LOCUS       NP_031602                469 aa            linear   ROD 02-MAY-2024
DEFINITION  C4b-binding protein isoform 1 precursor [Mus musculus].
ACCESSION   NP_031602
VERSION     NP_031602.3
DBSOURCE    REFSEQ: accession NM_007576.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 469)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 469)
  AUTHORS   Bierschenk,D., Papac-Milicevic,N., Bresch,I.P., Kovacic,V.,
            Bettoni,S., Dziedzic,M., Wetsel,R.A., Eschenburg,S., Binder,C.J.,
            Blom,A.M. and King,B.C.
  TITLE     C4b-binding protein inhibits particulate- and crystalline-induced
            NLRP3 inflammasome activation
  JOURNAL   Front Immunol 14, 1149822 (2023)
   PUBMED   37283747
  REMARK    GeneRIF: C4b-binding protein inhibits particulate- and
            crystalline-induced NLRP3 inflammasome activation.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 469)
  AUTHORS   Serrano,I., Luque,A., Mitjavila,F., Blom,A.M., Rodriguez de
            Cordoba,S., Vega,M.C., Torras,J. and Aran,J.M.
  TITLE     The Hidden Side of Complement Regulator C4BP: Dissection and
            Evaluation of Its Immunomodulatory Activity
  JOURNAL   Front Immunol 13, 883743 (2022)
   PUBMED   35547734
  REMARK    GeneRIF: The Hidden Side of Complement Regulator C4BP: Dissection
            and Evaluation of Its Immunomodulatory Activity.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 469)
  AUTHORS   Morita,N., Yamazaki,T., Murakami,Y., Fukui,R., Yamai,I.,
            Ichimonji,I., Nakashima,A., Nagaoka,F., Takagi,H., Miyake,K. and
            Akashi-Takamura,S.
  TITLE     C4b-binding protein negatively regulates TLR4/MD-2 response but not
            TLR3 response
  JOURNAL   FEBS Lett 591 (12), 1732-1741 (2017)
   PUBMED   28542817
  REMARK    GeneRIF: Data suggest that C4bp prevents interaction between
            Tlr4/MD-2 and its ligand; C4bp does not appear to interact with
            Tlr3; C4bp binds to macrophage surface Tlr4 and inhibits Tlr/Tlr
            ligand interaction, thereby inhibiting Tlr4 activation. (C4bp =
            complement component 4 binding protein; Tlr = toll-like receptor;
            MD-2 = myeloid differentiation protein-2)
REFERENCE   5  (residues 1 to 469)
  AUTHORS   Morita,N., Yamai,I., Takahashi,K., Kusumoto,Y., Shibata,T.,
            Kobayashi,T., Nonaka,M.I., Ichimonji,I., Takagi,H., Miyake,K. and
            Takamura,S.A.
  TITLE     C4b binding protein negatively regulates TLR1/2 response
  JOURNAL   Innate Immun 23 (1), 11-19 (2017)
   PUBMED   27794068
  REMARK    GeneRIF: this study shows that C4BP binds to TLR2, inhibits TLR1/2
            ligand binding and reduces cytokine production
REFERENCE   6  (residues 1 to 469)
  AUTHORS   Moffat,G.J., Vik,D.P., Noack,D. and Tack,B.F.
  TITLE     Complete structure of the murine C4b-binding protein gene and
            regulation of its expression by dexamethasone
  JOURNAL   J Biol Chem 267 (28), 20400-20406 (1992)
   PUBMED   1400358
REFERENCE   7  (residues 1 to 469)
  AUTHORS   Levan,G., Szpirer,J., Szpirer,C., Klinga,K., Hanson,C. and
            Islam,M.Q.
  TITLE     The gene map of the Norway rat (Rattus norvegicus) and comparative
            mapping with mouse and man
  JOURNAL   Genomics 10 (3), 699-718 (1991)
   PUBMED   1889815
REFERENCE   8  (residues 1 to 469)
  AUTHORS   Moseley,W.S. and Seldin,M.F.
