREEQRGS
                     GSSVLAPESPGTECGADLGADEEQPVPYPALAATVFFCLGQTTRPRSWCLRLVCNPWF
                     EHISMLVIMLNCVTLGMFRPCEDVECRSERCSILEAFDDFIFAFFAVEMVIKMVALGL
                     FGQKCYLGDTWNRLDFFIVMAGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPSMRI
                     LVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSAFVRNNNLTFLR
                     PYYQTEEGEENPFICSSRRDNGMQKCSHIPSRRELRVQCTLGWEAYGQPQAEDGGAGR
                     NACINWNQYYNVCRSGEFNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHS
                     FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRENQLMREQRARYLSNDSTLASF
                     SEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSSTLHGQGPRRRPRRA
                     GRRTASVHHLVYHHHHHHHHHYHFSHGGPRRPSPEPGAGDTRLVRACVPPSPPSPGHG
                     PPDSESVHSIYHADCHVEGPQERARVAHTIATAASLKLASGLGTMNYPTILPSGAVNS
                     KGSTSSRPKGLRSAGTPGATAHSPLSLGSPSPYEKIQHVVGEQGLGRASSHLSGLSVP
                     CPLPSPQAGTLTCELKSCPYCASALEDPEFEFSGSESGDSDAHGVYEFTQDVRHGDCR
                     DPVQQPHEGGTPGHGNERWRPPLRTASQPGGLGRLWASFSSKLRRIVDSKYFNRGIMA
                     AILVNTLSMGVEYHEQPDELTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNI
                     FDGIVVIISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLMRTMDNVAT
                     FCMLLMLFIFIFSILGMHLFGCKFSLKTDSGDTVPDRKNFDSLLWAIVTVFQILTQED
                     WNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDATRSDTDEDK
                     TSTHLEEDFDKLRDVQATEMKMYSLAVTPNGHLEGRGSLPPPLITHTAATPMPTPKSS
                     PHLDMAHTLLDSRRSSSGSVDPQLGDQKSLASLRSSPCAPWGPNSAGSSRRSSWNSLG
                     RAPSLKRRSQCGERESLLSGEGKGSTDDEAEDSRPNSGTHPGASPGPRATPLRRAESL
                     GHRSTMDLCPPRPATLLPTKFRDCNGQMVALPSEFFLRIDSHKEDAAEFDDDIEDSCC
                     FRLHKVLEPYAPQWCSSRESWALYLFPPQNRLRVSCQKVIAHKMFDHVVLVFIFLNCI
                     TIALERPDIDPGSTERAFLSVSNYIFTAIFVVEMMVKVVALGLLWGEHAYLQSSWNVL
                     DGLLVLVSLVDIIVAVASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLIS
                     SLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGTDTRNITTKAECHAAHYRWVRR
                     KYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGIDQQPVQNHNPWMLLYFISFLLI
                     VSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRKAQRRPYYADYSH
                     TRRSIHSLCTSHYLDLFITFIICLNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFE
                     AALKLVAFGFRRFFKDRWNQLDLAIVLLSIMGIALEEIEMNAALPINPTIIRIMRVLR
                     IARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSED
                     NPCEGLSRHATFTNFGMAFLTLFRVSTGDNWNGIMKDTLRECTREDKHCLSYLPALSP
                     VYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAEMDAEIELEIAQGSTAQPPST
                     AQESQGTEPDTPNLLVVRKVSVSRMLSLPNDSYMFRPVAPAAAPHSHPLQEVEMETYT
                     GPVTSAHSPSLEPRTSFQVPSAASSPARVSDPLCALSPRDTPRSLSLSRILCRQEAMH
                     AESLEGQIDDAGEDSIPDYTEPAENISMSQAPLGTLRSPPCSPRPASVRTRKHTFGQH
                     CISSRPPTLGGDDAEAADPADEEVSHITSSAHPWPATEPHSPEASPTASPAKGTVGSG
                     RDPHRFCSVDAQSFLDKPGRPDAQRWSSVELDNGDGHLESGEVRARASELEPALGARR
                     KKKMSPPCISIDPPTEDEGSSRPPAAEGGNTTLRRRTPSCEAALHRDCPESTEGPGTG
