LOCUS       NM_001146287            3071 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus CDK5 and Abl enzyme substrate 1 (Cables1), transcript
            variant 1, mRNA.
ACCESSION   NM_001146287
VERSION     NM_001146287.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3071)
  AUTHORS   He,L., Beghi,F., Baral,V., Depond,M., Zhang,Y., Joulin,V.,
            Rueda,B.R., Gonin,P., Foudi,A., Wittner,M. and Louache,F.
  TITLE     CABLES1 Deficiency Impairs Quiescence and Stress Responses of
            Hematopoietic Stem Cells in Intrinsic and Extrinsic Manners
  JOURNAL   Stem Cell Reports 13 (2), 274-290 (2019)
   PUBMED   31327733
  REMARK    GeneRIF: Overexpression and short hairpin RNA-mediated depletion of
            CABLES1 protein resulted in p21(Cip/waf) up- and down-regulation.
            Aged mice lacking Cables1 displayed abnormalities in peripheral
            blood cell counts accompanied by a significant reduction in
            hematopoietic stem cells compartment, concomitant with an increased
            mobilization of progenitor cells.
REFERENCE   2  (bases 1 to 3071)
  AUTHORS   Mizuno,S., Tra,D.T., Mizobuchi,A., Iseki,H., Mizuno-Iijima,S.,
            Kim,J.D., Ishida,J., Matsuda,Y., Kunita,S., Fukamizu,A.,
            Sugiyama,F. and Yagami,K.
  TITLE     Truncated Cables1 causes agenesis of the corpus callosum in mice
  JOURNAL   Lab Invest 94 (3), 321-330 (2014)
   PUBMED   24336072
  REMARK    GeneRIF: Agenesis of the corpus callosum frequency in
            Cables1(+/TAS) mice was significantly lower than that in
            Cables1(-/TAS) mice, indicating that wild-type Cables1 interfered
            with the dominant negative effect of Cables1(TAS).
REFERENCE   3  (bases 1 to 3071)
  AUTHORS   Arnason,T., Pino,M.S., Yilmaz,O., Kirley,S.D., Rueda,B.R.,
            Chung,D.C. and Zukerberg,L.R.
  TITLE     Cables1 is a tumor suppressor gene that regulates intestinal tumor
            progression in Apc(Min) mice
  JOURNAL   Cancer Biol Ther 14 (7), 672-678 (2013)
   PUBMED   23792637
  REMARK    GeneRIF: Loss of Cables1 enhances tumor progression in the
            Apc(Min/+) mouse model and activates the Wnt/beta-catenin signaling
            pathway. Cables1 is a tumor suppressor gene on chromosome 18q in
            this in vivo mouse model.
REFERENCE   4  (bases 1 to 3071)
  AUTHORS   Mizuno,S., Mizobuchi,A., Iseki,H., Iijima,S., Matsuda,Y.,
            Kunita,S., Sugiyama,F. and Yagami,K.
  TITLE     A novel locus on proximal chromosome 18 associated with agenesis of
            the corpus callosum in mice
  JOURNAL   Mamm Genome 21 (11-12), 525-533 (2010)
   PUBMED   20967545
REFERENCE   5  (bases 1 to 3071)
  AUTHORS   Wang,N., Guo,L., Rueda,B.R. and Tilly,J.L.
  TITLE     Cables1 protects p63 from proteasomal degradation to ensure
            deletion of cells after genotoxic stress
  JOURNAL   EMBO Rep 11 (8), 633-639 (2010)
   PUBMED   20559324
  REMARK    GeneRIF: Data show that oocytes lacking Cables1 exhibit lower basal
            levels of TAp63alpha and reduced accumulation of phosphorylated
            TAp63alpha in response to genotoxic stress.
REFERENCE   6  (bases 1 to 3071)
  AUTHORS   Tsuji,K., Mizumoto,K., Yamochi,T., Nishimoto,I. and Matsuoka,M.
