LOCUS       NM_009780               5427 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus complement C4B (Chido blood group) (C4b), mRNA.
ACCESSION   NM_009780 XM_910426 XM_921643 XM_921648 XM_921655 XM_921660
            XM_921663 XM_921673 XM_921676 XM_921678
VERSION     NM_009780.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5427)
  AUTHORS   Stark,K., Kilani,B., Stockhausen,S., Busse,J., Schubert,I.,
            Tran,T.D., Gaertner,F., Leunig,A., Pekayvaz,K., Nicolai,L.,
            Fumagalli,V., Stermann,J., Stephan,F., David,C., Muller,M.B.,
            Heyman,B., Lux,A., da Palma Guerreiro,A., Frenzel,L.P.,
            Schmidt,C.Q., Dopler,A., Moser,M., Chandraratne,S., von Bruhl,M.L.,
            Lorenz,M., Korff,T., Rudelius,M., Popp,O., Kirchner,M., Mertins,P.,
            Nimmerjahn,F., Iannacone,M., Sperandio,M., Engelmann,B.,
            Verschoor,A. and Massberg,S.
  TITLE     Antibodies and complement are key drivers of thrombosis
  JOURNAL   Immunity 57 (9), 2140-2156 (2024)
   PUBMED   39226900
REFERENCE   2  (bases 1 to 5427)
  AUTHORS   Fournier,L.A., Phadke,R.A., Salgado,M., Brack,A., Nocon,J.C.,
            Bolshakova,S., Grant,J.R., Padro Luna,N.M., Sen,K. and
            Cruz-Martin,A.
  TITLE     Overexpression of the schizophrenia risk gene C4 in PV cells drives
            sex-dependent behavioral deficits and circuit dysfunction
  JOURNAL   iScience 27 (9), 110800 (2024)
   PUBMED   39310747
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5427)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 5427)
  AUTHORS   Veremeyko,T., Jiang,R., He,M. and Ponomarev,E.D.
  TITLE     Complement C4-deficient mice have a high mortality rate during
            PTZ-induced epileptic seizures, which correlates with cognitive
            problems and the deficiency in the expression of Egr1 and other
            immediate early genes
  JOURNAL   Front Cell Neurosci 17, 1170031 (2023)
   PUBMED   37234916
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5427)
  AUTHORS   Zhou,T., Li,Y., Li,X., Zeng,F., Rao,Y., He,Y., Wang,Y., Liu,M.,
            Li,D., Xu,Z., Zhou,X., Du,S., Niu,F., Peng,J., Mei,X., Ji,S.J.,
            Shu,Y., Lu,W., Guo,F., Wu,T., Yuan,T.F., Mao,Y. and Peng,B.
  TITLE     Microglial debris is cleared by astrocytes via C4b-facilitated
            phagocytosis and degraded via RUBICON-dependent noncanonical
            autophagy in mice
  JOURNAL   Nat Commun 13 (1), 6233 (2022)
   PUBMED   36280666
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5427)
  AUTHORS   Miller,R.D., Aizawa,Y. and Shreffler,D.C.
  TITLE     Restriction fragment length polymorphism of the murine C4 and Slp
            genes: two C4 groups
  JOURNAL   J Immunol 149 (9), 2926-2934 (1992)
   PUBMED   1357031
REFERENCE   7  (bases 1 to 5427)
  AUTHORS   Pattanakitsakul,S., Zheng,J.H., Natsuume-Sakai,S., Takahashi,M. and
            Nonaka,M.
  TITLE     Aberrant splicing caused by the insertion of the B2 sequence into
            an intron of the complement C4 gene is the basis for low C4
            production in H-2k mice
  JOURNAL   J Biol Chem 267 (11), 7814-7820 (1992)
   PUBMED   1373139
REFERENCE   8  (bases 1 to 5427)
  AUTHORS   Natsuume-Sakai,S., Hayakawa,J.I. and Takahashi,M.
  TITLE     Genetic polymorphism of murine C3 controlled by a single
            co-dominant locus on chromosome 17
  JOURNAL   J Immunol 121 (2), 491-498 (1978)
   PUBMED   681746
REFERENCE   9  (bases 1 to 5427)
  AUTHORS   Carroll,M.C. and Capra,J.D.
