LOCUS       NM_198037               5767 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus cache domain containing 1 (Cachd1), mRNA.
ACCESSION   NM_198037 XM_204075
VERSION     NM_198037.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5767)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5767)
  AUTHORS   Tian,C., Johnson,K.R., Lett,J.M., Voss,R., Salt,A.N.,
            Hartsock,J.J., Steyger,P.S. and Ohlemiller,K.K.
  TITLE     CACHD1-deficient mice exhibit hearing and balance deficits
            associated with a disruption of calcium homeostasis in the inner
            ear
  JOURNAL   Hear Res 409, 108327 (2021)
   PUBMED   34388681
REFERENCE   3  (bases 1 to 5767)
  AUTHORS   Rudan Njavro,J., Klotz,J., Dislich,B., Wanngren,J., Shmueli,M.D.,
            Herber,J., Kuhn,P.H., Kumar,R., Koeglsperger,T., Conrad,M.,
            Wurst,W., Feederle,R., Vlachos,A., Michalakis,S., Jedlicka,P.,
            Muller,S.A. and Lichtenthaler,S.F.
  TITLE     Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo
            substrates of the Alzheimer protease BACE1
  JOURNAL   FASEB J 34 (2), 2465-2482 (2020)
   PUBMED   31908000
  REMARK    GeneRIF: Mouse brain proteomics establishes MDGA1 and CACHD1 as in
            vivo substrates of the Alzheimer protease BACE1.
REFERENCE   4  (bases 1 to 5767)
  AUTHORS   Rutledge,E.A., Benazet,J.D. and McMahon,A.P.
  TITLE     Cellular heterogeneity in the ureteric progenitor niche and
            distinct profiles of branching morphogenesis in organ development
  JOURNAL   Development 144 (17), 3177-3188 (2017)
   PUBMED   28705898
REFERENCE   5  (bases 1 to 5767)
  AUTHORS   Hasenpusch-Theil,K., Magnani,D., Amaniti,E.M., Han,L., Armstrong,D.
            and Theil,T.
  TITLE     Transcriptional analysis of Gli3 mutants identifies Wnt target
            genes in the developing hippocampus
  JOURNAL   Cereb Cortex 22 (12), 2878-2893 (2012)
   PUBMED   22235033
REFERENCE   6  (bases 1 to 5767)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   7  (bases 1 to 5767)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627083.18 and AL670223.7.
            
            On Jan 23, 2023 this sequence version replaced NM_198037.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058676.1, SRR7652917.403131.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-696               AL627083.18        131455-132150
            697-759             AL670223.7         2385-2447
            760-908             AL670223.7         35060-35208
            909-1015            AL670223.7         55445-55551
            1016-1142           AL670223.7         86476-86602
            1143-1287           AL670223.7         89409-89553
            1288-1504           AL670223.7         90437-90653
            1505-1654           AL670223.7         96853-97002
            1655-1888           AL670223.7         101829-102062
            1889-2038           AL670223.7         103588-103737
            2039-2162           AL670223.7         104349-104472
            2163-2280           AL670223.7         105460-105577
            2281-2449           AL670223.7         108284-108452
            2450-2592           AL670223.7         111409-111551
            2593-2774           AL670223.7         112182-112363
