LOCUS       NM_019582               6075 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus calcium channel, voltage-dependent, alpha 1F subunit
            (Cacna1f), mRNA.
ACCESSION   NM_019582
VERSION     NM_019582.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6075)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6075)
  AUTHORS   Laird,J.G., Kopel,A., Lankford,C.K. and Baker,S.A.
  TITLE     Mouse all-cone retina models of Cav1.4 synaptopathy
  JOURNAL   Front Mol Neurosci 16, 1155955 (2023)
   PUBMED   37181655
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6075)
  AUTHORS   Erdogmus,S., Concepcion,A.R., Yamashita,M., Sidhu,I., Tao,A.Y.,
            Li,W., Rocha,P.P., Huang,B., Garippa,R., Lee,B., Lee,A., Hell,J.W.,
            Lewis,R.S., Prakriya,M. and Feske,S.
  TITLE     Cavbeta1 regulates T cell expansion and apoptosis independently of
            voltage-gated Ca2+ channel function
  JOURNAL   Nat Commun 13 (1), 2033 (2022)
   PUBMED   35440113
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6075)
  AUTHORS   Gao,S., Li,Y., Bissig,D., Cohen,E.D., Podolsky,R.H., Childers,K.L.,
            Vernon,G., Chen,S., Berkowitz,B.A. and Qian,H.
  TITLE     Functional regulation of an outer retina hyporeflective band on
            optical coherence tomography images
  JOURNAL   Sci Rep 11 (1), 10260 (2021)
   PUBMED   33986362
  REMARK    Erratum:[Sci Rep. 2022 May 16;12(1):8091. doi:
            10.1038/s41598-022-12279-1.. PMID: 35577893]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6075)
  AUTHORS   Zanetti,L., Kilicarslan,I., Netzer,M., Babai,N., Seitter,H. and
            Koschak,A.
  TITLE     Function of cone and cone-related pathways in CaV1.4 IT mice
  JOURNAL   Sci Rep 11 (1), 2732 (2021)
   PUBMED   33526839
  REMARK    GeneRIF: Function of cone and cone-related pathways in CaV1.4 IT
            mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6075)
  AUTHORS   Berntson,A., Taylor,W.R. and Morgans,C.W.
  TITLE     Molecular identity, synaptic localization, and physiology of
            calcium channels in retinal bipolar cells
  JOURNAL   J Neurosci Res 71 (1), 146-151 (2003)
   PUBMED   12478624
  REMARK    GeneRIF: report the presence of the alpha(1F) subunit in mouse
            retinal bipolar cell synaptic terminals
REFERENCE   7  (bases 1 to 6075)
  AUTHORS   Morgans,C.W., Gaughwin,P. and Maleszka,R.
  TITLE     Expression of the alpha1F calcium channel subunit by photoreceptors
            in the rat retina
  JOURNAL   Mol Vis 7, 202-209 (2001)
   PUBMED   11526344
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 6075)
  AUTHORS   Brunkow,M.E., Jeffery,E.W., Hjerrild,K.A., Paeper,B., Clark,L.B.,
            Yasayko,S.A., Wilkinson,J.E., Galas,D., Ziegler,S.F. and
            Ramsdell,F.
  TITLE     Disruption of a new forkhead/winged-helix protein, scurfin, results
            in the fatal lymphoproliferative disorder of the scurfy mouse
  JOURNAL   Nat Genet 27 (1), 68-73 (2001)
   PUBMED   11138001
REFERENCE   9  (bases 1 to 6075)
  AUTHORS   Naylor,M.J., Rancourt,D.E. and Bech-Hansen,N.T.
  TITLE     Isolation and characterization of a calcium channel gene, Cacna1f,
            the murine orthologue of the gene for incomplete X-linked
            congenital stationary night blindness
  JOURNAL   Genomics 66 (3), 324-327 (2000)
   PUBMED   10873387
REFERENCE   10 (bases 1 to 6075)
  AUTHORS   Means,G.D., Toy,D.Y., Baum,P.R. and Derry,J.M.
  TITLE     A transcript map of a 2-Mb BAC contig in the proximal portion of
            the mouse X chromosome and regional mapping of the scurfy mutation
  JOURNAL   Genomics 65 (3), 213-223 (2000)
   PUBMED   10857745
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672231.7 and AJ579852.2.
