LOCUS       NM_001355046            3923 bp    mRNA    linear   ROD 24-DEC-2022
DEFINITION  Mus musculus calcium binding protein 39 (Cab39), transcript variant
            2, mRNA.
ACCESSION   NM_001355046 XM_006529090
VERSION     NM_001355046.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3923)
  AUTHORS   Liu Q, Pian K, Tian Z, Duan H, Wang Q, Zhang H, Shi L and Song D.
  TITLE     Calcium-binding protein 39 overexpression promotes macrophages from
            'M1' into 'M2' phenotype and improves chondrocyte damage in
            osteoarthritis by activating the AMP-activated protein
            kinase/sirtuin 1 axis
  JOURNAL   Bioengineered 13 (4), 9855-9871 (2022)
   PUBMED   35412939
  REMARK    GeneRIF: Calcium-binding protein 39 overexpression promotes
            macrophages from 'M1' into 'M2' phenotype and improves chondrocyte
            damage in osteoarthritis by activating the AMP-activated protein
            kinase/sirtuin 1 axis.
REFERENCE   2  (bases 1 to 3923)
  AUTHORS   Fang X, Shen F, Lechauve C, Xu P, Zhao G, Itkow J, Wu F, Hou Y, Wu
            X, Yu L, Xiu H, Wang M, Zhang R, Wang F, Zhang Y, Wang D, Weiss MJ
            and Yu D.
  TITLE     miR-144/451 represses the LKB1/AMPK/mTOR pathway to promote red
            cell precursor survival during recovery from acute anemia
  JOURNAL   Haematologica 103 (3), 406-416 (2018)
   PUBMED   29269522
  REMARK    GeneRIF: miR-144/451 facilitates recovery from acute anemia by
            repressing Cab39/AMPK/mTOR
REFERENCE   3  (bases 1 to 3923)
  AUTHORS   Jiao S, Zhang Z, Li C, Huang M, Shi Z, Wang Y, Song X, Liu H, Li C,
            Chen M, Wang W, Zhao Y, Jiang Z, Wang H, Wong CC, Wang C and Zhou
            Z.
  TITLE     The kinase MST4 limits inflammatory responses through direct
            phosphorylation of the adaptor TRAF6
  JOURNAL   Nat Immunol 16 (3), 246-257 (2015)
   PUBMED   25642822
REFERENCE   4  (bases 1 to 3923)
  AUTHORS   Ponce-Coria J, Markadieu N, Austin TM, Flammang L, Rios K, Welling
            PA and Delpire E.
  TITLE     A novel Ste20-related proline/alanine-rich kinase
            (SPAK)-independent pathway involving calcium-binding protein 39
            (Cab39) and serine threonine kinase with no lysine member 4 (WNK4)
            in the activation of Na-K-Cl cotransporters
  JOURNAL   J Biol Chem 289 (25), 17680-17688 (2014)
   PUBMED   24811174
  REMARK    GeneRIF: Cab39 differentially interacts with WNK4 and SPAK/OSR1 to
            switch the classic two kinase cascade into a signal kinase
            transduction
REFERENCE   5  (bases 1 to 3923)
  AUTHORS   Veleva-Rotse BO, Smart JL, Baas AF, Edmonds B, Zhao ZM, Brown A,
            Klug LR, Hansen K, Reilly G, Gardner AP, Subbiah K, Gaucher EA,
            Clevers H and Barnes AP.
  TITLE     STRAD pseudokinases regulate axogenesis and LKB1 stability
  JOURNAL   Neural Dev 9, 5 (2014)
   PUBMED   24594058
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3923)
  AUTHORS   Chen H, Untiveros GM, McKee LA, Perez J, Li J, Antin PB and
            Konhilas JP.
  TITLE     Micro-RNA-195 and -451 regulate the LKB1/AMPK signaling axis by
            targeting MO25
  JOURNAL   PLoS One 7 (7), e41574 (2012)
   PUBMED   22844503
  REMARK    GeneRIF: Elevated miR-195 targets the LKB1/AMPK signaling axis in
            hypertrophic cardiomyopathy
REFERENCE   7  (bases 1 to 3923)
  AUTHORS   Smith CD, Compton RA, Bowler JS, Kemp JT, Sudweeks SN, Thomson DM
            and Winder WW.