            2775-2885           AL670223.7         113749-113859
            2886-3008           AL670223.7         118374-118496
            3009-3108           AL670223.7         120708-120807
            3109-3225           AL670223.7         120897-121013
            3226-3386           AL670223.7         125485-125645
            3387-3473           AL670223.7         125954-126040
            3474-3590           AL670223.7         126782-126898
            3591-3742           AL670223.7         128227-128378
            3743-3904           AL670223.7         130132-130293
            3905-3982           AL670223.7         131438-131515
            3983-4084           AL670223.7         132138-132239
            4085-5767           AL670223.7         140265-141947
FEATURES             Location/Qualifiers
     source          1..5767
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 45.76 cM"
     gene            1..5767
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /note="cache domain containing 1"
                     /db_xref="GeneID:320508"
                     /db_xref="MGI:MGI:2444177"
     exon            1..696
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             457..4323
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /note="von Willebrand factor type A and cache domain
                     containing 1; VWFA and cache domain-containing protein 1"
                     /codon_start=1
                     /product="VWFA and cache domain-containing protein 1
                     precursor"
                     /protein_id="NP_932154.1"
                     /db_xref="CCDS:CCDS18391.1"
                     /db_xref="GeneID:320508"
                     /db_xref="MGI:MGI:2444177"
                     /translation="MAREPEEEETVRPAAVVRRCPRCPGWPGAPRPPLWLLCLVACWI
                     LGAVADADFSILDEAQVLASQMRRLAAEELGVVTMQRIFNSLVYTEKISNGESEVQQL
                     AKKIREKFNRYLDVVNRNKQVVEASYTAHLTSPLTAIQDCCTIPPSMMEFDGNFNTNV
                     SRTVSCDRLSTTVNSRAFNPGRDLNSVLADNLKSNPGIKWQYFSSEEGIFTVFPAHKF
                     RCKGSYEHRSRPIYVSTVRPQSKHIVVILDHGASVTDTQLQIAKDAAQVILSAIDEHD
                     KISVLTVADAVRTCSLDQCYKTYLSPATSETKRKMSTFVSSVKPSDSPTQHAVGFHRA
                     FQLIRSTSNSTRFQANTDMVIIYLSAGITSKDSSEEDKKATLRVINEENGFLNNSVMI
                     LTYALMNDGVTGLKELAFLRDLAEQNSGKYGIPDRTALPVIKGSMMVLNQLSNLETTV
                     GRFYTNLPNRMIDEAVFSLPFSDEMGDGLIMTVSKPCYFGNLLLGIVGVDVNLAYILE
                     DVTYYQDSLASYTFLIDDKGYTLMHPSLTRPYLLSEPPLHTDIIHYENIPKFELVRQN
                     ILSLPLGSQIITVPVNSSLSWHINKLRETGKEAYNVSYAWKMVQDTSFILCIVVIQPE
                     IPVKQLKNLNTVPSSKLLYHRLDLLGQPSACLHFKQLATLESPTVMLSAGSFSSPYEH
                     LSQPETKRMVEHYTAYLSDNTRLIANPGLKFSVRNEVMATSHVTDEWMTQMEMSSLNT
                     YIVRRYIATPNGVLRIYPGSLMDKAFDPTRRQWYLHAVANPGLISLTGPYLDVGGAGY
                     VVTISHTIHSSSTQLSSGHTVAVMGIDFTLRYFYKVLMDLLPVCNQDGGNKIRCFIME
                     DRGYLVAHPTLVDPKGHAPLEQQHITHKEPLVANDILNHPNFVKKNLCNSFSDRTVQR
                     SYKFNTSLVGDLTNLVHGSHCSKYRLTRIPGTNAFVGIVNETCDSLAFCACSMVDRLC
                     LNCHRMEQNECECPCECPLEVNECTGNLTNAENRNPSCEVHQEPVTYTAIDPGLQDAL
                     QQCVNSRCNQRMESGDCFGVLDCEWCVVDSDGKTHLDKSYCAPQKECFGGIVGAKSPY