  TITLE     Studies on the murine Ss protein: demonstration that the Ss protein
            is functionally the fourth component of complement
  JOURNAL   Proc Natl Acad Sci U S A 75 (5), 2424-2428 (1978)
   PUBMED   276882
REFERENCE   10 (bases 1 to 5427)
  AUTHORS   Meo,T., Douglas,T. and Rijnbeek,A.M.
  TITLE     Glyoxalase I polymorphism in the mouse: a new genetic marker linked
            to H-2
  JOURNAL   Science 198 (4314), 311-313 (1977)
   PUBMED   910130
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY785731.1, BC067394.1, CA459454.1, AK158475.1, AK158256.1,
            AK128974.1, K02798.1 and AK157954.1.
            
            On Oct 6, 2007 this sequence version replaced NM_009780.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067394.1, AK157954.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-312               BY785731.1         2-313
            313-499             BC067394.1         283-469
            500-521             CA459454.1         522-543
            522-1388            BC067394.1         492-1358
            1389-2094           AK158475.1         1375-2080
            2095-3631           AK158256.1         2081-3617
            3632-3808           AK128974.1         2058-2234
            3809-4015           K02798.1           426-632
            4016-5391           AK157954.1         4002-5377
            5392-5427           BC067394.1         5362-5397
FEATURES             Location/Qualifiers
     source          1..5427
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.29 cM"
     gene            1..5427
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /note="complement C4B (Chido blood group)"
                     /db_xref="GeneID:12268"
                     /db_xref="MGI:MGI:88228"
     exon            1..136
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..5288
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /note="complement C4-B; complement component 4 (within
                     H-2S); complement component 4B (Childo blood group);
                     complement component 4B (Chido blood group)"
                     /codon_start=1
                     /product="complement C4-B precursor"
                     /protein_id="NP_033910.2"
                     /db_xref="CCDS:CCDS28657.1"
                     /db_xref="GeneID:12268"
                     /db_xref="MGI:MGI:88228"
                     /translation="MRLLWGLAWVFSFCASSLQKPRLLLFSPSVVNLGTPLSVGVQLL
                     DAPPGQEVKGSVFLRNPKGGSCSPKKDFKLSSGDDFVLLSLEVPLEDVRSCGLFDLRR
                     APHIQLVAQSPWLRNTAFKATETQGVNLLFSSRRGHIFVQTDQPIYNPGQRVRYRVFA
                     LDQKMRPSTDFLTITVENSHGLRVLKKEIFTSTSIFQDAFTIPDISEPGTWKISARFS
                     DGLESNRSTHFEVKKYVLPNFEVKITPWKPYILMVPSNSDEIQLDIQARYIYGKPVQG
                     VAYTRFALMDEQGKRTFLRGLETQAKLVEGRTHISISKDQFQAALDKINIGVRDLEGL
                     RLYAATAVIESPGGEMEEAELTSWRFVSSAFSLDLSRTKRHLVPGAHFLLQALVQEMS
                     GSEASNVPVKVSATLVSGSDSQVLDIQQSTNGIGQVSISFPIPPTVTELRLLVSAGSL
                     YPAIARLTVQAPPSRGTGFLSIEPLDPRSPSVGDTFILNLQPVGIPAPTFSHYYYMII
                     SRGQIMAMGREPRKTVTSVSVLVDHQLAPSFYFVAYFYHQGHPVANSLLINIQSRDCE
                     GKLQLKVDGAKEYRNADMMKLRIQTDSKALVALGAVDMALYAVGGRSHKPLDMSKVFE
                     VINSYNVGCGPGGGDDALQVFQDAGLAFSDGDRLTQTREDLSCPKEKKSRQKRNVNFQ
                     KAVSEKLGQYSSPDAKRCCQDGMTKLPMKRTCEQRAARVPQQACREPFLSCCKFAEDL
                     RRNQTRSQAHLARNNHNMLQEEDLIDEDDILVRTSFPENWLWRVEPVDSSKLLTVWLP
                     DSMTTWEIHGVSLSKSKGLCVAKPTRVRVFRKFHLHLRLPISIRRFEQFELRPVLYNY
                     LNDDVAVSVHVTPVEGLCLAGGGMMAQQVTVPAGSARPVAFSVVPTAAANVPLKVVAR