            
            On Oct 7, 2006 this sequence version replaced NM_019582.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF192497.1, AJ579852.2 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AL672231.7         23859-23901
            44-5998             AJ579852.2         1-5955
            5999-6075           AL672231.7         51876-51952
FEATURES             Location/Qualifiers
     source          1..6075
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 3.42 cM"
     gene            1..6075
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /note="calcium channel, voltage-dependent, alpha 1F
                     subunit"
                     /db_xref="GeneID:54652"
                     /db_xref="MGI:MGI:1859639"
     exon            1..68
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..5998
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /note="L-type dihydropyridine-sensitive calcium channel
                     alpha-1f subunit; voltage-gated calcium channel subunit
                     alpha Cav1.4"
                     /codon_start=1
                     /product="voltage-dependent L-type calcium channel subunit
                     alpha-1F"
                     /protein_id="NP_062528.2"
                     /db_xref="CCDS:CCDS40840.1"
                     /db_xref="GeneID:54652"
                     /db_xref="MGI:MGI:1859639"
                     /translation="MSESEVGKDTTPEPSPANGTGPGPEWGLCPGPPTVGTDTSGASG
                     LGTPRRRTQHNKHKTVAVASAQRSPRALFCLTLTNPIRRSCISIVEWKPFDILILLTI
                     FANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIR
                     NGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVS
                     GVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEA
                     EEDPSPCASSGSGRSCTLNHTECRGRWPGPNGGITNFDNFFFAMLTVFQCITMEGWTD
                     VLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLR
                     EKQQMEEDLRGYLDWITQAEELDLHDPSVDGNLASLAEEGRAGHRPQLSELTNRRRGR
                     LRWFSHSTRSTHSTSSHASLPASDTGSMTDTPGDEDEEEGTMASCTRCLNKIMKTRIC
                     RHFRRANRGLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPLWLTQTQEYANK
                     VLLCLFTVEMLLKLYGLGPSVYVASFFNRFDCFVVCGGILETTLVEVGAMQPLGISVL
                     RCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF
                     NFDQTHTKRSTFDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCVYFII
                     LFICGNYILLNVFLAIAVDNLASGDAGTAKDKGREKSSEGNPPKENKVLVPGGENEDA
                     KGARSEGAAPGMEEEEEEEEEEEEEEEEENGAGHVELLQEVVPKEKVVPIPEGSAFFC
                     LSQTNPLRKACHTLIHHHIFTSLILVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAF
                     TSIFTVEILLKMTVFGAFLHRGSFCRSWFNLLDLLVVSVSLISFGIHSSAISVVKILR
                     VLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY
                     SCTDEAKHTLKECKGSFLIYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTF
                     EGWPALLYKAIDANAEDEGPIYNYHVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQ
                     GEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAFEYLMFLLIL
                     LNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFADAWNTFDA
                     LIVVGSVVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLL
                     WTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLL
                     LFRCATGEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSSFAIVYFISFFMLCAFLII
                     NLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQP
                     PLGFGKLCPHRVACKRLVAMNVPLNSDGTVTFNATLFALVRTSLKIKTEGNLDQANQE
                     LRMVIKKIWKRIKQKLLDEVIPPPDEEEVTVGKFYATFLIQDYFRKFRRRKEKGLLGR
                     EAPTSTSSALQAGLRSLQDLGPEIRQALTYDTEEEEEEEEAVGQEAEEEEAENNPEPY
