LOCUS       NM_001173550            2540 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus complement component 5a receptor 1 (C5ar1), transcript
            variant 2, mRNA.
ACCESSION   NM_001173550
VERSION     NM_001173550.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2540)
  AUTHORS   Yu,S.M., King,E., Fribourg,M., Hartzell,S., Tsou,L., Gee,L.,
            D'Agati,V.D., Thurman,J.M., He,J.C. and Cravedi,P.
  TITLE     A Newly Identified Protective Role of C5a Receptor 1 in Kidney
            Tubules against Toxin-Induced Acute Kidney Injury
  JOURNAL   Am J Pathol 195 (1), 126-142 (2025)
   PUBMED   39427763
REFERENCE   2  (bases 1 to 2540)
  AUTHORS   Stark,K., Kilani,B., Stockhausen,S., Busse,J., Schubert,I.,
            Tran,T.D., Gaertner,F., Leunig,A., Pekayvaz,K., Nicolai,L.,
            Fumagalli,V., Stermann,J., Stephan,F., David,C., Muller,M.B.,
            Heyman,B., Lux,A., da Palma Guerreiro,A., Frenzel,L.P.,
            Schmidt,C.Q., Dopler,A., Moser,M., Chandraratne,S., von Bruhl,M.L.,
            Lorenz,M., Korff,T., Rudelius,M., Popp,O., Kirchner,M., Mertins,P.,
            Nimmerjahn,F., Iannacone,M., Sperandio,M., Engelmann,B.,
            Verschoor,A. and Massberg,S.
  TITLE     Antibodies and complement are key drivers of thrombosis
  JOURNAL   Immunity 57 (9), 2140-2156 (2024)
   PUBMED   39226900
REFERENCE   3  (bases 1 to 2540)
  AUTHORS   Zhang,T., Ma,N., Wang,J., Min,X., Wei,L. and Li,K.
  TITLE     C5aR2 Deficiency Lessens C5aR1 Distribution and Expression in
            Neutrophils and Macrophages
  JOURNAL   J Immunol Res 2024, 2899154 (2024)
   PUBMED   39021433
  REMARK    GeneRIF: C5aR2 Deficiency Lessens C5aR1 Distribution and Expression
            in Neutrophils and Macrophages.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2540)
  AUTHORS   Kang,L., Kohen,M., McCarthy,I., Hammelef,E., Kim,H.S., Bapputty,R.,
            Gubitosi-Klug,R., Orge,F.H., Kern,T. and Medof,M.E.
  TITLE     Critical Role of CD55 in Controlling Wound Healing
  JOURNAL   J Immunol 212 (7), 1142-1149 (2024)
   PUBMED   38372645
REFERENCE   5  (bases 1 to 2540)
  AUTHORS   Okada,A., Shimizu,K., Kawashima,A., Kayahara,T., Itani,M.,
            Kurita,H., Miyamoto,S., Kataoka,H. and Aoki,T.
  TITLE     C5a-C5AR1 axis as a potential trigger of the rupture of
            intracranial aneurysms
  JOURNAL   Sci Rep 14 (1), 3105 (2024)
   PUBMED   38326494
  REMARK    GeneRIF: C5a-C5AR1 axis as a potential trigger of the rupture of
            intracranial aneurysms.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2540)
  AUTHORS   Clynes,R., Maizes,J.S., Guinamard,R., Ono,M., Takai,T. and
            Ravetch,J.V.
  TITLE     Modulation of immune complex-induced inflammation in vivo by the
            coordinate expression of activation and inhibitory Fc receptors
  JOURNAL   J Exp Med 189 (1), 179-185 (1999)
   PUBMED   9874574
REFERENCE   7  (bases 1 to 2540)
  AUTHORS   Hopken,U.E., Lu,B., Gerard,N.P. and Gerard,C.
  TITLE     Impaired inflammatory responses in the reverse arthus reaction
            through genetic deletion of the C5a receptor
  JOURNAL   J Exp Med 186 (5), 749-756 (1997)
   PUBMED   9271590
REFERENCE   8  (bases 1 to 2540)
  AUTHORS   Bozic,C.R., Lu,B., Hopken,U.E., Gerard,C. and Gerard,N.P.
