LOCUS       NM_007578               7929 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus calcium channel, voltage-dependent, P/Q type, alpha 1A
            subunit (Cacna1a), transcript variant 1, mRNA.
ACCESSION   NM_007578 XM_986985
VERSION     NM_007578.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7929)
  AUTHORS   Chin,M. and Kaeser,P.S.
  TITLE     The intracellular C-terminus confers compartment-specific targeting
            of voltage-gated calcium channels
  JOURNAL   Cell Rep 43 (7), 114428 (2024)
   PUBMED   38996073
REFERENCE   2  (bases 1 to 7929)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 7929)
  AUTHORS   Wang,D., Honda,S., Shin,M.K., Watase,K., Mizusawa,H., Ishikawa,K.
            and Shimizu,S.
  TITLE     Subcellular localization and ER-mediated cytotoxic function of
            alpha1A and alpha1ACT in spinocerebellar ataxia type 6
  JOURNAL   Biochem Biophys Res Commun 695, 149481 (2024)
   PUBMED   38211534
  REMARK    GeneRIF: Subcellular localization and ER-mediated cytotoxic
            function of alpha1A and alpha1ACT in spinocerebellar ataxia type 6.
REFERENCE   4  (bases 1 to 7929)
  AUTHORS   Li,J., Veeraraghavan,P. and Young,S.M. Jr.
  TITLE     CaV 2.1 alpha1 subunit motifs that control presynaptic CaV 2.1
            subtype abundance are distinct from CaV 2.1 preference
  JOURNAL   J Physiol 602 (3), 485-506 (2024)
   PUBMED   38155373
REFERENCE   5  (bases 1 to 7929)
  AUTHORS   Cook,A.A., Leung,T.C.S., Rice,M., Nachman,M., Zadigue-Dube,E. and
            Watt,A.J.
  TITLE     Endosomal dysfunction contributes to cerebellar deficits in
            spinocerebellar ataxia type 6
  JOURNAL   Elife 12, 90510 (2023)
   PUBMED   38084749
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7929)
  AUTHORS   Austin,M.C., Schultzberg,M., Abbott,L.C., Montpied,P., Evers,J.R.,
            Paul,S.M. and Crawley,J.N.
  TITLE     Expression of tyrosine hydroxylase in cerebellar Purkinje neurons
            of the mutant tottering and leaner mouse
  JOURNAL   Brain Res Mol Brain Res 15 (3-4), 227-240 (1992)
   PUBMED   1279353
REFERENCE   7  (bases 1 to 7929)
  AUTHORS   Perez-Reyes,E., Castellano,A., Kim,H.S., Bertrand,P., Baggstrom,E.,
            Lacerda,A.E., Wei,X.Y. and Birnbaumer,L.
  TITLE     Cloning and expression of a cardiac/brain beta subunit of the
            L-type calcium channel
  JOURNAL   J Biol Chem 267 (3), 1792-1797 (1992)
   PUBMED   1370480
REFERENCE   8  (bases 1 to 7929)
  AUTHORS   Kostopoulos,G.K. and Psarropoulou,C.T.
  TITLE     Possible mechanisms underlying hyperexcitability in the epileptic
            mutant mouse tottering
  JOURNAL   J Neural Transm Suppl 35, 109-124 (1992)
   PUBMED   1355109
REFERENCE   9  (bases 1 to 7929)
  AUTHORS   Isaacs,K.R. and Abbott,L.C.
  TITLE     Development of the paramedian lobule of the cerebellum in wild-type
            and tottering mice
  JOURNAL   Dev Neurosci 14 (5-6), 386-393 (1992)
   PUBMED   1306163
REFERENCE   10 (bases 1 to 7929)
  AUTHORS   Noebels,J.L. and Sidman,R.L.
  TITLE     Inherited epilepsy: spike-wave and focal motor seizures in the
            mutant mouse tottering
  JOURNAL   Science 204 (4399), 1334-1336 (1979)
   PUBMED   572084
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147288.1, AK147498.1 and AV375776.1.