  TITLE     Differential effect of ik3-1/cables on p53- and p73-induced cell
            death
  JOURNAL   J Biol Chem 277 (4), 2951-2957 (2002)
   PUBMED   11706030
  REMARK    Erratum:[J Biol Chem 2002 May 10;277(19):17374]
REFERENCE   7  (bases 1 to 3071)
  AUTHORS   Wu,C.L., Kirley,S.D., Xiao,H., Chuang,Y., Chung,D.C. and
            Zukerberg,L.R.
  TITLE     Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits
            cell growth, and is lost in many human colon and squamous cancers
  JOURNAL   Cancer Res 61 (19), 7325-7332 (2001)
   PUBMED   11585773
REFERENCE   8  (bases 1 to 3071)
  AUTHORS   Yamochi,T., Nishimoto,I., Okuda,T. and Matsuoka,M.
  TITLE     ik3-1/Cables is associated with Trap and Pctaire2
  JOURNAL   Biochem Biophys Res Commun 286 (5), 1045-1050 (2001)
   PUBMED   11527406
REFERENCE   9  (bases 1 to 3071)
  AUTHORS   Matsuoka,M., Matsuura,Y., Semba,K. and Nishimoto,I.
  TITLE     Molecular cloning of a cyclin-like protein associated with
            cyclin-dependent kinase 3 (cdk 3) in vivo
  JOURNAL   Biochem Biophys Res Commun 273 (2), 442-447 (2000)
   PUBMED   10873625
  REMARK    Erratum:[Biochem Biophys Res Commun 2000 Aug 11;274(3):880]
REFERENCE   10 (bases 1 to 3071)
  AUTHORS   Zukerberg,L.R., Patrick,G.N., Nikolic,M., Humbert,S., Wu,C.L.,
            Lanier,L.M., Gertler,F.B., Vidal,M., Van Etten,R.A. and Tsai,L.H.
  TITLE     Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine
            phosphorylation, kinase upregulation, and neurite outgrowth
  JOURNAL   Neuron 26 (3), 633-646 (2000)
   PUBMED   10896159
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC100751.6 and AC132941.21.
            
            On Dec 23, 2022 this sequence version replaced NM_001146287.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156273.1, AK158396.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-991               AC100751.6         93799-94789         c
            992-1063            AC100751.6         51547-51618         c
            1064-1156           AC100751.6         45503-45595         c
            1157-1234           AC100751.6         28330-28407         c
            1235-1331           AC100751.6         10876-10972         c
            1332-1488           AC100751.6         9361-9517           c
            1489-1592           AC100751.6         7968-8071           c
            1593-1699           AC132941.21        20913-21019
            1700-1907           AC132941.21        22374-22581
            1908-3071           AC132941.21        25655-26818
FEATURES             Location/Qualifiers
     source          1..3071
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 5.88 cM"
     gene            1..3071
                     /gene="Cables1"
                     /gene_synonym="Cables; ik3-1"
                     /note="CDK5 and Abl enzyme substrate 1"
                     /db_xref="GeneID:63955"
                     /db_xref="MGI:MGI:1927065"
     exon            1..991
                     /gene="Cables1"
                     /gene_synonym="Cables; ik3-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..2048
                     /gene="Cables1"
                     /gene_synonym="Cables; ik3-1"
                     /note="isoform 1 is encoded by transcript variant 1; CDK5
                     and ABL1 enzyme substrate 1; interactor with CDK3 1;
