LOCUS       NM_001243837            2709 bp    mRNA    linear   ROD 26-DEC-2023
DEFINITION  Mus musculus complement component 7 (C7), mRNA.
ACCESSION   NM_001243837 XM_356827 XM_904680
VERSION     NM_001243837.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2709)
  AUTHORS   Zhou Z, Jia D, Kwon O, Li S, Sun H, Roudier MP, Lin DW, True L,
            Morrissey C, Creighton CJ, Lee JK and Xin L.
  TITLE     Androgen-regulated stromal complement component 7 (C7) suppresses
            prostate cancer growth
  JOURNAL   Oncogene 42 (32), 2428-2438 (2023)
   PUBMED   37400528
REFERENCE   2  (bases 1 to 2709)
  AUTHORS   Zelek WM and Morgan BP.
  TITLE     Monoclonal Antibodies Capable of Inhibiting Complement Downstream
            of C5 in Multiple Species
  JOURNAL   Front Immunol 11, 612402 (2020)
   PUBMED   33424866
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2709)
  AUTHORS   Menny A, Serna M, Boyd CM, Gardner S, Joseph AP, Morgan BP, Topf M,
            Brooks NJ and Bubeck D.
  TITLE     CryoEM reveals how the complement membrane attack complex ruptures
            lipid bilayers
  JOURNAL   Nat Commun 9 (1), 5316 (2018)
   PUBMED   30552328
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2709)
  AUTHORS   Welsh KJ, Lewis CT, Boyd S, Braun MC and Actor JK.
  TITLE     Complement factor C7 contributes to lung immunopathology caused by
            Mycobacterium tuberculosis
  JOURNAL   Clin Dev Immunol 2012, 429675 (2012)
   PUBMED   22973398
  REMARK    GeneRIF: data indicate a role for complement C7 in the development
            of lung histopathology in Mycobacterium tuberculosis infection,
            with a potential role for dysregulation in innate interaction with
            lymphocytes and their subsequent production of cytokines
REFERENCE   5  (bases 1 to 2709)
  AUTHORS   Adams AC, Astapova I, Fisher FM, Badman MK, Kurgansky KE, Flier JS,
            Hollenberg AN and Maratos-Flier E.
  TITLE     Thyroid hormone regulates hepatic expression of fibroblast growth
            factor 21 in a PPARalpha-dependent manner
  JOURNAL   J Biol Chem 285 (19), 14078-14082 (2010)
   PUBMED   20236931
REFERENCE   6  (bases 1 to 2709)
  AUTHORS   Schauwecker PE, Williams RW and Santos JB.
  TITLE     Genetic control of sensitivity to hippocampal cell death induced by
            kainic acid: a quantitative trait loci analysis
  JOURNAL   J Comp Neurol 477 (1), 96-107 (2004)
   PUBMED   15281082
REFERENCE   7  (bases 1 to 2709)
  AUTHORS   Tanaka K, Tamura H, Tanaka H, Katoh M, Futamata Y, Seki N,
            Nishimune Y and Hara T.
  TITLE     Spermatogonia-dependent expression of testicular genes in mice
  JOURNAL   Dev Biol 246 (2), 466-479 (2002)
   PUBMED   12051830
REFERENCE   8  (bases 1 to 2709)
  AUTHORS   Beebe AM, Mauze S, Schork NJ and Coffman RL.
  TITLE     Serial backcross mapping of multiple loci associated with
            resistance to Leishmania major in mice
  JOURNAL   Immunity 6 (5), 551-557 (1997)
   PUBMED   9175833
REFERENCE   9  (bases 1 to 2709)
  AUTHORS   van Oorschot RA, Birmingham V, Porter PA, Kammerer CM and VandeBerg
            JL.