  TITLE     Neurogenic amplification of immune complex inflammation
  JOURNAL   Science 273 (5282), 1722-1725 (1996)
   PUBMED   8781237
REFERENCE   9  (bases 1 to 2540)
  AUTHORS   Hopken,U.E., Lu,B., Gerard,N.P. and Gerard,C.
  TITLE     The C5a chemoattractant receptor mediates mucosal defence to
            infection
  JOURNAL   Nature 383 (6595), 86-89 (1996)
   PUBMED   8779720
REFERENCE   10 (bases 1 to 2540)
  AUTHORS   Gerard,C., Bao,L., Orozco,O., Pearson,M., Kunz,D. and Gerard,N.P.
  TITLE     Structural diversity in the extracellular faces of peptidergic
            G-protein-coupled receptors. Molecular cloning of the mouse C5a
            anaphylatoxin receptor
  JOURNAL   J Immunol 149 (8), 2600-2606 (1992)
   PUBMED   1401897
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156630.6.
            
            Transcript Variant: This variant (2) has an alternate 5' UTR, as
            compared to variant 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158027.1, BC125641.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               AC156630.6         139831-140024       c
            195-2540            AC156630.6         127431-129776       c
FEATURES             Location/Qualifiers
     source          1..2540
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 8.77 cM"
     gene            1..2540
                     /gene="C5ar1"
                     /gene_synonym="C5aR; C5r1; Cd88; D7Msu1"
                     /note="complement component 5a receptor 1"
                     /db_xref="GeneID:12273"
                     /db_xref="MGI:MGI:88232"
     exon            1..194
                     /gene="C5ar1"
                     /gene_synonym="C5aR; C5r1; Cd88; D7Msu1"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..1247
                     /gene="C5ar1"
                     /gene_synonym="C5aR; C5r1; Cd88; D7Msu1"
                     /note="C5a anaphylatoxin receptor; C5a-R; complement
                     component 5, receptor 1; C5a ligand"
                     /codon_start=1
                     /product="C5a anaphylatoxin chemotactic receptor 1"
                     /protein_id="NP_001167021.1"
                     /db_xref="CCDS:CCDS20846.1"
                     /db_xref="GeneID:12273"
                     /db_xref="MGI:MGI:88232"
                     /translation="MDPIDNSSFEINYDHYGTMDPNIPADGIHLPKRQPGDVAALIIY
                     SVVFLVGVPGNALVVWVTAFEARRAVNAIWFLNLAVADLLSCLALPVLFTTVLNHNYW
                     YFDATACIVLPSLILLNMYASILLLATISADRFLLVFKPIWCQKVRGTGLAWMACGVA
                     WVLALLLTIPSFVYREAYKDFYSEHTVCGINYGGGSFPKEKAVAILRLMVGFVLPLLT
                     LNICYTFLLLRTWSRKATRSTKTLKVVMAVVICFFIFWLPYQVTGVMIAWLPPSSPTL
                     KRVEKLNSLCVSLAYINCCVNPIIYVMAGQGFHGRLLRSLPSIIRNALSEDSVGRDSK
                     TFTPSTTDTSTRKSQAV"
     exon            195..2540
                     /gene="C5ar1"
                     /gene_synonym="C5aR; C5r1; Cd88; D7Msu1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2006..2011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C5ar1"
                     /gene_synonym="C5aR; C5r1; Cd88; D7Msu1"
                     /note="hexamer: GATAAA"
     polyA_site      2021
                     /gene="C5ar1"
                     /gene_synonym="C5aR; C5r1; Cd88; D7Msu1"
