LOCUS       NM_027631               1490 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus calcium binding protein, spermatid specific 1 (Cabs1),
            mRNA.
ACCESSION   NM_027631 XM_132142
VERSION     NM_027631.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1490)
  AUTHORS   Zhao,X., Nie,J., Zhou,W., Zeng,X. and Sun,X.
  TITLE     The metabolomics changes in epididymal lumen fluid of CABS1
            deficient male mice potentially contribute to sperm deformity
  JOURNAL   Front Endocrinol (Lausanne) 15, 1432612 (2024)
   PUBMED   39234505
  REMARK    GeneRIF: The metabolomics changes in epididymal lumen fluid of
            CABS1 deficient male mice potentially contribute to sperm
            deformity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1490)
  AUTHORS   Cai,H., Zhang,B., Ahrenfeldt,J., Joseph,J.V., Riedel,M., Gao,Z.,
            Thomsen,S.K., Christensen,D.S., Bak,R.O., Hager,H., Vendelbo,M.H.,
            Gao,X., Birkbak,N. and Thomsen,M.K.
  TITLE     CRISPR/Cas9 model of prostate cancer identifies Kmt2c deficiency as
            a metastatic driver by Odam/Cabs1 gene cluster expression
  JOURNAL   Nat Commun 15 (1), 2088 (2024)
   PUBMED   38453924
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1490)
  AUTHORS   Zhang,X., Zhou,W., Zhang,P., Gao,F., Zhao,X., Shum,W.W. and Zeng,X.
  TITLE     Cabs1 Maintains Structural Integrity of Mouse Sperm Flagella during
            Epididymal Transit of Sperm
  JOURNAL   Int J Mol Sci 22 (2), 652 (2021)
   PUBMED   33440775
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1490)
  AUTHORS   Sun,J., Lu,Y., Nozawa,K., Xu,Z., Morohoshi,A., Castaneda,J.M.,
            Noda,T., Miyata,H., Abbasi,F., Shawki,H.H., Takahashi,S.,
            Devlin,D.J., Yu,Z., Matzuk,R.M., Garcia,T.X., Matzuk,M.M. and
            Ikawa,M.
  TITLE     CRISPR/Cas9-based genome editing in mice uncovers 13 testis- or
            epididymis-enriched genes individually dispensable for male
            reproductiondagger
  JOURNAL   Biol Reprod 103 (2), 183-194 (2020)
   PUBMED   32588039
REFERENCE   5  (bases 1 to 1490)
  AUTHORS   Shawki,H.H., Kigoshi,T., Katoh,Y., Matsuda,M., Ugboma,C.M.,
            Takahashi,S., Oishi,H. and Kawashima,A.
  TITLE     Identification, localization, and functional analysis of the
            homologues of mouse CABS1 protein in porcine testis
  JOURNAL   Exp Anim 65 (3), 253-265 (2016)
   PUBMED   26960363
  REMARK    GeneRIF: It plays an important role in controlling calcium ion
            signaling during the acrosome reaction.
REFERENCE   6  (bases 1 to 1490)
  AUTHORS   Calvel,P., Kervarrec,C., Lavigne,R., Vallet-Erdtmann,V.,
            Guerrois,M., Rolland,A.D., Chalmel,F., Jegou,B. and Pineau,C.
  TITLE     CLPH, a novel casein kinase 2-phosphorylated disordered protein, is
            specifically associated with postmeiotic germ cells in rat
            spermatogenesis
  JOURNAL   J Proteome Res 8 (6), 2953-2965 (2009)
   PUBMED   19271754
  REMARK    GeneRIF: This publication characterizes the rat ortholog,
            casein-like phosphoprotein, and proposes a functional role in
            structural rearrangements during spermatogenesis.
REFERENCE   7  (bases 1 to 1490)
  AUTHORS   Kawashima,A., Osman,B.A., Takashima,M., Kikuchi,A., Kohchi,S.,
            Satoh,E., Tamba,M., Matsuda,M. and Okamura,N.
  TITLE     CABS1 is a novel calcium-binding protein specifically expressed in
            elongate spermatids of mice
  JOURNAL   Biol Reprod 80 (6), 1293-1304 (2009)
   PUBMED   19208547
  REMARK    GeneRIF: study found for the first time that CABS1 is a
            calcium-binding protein that binds calcium during the maturation in
            the epididymis
REFERENCE   8  (bases 1 to 1490)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: 4931407G18Rik is most abundantly expressed in tissues rich
            in highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154123.10.
