LOCUS       NM_001042528            9791 bp    mRNA    linear   ROD 07-DEC-2024
DEFINITION  Mus musculus calcium channel, voltage-dependent, N type, alpha 1B
            subunit (Cacna1b), transcript variant 1, mRNA.
ACCESSION   NM_001042528
VERSION     NM_001042528.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9791)
  AUTHORS   Chin,M. and Kaeser,P.S.
  TITLE     The intracellular C-terminus confers compartment-specific targeting
            of voltage-gated calcium channels
  JOURNAL   Cell Rep 43 (7), 114428 (2024)
   PUBMED   38996073
REFERENCE   2  (bases 1 to 9791)
  AUTHORS   Peters,C., Aberle,T., Sock,E., Brunner,J., Kuspert,M.,
            Hillgartner,S., Wust,H.M. and Wegner,M.
  TITLE     Voltage-Gated Ion Channels Are Transcriptional Targets of Sox10
            during Oligodendrocyte Development
  JOURNAL   Cells 13 (13), 1159 (2024)
   PUBMED   38995010
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9791)
  AUTHORS   Salib,A.N., Crane,M.J., Lee,S.H., Wainger,B.J., Jamieson,A.M. and
            Lipscombe,D.
  TITLE     Interleukin-1alpha links peripheral CaV2.2 channel activation to
            rapid adaptive increases in heat sensitivity in skin
  JOURNAL   Sci Rep 14 (1), 9051 (2024)
   PUBMED   38643253
  REMARK    GeneRIF: Interleukin-1alpha links peripheral CaV2.2 channel
            activation to rapid adaptive increases in heat sensitivity in skin.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9791)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 9791)
  AUTHORS   Guo,P., Lim,R.C., Rajawasam,K., Trinh,T., Sun,H. and Zhang,H.
  TITLE     A methylation-phosphorylation switch controls EZH2 stability and
            hematopoiesis
  JOURNAL   Elife 13, e86168 (2024)
   PUBMED   38346162
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9791)
  AUTHORS   Girard,L., Hanna,Z., Beaulieu,N., Hoemann,C.D., Simard,C.,
            Kozak,C.A. and Jolicoeur,P.
  TITLE     Frequent provirus insertional mutagenesis of Notch1 in thymomas of
            MMTVD/myc transgenic mice suggests a collaboration of c-myc and
            Notch1 for oncogenesis
  JOURNAL   Genes Dev 10 (15), 1930-1944 (1996)
   PUBMED   8756350
REFERENCE   7  (bases 1 to 9791)
  AUTHORS   Waterman,S.A.
  TITLE     Multiple subtypes of voltage-gated calcium channel mediate
            transmitter release from parasympathetic neurons in the mouse
            bladder
  JOURNAL   J Neurosci 16 (13), 4155-4161 (1996)
   PUBMED   8753877
REFERENCE   8  (bases 1 to 9791)
  AUTHORS   Chin,H., Kwon,O.J., Jung,H.H., Kim,D.S. and Kozak,C.A.
  TITLE     Genetic mapping of the mouse genes encoding the voltage-sensitive
            calcium channel subunits
  JOURNAL   Genomics 28 (3), 592-595 (1995)
   PUBMED   7490102
REFERENCE   9  (bases 1 to 9791)
  AUTHORS   Mynlieff,M. and Beam,K.G.
  TITLE     Adenosine acting at an A1 receptor decreases N-type calcium current
            in mouse motoneurons
  JOURNAL   J Neurosci 14 (6), 3628-3634 (1994)
   PUBMED   8207477
REFERENCE   10 (bases 1 to 9791)
  AUTHORS   Coppola,T., Waldmann,R., Borsotto,M., Heurteaux,C., Romey,G.,
            Mattei,M.G. and Lazdunski,M.
