LOCUS       NM_145851               2945 bp    mRNA    linear   ROD 28-MAY-2024
DEFINITION  Mus musculus CDK5 and Abl enzyme substrate 2 (Cables2), transcript
            variant 1, mRNA.
ACCESSION   NM_145851
VERSION     NM_145851.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2945)
  AUTHORS   Kuno,A., Ikeda,Y., Ayabe,S., Kato,K., Sakamoto,K., Suzuki,S.R.,
            Morimoto,K., Wakimoto,A., Mikami,N., Ishida,M., Iki,N., Hamada,Y.,
            Takemura,M., Daitoku,Y., Tanimoto,Y., Dinh,T.T.H., Murata,K.,
            Hamada,M., Muratani,M., Yoshiki,A., Sugiyama,F., Takahashi,S. and
            Mizuno,S.
  TITLE     DAJIN enables multiplex genotyping to simultaneously validate
            intended and unintended target genome editing outcomes
  JOURNAL   PLoS Biol 20 (1), e3001507 (2022)
   PUBMED   35041655
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2945)
  AUTHORS   Dinh,T.T.H., Iseki,H., Mizuno,S., Iijima-Mizuno,S., Tanimoto,Y.,
            Daitoku,Y., Kato,K., Hamada,Y., Hasan,A.S.H., Suzuki,H., Murata,K.,
            Muratani,M., Ema,M., Kim,J.D., Ishida,J., Fukamizu,A., Kato,M.,
            Takahashi,S., Yagami,K.I., Wilson,V., Arkell,R.M. and Sugiyama,F.
  TITLE     Disruption of entire Cables2 locus leads to embryonic lethality by
            diminished Rps21 gene expression and enhanced p53 pathway
  JOURNAL   Elife 10, e50346 (2021)
   PUBMED   33949947
  REMARK    GeneRIF: Disruption of entire Cables2 locus leads to embryonic
            lethality by diminished Rps21 gene expression and enhanced p53
            pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2945)
  AUTHORS   Hasan,A.S.H., Dinh,T.T.H., Le,H.T., Mizuno-Iijima,S., Daitoku,Y.,
            Ishida,M., Tanimoto,Y., Kato,K., Yoshiki,A., Murata,K., Mizuno,S.
            and Sugiyama,F.
  TITLE     Characterization of a bicistronic knock-in reporter mouse model for
            investigating the role of CABLES2 in vivo
  JOURNAL   Exp Anim 70 (1), 22-30 (2021)
   PUBMED   32779618
  REMARK    GeneRIF: Characterization of a bicistronic knock-in reporter mouse
            model for investigating the role of CABLES2 in vivo.
REFERENCE   4  (bases 1 to 2945)
  AUTHORS   Hou,T., Chen,K., McLaughlin,W.A., Lu,B. and Wang,W.
  TITLE     Computational analysis and prediction of the binding motif and
            protein interacting partners of the Abl SH3 domain
  JOURNAL   PLoS Comput Biol 2 (1), e1 (2006)
   PUBMED   16446784
REFERENCE   5  (bases 1 to 2945)
  AUTHORS   Sato,H., Nishimoto,I. and Matsuoka,M.
  TITLE     ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5,
            and c-abl
  JOURNAL   Biochim Biophys Acta 1574 (2), 157-163 (2002)
   PUBMED   11955625
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL663027.9.