                     GDPVAKGERWGQASCRAEHLTVPNFAFEPLDMGGPGGDCFLDSDQSVTPEPRVSSLGA
                     IVPLILETELSMPSGDPPEKEQGLYLTVPQTPLKKPGSPPATPAPDDSGDEPV"
     exon            632..743
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            744..877
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            878..975
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1135
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1451
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1544
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..2334
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2774
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2926
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            2927..3112
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            3113..3230
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            3231..3386
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            3387..3477
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            3478..3686
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            3687..4109
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            4110..4210
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            4211..4334
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            4335..4403
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            4404..4588
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            4589..4715
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            4716..4841
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            4842..4931
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            4932..5124
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            5125..5276
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            5277..5386
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            5387..5520
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            5521..5591
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            5592..5670
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            5671..5792
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            5793..6038
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            6039..6207
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            6208..6368
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     exon            6369..8228
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8202..8207
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /note="hexamer: AATAAA"
     polyA_site      8228
                     /gene="Cacna1h"
                     /gene_synonym="alpha13.2; Cav3.2; MNCb-1209"
                     /note="major polyA site"
ORIGIN      
        1 actccgaagt ttcctgcgct gtgcgcggac gggctccagg gctcgctcgc tccctctctg
       61 gctcggccgc gcccccggcc cgtgcctgcg gtccgcgccc gccccgccgt gcatttagcg
      121 gttttccgca tcgggacacc gttgctgctg ctgggcgggc cggagctaga gcttccgcga
      181 gagctggtgc cgggtgggcc gggggcgcgg gccgaggagg cgatactggc ccagctccgg
      241 gctctggact gggtccccag tgacagcgcc gcccgggcta tgcccacagg gacgccgctg
      301 gccaccggag cgaggtgctg ccctctgcca ccatgaccga gggcacgctg gcagcggacg
      361 aggtccgggt gcccctgggc gcttcgcctt cggctcctgc agcgccggtg agggcttccc