                     VDDMGAIGDEVITLNMIKSAPVGPVAGGIMGCIMVLVLAVYAYRHQIHRRSHQHMSPL
                     AAQEMSVRMSNLENDRDERDDDSHEDRGIISNTRFIAAVMERHVHSPERRRRYWGRSG
                     TESDHGYSTMSPQEDSENPPCNNDPLSAGVDVGNHDDDLDLDTPPQTAALLSHKFHHY
                     RPHHPTLHHSHHLQAAVTVHTVDAEC"
     exon            697..759
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            760..908
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1015
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1142
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1287
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1504
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1654
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1888
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2038
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2162
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2280
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2449
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2592
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..2774
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2885
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2886..3008
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3009..3108
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3109..3225
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3226..3386
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3387..3473
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3474..3590
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3591..3742
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3743..3904
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3905..3982
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3983..4084
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4085..5767
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4768..4773
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /note="hexamer: AGTAAA"
     polyA_site      4790
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /note="major polyA site"
     regulatory      5743..5748
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /note="hexamer: AATAAA"
     polyA_site      5767
                     /gene="Cachd1"
                     /gene_synonym="1190007F10Rik; B430218L07Rik; mKIAA1573;
                     Vwcd1"
                     /note="major polyA site"
ORIGIN      
        1 gagccgggaa gtgtacggag ccggagcgca gcgtggtggc accagacacc tcccttttcc
       61 ccgccgcttt ctttcctttc tcttctctca cttcggtctt ttaaacctcc ctctccctcc
      121 tcgccgggag accgccccgg tcgcctcgcc gcgcctacac tggtggcgcc gccgccgtct
      181 ccgggctgcg ccgggactcg ggaaagcgaa ggcggcgccg ctccgccggt gctctcagcc
      241 gcccgcccgg cctgcgggcg ccgcggtctt cgagccgctg ccgccgggcg atggtggccg
      301 cccgcgcgcc cgcgctgcag ccgggcgccc cctaagtttt ccagctacag ccgccgcgcc
      361 gtggagccga gagcgcagga gacgaggaaa gtttggcggg ctgcgcctcc cgcggccagc
      421 gcccgaatcc cgtcggcggg agtggccgga ggcggcatgg cccgcgagcc ggaggaagag
      481 gagaccgtaa ggccggccgc tgtggtccgc cgctgtcctc gctgccctgg ctggcctggg
      541 gccccgcggc cgcccctttg gctgctctgc cttgtggcat gctggatctt gggcgccgtg