            
            On Jan 24, 2007 this sequence version replaced NM_145851.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.53226.1,
                                           SRR13948564.666243.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-366               AL663027.9         144018-144383       c
            367-438             AL663027.9         135321-135392       c
            439-531             AL663027.9         135132-135224       c
            532-609             AL663027.9         133996-134073       c
            610-718             AL663027.9         133035-133143       c
            719-884             AL663027.9         132434-132599       c
            885-988             AL663027.9         131995-132098       c
            989-1095            AL663027.9         131562-131668       c
            1096-1300           AL663027.9         131193-131397       c
            1301-2945           AL663027.9         129457-131101       c
FEATURES             Location/Qualifiers
     source          1..2945
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 102.78 cM"
     gene            1..2945
                     /gene="Cables2"
                     /gene_synonym="ik3-2"
                     /note="CDK5 and Abl enzyme substrate 2"
                     /db_xref="GeneID:252966"
                     /db_xref="MGI:MGI:2182335"
     exon            1..366
                     /gene="Cables2"
                     /gene_synonym="ik3-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..1441
                     /gene="Cables2"
                     /gene_synonym="ik3-2"
                     /note="isoform 1 is encoded by transcript variant 1; CDK5
                     and ABL1 enzyme substrate 2; interactor with CDK3 2"
                     /codon_start=1
                     /product="CDK5 and ABL1 enzyme substrate 2 isoform 1"
                     /protein_id="NP_665850.2"
                     /db_xref="CCDS:CCDS38377.1"
                     /db_xref="GeneID:252966"
                     /db_xref="MGI:MGI:2182335"
                     /translation="MAAAAAGGAPGPAPGPSRPAPAARNPPAVPRRRGDSRRRQAALF
                     FLNNISLDGRPPSLGPGGEKPAPPPPPPTEAREAPAPPPAPPGGLPGLPARPAPQGLL
                     SPTTAPAGLGLDGQRQRRRVTSQRCSLEFLEDTVGCASVQRTKHASGSPRHKGLKKTH
                     FIKNMRQYDTKNSRIVLICAKRSLCAAFSVLPYGEGLRISDLRVDSQKQRHPSGGVSV
                     SSEMVFELEGVELGADGKVVSYAKFLYPTNALVIHKNDSHGLLPQPRPSIPRAPPGSR
                     HKPVPTKSTPAGTELGSDGGDAVEYNPNLLDDPQWPCGKHKRVLIFASYMTTVIEYVK
                     PADLKKDMNETFREKFPHIKLTLSKIRSLKREMRNLSEECSLEPVTVSMAYVYFEKLV
                     LQGKLNKQNRKLCAGACVLLAAKISSDLRKSEVKQLIDKLEERFRFNRKDLIGFEFTV
                     LVALELALYLPENQVLPHYRRLTQQF"
     exon            367..438
                     /gene="Cables2"
                     /gene_synonym="ik3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            439..531
                     /gene="Cables2"
                     /gene_synonym="ik3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            532..609
                     /gene="Cables2"
                     /gene_synonym="ik3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            610..718
                     /gene="Cables2"
                     /gene_synonym="ik3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            719..884
                     /gene="Cables2"
                     /gene_synonym="ik3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            885..988
                     /gene="Cables2"
                     /gene_synonym="ik3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1095
                     /gene="Cables2"
                     /gene_synonym="ik3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1300
                     /gene="Cables2"
                     /gene_synonym="ik3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..2945
                     /gene="Cables2"
                     /gene_synonym="ik3-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2922..2927