                     KDSIDSQPQSRWNSRISVSLPVKEKLPDSLSTGPSDDDGLAPNSRQPSVIQAGSQPHR
                     RSSGVFMFTIPEEGSIQLKGTQGQDNQNEEQEVPDWTPDLDEQAGTPSNPVLLPPHWS
                     QQHVNGHHVPRRRLLPPTPAGRKPSFTIQCLQRQGSCEDLPIPGTYHRGRTSGPSRAQ
                     GSWAAPPQKGRLLYAPLLLVEESTVGEGYLGKLGGPLRTFTCLQVPGAHPNPSHRKRG
                     SADSLVEAVLISEGLGLFAQDPRFVALAKQEIADACHLTLDEMDSAASDLLAQRTTSL
                     YSDEESILSRFDEEDLGDEMACVHAL"
     exon            69..318
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            319..424
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            425..564
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            565..707
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            708..860
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1057
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1161
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1352
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1445
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1539
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1566
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1727
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1953
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2161
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2282
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2364
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            2365..2410
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            2411..2462
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..2628
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..2758
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..2818
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            2819..2925
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            2926..3013
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            3014..3121
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            3122..3174
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            3175..3321
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            3322..3523
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            3524..3682
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            3683..3793
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            3794..3877
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            3878..3898
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            3899..4027
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            4028..4093
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            4094..4185
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            4186..4345
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            4346..4473
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            4474..4570
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            4571..4673
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            4674..4775
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            4776..4906
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            4907..5050
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            5051..5220
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            5221..5328
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            5329..5456
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            5457..5569
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            5570..5767
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
     exon            5768..6075
                     /gene="Cacna1f"
                     /gene_synonym="A930034B14; Cav1.4; nerg1; nob2; Sfc17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggaggact gtgtgcagat ggtccttata tctcctgagg aggatgtcgg aatctgaagt
