LOCUS       NM_144532               1472 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus calcium binding protein 4 (Cabp4), mRNA.
ACCESSION   NM_144532
VERSION     NM_144532.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1472)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1472)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1472)
  AUTHORS   Park,S., Li,C., Haeseleer,F., Palczewski,K. and Ames,J.B.
  TITLE     Structural insights into activation of the retinal L-type Ca(2)
            channel (Cav1.4) by Ca(2)-binding protein 4 (CaBP4)
  JOURNAL   J Biol Chem 289 (45), 31262-31273 (2014)
   PUBMED   25258313
  REMARK    GeneRIF: CaBP4 forms a collapsed structure around the IQ motif in
            Cav1.4 that may promote channel activation by disrupting an
            interaction between IQ and the inhibitor of Ca(2+)-dependent
            inactivation domain
REFERENCE   4  (bases 1 to 1472)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 1472)
  AUTHORS   Haeseleer,F., Sokal,I., Gregory,F.D. and Lee,A.
  TITLE     Protein phosphatase 2A dephosphorylates CaBP4 and regulates CaBP4
            function
  JOURNAL   Invest Ophthalmol Vis Sci 54 (2), 1214-1226 (2013)
   PUBMED   23341017
  REMARK    GeneRIF: This study provides evidence that CaBP4 is
            dephosphorylated by PP2A in the retina.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1472)
  AUTHORS   Cui,G., Meyer,A.C., Calin-Jageman,I., Neef,J., Haeseleer,F.,
            Moser,T. and Lee,A.
  TITLE     Ca2+-binding proteins tune Ca2+-feedback to Cav1.3 channels in
            mouse auditory hair cells
  JOURNAL   J Physiol 585 (Pt 3), 791-803 (2007)
   PUBMED   17947313
  REMARK    GeneRIF: our results implicate CaBP1 rather than CaBP4 in
            conferring the anomalous slow inactivation of Ca(v)1.3 Ca(2+)
            currents required for auditory transmission
REFERENCE   7  (bases 1 to 1472)
  AUTHORS   Lee,A., Jimenez,A., Cui,G. and Haeseleer,F.
  TITLE     Phosphorylation of the Ca2+-binding protein CaBP4 by protein kinase
            C zeta in photoreceptors
  JOURNAL   J Neurosci 27 (46), 12743-12754 (2007)
   PUBMED   18003854
  REMARK    GeneRIF: These findings demonstrate how light-stimulated changes in
            CaBP4 phosphorylation and Ca2+ binding may regulate presynaptic
            Ca2+ signals in photoreceptors.
REFERENCE   8  (bases 1 to 1472)
  AUTHORS   Maeda,T., Lem,J., Palczewski,K. and Haeseleer,F.
  TITLE     A critical role of CaBP4 in the cone synapse
  JOURNAL   Invest Ophthalmol Vis Sci 46 (11), 4320-4327 (2005)
   PUBMED   16249514
REFERENCE   9  (bases 1 to 1472)
  AUTHORS   Haeseleer,F., Imanishi,Y., Maeda,T., Possin,D.E., Maeda,A., Lee,A.,
            Rieke,F. and Palczewski,K.
  TITLE     Essential role of Ca2+-binding protein 4, a Cav1.4 channel
            regulator, in photoreceptor synaptic function
  JOURNAL   Nat Neurosci 7 (10), 1079-1087 (2004)
   PUBMED   15452577
  REMARK    GeneRIF: important for normal synaptic function, probably through
            regulation of Ca(2+) influx and neurotransmitter release in
            photoreceptor synaptic terminals
REFERENCE   10 (bases 1 to 1472)
  AUTHORS   Haeseleer,F., Sokal,I., Verlinde,C.L., Erdjument-Bromage,H.,
            Tempst,P., Pronin,A.N., Benovic,J.L., Fariss,R.N. and Palczewski,K.
  TITLE     Five members of a novel Ca(2+)-binding protein (CABP) subfamily
            with similarity to calmodulin
  JOURNAL   J Biol Chem 275 (2), 1247-1260 (2000)
   PUBMED   10625670
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC049263.1.