                     GVFDLGDAVSKILQIEKEGAIHREELVYNLDPLNNLGRTLEIPGSSDPNIVPDGDFSS
                     LVRVTASEPLETMGSEGALSPGGVASLLRLPQGCAEQTMIYLAPTLTASNYLDRTEQW
                     SKLSPETKDHAVDLIQKGYMRIQQFRKNDGSFGAWLHRDSSTWLTAFVLKILSLAQEQ
                     VGNSPEKLQETASWLLAQQLGDGSFHDPCPVIHRAMQGGLVGSDETVALTAFVVIALH
                     HGLDVFQDDDAKQLKNRVEASITKANSFLGQKASAGLLGAHAAAITAYALTLTKASED
                     LRNVAHNSLMAMAEETGEHLYWGLVLGSQDKVVLRPTAPRSPTEPVPQAPALWIETTA
                     YALLHLLLREGKGKMADKAASWLTHQGSFHGAFRSTQDTVVTLDALSAYWIASHTTEE
                     KALNVTLSSMGRNGLKTHGLHLNNHQVKGLEEELKFSLGSTISVKVEGNSKGTLKILR
                     TYNVLDMKNTTCQDLQIEVKVTGAVEYAWDANEDYEDYYDMPAADDPSVPLQPVTPLQ
                     LFEGRRSRRRREAPKVVEEQESRVQYTVCIWRNGKLGLSGMAIADITLLSGFHALRAD
                     LEKLTSLSDRYVSHFETDGPHVLLYFDSVPTTRECVGFGASQEVVVGLVQPSSAVLYD
                     YYSPDHKCSVFYAAPTKSQLLATLCSGDVCQCAEGKCPRLLRSLERRVEDKDGYRMRF
                     ACYYPRVEYGFTVKVLREDGRAAFRLFESKITQVLHFRKDTMASIGQTRNFLSRASCR
                     LRLEPNKEYLIMGMDGETSDNKGDPQYLLDSNTWIEEMPSEQMCKSTRHRAACFQLKD
                     FLMEFSSRGCQV"
     exon            137..329
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            330..531
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            532..602
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            603..691
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            692..774
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            775..871
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            872..977
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1110
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1226
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1403
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1589
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1775
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1934
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2061
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2136
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2331
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2446
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..2517
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            2518..2657
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2861
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..2913
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            2914..3003
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            3004..3213
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            3214..3289
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            3290..3446
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            3447..3563
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            3564..3735
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            3736..3968
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            3969..4136
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            4137..4196
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            4197..4290
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            4291..4471
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            4472..4562
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            4563..4637
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            4638..4740
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            4741..4830
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            4831..4929
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            4930..5013