      421 cagcgagccc tggggtgccg gggcgcgagg agcagcgagg atccgggtcg agcgtgttgg
      481 ctcccgagag cccagggacc gagtgtggtg cggacctggg cgccgacgag gaacagcccg
      541 tcccataccc cgctctggct gccacagtct tcttctgcct cgggcaaacc acgcggcccc
      601 gcagctggtg cctccgactg gtttgtaacc cgtggttcga gcacattagc atgctggtca
      661 tcatgctgaa ctgcgtgaca ctgggcatgt tccggccctg tgaggatgtt gagtgccgtt
      721 cagaacgttg cagcatcttg gaggcctttg atgacttcat ctttgccttc tttgctgtgg
      781 agatggttat caagatggtg gctttgggac tgttcggcca gaaatgctac ctgggtgaca
      841 cctggaacag gctggacttc ttcattgtca tggctggcat gatggaatac tctctggacg
      901 gacacaacgt gagcctctct gccatccgaa cagtgcgtgt gctgcggccc ctccgcgcca
      961 tcaaccgggt ccccagcatg cgaatcctgg tcacactgct gctggacaca ctgcccatgc
     1021 ttgggaacgt gcttcttctc tgcttcttcg tcttcttcat cttcggcatc gttggggtcc
     1081 agctctgggc tggcctgctg cggaaccgat gcttcctgga cagcgccttc gtcaggaaca
     1141 acaacctgac cttcttgcgg ccatactacc agacagagga gggcgaggag aacccattca
     1201 tctgctcctc acgccgcgac aacggcatgc agaaatgctc acacatcccc agccgccgtg
     1261 agcttcgcgt gcagtgcacg ctcggctggg aggcctacgg gcagccacag gctgaggatg
     1321 ggggtgccgg ccgaaatgcc tgcatcaact ggaaccagta ctacaacgtg tgccgctcgg
     1381 gggaattcaa ccctcacaat ggtgccatca actttgacaa cattggctat gcttggatcg
     1441 ccatcttcca ggtcatcaca ctggagggct gggtggacat catgtactac gtcatggatg
     1501 cccactcgtt ctacaacttc atctacttca tcctcctcat cattgtgggc tccttcttca
     1561 tgatcaacct gtgcctggtg gtgatagcca cacagttctc agagacaaag cagagggaaa
     1621 accagctgat gcgtgaacag cgggcccgct atctgtccaa cgacagcact ctggccagct
     1681 tctcggagcc tggcagctgc tacgaggagc tcctcaagta tgtgggccac atcttccgaa
     1741 aggttaaacg ccggagcctg cgcctttacg cccgctggca gagccgttgg cgtaagaagg
     1801 tagatcccag cagcactctg catggccaag gccccaggcg gcggccacgg cgcgcaggca
     1861 ggcgcacagc ttctgtgcac catctggtct accaccacca ccaccaccat caccaccatt
     1921 accacttcag ccacggtggc ccacgcaggc ctagcccaga gccaggtgct ggtgacacca
     1981 ggttggtcag ggcctgtgtg ccaccctcgc caccatcccc aggccacggg ccaccagact
     2041 ctgagtctgt gcacagtatc taccatgctg actgccacgt ggaggggcca caggaaagag
     2101 cccgtgtggc gcacaccata gccactgctg ccagcctcaa gctggcctca ggcttgggca
     2161 ccatgaacta ccccaccatc ctaccttcag gagcagtcaa cagcaaaggc agtaccagct
     2221 cgcgacccaa ggggcttcgg agtgctggca ccccaggggc cacagcacac agccctctga
     2281 gcctggggag ccccagcccc tatgagaaga tccagcacgt ggttggagaa caaggactag
     2341 gccgagcctc tagtcacctg tcaggcctga gtgtgccttg ccccctgccc agcccccagg
     2401 ctggcacact gacctgtgag ctgaagagct gcccatattg tgccagcgcc ctggaggacc
     2461 ccgagtttga gttcagtggc tcagagagtg gggactcgga tgcccatgga gtctatgagt
     2521 ttacacagga cgtacggcat ggggattgcc gagatcctgt gcagcagccc catgaagggg
     2581 gcacgccggg ccatggcaac gaacggtggc ggccaccact gcggacagcc tcacagccag
     2641 gagggttagg ccgcctctgg gcttccttta gtagcaagct gcgtcgcatt gtagacagca
     2701 agtacttcaa ccgaggcatc atggcagcca tcctcgtcaa tactctgagc atgggtgttg
     2761 agtatcatga gcagcctgat gagctgacta acgcgctgga gataagcaac atcgtgttca
     2821 ccagcatgtt tgccttggag atgctactga agttgctggc ctgtggcccg ctgggctaca
     2881 ttcggaaccc ctacaacatc tttgatggca ttgttgtcat cataagcgtc tgggagattg
     2941 tggggcaggc agatggtggc ctgtcagtgc tccgtacgtt ccggctgctg cgggtgctga