            
            On Oct 14, 2006 this sequence version replaced NM_007578.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147288.1, AY714490.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2206              AK147288.1         1-2206
            2207-2481           AK147498.1         2054-2328
            2482-3063           AK147288.1         2482-3063
            3064-6710           AK147498.1         2911-6557
            6711-7509           AK147288.1         6711-7509
            7510-7743           AK147498.1         7357-7590
            7744-7926           AK147288.1         7744-7926
            7927-7929           AV375776.1         190-192
FEATURES             Location/Qualifiers
     source          1..7929
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 40.95 cM"
     gene            1..7929
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /note="calcium channel, voltage-dependent, P/Q type, alpha
                     1A subunit"
                     /db_xref="GeneID:12286"
                     /db_xref="MGI:MGI:109482"
     exon            1..580
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..7388
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /note="isoform 1 is encoded by transcript variant 1;
                     leaner; rocker; tottering; voltage-dependent P/Q-type
                     calcium channel subunit alpha-1A; brain calcium channel I;
                     voltage-gated calcium channel subunit alpha Cav2.1;
                     calcium channel, L type, alpha-1 polypeptide"
                     /codon_start=1
                     /product="voltage-dependent P/Q-type calcium channel
                     subunit alpha-1A isoform 1"
                     /protein_id="NP_031604.3"
                     /db_xref="CCDS:CCDS52618.1"
                     /db_xref="GeneID:12286"
                     /db_xref="MGI:MGI:109482"
                     /translation="MARFGDEMPGRYGAGGGGSGPAAGVVVGAAGGRGAGGSRQGGQP
                     GAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPF
                     EYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIVALGFA
                     FHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRTLRAVRVLRPLKLVSGIPSLQVVL
                     KSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGT
                     EEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASG
                     NTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELN
                     GYMEWISKAEEVILAEDETDVEQRHPFDGALRRATLKKSKTDLLNPEEAEDQLADIAS
                     VGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAI
                     VHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIF
                     EVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLF
                     LFIVVFALLGMQLFGGQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKS
                     QGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKL
                     ALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPTKSVWEQRTSEMRKQNLLASREALYG
                     DAAERWPTPYARPLRPDVKTHLDRPLVVDPQENRNNNTNKSRAPEALRPTARPRESAR
                     DPDARRAWPGSPERAPGREGPYGRESEPQQREHAPPREHAPWDADTERAKAGDAPRRH
                     THRPVAEGEPRRHRARRRPGDEPDDRPERRPRPRDATRPARAADGEGDDGERKRRHRH
                     GPPAHDDRERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDLPLAEDLDNMKNNK
                     LATGEPASPHDSLGHSGLPPSPAKIGNSTNPGPALATNPQNAASRRTPNNPGNPSNPG
                     PPKTPENSLIVTNPSSTQPNSAKTARKPEHMAVEIPPACPPLNHTVVQVNKNANPDPL
                     PKKEEEKKEEEEADPGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMV
                     IAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRD
                     LWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDC
                     VVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFERDCRGKYLLYEKN
                     EVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRM
                     EMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKP
                     LTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVF
                     NIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSF
                     LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNI
                     GIDGEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNS
                     GILTADCGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYV
                     RVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADDNTV
                     HFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKST
                     DLTVGKIYAAMMIMEYYRQSKAKKLQAMREEQNRTPLMFQRMEPPSPTQEGGPSQNAL
                     PSTQLDPGGGLMAHEGGMKESPSWVTQRAQEMFQKTGTWSPERGPPIDMPNSQPNSQS
                     VEMREMGTDGYSDSEHYLPMEGQTRAASMPRLPAENQRRRGRPRGNDLSTISDTSPMK
                     RSASVLGPKARRLDDYSLERVPPEENQRYHQRRRDRGHRTSERSLGRYTDVDTGLGTD
                     LSMTTQSGDLPSKDRDQDRGRPKDRKHRPHHHHHHHHHHPPAPDRDRYAQERPDTGRA
                     RAREQRWSRSPSEGREHTTHRQGSSSVSGSPAPSTSGTSTPRRGRRQLPQTPCTPRPL
                     VSYSPAPRRPAARRMAGPAAPPGGSPRGCRRAPRWPAHAPEGPRPRGADYTEPDSPRE
                     PPGGAHDPAPRSPRTPRAAGCASPRHGRRLPNGYYAGHGAPRPRTARRGAHDAYSESE
                     DDWC"
     exon            581..686
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            687..826
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            827..918
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1071
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1265
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1369
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1485
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1542
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1635
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1845
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1958
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2071
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2203
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2276
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2394
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2462
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..2569
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            2570..3244
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            3245..3690
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            3691..3829
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            3830..3959
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            3960..4019
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            4020..4126
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            4127..4226
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            4227..4387
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            4388..4525
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            4526..4727
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            4728..4892
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            4893..5003
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            5004..5087
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            5088..5204
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            5205..5270
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            5271..5386
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            5387..5537