      601 gccgacgccg acttctccat cctggacgag gcgcaagtgc tggcgagcca gatgcggagg
      661 ctggctgccg aggagctggg ggtggtcacc atgcagagga tcttcaattc gttggtttac
      721 acagagaaga tctcaaatgg agagagcgaa gttcagcagc tagccaaaaa aatccgggag
      781 aagttcaacc gctacctgga tgtggtcaat cggaacaagc aagtggtaga agcctcctat
      841 acagcccacc tgacatcccc gctgaccgcc atccaggact gctgcacaat tccgccttcc
      901 atgatggagt ttgatgggaa cttcaacacc aatgtatcaa gaacagtgag ttgcgatcga
      961 ctctctacta ccgtgaacag ccgagccttc aacccaggac gagacttaaa ttcggttctc
     1021 gcagacaacc tgaaatctaa ccctggaatc aagtggcaat atttcagctc agaagaaggg
     1081 attttcaccg tcttcccagc acacaagttc cggtgtaagg gcagctacga gcaccgcagt
     1141 cgacccatct acgtctctac cgtccggcca cagtccaagc acatagtcgt gattctggac
     1201 catggggcct cagtcacgga cacccagctc cagattgcca aggacgccgc ccaggtcatc
     1261 ctcagtgcca ttgatgagca tgacaagatt tctgtgttga ctgtggcaga cgctgtcagg
     1321 acctgttcgt tggaccagtg ctataagacg tacctgtctc cagccaccag tgagaccaaa
     1381 aggaaaatgt ccacatttgt tagcagcgtc aagccctccg acagccccac ccagcacgca
     1441 gtaggctttc acagggcgtt ccagctgatt cgaagcacca gcaacagcac tcggttccaa
     1501 gcaaacacag acatggtcat catttacctg tcagcaggca tcacatcaaa ggactcctcg
     1561 gaagaagata aaaaggcgac tctccgcgtc atcaacgaag aaaatggctt tctgaacaac
     1621 tccgtaatga ttcttaccta cgccctcatg aacgatgggg tcactggttt gaaagagttg
     1681 gcgttcctca gggatctggc tgaacagaac tctgggaagt atggaatccc agaccggaca
     1741 gccttgcctg tgatcaaagg cagcatgatg gtgctgaacc agctgagcaa cctggagacc
     1801 acagtcggca ggttctacac taaccttccc aaccggatga ttgatgaggc tgtcttcagc
     1861 ctccccttct ctgatgagat gggagatggt ttgataatga ctgtgagtaa accctgttac
     1921 tttggaaacc tcctcctggg aatcgtaggc gtggacgtga atctggctta catccttgaa
     1981 gatgtgacat attaccaaga ctctttagct tcctatactt tcctcataga tgacaaaggg
     2041 tatactctta tgcatccgtc tctcaccagg ccatacttac tgtcagagcc tccccttcat
     2101 actgacatca tacattatga aaacatcccc aagtttgaat tggttcggca aaatatccta
     2161 agcctccctc tcggcagcca gattatcact gtccctgtga actcgtccct gtcttggcac
     2221 atcaacaagt tgagggagac tgggaaggag gcctacaacg tgagctacgc ctggaagatg
     2281 gtacaggaca cttccttcat tctgtgtatt gtggtgatac aaccggaaat acccgtcaaa
     2341 caattgaaaa acctcaacac tgtaccgagc agcaagctcc tgtaccaccg actggatctt
     2401 ctgggccaac ccagtgcttg cctccacttc aagcagctgg caacactaga aagtccaacc
     2461 gtcatgctgt ctgccggcag cttttcctcc ccctatgagc acctcagcca gccagagacc
     2521 aaacgcatgg tggagcatta cacggcctat ctcagtgaca acacgcgcct cattgctaac
     2581 ccggggctca aattctctgt cagaaatgaa gtaatggcga ccagccacgt cacagatgaa
     2641 tggatgacac aaatggaaat gagcagcctg aacacgtaca ttgtccgccg ttacatagca
     2701 acacccaatg gcgtcctcag aatttatcct ggttccctta tggacaaagc atttgatccc
     2761 actaggagac agtggtatct tcatgcagta gccaatccag ggctgatttc cttgacgggc
     2821 ccttacctgg atgttggagg agctggctat gtcgtgacaa tcagccacac aattcactca
     2881 tccagtacac agctgtcttc cgggcacacc gtggctgtga tgggtatcga cttcacactg
     2941 aggtacttct acaaggttct gatggacctc ttaccagttt gtaaccaaga tggtggcaac
     3001 aaaataaggt gcttcataat ggaggacaga ggctatctgg tggctcatcc gaccctcgtt
     3061 gaccccaagg gtcatgcacc tctggagcag caacacatta cccacaagga gcccctggta
     3121 gcaaatgata tcctgaacca tcccaacttt gtgaagaaga acttgtgtaa cagcttcagt
