LOCUS       NM_181731               1301 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus calcium binding tyrosine phosphorylation regulated
            (Cabyr), transcript variant 2, mRNA.
ACCESSION   NM_181731
VERSION     NM_181731.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1301)
  AUTHORS   Wang,Y., Huang,X., Sun,G., Chen,J., Wu,B., Luo,J., Tang,S., Dai,P.,
            Zhang,F., Li,J. and Wang,L.
  TITLE     Coiled-coil domain-containing 38 is required for acrosome
            biogenesis and fibrous sheath assembly in mice
  JOURNAL   J Genet Genomics 51 (4), 407-418 (2024)
   PUBMED   37709195
REFERENCE   2  (bases 1 to 1301)
  AUTHORS   Young,S.A., Miyata,H., Satouh,Y., Aitken,R.J., Baker,M.A. and
            Ikawa,M.
  TITLE     CABYR is essential for fibrous sheath integrity and progressive
            motility in mouse spermatozoa
  JOURNAL   J Cell Sci 129 (23), 4379-4387 (2016)
   PUBMED   27802166
  REMARK    GeneRIF: it is the role of CABYR in the formation of the fibrous
            sheath that is essential for male fertility.
REFERENCE   3  (bases 1 to 1301)
  AUTHORS   Li,Y.F., He,W., Kim,Y.H., Mandal,A., Digilio,L., Klotz,K.,
            Flickinger,C.J. and Herr,J.C.
  TITLE     CABYR isoforms expressed in late steps of spermiogenesis bind with
            AKAPs and ropporin in mouse sperm fibrous sheath
  JOURNAL   Reprod Biol Endocrinol 8, 101 (2010)
   PUBMED   20731842
  REMARK    GeneRIF: CABYR expresses at the late stage of spermiogenesis and
            its isoforms oligomerize and bind with AKAPs and ropporin; which
            suggests that CABYR participates in the assembly of the fibrous
            sheath.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1301)
  AUTHORS   Li,Y.F., He,W., Jha,K.N., Klotz,K., Kim,Y.H., Mandal,A., Pulido,S.,
            Digilio,L., Flickinger,C.J. and Herr,J.C.
  TITLE     FSCB, a novel protein kinase A-phosphorylated calcium-binding
            protein, is a CABYR-binding partner involved in late steps of
            fibrous sheath biogenesis
  JOURNAL   J Biol Chem 282 (47), 34104-34119 (2007)
   PUBMED   17855365
REFERENCE   5  (bases 1 to 1301)
  AUTHORS   Sen,B., Mandal,A., Wolkowicz,M.J., Kim,Y.H., Reddi,P.P., Shetty,J.,
            Bush,L.A., Flickinger,C.J. and Herr,J.C.
  TITLE     Splicing in murine CABYR and its genomic structure
  JOURNAL   Gene 310, 67-78 (2003)
   PUBMED   12801634
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF359383.1 and BC107272.1.
            
            On Jun 19, 2006 this sequence version replaced NM_181731.2.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the coding region, compared to variant 1. The encoded isoform
            (c) is shorter and has a distinct C-terminus compared to isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF359383.1, AK075751.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AF359383.1         1-121
            122-193             BC107272.1         102-173
            194-1301            AF359383.1         194-1301
FEATURES             Location/Qualifiers
     source          1..1301
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 6.77 cM"
     gene            1..1301
                     /gene="Cabyr"
                     /gene_synonym="1700016C01Rik; 4933421A18Rik; CBP86; FSP-2"
                     /note="calcium binding tyrosine phosphorylation regulated"
                     /db_xref="GeneID:71132"
                     /db_xref="MGI:MGI:1918382"
     exon            1..47
                     /gene="Cabyr"
                     /gene_synonym="1700016C01Rik; 4933421A18Rik; CBP86; FSP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            48..220
                     /gene="Cabyr"
                     /gene_synonym="1700016C01Rik; 4933421A18Rik; CBP86; FSP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1218