  TITLE     Molecular cloning of a murine N-type calcium channel alpha 1
            subunit. Evidence for isoforms, brain distribution, and chromosomal
            localization
  JOURNAL   FEBS Lett 338 (1), 1-5 (1994)
   PUBMED   8307146
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732525.13, BX294112.6 and AL732546.13.
            
            On Oct 27, 2022 this sequence version replaced NM_001042528.2.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF042317.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-408               AL732525.13        25776-26183         c
            409-514             AL732525.13        24788-24893         c
            515-654             AL732525.13        21294-21433         c
            655-746             BX294112.6         18547-18638         c
            747-899             BX294112.6         16798-16950         c
            900-1090            BX294112.6         15273-15463         c
            1091-1194           BX294112.6         5910-6013           c
            1195-1310           BX294112.6         4543-4658           c
            1311-1367           BX294112.6         3647-3703           c
            1368-1457           BX294112.6         2632-2721           c
            1458-1667           AL732546.13        222058-222267       c
            1668-1780           AL732546.13        218431-218543       c
            1781-1893           AL732546.13        215849-215961       c
            1894-2025           AL732546.13        213496-213627       c
            2026-2098           AL732546.13        213198-213270       c
            2099-2216           AL732546.13        206664-206781       c
            2217-2284           AL732546.13        203623-203690       c
            2285-2391           AL732546.13        201691-201797       c
            2392-3159           AL732546.13        194799-195566       c
            3160-3377           AL732546.13        193745-193962       c
            3378-3504           AL732546.13        177677-177803       c
            3505-3634           AL732546.13        174788-174917       c
            3635-3694           AL732546.13        174414-174473       c
            3695-3801           AL732546.13        173214-173320       c
            3802-3813           AL732546.13        172634-172645       c
            3814-3910           AL732546.13        170307-170403       c
            3911-4071           AL732546.13        168827-168987       c
            4072-4209           AL732546.13        167004-167141       c
            4210-4411           AL732546.13        166350-166551       c
            4412-4576           AL732546.13        165917-166081       c
            4577-4687           AL732546.13        164820-164930       c
            4688-4771           AL732546.13        164402-164485       c
            4772-4888           AL732546.13        155017-155133       c
            4889-4954           AL732546.13        154595-154660       c
            4955-5046           AL732546.13        153349-153440       c
            5047-5191           AL732546.13        151019-151163       c
            5192-5319           AL732546.13        147822-147949       c
            5320-5416           AL732546.13        141161-141257       c
            5417-5525           AL732546.13        138522-138630       c
            5526-5633           AL732546.13        134178-134285       c