     3181 gaccggacag tgcagagatc ttacaaattc aacactagcc tggtggggga tttgacgaac
     3241 cttgtgcacg gcagccactg ctctaagtac cgcctgacaa ggatcccagg aaccaacgcg
     3301 tttgtcggca tcgtcaacga gacctgcgac tctcttgcct tctgtgcttg cagcatggtg
     3361 gaccgtctct gtctcaactg ccaccgaatg gagcaaaatg aatgtgaatg tccttgtgag
     3421 tgccccctgg aggtcaatga gtgtactggc aacctcacca atgcagagaa cagaaacccg
     3481 agctgtgagg ttcaccagga gccagtgaca tacacggcta tcgacccagg cctgcaagat
     3541 gccctgcagc agtgtgtcaa cagcagatgt aaccagagga tggaaagtgg ggactgtttc
     3601 ggtgtgctgg actgcgaatg gtgtgtggtg gacagtgatg gaaagactca cctggacaaa
     3661 tcctactgtg cgccccagaa agaatgcttc ggggggatcg tgggagccaa aagtccctat
     3721 gttgatgaca tgggagccat cggtgatgag gtgatcacac taaacatgat taagagtgct
     3781 ccggtgggcc ctgtggccgg aggcatcatg ggctgcatca tggtgctggt ccttgccgtg
     3841 tatgcttacc gccaccagat ccatcgccgc agccaccagc acatgtcacc tcttgctgct
     3901 caagaaatgt cagtgcgtat gtccaacctg gagaatgaca gagatgaaag agacgatgac
     3961 agtcatgaag acagaggcat catcagcaac acccggttca tagctgcagt catggagcga
     4021 cacgtacaca gtccagaaag gaggcgacgc tactggggcc gctcgggaac tgaaagtgat
     4081 catgggtaca gcaccatgag cccacaggaa gacagcgaga accctccatg caacaatgac
     4141 cctttgtcag ctggggtgga cgtagggaac catgatgacg acttggacct ggacaccccg
     4201 cctcagactg cagccctgct gagccacaag ttccaccact accgcccaca ccacccgact
     4261 ctccatcaca gccaccacct gcaggcggca gtgaccgtgc acactgtgga tgctgagtgc
     4321 taacaaccct ctcgcctccc ggagcagagt ggccctgcgt gacacagaat tctctgcgaa
     4381 gaaatgagcc ggcatacagc cctgtcacgt gacgcactct gtccagtgtg gttccactgg
     4441 tttgctgcct actggcttgt ggggatctga tgctggttct gtaacggagg gggagcctga
     4501 tgaactgacc tgacatgatg gaatgggacc gtaggcacac cgccaacaca gacaaacata
     4561 gagggaactg agccggagga gtgctcccag caccagaagc actcagtccc ttaactggaa
     4621 gaaagctgga gccgaggccc atgaacgtgg cacgccagat gctaccagcc gctggacgga
     4681 ctcccgtgtt tcctagcggt acctggacac caccattact gtacagagct caccttaggc
     4741 tctaaacgat gcatctcaaa atttctaagt aaaggattat ttttctacta tttattgaac
     4801 tttcaaactt tgtgggaggg gaaaggaact gagagattct cagccttcac cctggctgtt
     4861 atgtgcgatg tggttctctg attaaggagt tgtgtttctt aatttaactg gtgatctgcc
     4921 cactgtcctc atccacaaaa cacacaaaca aacaaacaaa caaacaagga aaggaaagga
     4981 aaggaaagga aaggaaagga aaggaaagga aaggaaagga atggaattgg ggaaatgaag
     5041 aaatctttct ctggcttatt tatgtcactt cctagaaaaa aaaaatgtca tctgtgatag
     5101 tgtcccctct ttcaaggggc agtgatctaa gatgctttca aagaaacttc attcctttag
     5161 aattcatttc cacctcccat gtgatggttt tccttaggtt tctacgaaat ctactattat
     5221 aaccgtagcc ttccagttta gggaggcatg ggtttattct ctttgtttta aagactataa
     5281 attttaagat gtctcctttt ttactctgag aatataaaac aggtaaaggg agacatttta
     5341 aaattgtaaa attgtggttc ttaaaagatt tcttttgaaa tcacagctcc aagctgctgc
     5401 cacggatcca ccaaactgct tttggcttcc acggggcttc atcaaatggc tactcggacg
     5461 tggggcattg ggattttaaa gtagtgttct aattccagtg gtgtatctta gatccacgct
     5521 ttgtgattca aatatgttat gaaggcgttc tttgcaccgt gtgtgtgtaa atctccattt
     5581 atatatagtt ggaaaaaaaa atcaccaaat aatgttttaa tgatagggta tcatgatata
     5641 ctgtaaaaaa taaaaattgg gtcctcagca ctacagaaag taaactatat atgtgctccc
     5701 tggaaagccc ttcatactgt gtataaagtt gcagtctagt gaaataaact gtatgcaatg
     5761 gacagtc
//