  TITLE     Linkage between complement components 6 and 7 and glutamic pyruvate
            transaminase in the marsupial Monodelphis domestica
  JOURNAL   Biochem Genet 31 (5-6), 215-222 (1993)
   PUBMED   8259924
REFERENCE   10 (bases 1 to 2709)
  AUTHORS   Orren,A., Hobart,M.J., Nash,H.R. and Lachmann,P.J.
  TITLE     Close linkage between mouse genes determining the two forms of
            complement component C6 and component C7, and cis action of a C6
            regulatory gene
  JOURNAL   Immunogenetics 21 (6), 591-599 (1985)
   PUBMED   4007963
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131919.13 and AC115877.13.
            
            [WARNING] On Jan 9, 2024 this sequence was replaced by
            NM_001243837.2.
            
            On or before Sep 1, 2011 this sequence version replaced
            XM_904680.4, XM_356827.7.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               AC131919.13        76571-76687         c
            118-173             AC131919.13        72310-72365         c
            174-249             AC131919.13        69934-70009         c
            250-391             AC131919.13        62459-62600         c
            392-536             AC131919.13        59778-59922         c
            537-675             AC131919.13        58559-58697         c
            676-843             AC115877.13        3448-3615
            844-1090            AC115877.13        5668-5914
            1091-1204           AC115877.13        15102-15215
            1205-1371           AC115877.13        22340-22506
            1372-1600           AC115877.13        25639-25867
            1601-1772           AC115877.13        26749-26920
            1773-1860           AC115877.13        30068-30155
            1861-1993           AC115877.13        32487-32619
            1994-2185           AC115877.13        34956-35147
            2186-2279           AC115877.13        43551-43644
            2280-2464           AC115877.13        47306-47490
            2465-2709           AC115877.13        48795-49039
FEATURES             Location/Qualifiers
     source          1..2709
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 1.98 cM"
     gene            1..2709
                     /gene="C7"
                     /gene_synonym="A530026G17; Gm1238"
                     /note="complement component 7"
                     /db_xref="GeneID:109828"
                     /db_xref="MGI:MGI:88235"
     exon            1..117
                     /gene="C7"
                     /gene_synonym="A530026G17; Gm1238"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..2649
                     /gene="C7"
                     /gene_synonym="A530026G17; Gm1238"
                     /codon_start=1
                     /product="complement component C7 precursor"
                     /protein_id="NP_001230766.1"
                     /db_xref="CCDS:CCDS56974.1"
                     /db_xref="GeneID:109828"
                     /db_xref="MGI:MGI:88235"
                     /translation="MQVTSLLILVCFIAAFQVFSRASSPVNCKWDSYGPWSECNGCTK
                     TQTRRRSVAVYGQYGGYPCEGSAFETQSCKPERGCPTEEGCGDRFRCFSGQCISKSLV
                     CNGDPDCEEDGADEDKCENVANPSCNIDKPPPNIELTGYGYNVVTGQGKKRVINTKSF
                     GGQCRKVFSGDGKDFYRLSGNILSYTFQVKVDNDFNYEFYNSSWSYIKHTSTEQNTFY
                     SWKGLFSHSRNTYGHGSAKEEIDTKMKSYKLLVVQNTVEVAQFTNNNPEFLQVAEPFW
