LOCUS       NM_172549               7483 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus calcineurin binding protein 1 (Cabin1), mRNA.
ACCESSION   NM_172549 XM_354545 XM_354546 XM_359256 XM_359258
VERSION     NM_172549.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7483)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7483)
  AUTHORS   Smith,R., Susor,A., Ming,H., Tait,J., Conti,M., Jiang,Z. and
            Lin,C.J.
  TITLE     The H3.3 chaperone Hira complex orchestrates oocyte developmental
            competence
  JOURNAL   Development 149 (5) (2022)
   PUBMED   35112132
REFERENCE   3  (bases 1 to 7483)
  AUTHORS   Reddy,H.M., Bhattacharya,R., Tiwari,S., Mishra,K., Annapurna,P.,
            Jehan,Z., Praveena,N.M., Alex,J.L., Dhople,V.M., Singh,L.,
            Sivaramakrishnan,M., Chaturvedi,A., Rangaraj,N., Shiju,T.M.,
            Sreedevi,B., Kumar,S., Dereddi,R.R., Rayabandla,S.M. and
            Jesudasan,R.A.
  TITLE     Y chromosomal noncoding RNAs regulate autosomal gene expression via
            piRNAs in mouse testis
  JOURNAL   BMC Biol 19 (1), 198 (2021)
   PUBMED   34503492
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7483)
  AUTHORS   Smith,R., Pickering,S.J., Kopakaki,A., Thong,K.J., Anderson,R.A.
            and Lin,C.J.
  TITLE     HIRA contributes to zygote formation in mice and is implicated in
            human 1PN zygote phenotype
  JOURNAL   Reproduction 161 (6), 697-707 (2021)
   PUBMED   33835048
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7483)
  AUTHORS   Nishimura,M., Casanova,J.R. and Swann,J.W.
  TITLE     The Impact of Electrographic Seizures on Developing Hippocampal
            Dendrites Is Calcineurin Dependent
  JOURNAL   eNeuro 4 (2) (2017)
   PUBMED   28462391
  REMARK    GeneRIF: calcineurin B1 plays a key role in seizure-induced
            dendrite growth suppression and may contribute to the
            neurobehavioral comorbidities of childhood epilepsy
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7483)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 7483)
  AUTHORS   Kim,M.J., Jo,D.G., Hong,G.S., Kim,B.J., Lai,M., Cho,D.H., Kim,K.W.,
            Bandyopadhyay,A., Hong,Y.M., Kim,D.H., Cho,C., Liu,J.O.,
            Snyder,S.H. and Jung,Y.K.
  TITLE     Calpain-dependent cleavage of cain/cabin1 activates calcineurin to
            mediate calcium-triggered cell death
  JOURNAL   Proc Natl Acad Sci U S A 99 (15), 9870-9875 (2002)
   PUBMED   12114545
  REMARK    GeneRIF: Calpain-dependent cleavage activates calcineurin to
            mediate calcium-triggered cell death.
REFERENCE   8  (bases 1 to 7483)
  AUTHORS   Esau,C., Boes,M., Youn,H.D., Tatterson,L., Liu,J.O. and Chen,J.
  TITLE     Deletion of calcineurin and myocyte enhancer factor 2 (MEF2)
            binding domain of Cabin1 results in enhanced cytokine gene
            expression in T cells
  JOURNAL   J Exp Med 194 (10), 1449-1459 (2001)
   PUBMED   11714752
REFERENCE   9  (bases 1 to 7483)
  AUTHORS   Wiltshire,T., Pletcher,M., Cole,S.E., Villanueva,M., Birren,B.,
            Lehoczky,J., Dewar,K. and Reeves,R.H.
  TITLE     Perfect conserved linkage across the entire mouse chromosome 10
            region homologous to human chromosome 21
  JOURNAL   Genome Res 9 (12), 1214-1222 (1999)
   PUBMED   10613844
REFERENCE   10 (bases 1 to 7483)
  AUTHORS   Sun,L., Youn,H.D., Loh,C., Stolow,M., He,W. and Liu,J.O.
  TITLE     Cabin 1, a negative regulator for calcineurin signaling in T
            lymphocytes
  JOURNAL   Immunity 8 (6), 703-711 (1998)
   PUBMED   9655484
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN722898.1, BC057551.1, BU705499.1, BQ714836.1, CV884170.1,
            AK039606.1 and BC051668.1.
