LOCUS       NM_007576               1883 bp    mRNA    linear   ROD 19-DEC-2022
DEFINITION  Mus musculus complement component 4 binding protein (C4bp), mRNA.
ACCESSION   NM_007576
VERSION     NM_007576.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1883)
  AUTHORS   Serrano I, Luque A, Mitjavila F, Blom AM, Rodriguez de Cordoba S,
            Vega MC, Torras J and Aran JM.
  TITLE     The Hidden Side of Complement Regulator C4BP: Dissection and
            Evaluation of Its Immunomodulatory Activity
  JOURNAL   Front Immunol 13, 883743 (2022)
   PUBMED   35547734
  REMARK    GeneRIF: The Hidden Side of Complement Regulator C4BP: Dissection
            and Evaluation of Its Immunomodulatory Activity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1883)
  AUTHORS   Morita N, Yamazaki T, Murakami Y, Fukui R, Yamai I, Ichimonji I,
            Nakashima A, Nagaoka F, Takagi H, Miyake K and Akashi-Takamura S.
  TITLE     C4b-binding protein negatively regulates TLR4/MD-2 response but not
            TLR3 response
  JOURNAL   FEBS Lett 591 (12), 1732-1741 (2017)
   PUBMED   28542817
  REMARK    GeneRIF: Data suggest that C4bp prevents interaction between
            Tlr4/MD-2 and its ligand; C4bp does not appear to interact with
            Tlr3; C4bp binds to macrophage surface Tlr4 and inhibits Tlr/Tlr
            ligand interaction, thereby inhibiting Tlr4 activation. (C4bp =
            complement component 4 binding protein; Tlr = toll-like receptor;
            MD-2 = myeloid differentiation protein-2)
REFERENCE   3  (bases 1 to 1883)
  AUTHORS   Morita N, Yamai I, Takahashi K, Kusumoto Y, Shibata T, Kobayashi T,
            Nonaka MI, Ichimonji I, Takagi H, Miyake K and Takamura SA.
  TITLE     C4b binding protein negatively regulates TLR1/2 response
  JOURNAL   Innate Immun 23 (1), 11-19 (2017)
   PUBMED   27794068
  REMARK    GeneRIF: this study shows that C4BP binds to TLR2, inhibits TLR1/2
            ligand binding and reduces cytokine production
REFERENCE   4  (bases 1 to 1883)
  AUTHORS   Nonaka MI, Zsigmond E, Kudo A, Kawakami H, Yoshida K, Yoshida M,
            Kawano N, Miyado K, Nonaka M and Wetsel RA.
  TITLE     Epididymal C4b-binding protein is processed and degraded during
            transit through the duct and is not essential for fertility
  JOURNAL   Immunobiology 220 (4), 467-475 (2015)
   PUBMED   25468721
  REMARK    GeneRIF: These results suggest that EpC4BP is involved in male
            reproduction, but not essential for sperm maturation.
REFERENCE   5  (bases 1 to 1883)
  AUTHORS   Spijkers PP, Denis CV, Blom AM and Lenting PJ.
  TITLE     Cellular uptake of C4b-binding protein is mediated by heparan
            sulfate proteoglycans and CD91/LDL receptor-related protein
  JOURNAL   Eur J Immunol 38 (3), 809-817 (2008)
   PUBMED   18266273
  REMARK    GeneRIF: The cellular uptake of C4BP depends on both heparan
            sulfate proteoglycans and CD91, involving interactions with
            positively charged residues within C4BP alpha-chain.
REFERENCE   6  (bases 1 to 1883)
  AUTHORS   Moffat GJ, Vik DP, Noack D and Tack BF.
  TITLE     Complete structure of the murine C4b-binding protein gene and
            regulation of its expression by dexamethasone
  JOURNAL   J Biol Chem 267 (28), 20400-20406 (1992)
   PUBMED   1400358
REFERENCE   7  (bases 1 to 1883)
  AUTHORS   Levan G, Szpirer J, Szpirer C, Klinga K, Hanson C and Islam MQ.