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            5014..5146
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     exon            5147..5394
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5371..5376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /note="hexamer: AAGAAA"
     polyA_site      5394
                     /gene="C4b"
                     /gene_synonym="C4; Ss"
                     /note="major polyA site"
ORIGIN      
        1 aaccctaggt tgatcagaag ggagcagaca gtcagaccag acaggtctga cctttcctga
       61 atcctccagc catgcggctc ctctgggggc tggcctgggt gttcagcttc tgtgcctcat
      121 ccctgcagaa gcccaggttg ctcctgtttt ccccttctgt ggttaatttg gggacccccc
      181 tgtcggtggg ggtacagctc ctggatgccc ctccaggaca ggaggtaaaa ggatcagtgt
      241 tcctcagaaa cccaaagggt ggttcctgct ccccaaagaa ggactttaag ctgagctcgg
      301 gagatgactt tgtgctgctc agccttgagg tcccactgga agatgtgagg agctgtggcc
      361 tctttgacct gcgcagagcc ccccacatcc agctggtagc tcagtctccg tggctaagga
      421 acacagcttt caaagccaca gagactcagg gtgtcaactt gctcttctct tcccgacgag
      481 gccacatctt tgtgcagacc gatcagccta tctataatcc ggggcagcgg gttcgttatc
      541 gggtctttgc actggatcaa aagatgcgcc catccactga tttcctcacc atcacagtgg
      601 agaactccca tggcctccgt gtactcaaga aggagatatt tacttccaca tccatcttcc
      661 aagatgcctt caccattcca gacatctcag agcctgggac ctggaagatc tcagctaggt
      721 tctcagatgg actggagtcc aataggagca cccactttga agtgaagaag tatgtccttc
      781 ccaacttcga ggtgaagatt actccttgga agccatatat cctgatggtg cccagcaaca
      841 gtgatgaaat ccaattagac atccaggcca ggtacatcta tgggaagccc gtgcagggcg
      901 tggcatacac acggtttgcg ctcatggatg agcaagggaa gaggactttc cttcggggcc
      961 tagagacgca ggccaagttg gtggaaggcc ggacccacat ttccatctca aaggaccagt
     1021 tccaggctgc cctggataaa atcaatattg gggtcagaga cctggagggg ctgcgtctct
     1081 atgctgctac agctgtcatc gagtctccag gaggagagat ggaggaggca gaactcacgt
     1141 cctggcgctt tgtatcatct gccttctcct tggatctcag ccgcactaag aggcatcttg
     1201 tgcctggggc ccacttcctg ctgcaggctc tggtccaaga aatgtcaggc tctgaagcct
     1261 ccaacgttcc tgttaaagtc tctgccacat tggtgtcagg ctctgactcc caagtccttg
     1321 acattcaaca gagcaccaat ggaattggcc aagtcagcat ttccttcccc atcccaccaa
     1381 ctgtcacaga acttcgactc ttggtgtctg cgggctccct ctacccagcc atagccaggc
     1441 tcaccgtgca agccccacct tcaagaggca ctggctttct ttctattgag ccactagacc
     1501 ctcggtcccc tagtgtgggg gacaccttta tcctaaacct tcaacctgtg ggcatccctg
     1561 cacctacctt ctctcattac tactacatga tcatctccag aggccagatc atggctatgg
     1621 gtcgggagcc ccggaagact gtgacctccg tctctgtgtt ggtggaccat cagctggctc
     1681 cctcgttcta ctttgtggct tacttctatc accaaggaca cccggtggcc aactctctgc
     1741 tcatcaacat ccaatccagg gactgtgagg gcaagctgca attgaaggtg gatggtgcca
     1801 aggagtatcg taatgcggac atgatgaagc tccgaattca aactgactcc aaagccctgg
     1861 tggcactggg agctgtggac atggctctgt atgctgtggg tggtcggtct cacaaacccc
     1921 tcgacatgag caaggtcttt gaagtaatca acagctacaa tgttggctgt ggtcctggag
     1981 gtggggatga tgcccttcag gtgttccagg atgctggtct ggccttttct gatggtgatc
     2041 gactaactca aaccagagag gacctgagct gtcccaagga gaagaaaagt cggcaaaaga
     2101 gaaatgttaa cttccagaag gctgtcagtg agaagttggg ccagtattct tctccagatg
     2161 ccaagcgctg ctgccaagac gggatgacga agctgcccat gaagcgtacc tgtgagcagc
     2221 gggctgcccg tgtgcctcag caggcctgcc gtgagccctt cttgtcctgt tgcaagtttg
     2281 ctgaggacct tcgcaggaac cagaccagga gccaggcaca ccttgcccga aacaaccaca
     2341 acatgctgca ggaggaagac ttgatagatg aagacgacat tcttgtgcgc acctccttcc
     2401 cagagaactg gctctggaga gtggaacctg tagacagctc caaactgttg acagtgtggc
     2461 ttcctgattc tatgaccaca tgggagattc atggtgtgag cctgtccaaa agcaaaggtc