     3001 agctggtgcg cttcctgcca gccctgcggc ggcagctggt ggtgctcatg aggaccatgg
     3061 acaatgtggc caccttctgc atgctgctaa tgctcttcat cttcatcttc agcatcctgg
     3121 gcatgcacct gtttggctgt aagttcagcc tgaagacaga ctctggagac accgtccctg
     3181 acaggaagaa cttcgactct ctactgtggg ccatcgtcac tgtgtttcag atcttgacac
     3241 aggaagactg gaatgtggtt ctttacaacg gcatggcttc cacctcgtcc tgggctgccc
     3301 tttactttgt ggccctcatg acctttggga actatgtgct cttcaacctg ctggtagcca
     3361 tcctggtgga aggcttccag gcagagggtg atgccaccag atctgacacc gatgaggata
     3421 agacatctac ccacctagag gaagatttcg ataagctcag agacgttcaa gccacagaga
     3481 tgaagatgta ctcactggct gtgaccccta atgggcacct agagggccga ggcagtctgc
     3541 cgccgcctct catcacgcac acagcggcta cgcctatgcc tacccccaag agctcccctc
     3601 atctggacat ggcccacact cttttggact cacggcgcag cagcagtggc tctgtggacc
     3661 cccaactcgg ggaccagaag tctctggcta gcctgcgcag ctccccttgt gccccatggg
     3721 gccccaacag tgcaggaagc agccggcgct ccagctggaa cagcctgggc cgcgcaccca
     3781 gcctcaaacg ccgcagccag tgtggggagc gcgagtccct gctctctggt gaggggaagg
     3841 gcagcacgga tgatgaggcc gaggacagca gaccaaactc agggacccac ccaggagctt
     3901 cacccgggcc ccgggccaca cccctgcggc gggctgagtc gttgggccac cgcagcacaa
     3961 tggacctgtg ccccccacgg cctgccaccc tcctgcccac caagttccgt gactgcaacg
     4021 ggcagatggt ggccctgccc agcgagttct tcctgcgcat cgacagccac aaggaggacg
     4081 cagcagagtt tgatgatgac atagaagata gctgctgctt ccgcctgcac aaagtgctgg
     4141 agccctatgc accccagtgg tgcagcagcc gggagtcctg ggccctgtat ctcttcccgc
     4201 cgcagaacag gctacgcgtc tcctgccaga aagtcatcgc acacaagatg tttgaccacg
     4261 tggtccttgt cttcatcttc ctcaactgta tcaccattgc cctggagagg ccagacatcg
     4321 atccgggcag cactgaacgg gcctttctca gcgtctccaa ctacatcttc acagccatct
     4381 tcgtggtgga gatgatggtg aaggtggtag ccctggggct gctgtggggt gagcatgcct
     4441 acctgcagag cagctggaat gtgctggacg ggctgcttgt cctggtgtcc ctggttgaca
     4501 tcattgtggc cgtggcctct gccggtggtg ccaagatcct aggcgtcctg cgcgtgctgc
     4561 gcctgctgcg gaccctgagg cctctgaggg tcatcagccg agctccaggc ctcaagctgg
     4621 tcgtggagac tctgatatca tcgctcaggc ccatcgggaa catcgtcctc atctgctgcg
     4681 ccttcttcat tatctttggc atcctcgggg tgcagctttt caagggcaaa ttctactact
     4741 gcgagggtac agataccagg aatatcacca ccaaggccga gtgccatgcc gcccactacc
     4801 gctgggtgag gcgcaaatac aactttgaca acctgggtca ggcgctgatg tctctgttcg
     4861 tgctgtcatc caaggatggc tgggtaaaca tcatgtacga cgggctggac gccgtgggca
     4921 tcgaccagca gcctgtgcag aaccacaacc cctggatgct gctctacttc atctccttcc
     4981 tgctcatcgt cagcttcttc gtgctcaaca tgtttgtggg cgtggtggtg gagaacttcc
     5041 acaagtgccg gcagcaccag gaggcggagg aagcgcggcg gcgcgaggag aaacggctgc
     5101 ggcgcctgga gaggaggcgc aggaaggccc agcgccggcc ctactacgca gactattcac
     5161 acacgcgccg ctccatccat tcgctgtgca ccagccacta cctggacctc ttcatcacct
     5221 tcatcatctg cctcaatgtc atcaccatgt ccatggagca ctacaaccag cccaagtctc
     5281 tggacgaggc ccttaagtac tgcaactacg tctttaccat cgtcttcgtc tttgaggccg
     5341 cactgaagct ggtggccttt ggattccgga ggttcttcaa ggacaggtgg aaccagctgg
     5401 acttggccat cgtcctcctg tccatcatgg gcattgcgct ggaggagatt gagatgaatg
     5461 ctgccctccc catcaacccc accatcatcc gcatcatgcg cgtgcttcgc atcgcccgtg
     5521 tgctgaagct actgaagatg gccacaggca tgcgcgccct gctggacact gtggttcaag
     5581 ctctgcctca ggtagggaac cttggtcttc ttttcatgct cctgtttttt atctatgctg