  TITLE     The gene map of the Norway rat (Rattus norvegicus) and comparative
            mapping with mouse and man
  JOURNAL   Genomics 10 (3), 699-718 (1991)
   PUBMED   1889815
REFERENCE   8  (bases 1 to 1883)
  AUTHORS   Moseley WS and Seldin MF.
  TITLE     Definition of mouse chromosome 1 and 3 gene linkage groups that are
            conserved on human chromosome 1: evidence that a conserved linkage
            group spans the centromere of human chromosome 1
  JOURNAL   Genomics 5 (4), 899-905 (1989)
   PUBMED   2574151
REFERENCE   9  (bases 1 to 1883)
  AUTHORS   Mock B, Kozak C, Seldin MF, Ruff N, D'Hoostelaere L, Szpirer C,
            Levan G, Seuanez H, O'Brien S and Banner C.
  TITLE     A glutaminase (gis) gene maps to mouse chromosome 1, rat chromosome
            9, and human chromosome 2
  JOURNAL   Genomics 5 (2), 291-297 (1989)
   PUBMED   2571577
  REMARK    Erratum:[Genomics 1989 Nov;5(4):957]
REFERENCE   10 (bases 1 to 1883)
  AUTHORS   Kingsmore SF, Vik DP, Kurtz CB, Leroy P, Tack BF, Weis JH and
            Seldin MF.
  TITLE     Genetic organization of complement receptor-related genes in the
            mouse
  JOURNAL   J Exp Med 169 (4), 1479-1484 (1989)
   PUBMED   2564419
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M17122.1 and AK149477.1.
            
            [WARNING] On Apr 24, 2023 this sequence was replaced by
            NM_007576.4.
            
            On Sep 30, 2006 this sequence version replaced NM_007576.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149477.1, M17122.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1875              M17122.1           15-1889
            1876-1883           AK149477.1         1793-1800
FEATURES             Location/Qualifiers
     source          1..1883
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 56.89 cM"
     gene            1..1883
                     /gene="C4bp"
                     /gene_synonym="C4bpa"
                     /note="complement component 4 binding protein"
                     /db_xref="GeneID:12269"
                     /db_xref="MGI:MGI:88229"
     exon            1..171
                     /gene="C4bp"
                     /gene_synonym="C4bpa"
                     /inference="alignment:Splign:2.1.0"
     exon            172..354
                     /gene="C4bp"
                     /gene_synonym="C4bpa"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..1598
                     /gene="C4bp"
                     /gene_synonym="C4bpa"
                     /note="C4b-binding protein"
                     /codon_start=1
                     /product="C4b-binding protein precursor"
                     /protein_id="NP_031602.3"
                     /db_xref="CCDS:CCDS35700.1"
                     /db_xref="GeneID:12269"
                     /db_xref="MGI:MGI:88229"
                     /translation="MCAKQQQTLLPTRAAHGRLHRNRDAVAWPFSTLCRVSGPTLFQM
                     TFTAALWVAVFGKCGPPPAIPNALPASDVNRTDFESHTTLKYECLPGYGRGISRMMVY
                     CKPSGEWEISVSCAKKHCRNPGYLDNGYVNGETITFGSQIEFSCQEGFILVGSSTSSC
                     EVRGKGVAWSNPFPECVIVKCGPPPDISNGKHSGTEDFYPYNHGISYTCDPGFRLVGS
                     PFIGCTVVNKTVPVWSSSPPTCEKIICSQPNILHGVIVSGYKATYTHRDSVRLACLNG
                     TVLRGRHVIECQGNGNWSSLPTCEFDCDLPPAIVNGYYTSMVYSKITLVTYECDKGYR
                     LVGKAIISCSFSKWKGTAPQCKALCQKPEVGNGTLSDEKDQYVESENVTIQCDSGFAM
                     LGSQSISCSESGTWYPEVPRCEQEASEDLKPALTGNKTMQYVPNSHDVKMALEIYKLT
                     LEVELLQLQIQKEKHTEAH"
     exon            355..537