            
            On Apr 19, 2006 this sequence version replaced NM_172549.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC150825.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMN00849374,
                                    SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                CN722898.1         1-72
            73-3528             BC057551.1         1-3456
            3529-4201           BU705499.1         55-727
            4202-4762           BQ714836.1         155-715
            4763-5208           CV884170.1         254-699
            5209-6882           AK039606.1         912-2585
            6883-7483           BC051668.1         515-1115
FEATURES             Location/Qualifiers
     source          1..7483
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 38.56 cM"
     gene            1..7483
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /note="calcineurin binding protein 1"
                     /db_xref="GeneID:104248"
                     /db_xref="MGI:MGI:1298375"
     exon            1..333
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            334..465
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     CDS             463..7026
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /note="protein phosphatase 3 inhibitor; calcineurin
                     inhibitor"
                     /codon_start=1
                     /product="calcineurin-binding protein cabin-1"
                     /protein_id="NP_766137.2"
                     /db_xref="CCDS:CCDS35938.1"
                     /db_xref="GeneID:104248"
                     /db_xref="MGI:MGI:1298375"
                     /translation="MIRIAALNASSTIEDDHEGSFKSHKIQTKEAQEAEAFALYHKAL
                     DLQKHDRFEESAKAYHELLEARLLREAVSSGDEKEGLKHPGLILKYSTYKNLAQLAAQ
                     REDLETAMEFYLEAVMLDSTDVNLWYKIGHVALRLIRLPLARHAFEEGLRCNPDHWPC
                     LDNLITVLYTLSDYTTCLYFICKALEKDCRYSKGLVLKEKIFEEQPCLRKDSLRMFLK
                     CDMSIHDVSVSAAETQAIVDEALGLRKKRQALIVREKEPDLKLVQPIPFFTWKCLGES
                     LLAMYSHLTTCEPPRPSLGKRIDLSDYQDPSQLLASSVVVTPVSVVQPSPICTNPTVA
                     VAEPVLSYTSVTAASFPLHSPSLLDTGTPMGDVSGGDKSKKGVKRKKTVEESGETAKR
                     RSARVRNTKCKKEEKVDFQGLLVKFLPSRLRKLDPEEEDDPFNNYEVQAEAKLESFSN
                     VGPHRLSFDSATFMESEKQDVHAFLMENLTNGGLLELMMRYLKSMGHKFLLKWPPGLA
                     DVVLSVYHSWRRHSTSLPNPLLRDCSNKHIKDMMLMSLSCMELQLDQWLLTKGRSSAV
                     SPRNCPAGVVTGRFGPDFPGTHCLGDLLQLSFASSQRDLFEDGWLEFVVRVYWLKARF
                     LALQGDMEQALENYDICTEILQSSSAIQAQAGAEQGDIVIRLPNLHNDSVVSLEEIDK
                     NLKSLERCQSLEEIQRLFEAGDYKAVVHLLRPTLCTSGFDRAKHLEFMTSIPERPAQL
                     LLLQDSLLRLKDHRQCFECSDVALNEAVQQMLNSSESAAKEEWVATVTQLLLGIEQAL
                     SSDSSGSILKESSSTTGLVRLTNNLIQVIDCSMAVQEEPKEPYVSSVLPWIILHRIIW
                     QEEDTFRSLCHQQQLQNPTEEGIPEMPMLPSSLMLLNTAHEYLGRRSWCCNSDGALLR
                     FYVQVLQKELAASASEDTHPYKEELETALEQCFYCLYSFPSKKSKARYLEEHSAQQVD
                     LIWEDALFMFEYFKPKTLPEFDSYKTSTVSADLANLLKRIATIVPRTEKPALSMDKVS
                     AYIEGTSAEAPCLPEGADPTPPVLNELYYLLADYHFKNKEQSKAIKFYMHDICICPNR
                     FDSWAGMALARASRIQDKLNSNELKSDGPIWKHATPVLNCFRRALEIDSSNLSLWIEY
                     GTMSYALHSFASRQLKQWRSELPPELVQQMEDRRDSMLETARHCFTSAARCEGDGDEE
                     EWLIHYMLGKVAEKQQQPPTVYLLHYRQAGHYLHEEAARYPKKIHYHNPPELAMEALE