            5634-5746           AL732546.13        133597-133709       c
            5747-5874           AL732546.13        132742-132869       c
            5875-6010           AL732546.13        126034-126169       c
            6011-6127           AL732546.13        125766-125882       c
            6128-6332           AL732546.13        123865-124069       c
            6333-6577           AL732546.13        123365-123609       c
            6578-9791           AL732546.13        119810-123023       c
FEATURES             Location/Qualifiers
     source          1..9791
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 16.58 cM"
     gene            1..9791
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /note="calcium channel, voltage-dependent, N type, alpha
                     1B subunit"
                     /db_xref="GeneID:12287"
                     /db_xref="MGI:MGI:88296"
     exon            1..408
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            409..514
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            515..654
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            655..746
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            747..899
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1090
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1194
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1310
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1367
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1457
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1667
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1780
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1893
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2025
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2098
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2216
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2284
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2391
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..3159
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3160..3377
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3378..3504
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3505..3634
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3635..3694
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3695..3801
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3802..3813
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3814..3910
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3911..4071
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            4072..4209
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            4210..4411
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            4412..4576
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            4577..4687
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            4688..4771
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            4772..4888
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            4889..4954
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            4955..5046
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            5047..5191
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            5192..5319
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            5320..5416
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            5417..5525
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            5526..5633
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            5634..5746
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            5747..5874
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            5875..6010
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            6011..6127
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            6128..6332
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            6333..6577
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            6578..9791
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7282..7287
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /note="hexamer: AATAAA"
     polyA_site      7304
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /note="major polyA site"
     regulatory      9522..9527
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /note="hexamer: ATTATA"
     polyA_site      9543
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /note="major polyA site"
     regulatory      9676..9681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /note="hexamer: AATAAT"
     polyA_site      9695
                     /gene="Cacna1b"
                     /gene_synonym="alpha(1B); BIII; Cav2.2; Cchn1a"
                     /note="major polyA site"
ORIGIN      
        1 gggtgcggta gcagctggcg ggcgaggtcc aggcagctcg ctgcggctag gctaggagcc
       61 cttggcgcgc cgcgccctcg gtgccgggcc gcggagcccg ggatgctcgc ggcgcccggg
      121 agtcatggtc cgcttcgggg acgagctagg cggccgctat gggggcaccg gcggcgggga
      181 gcgggctcgg ggtggcgggg ccggcggggc gggtggcccg ggccaggggg gtctgccgcc
      241 gggccagcgg gtcctgtaca agcagtccat tgcgcagcgc gcacggacta tggccctgta
      301 caaccccatc ccagtcaagc agaactgctt caccgtcaac cgctcgctct tcgtcttcag
      361 cgaggacaac gtcgtccgca aatacgctaa gcgcatcacc gaatggccgc ccttcgaata
      421 catgatcctg gccaccatca tcgccaactg cattgttctg gccctggagc agcacctccc
      481 tgatggggac aagactccca tgtctgagcg actagatgac acggagcctt acttcatcgg
      541 gatcttttgc ttcgaggcgg gcatcaagat catagccctg ggctttgttt tccacaaggg
      601 ctcctacctt cggaacggct ggaatgtcat ggacttcgtg gtggtcctca cggggattct
      661 cgccacagct ggaactgact ttgacctgcg cacactgagg gctgtgcgtg tgcttaggcc
      721 cctgaagctg gtgtctggaa ttccaagctt gcaggtggtg cttaagtcca tcatgaaggc
      781 catggtcccg ctgctgcaga ttgggctgct gctcttcttt gccatcctca tgtttgccat
      841 catcggcctc gaattctata tgggcaaatt ccataaggcc tgtttcccca acagcacaga
      901 tacagagcct gtgggtgact ttccctgtgg caaagatccc cctgctcgtc agtgtgatgg
      961 tgacaccgaa tgccgggagt actggccagg acccaacttt ggcatcacca attttgacaa
     1021 catcctgttt gccatcttga cagtgttcca gtgtatcacc atggagggct ggactgacat
     1081 cctctacaat acaaatgatg cggctggcaa cacatggaac tggttgtact tcatccccct
     1141 catcatcatt ggctccttct tcatgctcaa cctggtgctg ggtgtgcttt ccggagagtt
     1201 tgccaaggag cgggagcgag tcgagaaccg ccgcgccttc ctgaagctcc gcaggcagca
     1261 gcagattgag cgagagctga atgggtactt ggagtggatc ttcaaggcag aggaagtcat
     1321 gttggcagag gaggacaaga atgcagaaga gaaatcccct ttggatgtgt tgaagagagc
     1381 tgccaccaag aagagccgaa atgacctcat ccatgcagaa gagggggagg accggtttgt
     1441 agacctctgt gcagttgggt ctccatttgc tcgtgccagc ctcaagagtg ggaagacgga
     1501 gagctcatcg tacttccgga gaaaggagaa gatgttccgg ttctttatcc ggcgtatggt
     1561 gaaagcacag agcttctact gggtggtact gtgtgtggtg gccctgaaca cactgtgtgt