                     /note="major polyA site"
ORIGIN      
        1 gtaagcaccg gtggagggag cctcagctag gatggtcagt gagtgaccaa tgagcacctc
       61 caggagacaa gacagtcatt tcctctcagt tgcctgcatc tcttcttgag ggtttaaaag
      121 gcacagcctg ggtgacaggg accttcaggc atccgtcgct ggttaccaca gaacccagga
      181 ggagccagga catggacccc atagataaca gcagctttga aatcaactat gatcactatg
      241 gaaccatgga tcctaacata cctgcggatg gcattcacct cccgaagcgg caacctgggg
      301 atgttgcagc ccttatcatc tactcggtgg tgttcctggt gggagtacct gggaatgccc
      361 tggtggtgtg ggtgacagcc ttcgaggcca gacgggccgt caacgccatc tggtttctga
      421 atctggcggt ggccgacctc ctctcgtgct tggcactgcc tgtcctgttc acgaccgttt
      481 taaatcataa ctactggtac tttgatgcca ccgcctgtat agtcctgccc tcgctcatcc
      541 tgctcaacat gtacgccagt atcctgctgc tggctaccat tagtgccgac cgtttcctgc
      601 tggtgttcaa gcccatctgg tgtcagaagg tccgcgggac tggcctggca tggatggcct
      661 gtggagtggc ctgggtctta gcattgctcc tcaccattcc atccttcgtg taccgggagg
      721 catataagga cttctactca gagcacactg tatgtggtat taactatggt gggggtagct
      781 tccccaaaga gaaggctgtg gccatcctgc ggctgatggt gggttttgtg ttgcctctgc
      841 tcactctaaa catctgctac accttcctcc tgctccggac ctggagtcgc aaggccacgc
      901 gctccaccaa gacgctcaaa gtggtgatgg ctgtggtcat ctgtttcttt atcttctggc
      961 tgccctatca ggtgaccggg gtgatgatag cgtggctgcc cccgtcctcg cccaccttga
     1021 agagggtgga gaagctgaac tccctgtgcg tgtccctggc ctacatcaac tgctgtgtta
     1081 accctatcat ctacgtcatg gctggccagg gtttccatgg acgactccta aggtctctcc
     1141 ccagcatcat acgaaacgct ctctctgagg attcagtggg cagggatagc aagactttca
     1201 ctccgtccac gacggacacc tcaacccgga agagtcaggc ggtgtagagg agaagccaca
     1261 actggcctag ctgctccttt tccagccctc ctaccccctc ctcttcttcc tcctcctgcc
     1321 tctcctcctt ccttccttcc ttctctttgc atgtttaatt ttctgcaatt ctctaagttg
     1381 ctctgactag ccttgagccc aggatcctca tgaaggctga gattataaat ataaattcct
     1441 ttgatgaaaa gcatcacatt aagatagtac tcggcttttt ttctaaggct tttttttttt
     1501 ttcttggcta cgttgcccac ctgcagtggc taggcagata cacctaatga tgacctccag
     1561 gggttggata acagagaaca agagaatttc ctggccttct tcttcctctc ttcctcttct
     1621 ttttccctcc tcctccttct tctcctcctc ctcccttttt ttttttatgg ttctggtctg
     1681 aacccaggtc tcaatggaac ccagggctta tggatatatc acataagcaa gctacagccc
     1741 caaaccccag gcaaccagta tccacccacc ctttatttct tttctatgtt tgattttttt
     1801 tttttttgag acaaggtctc atgtagggta gtctggcctt gaactccaga tcctcctgtg
     1861 accatctccc aagtgtcgtg actgtagacc tgtgctgttg tgtccgacct atcctttatt
     1921 tctacaattt tgtgttttca ggaatggtat ttaatggaac ccaacatatc caagctttgt
     1981 aaaaacaact atgcatggct tacttgataa attttttttt tttaaaaagg tacagaaatg
     2041 tgttgtttaa ctttttaaaa gcacgtattt atttattttg tggggggtga gggggtggtg
     2101 ctgggcaaat gtcatggtat atgtgtggag gtcagaggac aacctgttga aattggttct
     2161 ctcattgcaa ccatgaaggt cctcatggaa tcgaacccag gtcatcatac ttggcagcaa
     2221 acacctttac ctgctgagtc acatcactgg ccagaggtgt cctgtcttat aatgcgttct
     2281 ttcagcttaa tgaatgtgtg tgcatgagtg tatgtgttgg ctagaaaata tgtacagatc
     2341 aacaccagaa gtatcatgca agcatgggaa tggttttgaa tttcctggtc aaattaaaaa
     2401 tgtgaaagaa gacctgggtg tggtggcgca aacctatatc ccagcatgtg ggaggttcag
     2461 gggccagaat tgagttttag aacccagcct ggcttaccca gggagactgt ctcatgagat
     2521 ccaaataaac agtatatgat
//