                     VYFRLHASILKLLGKPDSGVGAEVLVSFMKEAAEGPFARGEEKNTPKASEKEKACLVD
                     EDSHSSAGTLPGPGASLPSSSGPGLTSPPYTATPIDHDYVKCKKPHQQAAPDDRSQDS
                     TAVALSDSSSTQDFFNEPTSLLEGSRKLFPEKRLSGLSAQAGPSGKDLPGPTEERGKT
                     EESLESTEAFRVVEQSVQKPVADSSASAYIPSKPPASTPPLWDGKKRGDSLGEPVAFP
                     QGLPAGAEEQRQFLTEQCISSFCLCLSRFPQHYKSLYRLAFLYTYSKTHRNLQWARDV
                     LLGSSIPWQQLQHMPAQGLFCERNKTNFFNGIWRIPVDEIDRPGSFAWHMNRSIVLLL
                     KVLAQLRDHSTLLKVSSMLQRTPDQGKKYLRDADRQVLAQRAFILTVKVLEDTLSELA
                     EGSEHPGSKACGLSGARMTTDVSHKASPEDGQESPQHPKKLPLADGSGPGPEPGGRMG
                     PLNQLPVVTDIRDNTDQGGEQKDKESPQVGPTEPMDTSEAAGRHSDLEQTSRLLPGRP
                     PRDRGPESRSAELSLEELSISTRQQPAPLAPSPAAPTTTAAPTTMAARGAGHSEEAPP
                     RPNRKRKLLEDTESGKTLLLDAYRVWQQGQKGMAYDLSRIEKIMSETYMLIKQVDEET
                     ALEQAVKFCQVHLGAATQRQASGDTPTTPKHPKDSRENFFPATVVPTVPDPTAPDALQ
                     RPSDSHLKPVLATVITCPPSASASIPDLSTDPGIPRPHRPETTPSRAPLSPEGEEASG
                     VTEGTSILPQEPRYSHQIKMAATGHLAEQHCWPVEVACQTGAEPTCSQASSTKVPSSG
                     STQTAESHQGKTESSRAKSRLLPNMPKLVIPSATTKSPPEITVTPPTPTLLSPKGSIS
                     EETKQKLKSAILSAQSAANVRKESLCQPALEVLETSSQESSLESETDEDDDFMDV"
     exon            466..558
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            559..672
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            673..807
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            808..988
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1118
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1268
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1555
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1724
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1861
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..2079
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2158
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2346
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2499
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2694
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            2695..2937
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            2938..3094
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            3095..3210
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            3211..3372
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            3373..3579
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            3580..3725
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            3726..3987
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            3988..4248
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            4249..4400
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            4401..4579
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            4580..4762
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            4763..5094
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            5095..5208
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            5209..5372
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            5373..5469
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            5470..6147