                     interactor-1 with cdk3; cdk3-binding protein ik3-1"
                     /codon_start=1
                     /product="CDK5 and ABL1 enzyme substrate 1 isoform 1"
                     /protein_id="NP_001139759.1"
                     /db_xref="CCDS:CCDS50220.1"
                     /db_xref="GeneID:63955"
                     /db_xref="MGI:MGI:1927065"
                     /translation="MAAATATAGTAACSSSSSSRGGSTDAAATSGVQPPPPPPATAPP
                     EPLRKPRMDPRRRQAALSFLTNISLDGRPPLQDHEWGGGEEGGGTKPGARARLSLLAA
                     GCNAFSAPGTAAAPWTAGSGSSPCPLPPSLVPRVLGEPSQPPRSAPAVTGAQLQLPDG
                     PGGAGQEELEEDDAFTNVQVPSASFLGSGTPGSTSGSRGRLNSFTQGILPIAFSRQNS
                     QNYCALEQSGQGGSTSALEQLQRSRRRLISQRSSLETLEDIEENAPLRRCRTLSGSPR
                     PKNFKKIHFIKNMRQHDTKNGRIVLISGRRSFCSIFSVLPYRDSTQVGDLKLDGGRQS
                     AGAMSLKEIIGLEGVELGADGKTVSYTQFLLPTNAFGNRRNTIDSTASFSQFRSLSHR
                     SLSMGRAGSTQGSLDAGSDLGDFMDYDPNLLDDPQWPCGKHKRVLTFPSYMTTVIDYV
                     KPSDLKKDMNETFKEKFPHIKLTLSKIRSLKREMRKLAQEDCGFEEPTVAMAFVYFEK
                     LALRGKLNKQNRKLCAGACVLLAAKVGSDLRKHEVKHLIDKLEEKFRLNRRELIAFEF
                     PVLVALEFALHLPEHEVMPHYRRLIQSS"
     exon            992..1063
                     /gene="Cables1"
                     /gene_synonym="Cables; ik3-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1156
                     /gene="Cables1"
                     /gene_synonym="Cables; ik3-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1234
                     /gene="Cables1"
                     /gene_synonym="Cables; ik3-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1331
                     /gene="Cables1"
                     /gene_synonym="Cables; ik3-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1488
                     /gene="Cables1"
                     /gene_synonym="Cables; ik3-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1592
                     /gene="Cables1"
                     /gene_synonym="Cables; ik3-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1699
                     /gene="Cables1"
                     /gene_synonym="Cables; ik3-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1907
                     /gene="Cables1"
                     /gene_synonym="Cables; ik3-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..3071
                     /gene="Cables1"
                     /gene_synonym="Cables; ik3-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3044..3049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cables1"
                     /gene_synonym="Cables; ik3-1"
                     /note="hexamer: ATTAAA"
     polyA_site      3071
                     /gene="Cables1"
                     /gene_synonym="Cables; ik3-1"
                     /note="major polyA site"
ORIGIN      
        1 gtgatcgcgc ggcacggagg gtcggccagg cgcgcgtggg tccgggacgc ggagggcgag
       61 ccaggcgcgt gtggctctca gcggcgcccg aacgcccagg gccgagcatg gcccgcccgc
      121 gggagggtag gaccgcctcg cacaccgccc gcgccccgcg ccctgcccag cccgggtcgc
      181 cggggctcgc ggccgcggct tagcactcgg cacccgccac tcgcttctcg ggtaccgggg
      241 aactgacgcc ccagacggac acaatggcgg cggcgaccgc caccgcgggc acggccgcct
      301 gcagcagcag cagcagcagt cgcggcggca gcacggacgc cgcggccacc agcggggtgc
      361 agccgccgcc gcctcctccg gccaccgcgc cgccggaacc tcttcgtaag ccgcgcatgg