  TITLE     Characterization of the liver kinase B1-mouse protein-25
            -Ste-20-related adaptor protein complex in adult mouse skeletal
            muscle
  JOURNAL   J Appl Physiol (1985) 111 (6), 1622-1628 (2011)
   PUBMED   21903876
  REMARK    GeneRIF: Quantitative PCR revealed significantly reduced LKB1,
            MO25alpha, and STRADbeta mRNA in LKB1(-/-) muscle. These findings
            demonstrate that the LKB1-MO25-STRAD complex is the principal AMPKK
            in skeletal muscle.
REFERENCE   8  (bases 1 to 3923)
  AUTHORS   Denison FC, Hiscock NJ, Carling D and Woods A.
  TITLE     Characterization of an alternative splice variant of LKB1
  JOURNAL   J Biol Chem 284 (1), 67-76 (2009)
   PUBMED   18854309
REFERENCE   9  (bases 1 to 3923)
  AUTHORS   Barnes AP, Lilley BN, Pan YA, Plummer LJ, Powell AW, Raines AN,
            Sanes JR and Polleux F.
  TITLE     LKB1 and SAD kinases define a pathway required for the polarization
            of cortical neurons
  JOURNAL   Cell 129 (3), 549-563 (2007)
   PUBMED   17482548
REFERENCE   10 (bases 1 to 3923)
  AUTHORS   Miyamoto H, Matsushiro A and Nozaki M.
  TITLE     Molecular cloning of a novel mRNA sequence expressed in cleavage
            stage mouse embryos
  JOURNAL   Mol Reprod Dev 34 (1), 1-7 (1993)
   PUBMED   8418809
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161342.10 and AC107707.10.
            
            [WARNING] On Apr 24, 2023 this sequence was replaced by
            NM_001355046.2.
            
            On Sep 20, 2017 this sequence version replaced XM_006529090.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.20475.1,
                                           SRR1660825.60980.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-381               AC161342.10        17991-18371         c
            382-498             AC161342.10        16339-16455         c
            499-655             AC107707.10        123744-123900       c
            656-820             AC107707.10        106770-106934       c
            821-939             AC107707.10        104853-104971       c
            940-1108            AC107707.10        99891-100059        c
            1109-1168           AC107707.10        97605-97664         c
            1169-1234           AC107707.10        94782-94847         c
            1235-1378           AC107707.10        93837-93980         c
            1379-3923           AC107707.10        90680-93224         c
FEATURES             Location/Qualifiers
     source          1..3923
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..3923
                     /gene="Cab39"
                     /gene_synonym="MO25; MO25alpha"
                     /note="calcium binding protein 39"
                     /db_xref="GeneID:12283"
                     /db_xref="MGI:MGI:107438"
     exon            1..381
                     /gene="Cab39"
                     /gene_synonym="MO25; MO25alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            382..498
                     /gene="Cab39"
                     /gene_synonym="MO25; MO25alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            499..655
                     /gene="Cab39"
                     /gene_synonym="MO25; MO25alpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             542..1567
                     /gene="Cab39"
                     /gene_synonym="MO25; MO25alpha"