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            6148..6222
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            6223..6490
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            6491..6655
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            6656..6882
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     exon            6883..7460
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7441..7446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /note="hexamer: AATAAA"
     polyA_site      7458
                     /gene="Cabin1"
                     /gene_synonym="A330070M20Rik; Cain; Ppp3in"
                     /note="major polyA site"
ORIGIN      
        1 ggagtctggg agctccggcc gttgccctgg agacgccggt cgagttccgg ggagcaaggg
       61 ctgtgtgtgt ctgctaagtg tgcgcacggc tcccgtgagc gcgaggaggt ggaaccacgc
      121 gagaagaccc gctcttcccc ttcctcccgg gcgcggtggg ccgaagccag gctcgagacc
      181 cgaaggcacg ggcgcgggtc ttctgcccac gctggcttct tctcgcttcc cgcagcctcg
      241 cccggtggcg cctagggtgg gtcacagtga ccgcagctcg aagccatccc tttcggtgcg
      301 tcctttcgtt caccttcacc gcagcccagc gaggtgggcc tgagcactgt gccgttccgt
      361 tcctggctcc tcctgaaccc ttctgtcctg tttgctctgc aggggactgt cgtgtcccag
      421 ggatgggaag tgatcctccg tggtggtgct gaatctctga atatgattcg aattgcagcc
      481 ttaaatgcca gctccacgat tgaggatgac catgaaggaa gcttcaaaag tcacaaaatc
      541 cagacaaagg aggctcagga agcagaagcc tttgccctat accacaaggc cctggatcta
      601 caaaaacatg acaggttcga ggagtccgcc aaggcctacc acgagcttct ggaggctcgc
      661 ctgctgcggg aggcagtgtc atccggagat gagaaggaag ggctgaaaca ccctggactg
      721 atactgaaat attctacata taagaacctg gcccagctgg cggcccagcg agaggacctg
      781 gagaccgcca tggaatttta tttggaggca gtgatgctgg attccacaga cgtcaacctt
      841 tggtacaaaa ttggacacgt cgccctgagg ctcatccggc ttcccctggc tcgccatgct
      901 tttgaggaag ggcttcggtg taaccctgac cactggccct gcctggacaa tctcatcact
      961 gttttgtaca ccctcagtga ttacacaaca tgtctttact tcatctgcaa agccctggag
     1021 aaagactgcc ggtacagcaa aggcctggtc ctcaaggaga agatttttga agagcagcct
     1081 tgtctccgaa aggactccct ccgaatgttt ctcaagtgtg acatgtcgat tcacgatgtg
     1141 tcagtgagtg cagcagagac gcaggccatt gtagatgagg ctctggggct gcggaagaag
     1201 aggcaagcgt tgatcgtgcg ggaaaaggaa ccagacctga aactagtgca gcccatccct
     1261 ttcttcacgt ggaagtgcct tggggagagc ttgcttgcca tgtacagtca cctcaccacc
     1321 tgtgagcccc cgaggcccag ccttgggaag aggattgacc tgtctgacta ccaggatccc
     1381 agccagctgc tagcatcctc tgtagtggtt acacctgtca gtgtggtcca gccaagtcct
     1441 atttgcacca atccaactgt tgccgtggct gagcctgtgc tctcctacac ctctgtgacc
     1501 gcagctagct tcccactgca cagtcccagc ctgctggaca caggcactcc tatgggtgat
     1561 gtttctggag gagataagtc taagaaaggg gtaaagcgta agaagactgt agaggaaagt
     1621 ggagagacag caaagcggag gtctgcccgg gtccgaaaca ccaagtgcaa aaaagaagag
     1681 aaagtggatt tccagggact gctagtaaag ttcctgccgt ccaggttaag aaaactggac
     1741 cctgaggagg aagatgatcc atttaataac tatgaagttc aggcagaagc caaactggag
     1801 agcttctcca atgtgggacc tcatcgcctg tccttcgact cagccacatt catggaatct
     1861 gagaagcagg atgtgcatgc gttcctgatg gagaacctga ccaacggggg cctcctggag
     1921 cttatgatgc gttatctgaa gagcatgggc cacaagttcc tgctcaagtg gcccccaggg
     1981 ctggcggatg tcgtccttag cgtttaccac agctggagga ggcatagcac cagcctgccc
     2041 aacccattgc tgagggactg cagcaacaag cacatcaagg acatgatgct gatgtctctc
     2101 tcctgcatgg agctccaact ggaccagtgg ttactgacca aaggcagaag ctccgcagtg