       61 cgggaaagat acaaccccag agcccagtcc agccaatggg actggccctg gccctgaatg
      121 ggggctctgt cctgggcctc caactgtggg gactgatacc agcggggcgt caggcctggg
      181 gaccccaaga agaaggaccc agcacaacaa acacaagact gtggcggtgg ccagtgctca
      241 gagatcacct cgagcgctct tctgcctcac ccttactaat cccattcgtc ggtcctgcat
      301 cagcattgta gagtggaagc cttttgatat tctcatcctc ctgacaatct ttgccaactg
      361 cgtggcattg ggggtatata tccccttccc tgaggacgac tccaacactg ctaaccacaa
      421 cttggaacag gtagaatacg tgttcctggt gattttcacc gtggagacag tgctcaagat
      481 cgtagcctat gggctggtgc tccatcccag cgcctatatt cgcaatggct ggaacctgct
      541 cgacttcatc atcgtcgtgg tcgggctgtt cagcgtgctg ctggaacaag gacctgggcg
      601 gccaggagat gccccgcata ctggaggaaa gccaggaggc ttcgatgtaa aggcactgcg
      661 ggcatttagg gtgctacgac ctctaaggct agtgtctggg gtcccgagtc tgcacatagt
      721 gctcaattcc atcatgaagg cgcttgtgcc gctgctgcac attgccctgt tggtgctctt
      781 cgtcattatc atttacgcca tcatcggact cgagctattc ctcggacgaa tgcacaagac
      841 atgctacttc ctgggatctg atatggaagc agaggaggac ccatcacctt gtgcatcttc
      901 tggctctggg cgttcatgca cactgaacca taccgagtgc cgcgggcgct ggccaggacc
      961 caacggtggc atcacgaact tcgacaattt tttctttgcc atgctaactg tgttccagtg
     1021 tattaccatg gaaggctgga cagacgtcct ctactggatg caggatgcca tggggtatga
     1081 gctgccttgg gtgtactttg tgagccttgt catctttggg tccttctttg tcctcaacct
     1141 tgtgcttgga gtcctaagcg gggagttctc caaggaaaga gaaaaggcaa aagcacgagg
     1201 tgactttcag aagcttcggg agaagcagca gatggaagaa gaccttcggg gctacctgga
     1261 ctggatcaca caggctgagg agttagacct tcatgacccc tcagtagacg gcaacttggc
     1321 ttctcttgct gaagagggac gggcgggcca tcggccacaa ctgtcagagc tgaccaatag
     1381 gaggcgcgga cggctgcgat ggttcagcca ctctactcgc tccacacact ccaccagcag
     1441 ccacgccagc ctcccagcca gtgacactgg ctccatgaca gacacccctg gagatgagga
     1501 tgaagaagag gggaccatgg ctagctgtac acgctgccta aacaagatta tgaaaacaag
     1561 gatctgccgc cacttccgcc gagccaaccg gggtctccgt gcacgctgcc gccgggccgt
     1621 caagtccaac gcctgctact gggctgtact gttgctcgtc ttcctcaaca cgttgaccat
     1681 agcttcagag caccatgggc agcctttgtg gctcacccag acccaagagt atgccaacaa
     1741 agttctgctc tgcctcttca ctgtggagat gctcctcaaa ctgtacggcc tgggcccctc
     1801 tgtctacgtt gcctcctttt tcaaccgctt tgactgcttc gtggtctgtg ggggcatcct
     1861 agaaaccact ttggtggagg tgggggccat gcagcctctt ggcatctcag tgctccgatg
     1921 tgtacgtctc ctcaggatct tcaaggtcac caggcactgg gcatccctga gcaatctggt
     1981 ggcatctttg ctcaattcca tgaagtccat cgcctccttg ctgcttctcc tctttctctt
     2041 catcatcatc ttctccctgc ttggcatgca gctgtttggg ggcaagttca actttgacca
     2101 gacccacacc aagaggagca cctttgatac cttcccccaa gccctcctca ctgtctttca
     2161 gatcctgact ggtgaggatt ggaacgttgt catgtatgat ggtatcatgg cctacggtgg
     2221 gcccttcttc ccagggatgc tggtgtgtgt ttatttcatc atcctcttca tctgtggcaa
     2281 ctacatcctg ctgaacgtgt ttcttgccat tgccgtggat aacctagcca gcggggatgc
     2341 aggcactgcc aaagacaagg gcagagagaa gagcagtgaa ggaaaccctc caaaggagaa
     2401 caaagtattg gtgcctggtg gagagaatga ggacgcaaag ggtgcaagaa gtgaaggagc
     2461 agcaccaggc atggaggagg aggaggagga ggaagaagaa gaagaggagg aggaggaaga
     2521 ggaaaatggt gcaggacatg tggaactctt gcaggaagta gtacccaagg agaaggtggt
     2581 acccatccct gaaggcagtg ccttcttctg ccttagccaa accaacccgc ttcggaaggc
     2641 ctgccacaca ctcatacatc accatatctt caccagtctc atcctagtgt tcatcatcct
     2701 cagtagtgtg tccctggctg ctgaggaccc catccgagct cactccttcc gaaaccatat
     2761 tctgggatat tttgattatg ccttcacctc catattcact gtggagattc tactcaagat
     2821 gacagtgttt ggggccttcc tgcaccgagg ctctttctgc cgtagctggt tcaatctgtt
     2881 ggatctcctt gtggtcagtg tgtccctcat ctccttcggc atccactcca gtgccatctc
     2941 agttgtgaag attctccgag tcctccgagt cctgcggcct ctccgagcca tcaacagagc
     3001 caagggactc aagcatgtgg tgcagtgtgt gttcgtggcc atccggacca tcggaaacat