     5641 ccctgggagt ggagctgttt gggaggctag aatgcagcga ggataatccc tgtgagggcc
     5701 tgagcagaca cgccaccttc accaactttg gcatggcctt cctcacgttg ttccgagtgt
     5761 ccactgggga caactggaat gggatcatga aggatactct ccgtgaatgt acccgtgaag
     5821 acaagcactg cctcagctac ctgcccgcgc tctcccccgt ctacttcgtc accttcgtgc
     5881 tggtcgccca gttcgtgctg gtcaacgtgg tggtggccgt gctcatgaag cacctggagg
     5941 agagcaacaa ggaggcccgg gaggatgcgg agatggatgc cgagatcgag ctggagatcg
     6001 cacaggggtc cacagcccag cccccgtcca cagcacagga aagccaaggt accgagccag
     6061 acaccccgaa cctcctggtc gtgcgcaaag tatctgtgtc caggatgctc tcgctaccca
     6121 atgacagcta catgttccgg ccggtggctc ctgcggctgc cccgcattcc cacccactgc
     6181 aggaagtgga gatggagacc tacacaggcc cggtcacctc tgctcactcg ccatccctgg
     6241 agccccgcac ctccttccag gtcccatcag ctgcgtcctc cccagccagg gtcagcgacc
     6301 ccctttgtgc cctctcaccc cgggatacgc cccgctctct gagcctctca cggatactct
     6361 gcagacagga ggccatgcac gcagagtccc tggaagggca gatagatgac gctggagaag
     6421 acagcatccc agactacacg gagcctgctg aaaatatctc catgagccag gcacctctgg
     6481 gtaccctgcg gtctcctcca tgctccccac ggcctgccag tgtccgtacc cgcaagcaca
     6541 cttttgggca gcactgcatc tccagccgcc ctcccaccct gggaggagat gatgctgaag
     6601 cagcagaccc ggccgatgag gaggtcagcc acatcaccag ctcagcccac ccttggccag
     6661 ctacagagcc ccacagccca gaggcctccc cgacagcctc tcctgcaaaa ggcacagtgg
     6721 gcagtgggcg ggacccacac aggttctgca gtgtagatgc tcagagcttc ctggacaaac
     6781 caggtcggcc agatgcacag cggtggtcct cggtggaact ggataatggg gatggccacc
     6841 tagagtctgg ggaagtgagg gcccgggcct cagagctaga accagctctt ggggcacgga
     6901 ggaagaagaa gatgagccct ccctgcatct ccattgaccc tcccactgaa gatgagggct
     6961 cctcccgccc ccctgcagca gaaggaggca acactactct gaggcgccga accccgtcct
     7021 gtgaggctgc cctccatagg gactgcccag agtctacaga gggcccaggc actggagggg
     7081 accctgtagc caagggtgag cgctggggcc aggcctcttg ccgggcagag catctgactg
     7141 tccccaactt tgcctttgag cctctggaca tgggcggacc tggtggagac tgtttcttgg
     7201 acagtgacca aagtgtgacc ccagaaccca gagtttcctc tttgggggct atagtgcctc
     7261 taatactaga aactgaactt tctatgccct ctggtgaccc cccagagaag gagcaaggac
     7321 tgtacctcac tgtgccccag acccccttga agaaaccagg gtctccccca gccactcctg
     7381 ccccagatga cagtggagat gagcctgtgt agactgggct gtgtgtccac agggctttgg
     7441 cattgaggtt gttggctccc tgcagggtgg tagccccagt cagggctatg agtggaccct
     7501 ggcttaggcc ccaccaaggc agagggaccg ggaaatacta tcccgggaga ggcagcagac
     7561 gttccgtctc tgcaccatga cacaggagca gcctcgggcc ccacgagcct ccctcgtggt
     7621 gattcaggtt tgggttttcc tgagttttaa ccaccaccag aagttgtacc aggaccaggt
     7681 catcagtctc aggaggagat actgtgtcct gagaaggacc agaaattcct catgggcagg
     7741 agggcaccac agctccatcc atgtgacaca caggttgccg atagggagta cacgcttgag
     7801 ccccttgtgc cctggtgggc agacatcggg tcctgtagcc gccacaaccc atatcacctt
     7861 cgttcacggt ctcgttcctg tccatcatca ctcggcatcc ttccctctca cagtacccca
     7921 cccccatcat tccatcctct taggtggttt agaaactttg cagtgaccct gggaagggcc
     7981 acatcaccaa ggagtactgg cccatgcaat aagacgtcac agtcccaaca gaggcggggc
     8041 ttcccctcca tcccaggctg tcaggctcag cgttcatttg acatccattt gctttatgtc
     8101 atccgttcta caaattcagg ttaaatgttg caataatctg atgcagaaaa cttggcttcc
     8161 taagtcaaag ctaaggggag gggaggggca aagcaaagct gaataaacac taacttattt
     8221 aagaaagaaa aaaaaaaaaa
//