     1621 ggccatggtg cactataatc agcctcagcg gcttaccact gcactgtact ttgcagagtt
     1681 tgttttcctg ggtctcttcc tcacagagat gtccctgaag atgtatggcc tagggcccag
     1741 aagttacttc aggtcttcct tcaactgctt tgactttggg gtgattgtgg ggagtatctt
     1801 tgaagtagtc tgggctgcca tcaagccagg aacctccttt ggaatcagtg tgctgcgggc
     1861 tctgcgactg ctgaggatat tcaaagttac caagtattgg aactctctga ggaacctggt
     1921 ggtttccctc ctcaattcca tgaagtccat catcagcctt ctcttcctgc ttttcctctt
     1981 catcgtggtc ttcgctctgt tggggatgca gctgtttggg ggacagttca actttcaaga
     2041 tgagactcca accaccaatt ttgatacctt cccagctgcc atcctcactg tctttcagat
     2101 cctgacagga gaggattgga atgccgtaat gtatcatggg attgagtcgc aaggtggagt
     2161 cagcaaaggc atgttttctt ccttttactt catcgtcctg acactgtttg gaaactacac
     2221 cctgctgaat gtttttctgg ccattgctgt ggacaacctt gccaatgccc aggagttgac
     2281 caaggatgaa gaggagatgg aagaagcagc caatcagaaa cttgctcttc agaaggccaa
     2341 agaagtagct gaagtcagcc ccatgtctgc tgccaatatc tccatcgctg ccaggcagca
     2401 gaactcggcc aaggcgcgct cagtatggga gcagcgggcc agtcagctaa ggctccagaa
     2461 tctgcgtgcc agctgtgagg cattgtacag tgagatggac cctgaggagc gcctgcgtta
     2521 tgccagcacg cgccatgtga ggccagacat gaagacacac atggaccgac ccctagtggt
     2581 ggagcctggt cgagatggct tgcggggacc cgttgggagc aagtcaaagc ctgaaggcac
     2641 ggaggccaca gaaagcgcgg acctacctcg caggcaccac cggcaccgtg atagggacaa
     2701 gacctcagcc acagcacctg ctggaggcga acaggacagg acagaaagca ccgagaccgg
     2761 ggcccgggag gaacgtgcgc gccctcgtcg aagtcacagc aaggagactc caggggctga
     2821 cacgcaagtg cgctgtgagc gcagtagacg tcaccaccgg cgcggctccc cggaggaggc
     2881 cactgaacgg gagcctcggc gccaccgtgc ccaccggcat gcacaggact caagcaagga
     2941 gggcacggcg ccggtgcttg tacccaaggg tgagcgacga gcaagacacc gaggcccacg
     3001 cacgggtcca cgtgaggcag agaacaacga ggagcccaca cgcaggcacc gtgcaaggca
     3061 taaggtgcca cccacactgc agcccccaga gagggaggct gcagagaagg agagcaacgc
     3121 ggtggaaggg gataaggaaa cccgaaatca ccagcccaag gaacctcact gtgacctgga
     3181 ggccattgca gttacaggtg tgggccctct gcacatgctg cccagcacct gtctccagaa
     3241 agtggacgag caaccagagg atgcagacaa ccagcgtaat gtcacccgga tgggcagtca
     3301 gccctcagat cccagcacca ctgtgcatgt cccagtgaca ctgacaggcc ctcctgggga
     3361 gacccctgta gttcccagtg gtaacatgaa cctggaaggc caagcagagg gcaagaagga
     3421 ggcagaggcg gatgatgtgc tgagaagagg ccccaggccc atcgttccct acagctccat
     3481 gttttgtctc agccccacca acctgcttcg tcgcttctgc cattacattg tgaccatgcg
     3541 gtactttgag atggtaattc ttgtggtcat tgccttgagc agcattgccc tggctgcaga
     3601 ggatcctgtg cggacagatt cattcaggaa caacgcttta aagtacatgg attacatctt
     3661 tacaggagtc ttcacctttg aaatggtcat aaagatgata gacttgggct tgctgctgca
     3721 ccctggtgcc tacttccggg acctgtggaa cattctggac ttcattgttg tcagtggagc
     3781 cctggtggca tttgcgttct cgagcttcat gggaggatcc aaagggaaag acatcaatac
     3841 catcaagtct ctgagagtcc tgcgtgtcct gaggcccctc aagaccatca agcggctgcc
     3901 taagctcaag gctgtctttg actgtgtggt gaactccctg aagaacgtct tgaacatcct
     3961 gattgtctac atgctcttca tgttcatatt tgccgtcatt gccgtccagc tcttcaaagg
     4021 gaagttcttt tactgtactg atgaatccaa ggagctggag agggactgcc ggggtcagta
     4081 tttggattat gagaaggaag aagtagaagc ccagccaagg cagtggaaga aatatgactt
     4141 ccactatgac aatgttctct gggccttgtt gacgctgttc acagtgtcca cgggagaggg
     4201 gtggcccatg gtgctgaaac actctgtgga tgccacctat gaggaacagg ggcccagtcc
     4261 cgggttccgg atggagctct ccatcttcta cgtggtctac tttgtggtct tccctttttt
     4321 ctttgtcaac atctttgtgg ccttgatcat tatcaccttc caggaacagg gagataaggt
