LOCUS       NM_016704               2863 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus complement component 6 (C6), mRNA.
ACCESSION   NM_016704
VERSION     NM_016704.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2863)
  AUTHORS   Linde,I.L., Prestwood,T.R., Qiu,J., Pilarowski,G., Linde,M.H.,
            Zhang,X., Shen,L., Reticker-Flynn,N.E., Chiu,D.K., Sheu,L.Y., Van
            Deursen,S., Tolentino,L.L., Song,W.C. and Engleman,E.G.
  TITLE     Neutrophil-activating therapy for the treatment of cancer
  JOURNAL   Cancer Cell 41 (2), 356-372 (2023)
   PUBMED   36706760
REFERENCE   2  (bases 1 to 2863)
  AUTHORS   Liu,X., Wang,Y., Bauer,A.T., Kirschfink,M., Ding,P., Gebhardt,C.,
            Borsig,L., Tuting,T., Renne,T., Haffner,K., Hu,W., Schneider,S.W.
            and Gorzelanny,C.
  TITLE     Neutrophils activated by membrane attack complexes increase the
            permeability of melanoma blood vessels
  JOURNAL   Proc Natl Acad Sci U S A 119 (33), e2122716119 (2022)
   PUBMED   35960843
REFERENCE   3  (bases 1 to 2863)
  AUTHORS   Jackson,W.D., Gulino,A., Fossati-Jimack,L., Castro Seoane,R.,
            Tian,K., Best,K., Kohl,J., Belmonte,B., Strid,J. and Botto,M.
  TITLE     C3 Drives Inflammatory Skin Carcinogenesis Independently of C5
  JOURNAL   J Invest Dermatol 141 (2), 404-414 (2021)
   PUBMED   32682912
REFERENCE   4  (bases 1 to 2863)
  AUTHORS   Fattahi,F., Grailer,J.J., Parlett,M., Lu,H., Malan,E.A., Abe,E.,
            Russell,M.W., Frydrych,L.M., Delano,M.J., Zetoune,F.S. and
            Ward,P.A.
  TITLE     Requirement of Complement C6 for Intact Innate Immune Responses in
            Mice
  JOURNAL   J Immunol 205 (1), 251-260 (2020)
   PUBMED   32444389
  REMARK    GeneRIF: Requirement of Complement C6 for Intact Innate Immune
            Responses in Mice.
REFERENCE   5  (bases 1 to 2863)
  AUTHORS   Zelek,W.M., Taylor,P.R. and Morgan,B.P.
  TITLE     Development and characterization of novel anti-C5 monoclonal
            antibodies capable of inhibiting complement in multiple species
  JOURNAL   Immunology 157 (4), 283-295 (2019)
   PUBMED   31120547
REFERENCE   6  (bases 1 to 2863)
  AUTHORS   Orren,A., Hayakawa,J., Johnson,J.E., Nash,H.R. and Hobart,M.J.
  TITLE     Allotypes of mouse complement component C6 in inbred strains and
            some wild populations
  JOURNAL   Immunogenetics 28 (3), 153-157 (1988)
   PUBMED   3410507
REFERENCE   7  (bases 1 to 2863)
  AUTHORS   Orren,A., Preece,C.J. and Dowdle,E.B.
  TITLE     Genetically determined molecular weight differences in murine
            complement component C6
  JOURNAL   Eur J Immunol 15 (1), 100-103 (1985)
   PUBMED   3967681
REFERENCE   8  (bases 1 to 2863)
  AUTHORS   Hayakawa,J., Nikaido,H. and Koizumi,T.
  TITLE     Assignment of the gene locus for the sixth component (C6) of
            complement in mice to chromosome 15
  JOURNAL   Immunogenetics 22 (6), 637-642 (1985)
   PUBMED   4077152
REFERENCE   9  (bases 1 to 2863)
  AUTHORS   Orren,A., Hobart,M.J., Nash,H.R. and Lachmann,P.J.
  TITLE     Close linkage between mouse genes determining the two forms of
            complement component C6 and component C7, and cis action of a C6
            regulatory gene
  JOURNAL   Immunogenetics 21 (6), 591-599 (1985)
   PUBMED   4007963
REFERENCE   10 (bases 1 to 2863)
  AUTHORS   Hayakawa,J.I., Nikaido,H. and Koizumi,T.
  TITLE     Genetic polymorphism of the sixth component of complement (C6) in
            mice
  JOURNAL   Immunogenetics 20 (6), 633-638 (1984)
   PUBMED   6510993
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY105449.1, BY088427.1, BB222000.2, AC117588.11, CB948485.1,
            BX515704.1 and AA212862.1.