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            5538..5665
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            5666..5762
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            5763..5868
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            5869..5976
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            5977..6077
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            6078..6187
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            6188..6326
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            6327..6440
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            6441..6476
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            6477..6663
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            6664..6917
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     exon            6918..7929
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7902..7907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /note="hexamer: AATAAA"
     polyA_site      7927
                     /gene="Cacna1a"
                     /gene_synonym="alpha1A; APCA; BI; Caca1a; Cacnl1a4;
                     Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352;
                     rkr; SCA6; smrl; tg"
                     /note="major polyA site"
ORIGIN      
        1 ggggtcaccg cctctgccgg catgtcccga gccgcgctcc ccggctcggc cgggccgtcc
       61 cgctcgtgag ccccccgagc tgaggccggg cgccgccgcc cgatgggctg ggccgtggag
      121 cgtctccgca gtcgcaggtg cagccgccgt ccccacagcc cggccagcct gagcagcggc
      181 ggcggtggtg gtggtggtgg tggcggtggc cgtggcttcc gcagcgctcg ccgcagcaac
      241 agcagccgcc gcgtaacccg aggccctttg ctctttgcag aatggcccgc tttggagacg
      301 agatgccggg ccgctacggc gcaggcggag gaggctcagg gccggccgcc ggggtggtcg
      361 tgggcgccgc gggcggccga ggagccgggg gcagccggca gggcgggcag cccggagcgc
      421 agaggatgta caagcagtcg atggcgcaga gagcgcggac catggccctc tacaacccca
      481 tccctgtccg ccagaactgc ctcacggtca accgctccct gttcctcttc agtgaagaca
      541 acgtggtgag aaaatacgcc aaaaagatca ctgaatggcc tcccttcgag tacatgatcc
      601 tggccaccat cattgctaac tgcatcgtcc tggccctgga gcagcacctc cctgatgatg
      661 acaagacacc catgtctgag cggctggatg acacggaacc atacttcatt ggaatcttct
      721 gttttgaggc tggaattaag atcgtggctc ttggctttgc cttccacaaa ggctcctacc
      781 tgaggaatgg ctggaacgtc atggactttg tcgtggtgct aacaggcatc ttggccactg
      841 tcgggacgga gtttgaccta cggacactga gggcggttcg tgtgctgcgg ccactcaagc
      901 tggtgtctgg aatcccaagt ttacaagtcg tcctgaagtc aatcatgaag gcgatgatcc
      961 ctctgctgca gatcggcctc ctcctgtttt ttgcaatcct tatttttgca atcatagggt
     1021 tagaatttta tatggggaaa tttcatacca cctgctttga agaggggaca gacgacatcc
     1081 agggtgagtc gccagctccg tgtgggacag aggagcctgc ccgcacctgc cccaacggga
     1141 ccaaatgtca gccgtactgg gaagggccca acaacggcat cactcagttc gacaacatcc
     1201 tgtttgctgt gctcactgtt ttccagtgca tcaccatgga aggctggact gatctcctct
     1261 acaatagcaa cgatgcctca gggaacactt ggaactggtt gtacttcatc cccctcatca
     1321 tcatcggctc cttttttatg ctgaaccttg ttctgggtgt gctgtctggg gagtttgcca
     1381 aagaaaggga acgtgtggag aaccggagag cttttctgaa gctcagaaga caacagcaga
     1441 ttgaacgtga gctcaatgga tacatggagt ggatctcaaa agcagaagag gtgattcttg
     1501 cggaggacga gacagacgtg gagcagaggc acccttttga tggagctctt cggagagcta
     1561 ctctgaagaa aagcaagaca gacctgctca accctgagga ggccgaggac cagctggctg
     1621 acatcgcgtc tgtggggtct cccttcgcca gagccagcat caaaagtgcc aagctggaga
     1681 actcgacttt ttttcacaag aaggagagaa gaatgcgttt ctacatccgc cgcatggtca
     1741 aaactcaggc cttctactgg accgtgctca gtctggtagc cctcaacacg ctgtgcgtcg
     1801 ccattgtcca ctacaaccag cccgagtggc tctccgactt cctctactat gcagaattca
     1861 ttttcttagg actctttatg tccgaaatgt ttataaaaat gtacgggctc gggacgcggc