                     /note="calcium binding protein, 39 kDa"
                     /codon_start=1
                     /product="calcium-binding protein 39"
                     /protein_id="NP_001341975.1"
                     /db_xref="CCDS:CCDS15112.1"
                     /db_xref="GeneID:12283"
                     /db_xref="MGI:MGI:107438"
                     /translation="MPFPFGKSHKSPADIVKNLKESMAVLEKQDISDKKAEKATEEVS
                     KNLVAMKEILYGTNEKEPQTEAVAQLAQELYNSGLLGTLVADLQLIDFEGKKDVAQIF
                     NNILRRQIGTRTPTVEYICTQQNILFMLLKGYESPEIALNCGIMLRECIRHEPLAKII
                     LWSEQFYDFFRYVEMSTFDIASDAFATFKDLLTRHKLLSAEFLEQHYDRFFSEYEKLL
                     HSENYVTKRQSLKLLGELLLDRHNFTIMTKYISKPENLKLMMNLLRDKSRNIQFEAFH
                     VFKVFVANPNKTQPILDILLKNQTKLIEFLSKFQNDRTEDEQFNDEKTYLVKQIRDLK
                     RAAQQEA"
     exon            656..820
                     /gene="Cab39"
                     /gene_synonym="MO25; MO25alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            821..939
                     /gene="Cab39"
                     /gene_synonym="MO25; MO25alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1108
                     /gene="Cab39"
                     /gene_synonym="MO25; MO25alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1168
                     /gene="Cab39"
                     /gene_synonym="MO25; MO25alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1234
                     /gene="Cab39"
                     /gene_synonym="MO25; MO25alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1378
                     /gene="Cab39"
                     /gene_synonym="MO25; MO25alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..3923
                     /gene="Cab39"
                     /gene_synonym="MO25; MO25alpha"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagccgggc tcaggccgga gctgggcgcg gggcgccagg agccgcgcgg cctgagagag
       61 tctggggctt cagtagccgc gcgaaggctg agacaacctc agaggcgaag gcagtgcggg
      121 acctcacggc cacagccgca gccctaccga gcgcagcacc gcggcggcca cagcaggaac
      181 ccctgggcca ccgtccgccc gcgcagccgc cgccgccgcc gcgggagccc gtcgcccgga
      241 gcagctgcgg gcggaggaca acggagggcc ggagcgtccg agccgcgccg cggggaccga
      301 gcgagcagcc cgaggcggcg gcggccgagg acggggacgg agacgaagca gagagggagc
      361 tccctggccc ggcccagccc gtaagatcta gctgctgctg ctgctgctgc tggtggtggt
      421 ggtggtgaac gcttttagcc tctgcacttt ggagacggag gagggccagg ccaggccagg
      481 ccagccggct agatcacagt caagcaggta gagtgccgtg gaagcctctg gcgctgccgt
      541 catgccgttc ccatttggca agtctcacaa gtctccggca gatattgtga agaacttgaa
      601 ggagagcatg gctgttttgg aaaagcagga catttctgac aaaaaggcag aaaaggctac
      661 agaagaagtt tccaaaaatt tggtcgccat gaaagaaatt ctgtacggca ccaatgagaa
      721 ggagcctcag acagaggcgg tagctcagct ggctcaggag ctgtacaata gcgggctcct
      781 cggcaccctg gtagctgact tacagctcat tgactttgag ggcaaaaaag acgtggctca
      841 aattttcaac aatattctca gaagacaaat tggtacaaga actcctactg ttgaatacat
      901 ctgcacccaa cagaatattt tgttcatgtt attgaaaggg tatgaatctc cagaaatagc
      961 tcttaattgt gggataatgt taagagaatg catcagacat gaaccacttg caaaaatcat
     1021 tttgtggtca gaacagtttt atgacttctt cagatatgtt gaaatgtcaa catttgacat
     1081 agcttcagat gcatttgcta cattcaagga tttacttaca agacataaat tgctcagtgc
     1141 agaatttttg gaacaacatt atgatagatt tttcagtgaa tatgaaaagc tacttcattc