  TITLE     Definition of mouse chromosome 1 and 3 gene linkage groups that are
            conserved on human chromosome 1: evidence that a conserved linkage
            group spans the centromere of human chromosome 1
  JOURNAL   Genomics 5 (4), 899-905 (1989)
   PUBMED   2574151
REFERENCE   9  (residues 1 to 469)
  AUTHORS   Mock,B., Kozak,C., Seldin,M.F., Ruff,N., D'Hoostelaere,L.,
            Szpirer,C., Levan,G., Seuanez,H., O'Brien,S. and Banner,C.
  TITLE     A glutaminase (gis) gene maps to mouse chromosome 1, rat chromosome
            9, and human chromosome 2
  JOURNAL   Genomics 5 (2), 291-297 (1989)
   PUBMED   2571577
  REMARK    Erratum:[Genomics 1989 Nov;5(4):957]
REFERENCE   10 (residues 1 to 469)
  AUTHORS   Kingsmore,S.F., Vik,D.P., Kurtz,C.B., Leroy,P., Tack,B.F.,
            Weis,J.H. and Seldin,M.F.
  TITLE     Genetic organization of complement receptor-related genes in the
            mouse
  JOURNAL   J Exp Med 169 (4), 1479-1484 (1989)
   PUBMED   2564419
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139231.11 and AC109283.8.
            
            On Sep 30, 2006 this sequence version replaced NP_031602.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB094485.1, M17122.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 56.89 cM"
     Protein         1..469
                     /product="C4b-binding protein isoform 1 precursor"
                     /note="C4b-binding protein"
                     /calculated_mol_wt=45282
     sig_peptide     1..56
                     /note="propagated from UniProtKB/Swiss-Prot (P08607.3)"
                     /calculated_mol_wt=6260
     Region          43..299
                     /region_name="PHA02927"
                     /note="secreted complement-binding protein; Provisional"
                     /db_xref="CDD:222943"
     mat_peptide     57..469
                     /product="C4b-binding protein. /id=PRO_0000005889"
                     /note="propagated from UniProtKB/Swiss-Prot (P08607.3)"
                     /calculated_mol_wt=45282
     Site            74
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P08607.3)"
     Site            227
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P08607.3)"
     Site            275
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:17330941; propagated from
                     UniProtKB/Swiss-Prot (P08607.3)"
     Region          <290..>420
                     /region_name="PHA02831"
                     /note="EEV host range protein; Provisional"
                     /db_xref="CDD:165176"
     Site            292
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P08607.3)"
     Site            366
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P08607.3)"
     Site            381
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P08607.3)"
     Region          416..464
                     /region_name="C4bp_oligo"
                     /note="Oligomerization domain of C4b-binding protein
                     alpha; pfam18453"
                     /db_xref="CDD:436513"
     Site            428
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P08607.3)"
     CDS             1..469
                     /gene="C4bp"
                     /gene_synonym="C4bpa"
                     /coded_by="NM_007576.4:199..1608"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS35700.1"
                     /db_xref="GeneID:12269"
                     /db_xref="MGI:MGI:88229"
ORIGIN      
        1 mcakqqqtll ptraahgrlh rnrdavawpf stlcrvsgpt lfqmtftaal wvavfgkcgp
       61 ppaipnalpa sdvnrtdfes httlkyeclp gygrgisrmm vyckpsgewe isvscakkhc
      121 rnpgyldngy vngetitfgs qiefscqegf ilvgsstssc evrgkgvaws npfpecvivk
      181 cgpppdisng khsgtedfyp ynhgisytcd pgfrlvgspf igctvvnktv pvwssspptc
      241 ekiicsqpni lhgvivsgyk atythrdsvr laclngtvlr grhviecqgn gnwsslptce
      301 fdcdlppaiv ngyytsmvys kitlvtyecd kgyrlvgkai iscsfskwkg tapqckalcq
      361 kpevgngtls dekdqyvese nvtiqcdsgf amlgsqsisc sesgtwypev prceqeased
      421 lkpaltgnkt mqyvpnshdv kmaleiyklt levellqlqi qkekhteah
//