            
            On Jun 19, 2003 this sequence version replaced NM_144532.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049263.1, AY039218.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1472
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 3.84 cM"
     gene            1..1472
                     /gene="Cabp4"
                     /gene_synonym="2410038D05Rik"
                     /note="calcium binding protein 4"
                     /db_xref="GeneID:73660"
                     /db_xref="MGI:MGI:1920910"
     exon            1..407
                     /gene="Cabp4"
                     /gene_synonym="2410038D05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..869
                     /gene="Cabp4"
                     /gene_synonym="2410038D05Rik"
                     /codon_start=1
                     /product="calcium-binding protein 4"
                     /protein_id="NP_653115.1"
                     /db_xref="CCDS:CCDS29416.1"
                     /db_xref="GeneID:73660"
                     /db_xref="MGI:MGI:1920910"
                     /translation="MATEHNVQLVPGSQKIPKGVVSPRSAAEGPALTRRRSKKESWHP
                     GSQKASSGDQSSSQGSEASGSSKHPPRTKVGQEEPSSAPARPASHRHSHRHRSDPQQD
                     AAQRTYGPLLNRMFGKDRELGPEELEELQAAFEEFDTDQDGYIGYRELGDCMRTLGYM
                     PTEMELLEVSQHVKMRMGGFVDFEEFVELISPKLREETAHMLGVRELRIAFREFDKDR
                     DGRITVAELRQAAPALLGEPLEGTELDEMLREMDLNGDGTIDFDEFVMMLSTG"
     exon            408..438
                     /gene="Cabp4"
                     /gene_synonym="2410038D05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            439..582
                     /gene="Cabp4"
                     /gene_synonym="2410038D05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            583..692
                     /gene="Cabp4"
                     /gene_synonym="2410038D05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            693..840
                     /gene="Cabp4"
                     /gene_synonym="2410038D05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1433
                     /gene="Cabp4"
                     /gene_synonym="2410038D05Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaagcaag ggcactccag ggagctacat cactgagtcc tgttatcttc tccatggcaa
       61 cagagcacaa tgtacagctg gttcctggct cccagaagat ccctaaagga gttgtatctc
      121 ccaggagtgc tgctgagggc cctgccttga ccaggagaag gagcaagaag gagagttggc
      181 acccagggtc ccagaaagcc agttctgggg accagtcctc tagccagggc tctgaggcct
      241 caggaagcag caagcacccc ccaaggacca aagtggggca ggaggaacca tcctcagccc
      301 ccgccaggcc agcgtctcac cgacactccc atcgacaccg ttctgacccc cagcaggatg
      361 ctgcccaaag gacttatggg cccttgctca accgcatgtt tggaaaggat cgtgaactgg
      421 gccctgagga gttggaggag ctccaggctg cctttgagga gtttgacact gaccaggacg
      481 gctacatcgg ctaccgcgag ctaggtgact gcatgcggac gctgggctac atgcccacgg
      541 agatggagct tctagaagtg tcgcagcacg tgaagatgcg catgggaggc tttgtggatt
      601 ttgaagagtt tgtggagctg ataagcccaa agctgaggga ggagacagct cacatgctgg
      661 gcgttcggga gctacgcatc gccttccgag agtttgacaa ggacagggat ggacggatca
      721 cggtggcgga gctgcggcag gcagcaccag ctctgctggg ggaaccacta gagggcactg
      781 aactggatga gatgttgcga gaaatggacc tcaatgggga tggcaccata gactttgacg
      841 agtttgtaat gatgctatct acaggctgag gcaccttcag ggacaaccta ctggccctgg
      901 aggccaagac accagcagac accagactac cacacccttc cccagcatgg agaaatcccc
      961 cttcccccag gctggttcac cccctcacca cacccaactc cagagtctgc ctgtgctgtc
     1021 ttctcccatc cccaagctgt ggagagaaaa aaaaaattga agctggttac agttttcact
     1081 ggagaacatg atttgaatct ctttagatcc tggagaggta gggagttccc cacaactggc
     1141 tgcattcaaa tgaatgaggc atagtgcatt gggggaattc ctaggacatg atgaattgag
     1201 agagtagcta gatcacttcc cactacttgt ttgtataaag ggttgttttt gaaaaatgaa
     1261 cttgggcctg gtaatgactt tgtaggtaaa agtttatgcc actaagcctg aatttgatcc
     1321 ctgaagtttg tgtggtggaa tgagagaacc aacttcacaa agttgctctt tggtaggcta
     1381 atgccctgtt cacaccccct tgaataaata aataaatgaa aagtgaactt gaaaaaaaaa
     1441 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