     1921 cttacttcca ctcttccttc aactgctttg actgtggggt catcattggg agcatctttg
     1981 aagtcatctg ggctgtcatc aaacctggta catcctttgg aatcagtgtg ttacgagctc
     2041 tcaggttatt gcgaattttc aaagtcacaa agtactgggc atctctcaga aacctggttg
     2101 tctccctcct caactccatg aagtccatca taagtctgtt gttcctcctt ttcctgttca
     2161 tcgttgtctt tgccctcctg gggatgcagc tgttcggtgg ccaatttaat tttgatgagg
     2221 ggactccgcc caccaacttc gacacttttc cagcagcaat aatgactgtg tttcagatcc
     2281 tgactggcga ggattggaat gaggtcatgt atgatgggat caagtctcag gggggcgtgc
     2341 agggcggcat ggtgttctcc atctacttca tcgtcctcac cctcttcggg aactacaccc
     2401 tgctgaacgt gttcttggcc atcgcagtgg acaacctggc caatgcccag gagctcacca
     2461 aggatgagca agaagaggaa gaggcagcca atcagaagct ggctctacag aaagccaagg
     2521 aggtagcaga agtgagtccc ctgtctgcag ccaacatgtc catagccgtg aaggagcagc
     2581 agaagaacca gaagcctacc aagtcggtgt gggagcagcg caccagcgag atgcgcaagc
     2641 agaacctgct ggccagccgc gaggcgctgt acggggacgc ggctgagcgc tggcccaccc
     2701 cctacgcgcg cccgctgcgg cccgacgtga agactcactt ggaccggccg cttgtggtgg
     2761 acccgcagga gaaccgtaac aacaacacca acaagagccg tgcgccagaa gcgctgcgcc
     2821 cgaccgcgcg gccccgcgaa agcgcgcgcg accccgacgc gcggcgcgcc tggcccggca
     2881 gccctgagcg cgcccctgga cgagagggcc cgtatgggcg cgagagcgag cctcagcagc
     2941 gcgagcacgc gccgccccgc gagcacgcac cctgggacgc ggacaccgag cgcgccaaag
     3001 ccggggacgc gccccgccgc cacacgcacc gacctgtggc ggagggcgag cctcgccgcc
     3061 accgcgcccg ccgccggccc ggggacgaac ccgacgacag gccagagcgc aggccacgtc
     3121 cccgcgacgc cactaggccg gcccgcgctg cagacggcga aggcgacgat ggggagcgca
     3181 agcggcgaca ccgacacggg ccgccggccc acgacgacag ggagcgcaga caccgacgca
     3241 gaaaagagaa ccagggctct ggggtccccg tgtctggtcc caacttgtcc accaccaggc
     3301 caatccagca ggacctgggc cgccaggacc tgccgctggc tgaggatctt gacaacatga
     3361 agaataacaa gctggccacc ggggaacctg ccagtcccca cgacagcctg ggccacagcg
     3421 gccttccccc cagccccgcc aaaatcggga acagcaccaa ccctggtccc gccttggcca
     3481 ccaatcccca gaacgctgcc agccgcagga cgcccaacaa tccgggcaac ccgtccaacc
     3541 ccggcccccc caagactccc gagaacagcc ttatcgtcac caaccccagc agcacccagc
     3601 ccaactcagc gaagactgcc aggaaacccg agcacatggc ggtggagatc cccccagcct
     3661 gcccgcccct caaccacacc gtggtccaag taaacaaaaa cgccaaccca gacccactgc
     3721 caaagaaaga ggaagagaag aaagaggaag aggaggcaga ccccggggag gacggcccaa
     3781 agcccatgcc gccctacagc tccatgttca tcctctccac caccaacccc cttcgccggc
     3841 tgtgccatta catcctgaac ctgcgctact tcgagatgtg catcctcatg gtcattgcca
     3901 tgagcagcat cgctctggcc gccgaggacc cggtgcagcc caacgcaccc cgcaacaatg
     3961 tgctgcgata ttttgactat gtttttacag gcgtgtttac ctttgagatg gtgatcaaga
     4021 tgatcgacct gggcctcgtc ttgcatcagg gggcctattt ccgtgaccta tggaacattc
     4081 tggacttcat agtggtcagt ggggccctgg tggcctttgc cttcactggc aatagcaaag
     4141 gaaaggacat taacaccatt aagtctctcc gagtcctccg ggtgctacga cctctaaaga
     4201 ccatcaagcg gctgccaaag ctgaaggccg tgtttgactg cgtggtgaac tcgctcaaga
     4261 acgtcttcaa catcctcatt gtgtacatgc tgttcatgtt catcttcgct gtggtagccg
     4321 tgcagctctt caagggcaag ttcttccact gcacggacga gtccaaggag ttcgagagag
     4381 actgtcgagg caagtacctc ctgtacgaga agaacgaagt gaaggcccgg gaccgcgagt
     4441 ggaagaagta cgagttccac tacgacaacg tgctctgggc tctgctcaca cttttcacag
     4501 tgtccacagg agagggctgg ccacaggtcc tcaagcactc agtggatgct acttttgaga
     4561 accagggccc cagccccggg taccgcatgg agatgtccat cttctacgtg gtgtactttg
     4621 tagtgtttcc cttcttcttt gtcaatatct tcgtggcctt gatcatcatc acctttcagg
     4681 agcagggaga caagatgatg gaagagtaca gcctggagaa aaatgagagg gcctgcatcg
     4741 actttgccat cagtgccaag ccgctgacca ggcacatgcc ccagaacaag cagagcttcc
     4801 agtatcgaat gtggcagttc gtcgtgtccc caccctttga gtacaccatc atggccatga
     4861 tcgctctcaa caccatcgtg ctaatgatga agttctacgg agcctcggtg gcctatgaaa