     2521 tgtgtgtagc caagccaact cgtgttcgag tgttcagaaa attccacctg cacctgcgcc
     2581 tgcccatctc catccgccgc tttgagcagt ttgaattacg gcctgttctt tacaactatc
     2641 tgaatgatga tgtggctgtg agtgtccatg tgaccccagt tgaggggctg tgcctggctg
     2701 gtggtggaat gatggcccag caggtgacag tgccagcagg ttctgcccgg cctgtggcct
     2761 tctctgtggt acccacagct gctgccaacg tgcccctgaa ggtggtggct cgaggggttt
     2821 ttgatttagg ggatgctgtg tctaagattc tccaaattga gaaggaagga gccatccaca
     2881 gagaagagtt agtctacaac ctcgaccccc taaataacct gggtcggact ttggagattc
     2941 ctggcagctc ggatcccaac atcgtccctg acggagactt cagcagctta gtcagggtta
     3001 cagcctcgga acccttggag actatgggtt ctgaaggtgc cttgtcccca ggaggtgtgg
     3061 cctccctcct gaggcttccc cagggctgtg cagagcaaac catgatctat ttggctccta
     3121 ccctgactgc ttccaactac ctggacagga cagaacagtg gagcaaactg tcccctgaaa
     3181 caaaggacca tgctgtggat ctgatccaaa aaggatacat gaggatccag cagtttcgga
     3241 agaatgatgg ctcctttggg gcttggttac accgggacag cagcacctgg ctgactgcct
     3301 tcgtgctgaa gattctgagt ttggcccagg aacaggtggg caactccccg gagaagctgc
     3361 aggagacggc tagctggctg ctggcccagc agctgggtga tggctccttc cacgacccat
     3421 gtccagtcat ccacagagca atgcaggggg gcttggtggg gtctgacgag acagtggcac
     3481 tgaccgcctt tgtggtcatt gcccttcacc atgggttgga cgtcttccag gatgacgatg
     3541 cgaagcagct gaagaacaga gtggaagcct ccatcaccaa ggcaaactca ttcttggggc
     3601 agaaggcaag tgctgggctc ctgggtgccc atgccgccgc catcacagcc tatgccctta
     3661 cgctgaccaa ggcctcggag gacctgcgga atgttgccca caacagcctg atggccatgg
     3721 ctgaggaaac aggggaacac ctctactggg gcttagtcct tggctctcag gacaaagttg
     3781 tgttgcgccc cacagccccc cgtagcccta cagaacctgt gccccaggcc ccagccttgt
     3841 ggatcgaaac cacagcctat gccctgctcc acctgcttct gcgggaggga aagggaaaaa
     3901 tggctgacaa ggctgcatcc tggctcaccc accagggaag cttccatggg gcattccgca
     3961 gtacccagga cactgtggtc accctggatg ccctgtctgc ctactggatc gcttcgcaca
     4021 ccactgagga gaaagcactg aacgtgacgc tcagctccat gggccgcaat gggcttaaga
     4081 cccacgggct acacttgaac aaccaccaag tcaagggcct ggaggaggag ctaaagttct
     4141 ccctgggcag cacaatcagt gtcaaggtgg aaggaaacag caaaggcacc ttgaagatcc
     4201 ttcgtaccta caatgtcctg gacatgaaga acaccacatg ccaggacctt cagatagaag
     4261 tgaaggtcac aggcgctgtg gaatacgcat gggatgccaa tgaagactac gaagactact
     4321 atgacatgcc agccgcagat gaccccagcg tccccttgca gcctgtcacg cccctgcagc
     4381 tttttgaggg tcgtaggagc cgccgcagga gggaggcccc caaggtggtc gaagagcagg
     4441 agtccagagt tcagtacact gtgtgtatct ggcgaaatgg caagctgggg ctgtctggca
     4501 tggccatcgc agacatcacc ctcctaagtg gattccacgc cctgagggct gacctggaga
     4561 agctgacctc tctctctgac cgttacgtga gtcactttga gactgacggg ccccatgtcc
     4621 tgttgtactt tgactcggtc cctaccaccc gggagtgtgt gggcttcgga gcctcgcagg
     4681 aggtggttgt gggactggtg cagccatcca gtgctgtcct gtatgactac tacagccctg
     4741 atcacaagtg ctctgtgttt tatgctgcac ccaccaagag ccagctcctg gccacactgt
     4801 gctctggaga tgtatgccag tgcgctgagg ggaagtgccc tcgactgcta aggtcactgg
     4861 agcgaagggt ggaggacaag gacggctacc ggatgaggtt cgcctgctat tatccccgag
     4921 tggagtatgg cttcacggtt aaggttcttc gagaagatgg cagagctgcc ttccgtctct
     4981 ttgagtccaa gatcacccaa gtcctgcatt tcagaaagga caccatggcc tccataggtc
     5041 agacccgcaa cttcctgagc cgggcctctt gccgccttcg tttggagcct aacaaagagt
     5101 acttgatcat ggggatggac ggggaaacca gtgacaacaa gggagacccc cagtacttgc
     5161 tggactcaaa tacctggatt gaggagatgc cttcagaaca aatgtgcaag agcacccgcc
     5221 atcgggcagc ctgtttccag ctcaaagact tcctgatgga gttcagcagc cgggggtgcc
     5281 aggtgtgagg ccttaggact ctggctctct gagctcagct cagggttagg gcctcactgg
     5341 attagaggct ctgctctaca gggtaaataa aagaaaagct ttttgacagc caaaaaaaaa
     5401 aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