            
            On Aug 22, 2018 this sequence version replaced NM_027631.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            CCDS Note: This CCDS ID represents the protein described in PMID:
            19208547 and is supported by AK076636.1. It should be noted this
            transcript is predicted to undergo nonsense-mediated mRNA decay
            (NMD). However, the protein is represented because it was detected
            endogenously in PMID: 19208547. It is likely that the majority of
            transcripts representing this variant will undergo NMD, while some
            low level of NMD escape may allow for the expression of this
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049750.1, AK076636.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01766828
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: PMID: 19208547
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1344              AC154123.10        108072-109415       c
            1345-1490           AC154123.10        107325-107470       c
FEATURES             Location/Qualifiers
     source          1..1490
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 43.56 cM"
     gene            1..1490
                     /gene="Cabs1"
                     /gene_synonym="4931407G18Rik; Clph"
                     /note="calcium binding protein, spermatid specific 1"
                     /db_xref="GeneID:70977"
                     /db_xref="MGI:MGI:1918227"
     exon            1..1344
                     /gene="Cabs1"
                     /gene_synonym="4931407G18Rik; Clph"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1217
                     /gene="Cabs1"
                     /gene_synonym="4931407G18Rik; Clph"
                     /note="casein-like phosphoprotein"
                     /codon_start=1
                     /product="calcium-binding and spermatid-specific protein
                     1"
                     /protein_id="NP_081907.1"
                     /db_xref="CCDS:CCDS39136.1"
                     /db_xref="GeneID:70977"
                     /db_xref="MGI:MGI:1918227"
                     /translation="MAEDGSPKIYSRPPRDNSKTPTEADIFFGADNTIPKSETTITSE
                     GDHVTSVNDCTPDGDFSTTVNKLTPTKEKLKLEDDIEGCLKLTTLPEKEITTPTETPN
                     SKPKGSITENFIPVKIGNTSSPVGTVSLIDFSSNTAKEDIFLTTIDTGEKEVVPTTEF
                     SGTLEDSAADVEDASGFPDESTETDVPSSATSDAPDDGAVQVTDSFSPEAGVPPSTEK
                     EVTTIPDITNIAEENVTEIKLIVSEDRPKTVTKLSDSEEEKFITVFELTNSAEKAKDN
                     VEDPLNDEESTDGANDWMEKETASEAESHAVLLTAVESRYDFIVTASETDNVMEESHV
                     NTTDLPENETTESVTNVTEELPSVTSIVDTLKDKEDLSTTNSGLFKLLKEEPDDLMM"
     exon            1345..1490
                     /gene="Cabs1"
                     /gene_synonym="4931407G18Rik; Clph"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaggaaaga tctgtgagag tgctcagtgc ccctctgccc catggctgaa gatggatcgc
       61 ccaaaattta ttctcgacct ccaagagaca acagtaaaac accaacggaa gcagacattt
      121 tctttggggc tgacaacacc attcctaaat cagaaacaac tattacctcg gaaggagacc
      181 acgttacttc agtaaatgac tgcacaccgg atggtgattt ttcaactaca gtcaacaagc
      241 tcacacctac aaaggaaaaa ctcaaattag aagatgatat tgaaggctgt ctgaaattaa
      301 caactcttcc agagaaagaa attaccactc caactgaaac tccaaactcc aaacctaagg
      361 ggtcaattac tgaaaatttc attccagtga aaattggaaa tacctcatcc ccagttggta
      421 ctgtttcttt aatagatttt tccagtaaca cggcaaaaga agatatcttc ttaaccacca
      481 ttgacacagg agaaaaagaa gtcgtaccca ctactgagtt ctctggcaca ctagaggaca
      541 gtgctgctga tgtggaggat gcctctggat ttccagatga aagcactgaa actgatgttc
      601 cttcctctgc cacctcagat gctcctgatg atggagctgt tcaggtcact gactccttta
      661 gtcctgaggc tggagtcccc ccctcaactg aaaaggaggt caccaccatt ccagacataa
      721 ccaacattgc agaagagaat gtaactgaga tcaaattgat tgtttcagaa gataggccca
      781 aaactgtgac taaactaagt gactccgaag aagaaaaatt tatcactgtt tttgaactca
      841 ctaactcggc tgaaaaagcc aaagataatg tggaagatcc tttaaatgat gaggaatcga
      901 ctgatggagc taatgattgg atggaaaaag aaactgcaag tgaggcagag tcccatgctg
      961 ttctgctcac tgctgtggaa tcgaggtatg actttattgt cactgcctca gaaactgaca
     1021 acgtcatgga ggaatcacat gtgaacacca cagatttgcc tgaaaacgag acaacagagt
     1081 ctgtcactaa tgtcacagag gagcttcctt cagtgacctc tatagtagat acccttaagg
     1141 acaaggagga cttatctacc accaactccg gtctcttcaa actgctgaaa gaagaaccag
     1201 acgatctcat gatgtaaaac cagtaacata agggaagcca catagacata cacgaggggt
     1261 taaacgatag tcagtcgtaa tgtctaagaa gttactcagc aagaaaaatc tttaaaagaa
     1321 aaaagaatat tgtgggcatt taagatctta aacgttgaat gttgtactct tcttaggcag
     1381 ttggttagca actcaaggac gcatatcttc attcttttct gatacagact ttgcaagtgg
     1441 gtctgttgtc gctgggctga ttctcctcaa taaattattc tgacagcaac
//