                     /gene="Cabyr"
                     /gene_synonym="1700016C01Rik; 4933421A18Rik; CBP86; FSP-2"
                     /note="isoform c is encoded by transcript variant 2;
                     calcium-binding tyrosine phosphorylation-regulated
                     protein; calcium-binding protein 86; testis-specific
                     calcium-binding protein CBP86; calcium-binding
                     tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)"
                     /codon_start=1
                     /product="calcium-binding tyrosine
                     phosphorylation-regulated protein isoform c"
                     /protein_id="NP_859420.2"
                     /db_xref="CCDS:CCDS50223.1"
                     /db_xref="GeneID:71132"
                     /db_xref="MGI:MGI:1918382"
                     /translation="MISSKPRLVVPYGLKTLLEGVSRAILKTNPTNITQFAAVYFKEL
                     IVFREGNSSLDIKDLIKQFHQMKVEKWAEGVTVEKKECIKEPIKPPPVPCKPTHMEKS
                     TDTEEDNVAGPLFSNKTTQFPSVHAEVQSEETSEGARGPSDKPTTPKTDYTPPSSPPP
                     APVSAEYAYVPADPAQFAAQMLALATSEAGQPPPYSNMWTLYCLTDMNQQSRPSPPPA
                     PGPFPQATLYLPNPKEPQFLQNPPKVTSPTYVMMDDSKKTNAPPFILVGSNVQEAQDW
                     NPLPGHAVVSQAEALKRYAAVQVPIAVPADQTFQRPAPNPQNASPPTSGQDGPRPKSP
                     VFLSVAFPVEDVAKKSSGSGDKRTPFGSYGIAGEITVTTAHVRRAEP"
     exon            221..274
                     /gene="Cabyr"
                     /gene_synonym="1700016C01Rik; 4933421A18Rik; CBP86; FSP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            275..619
                     /gene="Cabyr"
                     /gene_synonym="1700016C01Rik; 4933421A18Rik; CBP86; FSP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            620..1222
                     /gene="Cabyr"
                     /gene_synonym="1700016C01Rik; 4933421A18Rik; CBP86; FSP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1301
                     /gene="Cabyr"
                     /gene_synonym="1700016C01Rik; 4933421A18Rik; CBP86; FSP-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccggcaag ggggcaaaga ggaagctcta ttgaagccgg agagaagttg aaattacaga
       61 catcttgcca aaatgatttc ttcaaagccc agacttgttg taccctatgg cctcaagact
      121 ctgcttgagg gagttagcag agccattctc aaaaccaatc caacaaacat cacccagttt
      181 gcagccgttt attttaaaga actcattgtg tttagagaag ggaattcgtc tctagatata
      241 aaagatctga ttaaacagtt tcaccagatg aaagtagaga aatgggcaga aggagtgaca
      301 gtggagaaga aagaatgtat caaggaaccc ataaaaccac ctccagttcc ctgcaaaccc
      361 acacatatgg aaaaatccac agacacagag gaggacaatg tagctggacc actatttagc
      421 aacaaaacca ctcagtttcc atcagttcat gctgaagtac agtctgagga gacaagtgaa
      481 ggagctcggg gtccctctga caaaccgact actcctaaga ccgactacac cccaccctcg
      541 tcaccacctc cagcgcctgt ctctgccgag tacgcttatg tcccagctga cccagctcag
      601 tttgccgctc agatgttagc actagcaaca agcgaagcag gacaaccacc accatattct
      661 aatatgtgga cactttattg tctaactgat atgaatcaac aaagtcgccc atcaccgcca
      721 cctgcacctg ggccttttcc ccaagcaacc ctgtatttac ctaatcctaa ggagccacag
      781 tttctgcaga acccaccgaa agtcacgtct ccaacttatg tgatgatgga tgacagcaag
      841 aagaccaatg ccccaccttt tatattagta ggctcaaatg ttcaggaagc gcaggattgg
      901 aaccctcttc ctggacatgc tgttgtgtca caagcagagg ccttgaagag atatgctgca
      961 gtgcaagtgc ccattgctgt tcctgcagat cagacattcc agagacctgc cccaaatccc
     1021 cagaatgcta gtcctcctac aagtggacaa gatggcccca gaccgaaaag cccagtcttt
     1081 ctttctgttg ctttcccagt agaagatgta gctaaaaaga gttcaggatc tggtgacaaa
     1141 cgtactccct ttggaagtta tggtattgct ggcgaaatta ctgtgactac tgcccatgtc
     1201 cgcagagcag aaccttaaaa gaatgctgat gctgtttgat tcagcattca aggtggagtt
     1261 tgtcaccatg tgaactgtat caataaactt cctgcaagca t
//