            
            On Nov 27, 2007 this sequence version replaced NM_016704.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011251.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BY105449.1         2-5
            5-248               BY088427.1         2-245
            249-912             BB222000.2         1-664
            913-1055            AC117588.11        152287-152429       c
            1056-1296           AC117588.11        148706-148946       c
            1297-1419           AC117588.11        130326-130448       c
            1420-1586           AC117588.11        122643-122809       c
            1587-1625           AC117588.11        121283-121321       c
            1626-2124           CB948485.1         3-501
            2125-2538           BX515704.1         109-522
            2539-2863           AA212862.1         107-431
FEATURES             Location/Qualifiers
     source          1..2863
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 1.97 cM"
     gene            1..2863
                     /gene="C6"
                     /note="complement component 6"
                     /db_xref="GeneID:12274"
                     /db_xref="MGI:MGI:88233"
     exon            1..108
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     exon            109..271
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     exon            272..428
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     exon            429..573
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     exon            574..715
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     exon            716..854
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1055
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1296
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1419
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1586
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1812
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1984
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2096
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2229
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2418
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2841
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2812..2817
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C6"
                     /note="hexamer: AATAAA"
     polyA_site      2841
                     /gene="C6"
                     /note="major polyA site"
ORIGIN      
        1 agtagtatga aggacgcttt ggatgctcac acaaacccct gcttagcgtg cgtgtctttg
       61 gtttctacat ccattcaggt tcctgagcac aactaggtcg atttgaaggg tctggagatt
      121 gtggaagcat gaccagacat ctcaccttgt gtttcatttt gctggtcatg ctgattgaca
      181 agagtgaagc ctgtttctgt gaccactacc catggactca ctggtccagc tgttctaagt
      241 cctgcaattc tggaacccag agcagacaga gacaagtagt agtgaacgat tactattgga
      301 aaaacttatg cgataagctt tgtatcaagc aggagaccag agagtgcaac ttgcagacat
      361 gtcccatcaa ctgtgtccta ggagactatg ggacatggtc agactgtgac ccttgtactg
      421 aaaaacaggt taaagttaaa tctgtcctgc gcccaagtca gtttgggggg caaccatgca
      481 cagagcccct ggtgaccttt caaccatgtg tcccctccaa gctctgcaaa attgaagaga
      541 ctaactgcaa gaataagttc ctctgtgaca gtgggcgctg tattcccagc aagttagaat
      601 gcaatggaga gaatgactgt ggagacaatt cagatgaaag gaactgtggg aggacaaagc
      661 cagtgtgcac acggatatac actcccatcc ctagtgtgca gctgatgggc actgggtttc
      721 attttctggc aggagagccc agaggagaag ttcttgacaa ctctttcact ggaggaatat
      781 gtaaacttgt caagaccagt cgagccagta atccataccg tgtttcagcc aatctggaaa
      841 atgtcaactt tgaggtacaa actatagaag atgacttgaa aacagaattc tacaagaatt
      901 taatctcttt tgaaaaaaat aaaaatgaag acagtctttc agtggatgaa aggacaaaat
      961 ttttccctat accaattttc catttctcag agaaaaatga acattcccat tatagctctg
     1021 ccttcaacaa agtcattaaa gcttcccaca agaaggattc tagctttatc aggatccata
     1081 agctgataaa agtcttaaac ttcacaatga aagcaacaga cctacagctt tcagatgtct
     1141 tcctgaaagc ccttgtccac ctgcctttag aatacaactc tgctgtgtac agccggatat
     1201 ttgatgactt cgggacccac tacttcacct caggctccct tgggggcaag tatgacctta
     1261 tctaccaatt cagccgccag gagctacaga actcaggttt aacagaagaa gaagctcaaa
     1321 actgtgtcca gtatgaaaca aagaaactta agtttcttta tatggaaata cacaaggaag
     1381 acacgtgcac caaaaacaag ctgtctgaaa aatatggagg ttcctttttg cagggatcag
     1441 agaaatccat ttccctggtc cagggcggga ggagtcagca ggcagcagcc ttggcttggg
     1501 agaagggcac ctctggtcca gaggagaatg tctattctga gtggctagaa tcggtgaagg
     1561 aaaaccctgc tgtagttgat tataagcttg ccccaattac agacttggtc agaaacatcc
     1621 catgtgcagt gacaaaacgg aacaacctca ggagagcgct tcaagagtat gcagccaagt
     1681 ttgacccttg ccagtgtgct ccatgtccca ataatggccg ccccaggctc tcaggcacgg
     1741 aatgcctgtg tgtgtgccag agcggcacct acggtgagaa ctgtgagcgc aggtccccag
     1801 gttacaaatc tgatgcagtg gatggaaact ggggctgctg gtcttcctgg agtgcgtgca
     1861 atgctgctta taggagatca agaacccgag agtgtaataa ccctgcgcca cagcgaggag
     1921 gacaaagctg tggtggcaag gatcagcaag aagaagactg tacagtctca ataatggaaa
     1981 atgttggaca accatgtatc aatgatgatg aagaaatgaa agaagtagac cttgctgagc
     2041 cagaagcaga atcagggtgt tctcaaccac ctctcccaga aaacgcattt acctggaatg
     2101 agaagaaact gtactcagtt ggggaggaag ttgaaatttc atgtcttact ggattcacag
     2161 ctgttggatt ccagtacttg agatgtttac cagacagaac ctggagtcaa ggagatgtgg
     2221 aatgccaaag gacctcgtgc ctcaagcccg ttgttcagga tgtcctgacc atctccccat
     2281 ttcagagagt gtatcagatt ggggaatcca ttgagctgac atgccccaga ggctttgttg
     2341 ttgctggacc atcaaggtat acatgcaagg aagactcctg gacacctccc atttcaaatt
     2401 cattgacctg tgaacaaggt gtcagagacc atccgtgaga aagtgatccc ttcacaatct
     2461 ccttaacaag tcaaagggcc ttgaactaag agctggttgc cacccccttc ctccttattc
     2521 ccttcctaac acctaagact gtaaaatttg aataacagtc ccctcttccc tatctctttc
     2581 cgagttccca tgacatccaa ggacatgagc tgtgcctgag cccagcttga ctcccaaggc
     2641 tgttgaggag gatcaaggct ctggagataa gatgcaaagt gcctgctgct tggcgcctga
     2701 cttcagcccc catgtcagca gtcgtccttt cccttgttct ttgtacaact ctccctcgac
     2761 ccctccccta ttttccgcga tgtatgcttt ataaggaaag cacctcagct taataaatga
     2821 gaccttgata ggtttaatct aaaaaaaaaa aaaaaaaaaa aaa
//