      421 acccgcggcg ccgccaggct gccctgtcct tcctcaccaa catttctctg gacggacggc
      481 ctccgctgca ggaccacgag tggggcggcg gcgaggaggg cggcgggacc aagcccggag
      541 caagggctcg gctcagcctg ctggccgctg gctgcaacgc gttctcggca ccgggcaccg
      601 cggccgcgcc gtggaccgcc ggctcgggtt ccagcccttg cccgctgccg ccgtctctgg
      661 tcccccgggt gttgggagag ccatctcagc cgccccgttc agctccagct gtcaccggtg
      721 ctcagctgca gttgcctgac gggccgggag gcgccggaca ggaggagctg gaggaggacg
      781 atgccttcac caacgtgcag gtgccatcgg ccagcttttt gggctccggg acccccggga
      841 gtacgagcgg cagtcggggc cgcctcaact cgttcactca gggaatcctg cccatcgcct
      901 tctccaggca gaactcgcag aactactgcg ccttggagca gtcaggccag ggcggcagca
      961 ccagcgcctt ggagcagctg cagaggtcca gacgtcgcct catctcccag agatcatctt
     1021 tggagaccct ggaagatatt gaagagaatg cccctctccg gagatgtcga acactctcag
     1081 gttctcccag accaaagaat ttcaagaaaa ttcattttat caagaatatg cgacagcacg
     1141 ataccaagaa tggcagaata gtccttatca gtggcagaag atccttctgt agtatatttt
     1201 ccgtgctgcc gtatcgagac agtacccaag tcggggacct gaagttggat ggagggaggc
     1261 agtcagcagg ggccatgagc ctgaaggaga tcattggcct tgaaggtgtg gaactgggtg
     1321 ccgatgggaa gacagtgtct tatacccagt ttctactacc cacaaatgcc tttgggaacc
     1381 gtagaaatac catagactcc accgcctcct tctcccagtt tcggagcctg agccaccgaa
     1441 gcctctccat gggccgggct ggcagcaccc aggggagcct tgatgcagga agtgacctgg
     1501 gagactttat ggactatgac ccaaacctcc tggatgaccc ccagtggcct tgcggcaagc
     1561 acaagcgagt tctgaccttc ccttcataca tgaccacagt gattgactac gtgaagccct
     1621 cagatctcaa gaaggacatg aatgaaacct tcaaggagaa gtttcctcac attaaattaa
     1681 cactcagcaa aatcaggagc ctgaaaagag agatgcggaa gcttgcccag gaggactgtg
     1741 gctttgagga gcccacggtg gccatggcct ttgtctactt tgagaagctg gccctcaggg
     1801 ggaagctgaa caagcagaac cggaagctct gtgcgggagc ctgtgtgctg ctagcggcca
     1861 aggtcggaag tgacctcaga aagcacgagg tcaagcacct gattgacaaa ctggaagaga
     1921 agttccgact gaacagacga gaactgattg cctttgaatt cccagtgtta gtggccttgg
     1981 agtttgcact tcacctgcca gagcacgaag tcatgcccca ctatagacgc ctgatccaga
     2041 gctcctagca ctggcctcag gagggccaag actgcttcct gagcacagtg gagcctcgct
     2101 tactcccaga gaggggagag gagaggccag tcaactcgca gctctgcttt cgctgagaag
     2161 ccccgagttc ctggagactt gaggcttgct gagaaggcgt gtgctgggga tgatgaaggc
     2221 ctcccagctc ccacagccag agctaagctg tgcccagctc ttcctctcag gcacatgaga
     2281 aacttgaggc cgcctcgtca ccttcattcc aggcctgttc tgaatttgta gcatgatgtg
     2341 ctgggacaga ggagggaacc gagtgcgtgg gattccggga tgctgcttcg cggtccctcg
     2401 ccctgtgtcg agagtgtgcc aacctatttt tatatctgcc atcggaagtg cacttccctg
     2461 gggcacaggg gtgcgggtgt gcaagtgtct gcgggacact gttacactcg accccaaagc
     2521 caacgcccac cttctatgga gctgacttgt aatgccttct aggtaacagc gactcacatc
     2581 cagactgaca tctctgctct aggaaataac actgtttatg agactgtacc tgccacccac
     2641 tggacagggt gacagttctc agtgtagggt aagtcacgtg cagagtggtg cgctccgagc
     2701 tcctgctgtc acaccatggg ctcctgttta accctctagc tcttgcctgt ggagacatga
     2761 gggctgcact ccatagcgtg tattcctgtg ctctatgtta gagtgcataa tgagcgcgtt
     2821 tattgtgcta attacataca tgtgtgtttt ataaaagtct gtactggggt aagacgcatg
     2881 attggtgtct tgtggctttt gcagctggga caaactacat ttcaagctgt ggttgaactg
     2941 attgttagta caaaattgtg acttgtcctg aagcattatc catgctgtca cctggtggtc
     3001 atacaggtac agccttcttg aagagagcct gtggtcatgg aaaattaaaa tattttgtcg
     3061 ttttacatat a
//