     2161 tctccccgga actgccctgc tggtgtggtg acaggcaggt ttgggcctga cttcccgggc
     2221 acccactgcc tgggtgacct cctgcagctg tcatttgcat catctcagcg ggacctgttt
     2281 gaggatggct ggctggagtt tgttgtccgt gtttactggc tgaaggcacg tttcttggca
     2341 ctacagggag acatggaaca agccttggag aactatgata tctgcacaga aatactgcag
     2401 agctccagtg ctatccaagc ccaggcaggg gctgagcaag gggacatagt catccggctg
     2461 cccaaccttc acaatgactc cgttgtctct ctggaggaaa ttgataagaa cctgaagtct
     2521 ctggaaaggt gccagtccct ggaggagatc cagcggctgt ttgaggcagg tgactacaag
     2581 gctgtggtgc atctgctccg gcccactttg tgtaccagtg ggtttgaccg agccaaacac
     2641 ctggagttta tgacgtccat tcctgagagg ccagcccagc tgcttctgct gcaggactca
     2701 ttgctgcggc tgaaggacca cagacagtgt tttgaatgtt ctgatgtggc tctgaatgaa
     2761 gctgtccagc agatgctgaa ctcaagtgaa tctgcagcca aggaagagtg ggtggccaca
     2821 gtgacccaac tgctgctagg catcgagcaa gcactgtcgt cagacagcag tggcagtatc
     2881 cttaaggagt catcctcgac cactggcctt gtccgcctca ccaacaacct cattcaggtc
     2941 atcgactgca gcatggctgt gcaagaggag cccaaggaac cctatgtctc ctccgtgctg
     3001 ccctggatca tcctgcacag gatcatctgg caggaggaag acactttccg ctccctgtgc
     3061 caccagcagc agctccagaa cccaacagaa gaagggatac cggagatgcc catgctccca
     3121 tcttccctca tgctactcaa cacagcacat gagtacctgg gcaggaggtc ctggtgctgc
     3181 aattcagatg gagctctgct gcgattctat gtgcaagttc tccaaaagga gcttgctgcg
     3241 tcagcctctg aagacactca cccctacaag gaggagctgg agactgcctt ggagcagtgt
     3301 ttctactgcc tgtacagctt ccccagcaag aagagcaagg ccaggtacct ggaggaacac
     3361 tcagcccagc aggtggatct tatatgggag gatgccctgt ttatgtttga gtattttaag
     3421 cccaagaccc tccctgaatt tgatagctac aagacaagca ctgtttctgc tgacttggca
     3481 aacctgttga agagaattgc taccattgtg ccccgcacag agaagccagc tctgagcatg
     3541 gacaaagtct ctgcctacat tgagggaacc tcagctgagg cgccctgcct tccagaagga
     3601 gcggacccca cccctcccgt gctgaatgag ctctactacc tcctggctga ctaccatttc
     3661 aagaacaagg agcagtctaa agccatcaag ttctacatgc atgacatctg catctgccct
     3721 aacaggtttg actcctgggc gggaatggct ctggcccggg ccagccgaat tcaggacaag
     3781 ctgaactcaa atgagctgaa gagtgatggg cccatctgga aacatgccac acctgttctc
     3841 aactgcttcc ggagggccct tgagattgac agctctaatt tgtccttgtg gattgagtat
     3901 ggtaccatgt cctatgcctt acactctttc gcatcccgtc agctgaagca gtggagaagt
     3961 gagctgcccc cggagcttgt gcagcagatg gaggatcggc gagacagcat gctggagaca
     4021 gccaggcact gtttcacgtc tgcagcccgc tgtgagggcg atggtgatga ggaggagtgg
     4081 ctcattcact acatgctggg caaggtggct gagaagcagc agcagccgcc aactgtgtac
     4141 ctgctgcact accggcaggc tggccactac ttacacgagg aggctgcccg gtacccgaag
     4201 aagattcact accacaaccc acctgagctg gccatggaag ccctggaggt gtacttccgg
     4261 ctccatgcgt ccatcctgaa gctcctgggc aaacctgact ctggggttgg tgcagaggtc
     4321 ctggtcagct ttatgaagga ggcagcagaa ggaccttttg ccaggggcga ggagaagaat
     4381 acgcccaaag cttcagaaaa ggagaaggcc tgcctggtgg atgaggactc ccactcttca
     4441 gctgggacac tgccgggccc cggagcctcc cttccctcct cctctggccc aggtctgaca
     4501 tccccacctt acacagccac tccgattgac cacgattacg tcaaatgtaa aaaaccccat
     4561 cagcaggcgg cgccggacga ccgaagccag gacagcacag ctgtggcact gtcagactcc
     4621 agctcaacac aggacttctt taatgagccc acaagtttgc tggaaggttc tcgaaagctc
     4681 tttccagaga agaggctgtc tgggctcagt gctcaagcag gaccaagtgg taaagatctt
     4741 ccggggccca cagaagaaag aggaaaaaca gaagagtcct tggagagcac agaggccttc
