LOCUS       NM_001160253            1057 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus calcium binding protein 2 (Cabp2), transcript variant
            3, mRNA.
ACCESSION   NM_001160253
VERSION     NM_001160253.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1057)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1057)
  AUTHORS   Yang,T., Hu,N., Pangrsic,T., Green,S., Hansen,M. and Lee,A.
  TITLE     Functions of CaBP1 and CaBP2 in the peripheral auditory system
  JOURNAL   Hear Res 364, 48-58 (2018)
   PUBMED   29661613
  REMARK    GeneRIF: CaBP1 and CaBP2 are required for the normal function of
            the peripheral auditory system.
REFERENCE   3  (bases 1 to 1057)
  AUTHORS   Picher,M.M., Gehrt,A., Meese,S., Ivanovic,A., Predoehl,F., Jung,S.,
            Schrauwen,I., Dragonetti,A.G., Colombo,R., Van Camp,G., Strenzke,N.
            and Moser,T.
  TITLE     Ca2+-binding protein 2 inhibits Ca2+-channel inactivation in mouse
            inner hair cells
  JOURNAL   Proc Natl Acad Sci U S A 114 (9), E1717-E1726 (2017)
   PUBMED   28183797
  REMARK    GeneRIF: CaBP2 inhibits CaV1.3 Ca(2+)-channel inactivation.
REFERENCE   4  (bases 1 to 1057)
  AUTHORS   Sinha,R., Lee,A., Rieke,F. and Haeseleer,F.
  TITLE     Lack of CaBP1/Caldendrin or CaBP2 Leads to Altered Ganglion Cell
            Responses
  JOURNAL   eNeuro 3 (5) (2016)
   PUBMED   27822497
  REMARK    GeneRIF: Results show that CaBP1/caldendrin and CaBP2 are not
            required for normal gross retinal and synapse morphology but are
            necessary for the proper transmission of light responses through
            the retina; CaBP1/caldendrin and CaBP2 likely act by modulating
            presynaptic Ca(2+)-dependent signaling mechanisms.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1057)
  AUTHORS   Sokal,I., Li,N., Verlinde,C.L., Haeseleer,F., Baehr,W. and
            Palczewski,K.
  TITLE     Ca(2+)-binding proteins in the retina: from discovery to etiology
            of human disease(1)
  JOURNAL   Biochim Biophys Acta 1498 (2-3), 233-251 (2000)
   PUBMED   11108966
REFERENCE   6  (bases 1 to 1057)
  AUTHORS   Haeseleer,F., Sokal,I., Verlinde,C.L., Erdjument-Bromage,H.,
            Tempst,P., Pronin,A.N., Benovic,J.L., Fariss,R.N. and Palczewski,K.
  TITLE     Five members of a novel Ca(2+)-binding protein (CABP) subfamily
            with similarity to calmodulin
  JOURNAL   J Biol Chem 275 (2), 1247-1260 (2000)
   PUBMED   10625670
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK007488.1, BC107029.2 and AF169156.1.
            
            Transcript Variant: This variant (3) lacks two 5' exons, but has an
            alternate 5' exon, as compared to variant 1. The resulting isoform
            (3) is shorter and has a different N-terminus, as compared to
            isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007488.1, BY707547.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-674               AK007488.1         2-675
            675-996             BC107029.2         552-873
            997-1057            AF169156.1         743-803
FEATURES             Location/Qualifiers
     source          1..1057
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 3.79 cM"
     gene            1..1057
                     /gene="Cabp2"
                     /note="calcium binding protein 2"
                     /db_xref="GeneID:29866"
                     /db_xref="MGI:MGI:1352749"
     exon            1..380
                     /gene="Cabp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..830
                     /gene="Cabp2"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="calcium-binding protein 2 isoform 3"
                     /protein_id="NP_001153725.1"
                     /db_xref="CCDS:CCDS50348.1"
                     /db_xref="GeneID:29866"
                     /db_xref="MGI:MGI:1352749"
                     /translation="MALPEGPTDGSLPEGDSSPSSGTAGPSQDLASPTTRRRALLREL
                     EAQVQAAYGQDRELRPEEIEELQIAFQEFDRDRDGYIGYRELGACMRTLGYMPTEMEL
                     IEISQQISGGKVDFEDFVELMGPKLLAETADMIGVRELRDAFREFDTNGDGCISVGEL
                     RAALKALLGERLSQREVDEILQDIDLNGDGLVDFEEFVRMMSR"
     exon            381..411
                     /gene="Cabp2"
                     /inference="alignment:Splign:2.1.0"
     exon            412..546
                     /gene="Cabp2"
                     /inference="alignment:Splign:2.1.0"
     exon            547..656
                     /gene="Cabp2"
                     /inference="alignment:Splign:2.1.0"
     exon            657..804
                     /gene="Cabp2"
                     /inference="alignment:Splign:2.1.0"
     exon            805..1034
                     /gene="Cabp2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1006..1011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cabp2"
                     /note="hexamer: AATAAA"
     polyA_site      1034
                     /gene="Cabp2"
                     /note="major polyA site"
ORIGIN      
        1 gtggtcctgt gaaggttggg aagcactcta ggaggtaggt gaagatttca aagatggatt
       61 atgggagcag caatggaaga agacagtgac cttagaggac tcgggctctt ctaaccccca
      121 gagctagaaa caaaaacata gccacagctt gcactgagcc accgacctac aggtggagga
      181 gacccagctg gaacagaaaa cgtaccacac ctacatccat ggccctaccg gagggcccaa
      241 cagatggcag cctccctgaa ggagactcca gtccatcctc aggcactgca ggacccagcc
      301 aagacctagc cagccccact actcgcagaa gggcccttct ccgtgagctg gaagcccagg
      361 tgcaggctgc ctacggacag gatcgagagc tgagaccaga agagatcgaa gagctgcaga
      421 tcgccttcca ggagtttgac cgagaccggg acggctacat cggctaccgg gagctgggtg
      481 cctgcatgcg gacactgggc tacatgccca cggagatgga gctcattgag atatcacaac
      541 agatcagtgg tgggaaggtg gattttgaag attttgtgga gctgatgggt cccaagctgc
      601 tggcagagac ggcagacatg attggcgtga gggagcttcg agacgccttc cgggagttcg
      661 acaccaacgg tgatggctgc atcagcgtag gggagctccg ggcagccctc aaagctctgc
      721 tgggggaacg cctcagccaa cgggaagtag atgagatact ccaagacatt gacctcaatg
      781 gagatggcct ggttgacttt gaagaatttg ttcggatgat gtctcggtga gcctgtgtag
      841 aagctggagt ggaccggcct ggaggatccc agcctccgaa ttgcagagga tcctatatgt
      901 tctttgaagg tcactgtgta caggactgtg tgcctcctcc ccatccctgc ctgggcacag
      961 tgccctatcc tgtcatcacc ccatacctcg tcctggttct ctggcaataa aacatctcca
     1021 agcttgttgg gaaaaaaaaa aaaaaaaaaa aaaaaaa
//