     4381 gatgtctgaa tgcagcttag aaaagaatga gagggcttgc attgattttg ccatcagtgc
     4441 caagcccctg acacggtaca tgcctcaaaa caaacagtcg ttccagtata agacatggac
     4501 attcgtggtc tctccaccct ttgagtactt catcatggct atgatagccc tcaacacagt
     4561 ggtgctgatg atgaagttct atgatgcacc ttatgagtac gagctgatgc tgaaatgcct
     4621 gaacattgtc ttcacatcca tgttctcgat ggagtgcata ctgaagatca tcgcctttgg
     4681 ggtattgaac tacttcagag atgcctggaa cgtctttgac tttgtcacgg ttttgggaag
     4741 tattactgat attttagtaa cagagatagc gaacaacttc atcaacctaa gcttccttcg
     4801 cctcttccgg gcggcacggc tgatcaagct gcttcgccag ggctacacca tccgcatcct
     4861 attgtggacc ttcgtccagt cctttaaggc gctgccctac gtgtgcctcc tcattgccat
     4921 gctgttcttc atctacgcca tcatcggcat gcaggttttt ggaaacattg cccttgatga
     4981 tgacaccagt atcaaccgac acaacaactt ccggacattt ctgcaagcct taatgctatt
     5041 gttcaggagt gccactgggg aggcctggca tgagatcatg ctgtcttgtc tgggcaaccg
     5101 ggcctgtgac ccacatgcca acgccagtga gtgcgggagc gactttgcct atttttattt
     5161 tgtctccttc atcttcctct gttcctttct gatgttgaac ctctttgttg ctgtaatcat
     5221 ggacaatttt gagtacctca ctcgggactc ttccatccta gggcctcacc acttagacga
     5281 attcattcga gtctgggctg aatacgaccc agctgcgtgt gggcgcatca gttacaatga
     5341 catgtttgag atgctgaaac acatgtcccc acctctgggg ttggggaaga aatgcccggc
     5401 tcgagttgca tacaagcgcc tggttcgcat gaacatgccc atatccaatg aggacatgac
     5461 ggtgcacttt acgtccacac tgatggccct catccggaca gcactggaga tcaagcttgc
     5521 cccagcgggg acgaagcagc accagtgtga tgctgagctg agaaaagaga tctcttctgt
     5581 gtgggctaat ctgccccaga agactctgga cttactggta ccaccccaca aacctgacga
     5641 gatgacagtg gggaaggtct atgctgctct catgatattt gacttctaca aacagaacaa
     5701 aaccaccaga gatcagactc accaagctcc cggaggcctg tcccagatgg gtcccgtttc
     5761 cctgttccac cctctgaagg ccaccctgga acagacacag cccgctgtgc ttcgaggagc
     5821 tcgggttttc cttcggcaaa agagtgcaac ttccctcagc aatgggggtg ccatacaaac
     5881 ccaggaaagt ggcatcaagg agtcgctgtc ctggggcacg cagaggaccc aagatgcact
     5941 ttatgaggcc agagcacctc tagaacgtgg ccattctgca gagatccctg tggggcagtc
     6001 aggaacactg gctgtggatg tccagatgca gaacatgaca ctgagaggac cagatgggga
     6061 gccccagcct gggctggaaa gccaaggcag agctgcctct atgccacgcc tagcggcaga
     6121 aacacagccg gcccctaatg ccagccccat gaagcgctcc atctccacac tggctccacg
     6181 cccacatggg actcagcttt gcagcacagt tctggaccgg cctcctccta gccaggcatc
     6241 acatcaccac caccaccgct gccaccggcg cagagacaag aagcaaaggt ccctggaaaa
     6301 ggggcccagc ctgtctgttg acccagaagg tgcaccaagc actgctgcag gacctggtct
     6361 gccccatgga gaaggatcca ccgcctgccg gcgggaccgt aaacaggagc gaggccggtc
     6421 ccaggagcgg aggcagccct catcttcctc ttcagagaag cagcgcttct attcctgtga
     6481 ccgctttggg agccgggagc ccccgcaact gatgccctca ctcagtagcc accccacatc
     6541 gccaacagcg gcgctagagc cagcacccca cccacagggc agtggttccg ttaatgggag
     6601 ccccttgatg tcaacatccg gtgctagcac cccgggccga ggtgggcgga ggcagctccc
     6661 ccagactcct ctgaccccac gccccagcat cacctacaag accgccaatt cctcgcctgt
     6721 ccactttgct gagggtcaga gcggcctccc agccttctcc cctggccgtc tcagccgcgg
     6781 cctttctgaa cacaatgccc tgctccagaa agagcccctg agccagcctc tagctcctgg
     6841 ctcccgaatt ggctctgacc cttacctagg gcagcgtctg gacagtgagg cctccgccca
     6901 caccctgcct gaggatacac tcacctttga agaggcagtg gccaccaact ctggccgctc
     6961 ctccaggact tcctatgtgt cctccctcac ttcccaatcc caccctctcc gccgtgtacc
     7021 caatggctat cactgcactt tgggactcag cactggcgtc cgggcgcggc acagctacca
