LOCUS       NM_026368               2107 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus caspase activity and apoptosis inhibitor 1 (Caap1),
            transcript variant 1, mRNA.
ACCESSION   NM_026368
VERSION     NM_026368.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2107)
  AUTHORS   Aslam,M.A., Alemdehy,M.F., Pritchard,C.E.J., Song,J.Y.,
            Muhaimin,F.I., Wijdeven,R.H., Huijbers,I.J., Neefjes,J. and
            Jacobs,H.
  TITLE     Towards an understanding of C9orf82 protein/CAAP1 function
  JOURNAL   PLoS One 14 (1), e0210526 (2019)
   PUBMED   30629682
  REMARK    GeneRIF: C9orf82ko/ko mice were born at a Mendelian ratio and did
            not display any overt macroscopic or histological abnormalities.
            DNA double-strand breaks repair dependent processes like lymphocyte
            development and class switch recombination (CSR) appeared normal,
            arguing against a link between the C9orf82 encoded protein and
            V(D)J recombination or CSR.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2107)
  AUTHORS   Alvarez-Dominguez,J.R., Zhang,X. and Hu,W.
  TITLE     Widespread and dynamic translational control of red blood cell
            development
  JOURNAL   Blood 129 (5), 619-629 (2017)
   PUBMED   27899360
REFERENCE   3  (bases 1 to 2107)
  AUTHORS   Alvarez-Dominguez,J.R., Hu,W., Yuan,B., Shi,J., Park,S.S.,
            Gromatzky,A.A., van Oudenaarden,A. and Lodish,H.F.
  TITLE     Global discovery of erythroid long noncoding RNAs reveals novel
            regulators of red cell maturation
  JOURNAL   Blood 123 (4), 570-581 (2014)
   PUBMED   24200680
REFERENCE   4  (bases 1 to 2107)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL807252.5.
            
            On May 13, 2022 this sequence version replaced NM_026368.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020067.1, AK160572.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-335               AL807252.5         4477-4811
            336-536             AL807252.5         9808-10008
            537-621             AL807252.5         10767-10851
            622-697             AL807252.5         12079-12154
            698-771             AL807252.5         40138-40211
            772-2107            AL807252.5         59857-61192
FEATURES             Location/Qualifiers
     source          1..2107
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 43.32 cM"
     gene            1..2107
                     /gene="Caap1"
                     /gene_synonym="5830433M19Rik; CAAP"
                     /note="caspase activity and apoptosis inhibitor 1"
                     /db_xref="GeneID:67770"
                     /db_xref="MGI:MGI:1915020"
     exon            1..335
                     /gene="Caap1"
                     /gene_synonym="5830433M19Rik; CAAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1163
                     /gene="Caap1"
                     /gene_synonym="5830433M19Rik; CAAP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     likely ortholog of H. sapiens chromosome 9 open reading
                     frame 82 (C9orf82); conserved anti-apoptotic protein"
                     /codon_start=1
                     /product="caspase activity and apoptosis inhibitor 1
                     isoform 1"
                     /protein_id="NP_080644.2"
                     /db_xref="CCDS:CCDS18358.1"
                     /db_xref="GeneID:67770"
                     /db_xref="MGI:MGI:1915020"
                     /translation="MTGKKSSREKRRKRSGQEAAASLAAPDLVPVLSGSAGGCGSGGC
                     CGVAGGGTSVAGGAERSERRKRRSTDSSSSVSGSLQQETKYLLPSLEKELFLAEHSDL
                     EEGGLDLNVSLKPVSFYISDKKEMLQQCFCIIGEKKLQKMLPDVLKNCSVEEIKKLCQ
                     EQLELLSEKQILKILEGDNGLDSDMEEEADDGCKVAPDLISQQDTCVDSTSSLRENKQ
                     PEVLESKQGKGEDSDVLSINADAYDSDIEGPSIDEAAAAATATPAATAVATAASEVPE
                     NTVQSEAGQIDDLERDIEKSVNEILGLAESSPKEPKVATLTVPPAEDVQPSAQQLELL
                     ELEMRARAIKALMKAGDIKKPV"
     exon            336..536
                     /gene="Caap1"
                     /gene_synonym="5830433M19Rik; CAAP"