                     KELSHLPTLYDYSAYRRLIDQYGTHYLQSGSLGGEYRVLFYVDSGSAKETGFQSDQDN
                     ACSSADFQFLFTSSADQRCMKQLETEKSTSGNKGRLLRGKPLVRGGDSGFVADLSFLD
                     LDNPAGNKQRYSSWAGSVTRLPQVIKEKLAPLYELVKEVPCASVKRLYLKRAIEEYFD
                     EFDPCHCRPCQNGGLAIVVETQCQCLCKPYTFGSACEQGVLVGDQAGGVDGGWNCWSS
                     WSPCVQGKRTRSRECNNPPPRDDGKSCLGETTESKQCEDQDLEKLRLLEPHCFHSSLA
                     PKEFCLSPPALKDGFVQGEGTMVPVGQSVVYACDEGYSLIGDPVARCGEDLQWLVGEM
                     HCQKLACVLPGEMNGMQSHPQKPFYMVGEKVTLSCVGGMSLEGPSTLLCGSSLKWSPE
                     LKDAKCVQKATSTPPPAAPACQPWEKLQNSKCICKMPYECGSSLDVCARDESRNKILS
                     LTICKMHVVHCHKRNYTLVGKESCTLPSPAEKVCGACPIWSKCDAQNGKCICREASEC
                     QTAGYRICVEVNGKEETMSECEAGILRCRGQSISITAIKPCAEEAAQ"
     exon            118..173
                     /gene="C7"
                     /gene_synonym="A530026G17; Gm1238"
                     /inference="alignment:Splign:2.1.0"
     exon            174..249
                     /gene="C7"
                     /gene_synonym="A530026G17; Gm1238"
                     /inference="alignment:Splign:2.1.0"
     exon            250..391
                     /gene="C7"
                     /gene_synonym="A530026G17; Gm1238"
                     /inference="alignment:Splign:2.1.0"
     exon            392..536
                     /gene="C7"
                     /gene_synonym="A530026G17; Gm1238"
                     /inference="alignment:Splign:2.1.0"
     exon            537..675
                     /gene="C7"
                     /gene_synonym="A530026G17; Gm1238"
                     /inference="alignment:Splign:2.1.0"
     exon            676..843
                     /gene="C7"
                     /gene_synonym="A530026G17; Gm1238"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1090
                     /gene="C7"
                     /gene_synonym="A530026G17; Gm1238"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1204
                     /gene="C7"
                     /gene_synonym="A530026G17; Gm1238"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1371
                     /gene="C7"
                     /gene_synonym="A530026G17; Gm1238"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1600
                     /gene="C7"
                     /gene_synonym="A530026G17; Gm1238"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1772
                     /gene="C7"
                     /gene_synonym="A530026G17; Gm1238"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1860
                     /gene="C7"
                     /gene_synonym="A530026G17; Gm1238"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..1993
                     /gene="C7"
                     /gene_synonym="A530026G17; Gm1238"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2185
                     /gene="C7"
                     /gene_synonym="A530026G17; Gm1238"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2279
                     /gene="C7"
                     /gene_synonym="A530026G17; Gm1238"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2464
                     /gene="C7"
                     /gene_synonym="A530026G17; Gm1238"
                     /inference="alignment:Splign:2.1.0"
     exon            2465..2709
                     /gene="C7"
                     /gene_synonym="A530026G17; Gm1238"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgagcaga aaaagaattc agagcaggac agactgtggg ggagacaaga gcctgcctgt