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cables2"
                     /gene_synonym="ik3-2"
                     /note="hexamer: AGTAAA"
     polyA_site      2945
                     /gene="Cables2"
                     /gene_synonym="ik3-2"
                     /note="major polyA site"
ORIGIN      
        1 gcactcgagc atggccgcgg ctgcggcggg aggagccccg ggtccggccc ccggcccctc
       61 caggcccgcg ccggccgccc ggaacccgcc ggccgtgccg cggaggcgcg gggactcccg
      121 gcgccgtcag gccgccctct tctttctcaa caacatctcc ctggacggac ggcccccgag
      181 cctgggtccc ggaggcgaga agccagcgcc gccgccgcca ccgcccaccg aggcccgcga
      241 ggcgcccgcg ccgccgcccg ctccacctgg aggcctcccg gggctgccag ccaggcccgc
      301 gccccagggc ctgctcagcc ccacgacggc gcccgccggc cttggcctgg acgggcagcg
      361 ccaaaggaga cgagtcacat ctcagcgctg ttcccttgag tttctggaag acacagtggg
      421 atgtgcctcg gtgcagagaa ccaagcatgc atctggatca ccaagacaca aaggcctgaa
      481 gaaaacccac ttcatcaaga acatgaggca gtatgacaca aagaacagca ggattgtact
      541 catctgtgcc aagcggtccc tgtgtgcggc cttctcagtc ctgccctatg gagaaggcct
      601 acggatcagt gacctgaggg tggacagcca gaagcagagg cacccatccg gcggcgtttc
      661 tgtttcttct gagatggtct ttgaattgga aggcgttgag ctgggagcag atggaaaggt
      721 cgtgtcttat gcaaagttcc tgtaccctac taatgctctg gttatacaca agaatgacag
      781 ccatggcttg ctgccccagc ctcggcccag catccccagg gctccaccag gttcaagaca
      841 caaacctgtg cctaccaagt caacaccagc tggcacagaa ctaggaagcg acgggggaga
      901 tgcagtggaa tacaatccca acctcctgga cgacccacag tggccgtgtg gaaaacataa
      961 gcgtgtactc atctttgctt catacatgac caccgttata gagtatgtga aacctgcaga
     1021 cctcaagaag gatatgaatg agaccttcag ggaaaagttc cctcatatca aactgacatt
     1081 gagcaaaatt aggagtttaa aacgggagat gcggaacctt tctgaagagt gcagcttgga
     1141 gcctgtgacc gtgtccatgg catatgtgta ctttgagaag ctcgtactgc agggcaagct
     1201 caacaaacag aaccgcaaac tgtgtgctgg agcctgtgtt ctgttggctg ccaagatcag
     1261 cagtgacctc cgcaagagtg aagtgaagca gcttattgac aagctggagg aaaggttccg
     1321 gttcaacagg aaagacctca ttggctttga gttcacggtg ctcgtggctt tggaactggc
     1381 cctgtacctc ccagagaacc aagtgttacc tcactacaga cgcctcaccc agcagttcta
     1441 gcccaaacag tgcaccccag agggaggctg ctttggcagg aaggctgagt agcttggcta
     1501 gaggactagt gttcctgtcc ctcctccagt aactgcactt gcccctcaca acccacggca
     1561 gcttggcttc cttggaaagt ttttaatttt ggggcagagc acgccttgac ctcgagacgc
     1621 tccctgttga gggttttcct gaagcaagtg aacagtgtgg ggcttggttt gttcttcgtg
     1681 tggcgagacc agcctggctt atgttgtgaa tcctgagggc cagccttcct tctgcctacc
     1741 catgaaacca ttcctgtaga gacctaggtg tccagacctt ctgaacttgc tacaattgtc
     1801 aggcttctgt cttctggtgc ctccacccag gcagttcccc atcagcacta ttttatcttt
     1861 ggtcaagata caggataggg cagacacctt gattctgagt ctgctctcac tgcaccttgt
     1921 taaagcatct gccactgtga aacccgtgtc acatgcacag cagtgctttg gccaacccct
     1981 gctgcctcct gccagcacag cttttccctg tcactggaca accactgact gtgggctctt
     2041 gactttccta agcaatatcg tgatggagaa aagtcattat aacttgagat ttggtctcta
     2101 tgggaacaga caatggccca ttcaggcctg ctgctgactt tgaaccacac ttgatcctca
     2161 agcaggaagg caccgatcct gctacctact gtcaatgact acatgtcatc aggccaagtt
     2221 gccctgtgcc actgtcatca ctcaagagct atcctccacc tccccaggcc tgttatcctt
     2281 ccctagaaac tggtcaccag cctggcagac gccagccacc gcttggttcc agtctcatgt
     2341 cccagagatg ctcgtcctca agcctgacac cgaccaccta ggtctatcgg atcagtaaca
     2401 gctcagacag gagctcaaag gatagtaaat acgttttagc ctgtccatgc ttatgctggt
     2461 gtaagcatgc cacgttctca gagcatcttt aggtgcaata agtcgttcct gcaaacaggt
     2521 tatcttcagg gcagccccat catttttttt ttaaatgaac ttagatatat atggctgact
     2581 gatgggataa atgttattta agcttctaga tgtagtaagg tgtattcatt ttaccaagct
     2641 ggtctgctgt tagtccttcc taagcttcgc taagagctgc tggtttgtgg tattgagcac
     2701 tgttaaagcc aacccttaaa ccaaacacgg gctaaacaga gtcctataga ctgagtccag
     2761 aaatctgagg tatatccatg gtgtccagct ggactgtgac ccaatgccac agacctggtg
     2821 ctgcacccgc agcgctcaac aggacacagc tgtgtcagac ctcagaatgt ggtgtatgtc
     2881 cagtaggtta tgaatggaag gtgttaaaat gtttttgtta aagtaaaact ggtttttgca
     2941 acata
//