                     /gene="C4bp"
                     /gene_synonym="C4bpa"
                     /inference="alignment:Splign:2.1.0"
     exon            538..634
                     /gene="C4bp"
                     /gene_synonym="C4bpa"
                     /inference="alignment:Splign:2.1.0"
     exon            635..720
                     /gene="C4bp"
                     /gene_synonym="C4bpa"
                     /inference="alignment:Splign:2.1.0"
     exon            721..912
                     /gene="C4bp"
                     /gene_synonym="C4bpa"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1092
                     /gene="C4bp"
                     /gene_synonym="C4bpa"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1257
                     /gene="C4bp"
                     /gene_synonym="C4bpa"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1433
                     /gene="C4bp"
                     /gene_synonym="C4bpa"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1883
                     /gene="C4bp"
                     /gene_synonym="C4bpa"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaacttgtgt gggtggaatg caaggatcac ttgcgtgggt agacttcaga agcttttttg
       61 atggagcaag tactggccag ctttaggata atatgatcaa ctctcatctt gggagaaact
      121 agtacagtag agatccaagt accaccacag agtctttctc tgctattgca ggtttcctgg
      181 cagaacaaat gtgtgcaaag cagcagcaga ccctgctccc cacaagagct gcacatggga
      241 ggcttcatag aaacagagat gctgtggcct ggcccttttc tacgctctgc agagtctctg
      301 gcccaacttt gttccaaatg acctttactg ctgctctttg ggttgctgta tttggcaaat
      361 gtggtccacc acctgctata cccaatgccc tgccagcaag tgacgtgaat cggacagact
      421 tcgaaagtca caccaccctg aaatacgaat gcctccctgg ctatggtagg ggaatatcaa
      481 ggatgatggt ttactgcaaa ccttcgggag aatgggagat ttctgtctcc tgtgccaaaa
      541 aacattgccg taatccagga tatttagata atggatatgt aaatggagag actatcactt
      601 ttggatcaca gatagaattc agctgccagg aaggatttat cttagttggc tcatccacta
      661 gttcttgtga ggtccgaggc aaaggagttg cctggagtaa tcctttccca gaatgtgtaa
      721 ttgtaaagtg tgggccccct ccagacatca gcaatgggaa gcacagtggt acagaagact
      781 tctacccata taaccatgga atctcctata cctgtgatcc cggcttcagg ctcgttggca
      841 gccccttcat aggctgcact gtggtgaaca aaacagtacc tgtttggagc tcaagccctc
      901 ctacctgtga aaagatcatc tgttctcagc caaatatttt acatggtgta attgtttctg
      961 gatataaagc tacctataca cacagagact ctgttagatt ggcctgcctg aatgggactg
     1021 tcctcagagg cagacatgtc atcgagtgtc aaggtaatgg caattggagt tctctcccga
     1081 cttgtgagtt cgactgtgat ttaccgcctg ccattgtcaa tggatattat actagtatgg
     1141 tctactctaa gataactctg gttacatatg aatgtgataa aggatacaga ctggttggaa
     1201 aggcaatcat ctcctgcagc ttttcaaagt ggaaagggac agctccacag tgtaaagctc
     1261 tatgtcagaa accagaggta ggaaatggaa cgctgtctga tgagaaagat cagtatgttg
     1321 agtctgaaaa tgtcaccatc caatgtgact ctggctttgc catgctgggt tcccaaagca
     1381 tcagttgttc agagagtgga acctggtatc cagaggtgcc cagatgtgag caggaggcct
     1441 ctgaagacct taagcctgcg cttacaggca acaagaccat gcagtatgtg ccaaattcac
     1501 acgatgtgaa aatggctctg gagatctaca agctgactct ggaggttgaa ctactacagc
     1561 tccagataca aaaggagaaa cacactgaag cacactgacc gggagttatg actgtatgtt
     1621 ctcttaagga ggaagtagcg tctcattggc tttctgactt cagttccaaa cagattgcct
     1681 gcagttacca acctttgtaa tgctggcacc aatgttcatg ataataaata tctgcttaga
     1741 ataattcatt aattatgtta taattaatag gtagtaaatc tatgaaacta tcatcttgtg
     1801 gctcataaat ttgcttttct gaatgcaatg tgtacatttt gaatgtgtga attaaaagtc
     1861 aattttgctc ttgtcatcca ctt
//