     4801 cgggttgtag aacaaagcgt ccagaagcct gtggcagact cctcagcctc tgcttacatc
     4861 cccagcaagc ccccagcgtc cacacctcct ttgtgggatg ggaagaagag gggtgattcc
     4921 ctaggggagc cggtggcttt tccccagggg ctgccagcgg gtgctgagga gcagcgccag
     4981 ttccttacag agcagtgcat ctcctccttc tgcctgtgct tgagccgctt cccacagcac
     5041 tacaagagtc tctaccggct ggccttcctc tacacctaca gcaagactca ccggaacctc
     5101 cagtgggccc gtgatgtgtt gctaggcagc agtatcccat ggcaacagct gcagcacatg
     5161 ccggcacagg ggctcttctg cgagaggaac aagaccaatt tcttcaacgg catctggcgg
     5221 atccccgtgg atgagattga ccggccaggc agctttgcct ggcacatgaa ccgctccatc
     5281 gtgctgctgc tcaaggttct agcccagctc cgcgaccaca gcaccctgtt gaaggtgtcc
     5341 tccatgctgc agcggacacc agaccagggc aagaaatatc tgcgagatgc tgaccgccag
     5401 gtcctggcac agcgcgcctt catcctcact gtgaaagtgt tggaggacac actgagtgag
     5461 cttgcagagg ggtcagaaca cccaggatcc aaggcctgcg gcctctctgg agccaggatg
     5521 accactgatg tctcgcacaa agccagtccc gaggatggcc aggaaagccc ccaacacccc
     5581 aagaagctac ctctagctga tggctcagga ccagggcctg agccaggggg caggatgggc
     5641 cctcttaacc aattgccagt ggtcacagac ataagggaca acacagacca gggtggggag
     5701 cagaaagaca aagagagtcc ccaggtgggg cccactgaac ccatggatac cagtgaggct
     5761 gctggtcgcc actcagactt ggaacagaca tcacgtctgt tgccgggccg ccccccaagg
     5821 gaccggggcc ctgagagccg gtctgctgag ctttccttag aggagctgag tatcagcacc
     5881 cggcaacagc ccgctccact ggccccatcc ccagcagccc ccaccacaac tgctgctccc
     5941 actaccatgg cggccagggg agcggggcac tctgaggagg cacctccaag gcctaatcgg
     6001 aaaaggaaac tcctggagga cacggagtct ggcaagactc tcctactgga tgcctaccgt
     6061 gtgtggcagc agggccagaa gggcatggcc tatgacctga gccgcatcga gaagatcatg
     6121 tcggagactt acatgctcat caagcaggtg gatgaggaga ctgcactgga gcaggctgtg
     6181 aagttctgtc aggtccacct tggggccgct acccagagac aggcctcagg agatacgccc
     6241 actaccccca agcaccccaa ggacagcaga gagaatttct tccctgcaac agtggtcccc
     6301 acggtacctg accccacagc acctgatgct ctccagaggc ccagtgactc ccacctcaag
     6361 cctgtattgg ctactgtcat cacctgccct ccctcagctt cagcctctat cccagaccta
     6421 tccacagatc ctggaattcc ccggccacac aggccagaga ctacccccag cagggcccct
     6481 ttaagtcctg agggagaaga ggcatcagga gtgacggagg gcaccagcat tctaccccaa
     6541 gaaccacgct acagtcacca gataaaaatg gctgccacag gtcacctggc tgagcaacac
     6601 tgctggccag tggaggttgc ttgccagaca ggagctgagc ccacctgcag ccaagcctcc
     6661 agcactaagg tccccagcag tggaagtact cagacggctg agagccatca aggcaaaact
     6721 gagtccagca gggccaaatc ccgcctcctg cccaacatgc caaagctggt gatcccctcg
     6781 gccaccacca agtcccctcc tgagatcacc gtcacaccac ctacccctac cctgctttcc
     6841 cccaaaggca gcatctcgga ggagaccaag cagaagctga agtcagccat cctgtctgcc
     6901 caatccgctg ccaatgtgag gaaggagagc ctgtgccagc cagccctgga ggttctggag
     6961 acatccagcc aggagtcctc actggagagc gagacagacg aggatgatga cttcatggac
     7021 gtatgaagga gtccacccag aggcctgcag ccatagcagg gcaacagcaa ggcctgggat
     7081 ccctttgtcc agaccctggg caaggccaga agcctatgtg aggtagcgtg tcctgtggtc
     7141 tcctaagctg cccagccccc tctttacagc accctgcctg ggtccaggct gtccacacat
     7201 tgtgttggtc cagaggaaga taaggcctgt cttaggcacg tacgtgcact ggctgtgttt
     7261 tgcgcagtag ggatggcact tctttttgta atgaaatact gactttcttt ccaagcccat
     7321 gtccggctga tcaggcccac agccgagtgc ccagggaggc cagcttgggt tctggtagag
     7381 acattatcag gagcccagct caccccacac cctttttttg tcattgttgc ttctttttct
     7441 aataaaggtg gaaaatagtc aaaaaaaaaa aaaaaaaaaa aaa
//