     7081 ccaccccgat caggaccact ggtgctagct gcaccacgac cacccatgta ccagctccat
     7141 gggtgagggt tccagttgat gagttttatc atccgctctg ggctgtgggg tcacagccct
     7201 gggaggaggg ccctcacatc tcggcctctg tggtggaggc tcctgcttcc ctccctccct
     7261 cccttttaca ctggatagac taataaagcc ctttcttaga gggacatggt tctctctatc
     7321 ctcctgtgta ctgccttcct gggttccatg ccagatgttg gatcctaagc aggaggtagc
     7381 tgagttgaga tggacccagc aaatccaaat cctatgtcat ggcctccagc atccagggtg
     7441 ggtccttggg acttttctta ggagggactt tctgagcctc gtggagagtg tggtttgtcc
     7501 aaatgtgtgg catgggagat agggtacccc tgaaagcaag gaaaggagcc cagctgtggc
     7561 ctggtagcac ctgccggcac cagtgatctc acgtctcttg tggtcttgga gtcaaatagc
     7621 acatgtatgt agagatgcgc tcaagggcct gcctttcacc tacactgtca ccataacagg
     7681 gaccaaatct ggaggatgtc cttgctgttg attctggttt tcagtcacaa cactttcact
     7741 gtttgtcatt tctatgtagt tgatctagaa aaagcagaaa tcaaaacagg aaaggaaatg
     7801 tttgtgtaac tttaaaaaaa aagtcaacat gtaggaaggt ctccattttg cattgtttct
     7861 gtgtcttgta tgcaatgttc ctgtatgttt ctaccctgcc tgggatgtcc ccaatgaccc
     7921 tggctcctct gctcaaccaa gtgcctgatc tctggctctg agcatcgtgg atgaggtacg
     7981 gcctcaggaa gcatcgggtg gattgggtgg gagctgctca gagcagcacg ggggcttgtg
     8041 tcttagggac attgacagtg tccatcagca tgtcagagaa gcagctgtag tgcccgtgtt
     8101 tctccctgag tcatgggttc tgaagaagcc agagcggcac aatgcgtgct tgcatgaggc
     8161 actttcagcc tttttaaatc tgactctcag ggatgggatg cctgccaagt agggtgtaat
     8221 ctctgttgtg tttttaaaac aacaacaaca aaataaaaca aaaaaaaaaa acctagtatt
     8281 cactggatgc tgaagagtgc aaaacgctag caaagaagag gctggggtta gaggaagaag
     8341 cccgcactgg ccgtgttaca agaaactggc aggaaggaaa tggccctgga acaggccagg
     8401 tgcctagagc taagtcaggc ccctggctta gcactagaaa aaataaaacc tcatggctgc
     8461 tttgcaaagg gaaaacccat gctcaggaag gtgttcagtg tgcacagata gctgggaggc
     8521 cacgagagaa aggttgcaca cagacaggca ggcactcctt ggtgtggtct ctctgttttg
     8581 aaacttctga tgacttcttg gtggcttgtt gtcttctacc ccatgtttct cacaggatct
     8641 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgttagcat gtgtgtatta
     8701 gcgtgtgtga gtgtgtgagc atgcacgagt cataggagat gcaggtgtat gtgtgtggtg
     8761 tgcatatgtg tatgtgtgtg tgtgtgtgtg tgtgtgtagg tgtgttcagc aagtggctat
     8821 tgtcaaccat agggctatgc aacaaaagac acattactag aaacaaaaca caagaccacc
     8881 acttggtcta gggtttcagc atgattgtga ccaaaccttt tatagaattt ccttatacaa
     8941 aggcacaata ccctgaaact ttaacagagt attttattcc agtagggtaa aattaaacgg
     9001 gactcttgga ctgcgcatgt gactgcaccc acgttgcaac agagaaggat gtgcattttg
     9061 atactgatgt tctgtctctg ttccagcccc agcccccttt tctcttgagt gttgaatgta
     9121 tacattctgt gtggaactac agctgcctca gacaatcctg ggttgggaat catctttatc
     9181 ccacatcaac atagctggct tttcttccaa acattggtat acatgaaaat cacaagaaac
     9241 aaggaaagga gacatgacgt cttgcttcct gactttgggt ttgtttctgt attgtctctt
     9301 ttcaagatgt tgtctgtttc cccctgaagt ttcatagtga gttgccaaaa tttgaaatgc
     9361 aacaaccagc tgtctgcatc tggaacctgt caagcagtgg ctgtagtttg aacaagttat
     9421 gtgtgcatgt aaaatataca catatataca ttatacaagt atgtgcatga aatgtatatc
     9481 ttcgtacttt ttgatacaat gtattcattt gttaattttt aattatattt gatataaatt
     9541 gaaggtttgt cgcaaaaatt tatatttaac agtgttgaga gagagagaga gagagcgaga
     9601 gagagagaga tccagtcatg caacacaaat gggatctact tttaaacaac agtcctttga
     9661 ctagtttgct gcctgaataa tatttacaaa ctaaactttg gattctgctc ttgtttctac
     9721 aatgattttt tgtataaagc aaagtccttg gattaaataa aaacaaccca aaaaaaaaat
     9781 caaaatcaaa a
//