                     /inference="alignment:Splign:2.1.0"
     exon            537..621
                     /gene="Caap1"
                     /gene_synonym="5830433M19Rik; CAAP"
                     /inference="alignment:Splign:2.1.0"
     exon            622..697
                     /gene="Caap1"
                     /gene_synonym="5830433M19Rik; CAAP"
                     /inference="alignment:Splign:2.1.0"
     exon            698..771
                     /gene="Caap1"
                     /gene_synonym="5830433M19Rik; CAAP"
                     /inference="alignment:Splign:2.1.0"
     exon            772..2107
                     /gene="Caap1"
                     /gene_synonym="5830433M19Rik; CAAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1967..1972
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Caap1"
                     /gene_synonym="5830433M19Rik; CAAP"
                     /note="hexamer: AATAAA"
     polyA_site      1988
                     /gene="Caap1"
                     /gene_synonym="5830433M19Rik; CAAP"
     regulatory      2085..2090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Caap1"
                     /gene_synonym="5830433M19Rik; CAAP"
                     /note="hexamer: AACAAA"
     polyA_site      2107
                     /gene="Caap1"
                     /gene_synonym="5830433M19Rik; CAAP"
                     /note="major polyA site"
ORIGIN      
        1 aagtctgcga cagcagcgcc ggccgctacg gaagcggggt tctgttgctg cagagacggt
       61 cggctgtcgc cgatggttgc agcgcgagga ccatgacggg gaagaagtct tcccgagaaa
      121 agcggcgcaa gcggagcggg caggaggcag ccgcgtcgct cgcagccccg gacctggtgc
      181 ccgtgctgag cgggagcgcg ggtgggtgcg ggagcggcgg ctgctgcggg gtcgccggcg
      241 gcgggacgag tgtggcgggc ggcgcggaac gaagcgagcg ccgaaagcgg aggagcaccg
      301 attcgtcctc cagcgtctcg ggctccctgc agcaggaaac caagtatctt ttaccaagtc
      361 tggaaaaaga attattcttg gcagagcaca gtgatcttga agaaggtgga ctggatctga
      421 atgtctcctt aaaacctgtt agtttctata tatcagacaa aaaggaaatg ctgcagcaat
      481 gcttctgtat cataggagag aagaagttgc agaagatgct ccctgatgta ctgaagaact
      541 gttcagtaga agaaattaaa aaactatgcc aggaacaatt agagctcctg tctgaaaaac
      601 aaatcttgaa gattcttgag ggtgacaatg gtttggactc tgatatggaa gaggaggcag
      661 atgatggctg taaggtggca cctgatttaa tcagtcagca agatacctgt gtagattcta
      721 cttcatccct gagagagaac aaacaaccag aagttttgga atcaaaacaa ggcaaagggg
      781 aagatagtga tgtactcagt ataaatgcag atgcttatga cagcgatata gaagggccaa
      841 gcattgacga agctgctgcc gccgccaccg ccacccctgc tgctactgct gttgctactg
      901 ctgcttccga ggtcccagaa aatacagtcc agagtgaagc tggtcagata gatgacctgg
      961 agagagatat tgaaaaaagc gtgaatgaga ttttgggact ggcagagtct agcccaaagg
     1021 aacccaaagt ggccaccctg actgttcctc cagcagaaga cgttcagcct tctgcgcagc
     1081 aactggagct tctagaactt gaaatgaggg caagagcaat taaggctctc atgaaagctg
     1141 gtgatataaa aaagccagtg tagttttctg acttgaatat tatgtgtgtt tgaatgaagc
     1201 catgtcatat aattttgtat ctgatgttta tttgggtctt atgtgatatt tctcatgtaa
     1261 aacttattag gtaaactcat cttaggctga aagtatatat attttttact tttatattat
     1321 agattataga tgaatattta aattcatgac aaatatggtt ggataccctg gatatttctt
     1381 ttagttaatg tctgtaaact tggtatctta aaagccaaca ggaaggagaa agaatatttt
     1441 ttttcctttg tttttaaaag tttgggcaac aaactcaaaa gctttaagaa agattgacca
     1501 agcatgtttc tcttaaggct acctgtattt ttcaatagaa cattaaatta ttgctcctag
     1561 atttgttaac agtttaagaa ctttagtttt ctgtatatat acttttaaga tatgtactgt
     1621 gggaggattc cttttgtgga tgtgaatttc ctagcgaaac ctaatgaact gttttgttgt
     1681 aaggctcaga gatcgaactt gctttaagag cttttttaat aaagaaaaaa aaatcaactt
     1741 aaggctattt ttttaacaat gtaaagttaa tttgttcatg ttaaattcca gcaacaagtc
     1801 tttctgacat atgtttgatc ttttgttcac attttttcct tcaataaaat aaaacaaaat
     1861 aaaattttat ttacattcca aactatctgg aaagggacaa tatgatacag ggttttgttt
     1921 gatgtcattg tgagaaggtc tgatgtatag ttccataaat cacgataata aaaggctgtt
     1981 attctggata tgaagacttg atacttttcc aaaagcaaaa ttgactttaa gaacctttga
     2041 taagttgatg ttgtaattaa gctaattttg tatacttttt aataaacaaa ttagcacctt
     2101 gccacaa
//