       61 ctttacagat gaaattttct tgttctcttc tgtactgagt gtttcccaag catgcaggtg
      121 acaagcttat taattttggt gtgctttata gcagcgtttc aagtcttctc tagagcctcc
      181 tctccagtca actgcaagtg ggactcctat ggcccttggt cagaatgcaa tggctgtacc
      241 aagactcaga ctcgaaggcg ttcagttgct gtttatgggc aatatggagg ctatccatgt
      301 gaggggagtg cttttgaaac acaatcctgc aaacctgaac gaggctgtcc gacggaagag
      361 ggctgtgggg accggtttag gtgtttttca ggtcagtgca tcagcaaatc attggtttgc
      421 aatggagatc ctgactgtga ggaagacggt gctgatgaag acaaatgtga aaatgtggct
      481 aacccttcct gcaacattga taagcctcct cccaacatag aacttaccgg ttatggttac
      541 aacgtagtta ctggccaggg taagaaaaga gtcatcaaca ccaaaagttt cggtggtcag
      601 tgcaggaaag tgttcagcgg ggatggaaaa gatttctaca gactaagtgg aaatatcctc
      661 tcttatacat tccaggtcaa agtagataat gattttaact atgaatttta caacagcagt
      721 tggtcttaca taaagcacac atccacagag caaaacacat tttattcatg gaagggatta
      781 ttttcccact cacggaatac ttacggtcat ggttcagcaa aagaggaaat cgacacgaaa
      841 atgaagagtt ataaattgtt ggttgttcag aacactgttg aagtggccca gttcactaat
      901 aataatcctg aatttttaca agttgctgag ccattctgga aggaactctc ccatcttccc
      961 actctgtatg actacagtgc ctaccgacgg ttaatcgatc agtatgggac acattacctg
     1021 cagtctgggt ccttaggagg agaatataga gttctatttt atgtggattc aggaagtgcc
     1081 aaagaaactg gttttcagtc agaccaggat aacgcatgtt cgtctgcaga ctttcagttt
     1141 ctttttacat cgtcagcaga tcagagatgt atgaaacagc tagagactga aaaatcaact
     1201 tcaggaaata agggcaggtt gcttcgagga aaaccattgg tcagaggtgg agactctggc
     1261 tttgtagctg accttagttt cctggacctg gataatcctg ctggaaacaa gcagcgctat
     1321 tcctcctggg ctgggtctgt aaccagactt ccccaagtca taaaagaaaa gctggcgccg
     1381 ttgtatgagc tggtcaagga ggtgccctgt gcctctgtga aaagactgta cctgaagcgg
     1441 gctattgagg agtacttcga tgaatttgac ccctgccatt gccggccttg ccagaatggc
     1501 ggcctcgcta ttgttgtgga gacacagtgc cagtgtctgt gcaaaccata cacatttggt
     1561 tcagcgtgtg agcaaggagt ccttgtcggc gatcaagcag gaggggttga tggaggttgg
     1621 aattgttggt cctcttggag cccctgtgtt caagggaaga gaacaaggag ccgggaatgc
     1681 aataatcccc ctcccagaga tgatggaaag tcctgtcttg gagaaacaac tgagagtaag
     1741 cagtgtgaag accaggactt ggagaaactg cgattacttg agccacattg ctttcactcg
     1801 tctttggctc caaaagaatt ctgcctatca ccccctgcct taaaagatgg atttgttcaa
     1861 ggtgaaggta ccatggttcc tgttggacaa agcgtagtat atgcttgtga tgaggggtat
     1921 tctcttattg gagatcctgt tgccagatgt ggagaagact tacagtggct tgttggagaa
     1981 atgcattgtc aaaaattggc ctgcgttcta cctggagaga tgaatggcat gcagagtcac
     2041 ccgcagaaac ctttttacat ggttggagag aaggtgactc tttcctgtgt ggggggtatg
     2101 tccttagagg gtccttcaac cctcctctgt ggctccagcc tgaagtggag tcccgagctg
     2161 aaggatgcca agtgtgtgca aaaagctacc agcactccac caccagcagc ccctgcatgt
     2221 cagccttggg agaaactgca gaactcaaaa tgcatctgta aaatgcccta tgaatgtgga
     2281 tcctccttgg atgtatgtgc ccgagatgag agtagaaaca agattctgtc tctgaccatc
     2341 tgcaagatgc acgttgtcca ctgtcataaa agaaattaca ctcttgttgg caaggaaagc
     2401 tgtactctgc cttccccggc tgagaaagtc tgtggtgcat gcccaatatg gagtaaatgt
     2461 gatgctcaga atggcaaatg tatctgcaga gaagcatcgg agtgccagac agcaggctac
     2521 agaatctgtg tggaagtgaa tggcaaagag gaaacgatgt ctgagtgtga ggctggcatc
     2581 ttaagatgca gaggacagag catctccatc acagccataa agccctgtgc agaagaagca
     2641 gcccagtagg gcctggaggg ggtggggctt gatcctcttc atcagaatct agtgggcagt
     2701 ggatgctgg
//