     4921 acgcccttcg cgtgttcaac attgtcttca cctccctctt ctctctcgaa tgtgtgctca
     4981 aagtcatggc ttttgggatt ctgaattatt tccgcgatgc ctggaacatc ttcgactttg
     5041 tgactgttct gggcagcatc acagacatcc tcgtcaccga gtttgggaat aacttcatca
     5101 acctgagctt tctccgcctc ttccgtgctg ccagactcat caaactcctc cgccagggtt
     5161 acaccatccg cattctcctc tggactttcg tgcagtcctt caaggcccta ccttatgtct
     5221 gtctgctgat cgccatgctc ttcttcatct acgccatcat cgggatgcag gtgtttggca
     5281 acatcggcat tgacggggaa gacgaggaca gcgacgagga tgaattccaa atcacggagc
     5341 acaataactt ccggaccttc ttccaagcgc tcatgcttct cttccggagc gccacaggag
     5401 aagcgtggca caacatcatg ctctcctgcc tcagcgggaa gccgtgcgat aagaactctg
     5461 ggatcctcac ggcagactgc ggcaacgagt tcgcgtactt ctactttgtc tcgttcatct
     5521 tcctgtgctc gtttctgatg ctgaatctct ttgtcgctgt catcatggac aacttcgagt
     5581 acctcacccg agattcttcc atcctgggcc cccatcactt ggatgaatac gtgcgtgtct
     5641 gggcagagta tgaccctgct gcctgcggcc gcattcacta taaggacatg tacagtttat
     5701 tgcgagtaat atcgccccct ctcggcttag gcaagaaatg tcctcatagg gttgcttgca
     5761 agagactcct gcggatggac ctgccggtag cagatgacaa cacagttcac ttcaactcca
     5821 ccctgatggc tctgatccga accgcccttg atatcaaaat tgccaagggt ggagctgaca
     5881 agcagcagat ggatgcagag cttcgcaagg agatgatggc catttggccc aacctgtctc
     5941 agaagaccct ggatctgctg gtcacacctc acaagtccac ggacctgaca gtgggtaaga
     6001 tctacgcagc catgatgatc atggagtatt accggcagag caaggccaag aaactgcagg
     6061 ccatgcgaga ggagcagaac cggacaccac tcatgttcca gcgcatggag cctccatcac
     6121 caacacagga gggaggaccc agccagaatg cccttccctc cactcagctg gacccaggag
     6181 gaggcctgat ggctcacgaa ggcggcatga aggagagccc gtcctgggtg acccagcggg
     6241 cccaagagat gttccagaag actggcacct ggagcccaga gcgagggcca cccatcgaca
     6301 tgcctaacag ccagcccaac tcccagtctg tggagatgcg agaaatgggt actgatggct
     6361 actcagacag cgaacactac ctccccatgg aaggccagac cagggccgcc tccatgcccc
     6421 gcctcccagc agagaaccag aggagaaggg gccggccacg tggaaatgac ctcagtacca
     6481 tctctgatac cagccccatg aagcgctcag cctctgtgct gggacccaaa gcccggcgac
     6541 tggatgacta ctcactagag cgggtaccgc ctgaggagaa ccaacggtac caccaacgtc
     6601 gccgggaccg tggccaccgc acctctgagc gctctctggg ccgatacact gatgtggaca
     6661 caggtttggg gacagatctg agcatgacca cccaatcggg tgacctgccc tccaaagatc
     6721 gggaccagga ccggggccga cccaaggacc ggaagcatcg gccacaccac caccaccacc
     6781 accatcatca tcatcccccg gcccccgacc gggatcgcta cgcacaggag cggccggaca
     6841 ccggccgggc gcgggcccgg gagcagcgct ggtcccgctc gcccagcgaa ggtcgggagc
     6901 acacgacaca cagacagggc agtagttccg tcagtggaag cccagccccc tctacgtccg
     6961 gcaccagcac gccgcggcgc ggccgccgcc agctccccca gaccccctgc accccgcggc
     7021 cgcttgtgtc ctactcgccc gctccgcgca ggcctgcggc gcgcaggatg gcgggtcccg
     7081 cagcgccccc tggcggctcg ccgcggggtt gccgccgtgc gccgcgctgg cctgcgcatg
     7141 cgcctgaggg cccgcggccg cgcggtgccg actacaccga gcccgacagc ccgcgcgagc
     7201 cgccaggggg cgcgcacgat cccgcgccgc ggtcgcccag gactccgcgc gccgcgggct
     7261 gcgcgtcacc gcgccacggc cgcaggctgc ccaatggtta ctacgcgggg cacggcgcgc
     7321 cgcggccgcg cacagcccgc aggggcgcgc acgacgcgta cagcgagagc gaggacgact
     7381 ggtgctaagc cgccccgccc cccgcagcgc ccgtaaagtg cgggcgcact gcaaatgata
     7441 aacaataacg tttttaaaaa agaaaacccg ggagaaaaac aaaaatagct tctattgatg
     7501 agttttatca tctcgattga atctttcgtt ttcccggtga atgaaaccga ggtggctgca
     7561 agccggaagg acggctgcac gccccacaca cttctcagac ccacgggagt gcttgcgggc
     7621 cacgccaaac ttattactgc ctgcagagat caactacaag aaaacaacac taacagtttt
     7681 taaaaggaca aaaaaaaatt gagaaaagtt ttttttctga tatttggtcc tgcttgaaat
     7741 aacaaaagaa aaaagaaaaa attaccacca tcactgattc ccttgcttct ttttttcctt
     7801 tatcttttta aaaatttttt ttcctttttt tcctatcttg tttgaaaaac gtgggcttgg
     7861 gactgtgaaa tattgcatga cattaaaaag aacaaaaaaa taataaaaac gaaaaaactt
     7921 gaatccacg
//