     1201 agaaaattat gtgacaaaga gacagtcact gaagcttctg ggtgagctgc tgttggacag
     1261 acacaacttc acaattatga caaagtacat cagcaagcct gagaacctca agctaatgat
     1321 gaacctcctc cgagacaaga gccgcaacat ccagttcgag gccttccacg tgttcaaggt
     1381 gtttgtggcc aaccccaaca agacgcagcc catcctagac atcctcctca agaaccagac
     1441 caagctcatc gagttcctca gcaagtttca gaacgacagg accgaggacg agcagttcaa
     1501 cgacgagaag acctacttag tcaagcagat cagggatttg aagagagccg cccagcagga
     1561 agcctagtgt ctactcagcc ccggtcccat ccaagctcag cactggctgt cagctcctca
     1621 gcatcaggca ctctcatcgg ttcatgggga gcactactgc taatctgctg ttaagtgaac
     1681 ggtttttcat tttacctttt tgtttttcag tccaggttgg agaacgtagc tgctgctgct
     1741 tgcacattag agcgcacgtg gtctttcttt cccttgatct ctgtgtcatt tcagaactca
     1801 cagactccat ttgctacagg agttctgaac atggctgggt tcatgaaagc aaatgagagt
     1861 gagagtggtc tagggaaaag acggtgatac atcgctgaca cctgcccgtc catcggcact
     1921 gctctctgca ggtctgtgca gtatggcacg ggcataccca ccatctctgc cgaaggaaga
     1981 tggcgcatac agggattgtt ggagaactgt atccagtgtg agctttgggg aggataaagt
     2041 tggtgtgcaa ataaattgat actgaagctt agcaacttgt caagtgtgga gcttcataag
     2101 gtcataagaa agtgtatata tgctttttca cagctttcta gaactttgtg acatttgatt
     2161 ttcttgaaac ttgtaaacct ggataggttg aagggtgttt taattttact tttgaaggtg
     2221 ttttaaaaca gtagagctag cagcaacacc ttatgtttca tttcaacact gcttacaggt
     2281 ttcttttgta tataattctt agaatgctca tttcttttaa atcgtttaat ttgtacagca
     2341 gaggaatgtt attgtagtag tatgtaacta ttacctgagt tttgcaacaa acaaaaaaca
     2401 aaaaaaagaa tgctcatatg taattgaaat acttgagatt acatgaaaat gctgatttta
     2461 acatttaagg atcacagcat taaaagaaaa agaaccaatc ccttgtattc agttacccaa
     2521 tggggcgccg ttggcaggca gaactacata cctggaactc tgtctgctac atattcttgc
     2581 agaatattgg ccttattcat ttaaaatgag tcctaaggtt gccatatcta tgaatgatac
     2641 agattatgct aaataatgct ggtttttttg ttttgttttg ttttgtttgt gagggacctc
     2701 ctatagagca ccgtttcttt cttagagtaa tatccagtac agtagccgag taactgaata
     2761 attctaactt tggcttctct aagggaaaga agagccctgg tcctgatgtc ctgggagaga
     2821 tggatgggtt taatgtcctt ttccttaatg ctgcagatga tcagtattta taaagtaacc
     2881 gattttgcac cactttttgt gactgtgacc acagcagaac aatgtctcct agactgtatc
     2941 tacataaagt tactagaatg gtgtctgtct gtcttagtga cacacggatc acaactaaca
     3001 acttaaaatc agagtttgcc cgatccaatt cagcatggct gtagctgact aaaaaaattt
     3061 acataattat tctttgttag cctctcttac taactgaatt attcattggc cagtaaaagg
     3121 agcctcctag ctgacgtttt agcaggtttt aaggtttcct tcaaggaata caagtcagaa
     3181 aaaccactcc agaaaatata ggtctgttct atttcatcta aatggcagtc tacagtaaag
     3241 ggtttccaag gctctcttta cccatgtgcg tgcgtgtata gttgatggtc tctagtagag
     3301 atagagaaag cattcaggct tctggacaag gacattctca gctgggtagt gtgcagactc
     3361 agctgtgcta agtgacccag tccttgccac cgcgttgtga gtcaggattt ggtgacagag
     3421 tggccatttc accaagtgga aggagtgtct ctttgccaag ctagctctta gaacttgaga
     3481 caacagaaca gtttccactt gggctaacac agagagcggt gctagagtct tgctgtggaa
     3541 gatgggatgc agtgtgtcag ggaactgtca ctcacacatt ggaagctgag ggctgagaag
     3601 gctttctgga ttgtttttaa acagaacaat gtgaaaacat tcaagattga aaagttgcat
     3661 ttaaagtgtg atcactttct aggttcctat taccagaacg attatcctgg gtgtggtttc
     3721 tttggtgtta taaagggtta attttactta aggcagttac ttaatgtgat tttttttttt
     3781 ttaaccctta aaaaaagtgg gagatgtata caattgttaa tgacatgaaa gtgtttcctt
     3841 tctcctgagg aaaagtgaat ttcttatcag aatatctggc tggccctgta atttaaatta
     3901 aaataaaatt ttggagaaac tgt
//