     3061 catgattgtc accaccctct tgcagttcat gttcgcctgc attggtgttc agctgttcaa
     3121 gggaaaattc tacagttgca ctgatgaggc caaacacacc ctgaaagaat gcaagggctc
     3181 cttcctcatc taccctgatg gagatgtgtc acgacctttg gtccgggagc ggctctgggt
     3241 caacagtgat tttaactttg acaacgtcct ttcagccatg atggccctgt tcactgtctc
     3301 tacctttgaa ggctggcctg cgctactata caaggccata gatgcaaacg cagaagatga
     3361 gggccctatc tacaattacc atgtggagat atcagtattc ttcattgtct acatcatcat
     3421 catcgccttc ttcatgatga acatctttgt gggctttgtt atcatcacat tccgtgccca
     3481 gggagagcag gagtaccaaa actgtgaact ggacaagaac cagcgccagt gtgtggaata
     3541 tgccctcaaa gctcagccac tccgccgata catccctaag aatcctcatc agtaccgcgt
     3601 gtgggccact gtgaactctg ctgcctttga gtacctcatg tttctgctca tcctgctcaa
     3661 cacggtggcc ctagccatgc agcactatga acagactgct ccctttaact atgccatgga
     3721 catcctcaac atggtcttca ctggcctctt caccattgag atggtgctca aaatcatcgc
     3781 ctttaaaccc aagcattact ttgcagatgc ctggaatacg tttgatgctc tcattgtagt
     3841 gggcagtgta gtcgacatcg ccgtcacaga agtcaataac ggaggccatc ttggcgagag
     3901 ttcagaggac agctcccgca tatctatcac gttctttcgc ctcttccgag tcatgaggct
     3961 ggtcaagctt ctgagtaagg gtgaggggat ccgcacactg ctctggacat tcatcaagtc
     4021 tttccaggcc ttgccctatg tggcacttct catagcaatg atattcttca tctatgcagt
     4081 cattggcatg cagatgtttg gcaaggtggc tcttcaggac ggcacgcaga taaatcgaaa
     4141 caacaatttc cagacctttc cgcaggctgt gctgcttctg ttcaggtgtg ccactggtga
     4201 ggcctggcaa gagataatgc tagccagcct tccaggaaat cgatgtgacc ctgagtctga
     4261 ctttggccca ggcgaggaat ttacctgtgg tagcagtttt gccatcgtct acttcatcag
     4321 cttctttatg ctctgtgcct tcctgattat aaatctcttt gtggctgtaa tcatggataa
     4381 ctttgattac ctaaccagag attggtctat cctgggaccc caccaccttg atgaattcaa
     4441 gaggatctgg tctgaatatg accccggagc caagggccgc atcaagcact tggatgtggt
     4501 tgccctgctg agacgcatcc agcccccatt gggatttgga aagctatgcc cacaccgagt
     4561 ggcctgcaag agactcgtgg caatgaatgt gcccctcaac tcagatggaa cagtgacatt
     4621 caacgctaca ctctttgccc tggtgcggac atccctgaag atcaagacag aagggaacct
     4681 ggatcaagcc aaccaggagc ttcggatggt catcaaaaag atctggaagc ggataaagca
     4741 gaaattgttg gatgaggtca tccctcctcc cgatgaggag gaggtcactg tgggaaaatt
     4801 ctatgccaca ttcctgatcc aagattattt ccgaaaattc cggagaagga aagaaaaggg
     4861 gctactagga agagaggccc caacaagcac atcctctgcc ctccaggctg gtctaaggag
     4921 cctgcaggac ttgggtcctg agatccgtca agccctcacc tatgacactg aggaagaaga
     4981 ggaagaggaa gaggcagtgg gtcaggaggc tgaggaagag gaagctgaga acaacccaga
     5041 accatacaaa gactccatag actcccagcc ccaatctcga tggaactcta ggatttcggt
     5101 gtctctacct gttaaggaga aacttccaga ttctctctca actgggccga gtgatgatga
     5161 tgggctggct cccaactcca ggcagcccag tgtgatacag gctggctccc aaccacacag
     5221 gagaagctct ggggttttca tgttcactat cccggaagaa ggaagtattc agctcaaggg
     5281 aactcaaggg caggacaatc agaatgagga acaggaagtc cctgactgga ctcctgacct
     5341 ggatgagcag gccgggactc cttcgaaccc agtcctttta ccacctcact ggtcccagca
     5401 acacgtaaac gggcaccatg tgccacgccg acgtttgctg ccccccacgc ctgcaggtcg
     5461 gaagccctcc ttcaccatcc agtgtctgca acgccagggc agttgtgaag atttacctat
     5521 cccaggcacc taccatcgtg gacggacctc aggaccaagc agggctcagg gttcctgggc
     5581 agcccctcct cagaagggtc gactgctata tgcccccctg ttgttggtgg aggaatctac
     5641 agtgggtgaa ggataccttg gcaaacttgg cggcccactg cgtaccttca cctgtctgca
     5701 agtgcctgga gctcatccga atcccagcca ccgcaagagg ggcagtgctg acagtttggt
     5761 ggaggctgtg ctcatctccg aaggcctagg tctctttgcc caagacccac gatttgtggc
     5821 cctggccaag caggagattg cagatgcatg tcacctgacc ctggatgaga tggacagtgc
     5881 tgccagtgac ctgctggcac agagaaccac ctccctttac agtgatgagg agtctattct
     5941 ttcccgcttt gatgaagagg acctgggaga tgagatggcc tgtgtccatg ccctctaaat
     6001 ccttacccct catctactgc tcaataaact ccctgccctt ccttccccca gagggaggca
     6061 ggcatggacc acaca
//
