LOCUS       NM_009779               4299 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus complement component 3a receptor 1 (C3ar1), mRNA.
ACCESSION   NM_009779
VERSION     NM_009779.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4299)
  AUTHORS   Stark,K., Kilani,B., Stockhausen,S., Busse,J., Schubert,I.,
            Tran,T.D., Gaertner,F., Leunig,A., Pekayvaz,K., Nicolai,L.,
            Fumagalli,V., Stermann,J., Stephan,F., David,C., Muller,M.B.,
            Heyman,B., Lux,A., da Palma Guerreiro,A., Frenzel,L.P.,
            Schmidt,C.Q., Dopler,A., Moser,M., Chandraratne,S., von Bruhl,M.L.,
            Lorenz,M., Korff,T., Rudelius,M., Popp,O., Kirchner,M., Mertins,P.,
            Nimmerjahn,F., Iannacone,M., Sperandio,M., Engelmann,B.,
            Verschoor,A. and Massberg,S.
  TITLE     Antibodies and complement are key drivers of thrombosis
  JOURNAL   Immunity 57 (9), 2140-2156 (2024)
   PUBMED   39226900
REFERENCE   2  (bases 1 to 4299)
  AUTHORS   Yang,L., Wu,J., Zhang,F., Zhang,L., Zhang,X., Zhou,J., Pang,J.,
            Xie,B., Xie,H., Jiang,Y. and Peng,J.
  TITLE     Microglia aggravate white matter injury via C3/C3aR pathway after
            experimental subarachnoid hemorrhage
  JOURNAL   Exp Neurol 379, 114853 (2024)
   PUBMED   38866102
  REMARK    GeneRIF: Microglia aggravate white matter injury via C3/C3aR
            pathway after experimental subarachnoid hemorrhage.
REFERENCE   3  (bases 1 to 4299)
  AUTHORS   Gedam,M. and Zheng,H.
  TITLE     Complement C3aR signaling: Immune and metabolic modulation and its
            impact on Alzheimer's disease
  JOURNAL   Eur J Immunol 54 (8), e2350815 (2024)
   PUBMED   38778507
  REMARK    GeneRIF: Complement C3aR signaling: Immune and metabolic modulation
            and its impact on Alzheimer's disease.
            Review article
REFERENCE   4  (bases 1 to 4299)
  AUTHORS   Ma,L., Gilani,A., Rubio-Navarro,A., Cortada,E., Li,A., Reilly,S.M.,
            Tang,L. and Lo,J.C.
  TITLE     Adipsin and adipocyte-derived C3aR1 regulate thermogenic fat in a
            sex-dependent fashion
  JOURNAL   JCI Insight 9 (11), e178925 (2024)
   PUBMED   38713526
  REMARK    GeneRIF: Adipsin and adipocyte-derived C3aR1 regulate thermogenic
            fat in a sex-dependent fashion.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4299)
  AUTHORS   Sun,R., Tang,M.Y., Yang,D., Zhang,Y.Y., Xu,Y.H., Qiao,Y., Yu,B.,
            Cao,S.X., Wang,H., Huang,H.Q., Zhang,H., Li,X.M. and Lian,H.
  TITLE     C3aR in the medial prefrontal cortex modulates the susceptibility
            to LPS-induced depressive-like behaviors through glutamatergic
            neuronal excitability
  JOURNAL   Prog Neurobiol 236, 102614 (2024)
   PUBMED   38641040
  REMARK    GeneRIF: C3aR in the medial prefrontal cortex modulates the
            susceptibility to LPS-induced depressive-like behaviors through
            glutamatergic neuronal excitability.
REFERENCE   6  (bases 1 to 4299)
  AUTHORS   Humbles,A.A., Lu,B., Nilsson,C.A., Lilly,C., Israel,E.,
            Fujiwara,Y., Gerard,N.P. and Gerard,C.
  TITLE     A role for the C3a anaphylatoxin receptor in the effector phase of
            asthma
  JOURNAL   Nature 406 (6799), 998-1001 (2000)
   PUBMED   10984054
REFERENCE   7  (bases 1 to 4299)
  AUTHORS   Lawson,P.R. and Reid,K.B.
  TITLE     A novel PCR-based technique using expressed sequence tags and gene
            homology for murine genetic mapping: localization of the complement
            genes
  JOURNAL   Int Immunol 12 (3), 231-240 (2000)
   PUBMED   10700458
REFERENCE   8  (bases 1 to 4299)
  AUTHORS   Hollmann,T.J., Haviland,D.L., Kildsgaard,J., Watts,K. and
            Wetsel,R.A.
  TITLE     Cloning, expression, sequence determination, and chromosome
            localization of the mouse complement C3a anaphylatoxin receptor
            gene
  JOURNAL   Mol Immunol 35 (3), 137-148 (1998)
   PUBMED   9694514
REFERENCE   9  (bases 1 to 4299)
  AUTHORS   Tornetta,M.A., Foley,J.J., Sarau,H.M. and Ames,R.S.
  TITLE     The mouse anaphylatoxin C3a receptor: molecular cloning, genomic
            organization, and functional expression
  JOURNAL   J Immunol 158 (11), 5277-5282 (1997)
   PUBMED   9164946
REFERENCE   10 (bases 1 to 4299)
  AUTHORS   Hsu,M.H., Ember,J.A., Wang,M., Prossnitz,E.R., Hugli,T.E. and
            Ye,R.D.
  TITLE     Cloning and functional characterization of the mouse C3a
            anaphylatoxin receptor gene
  JOURNAL   Immunogenetics 47 (1), 64-72 (1997)
   PUBMED   9382922
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB665738.1, U77460.1 and AK080984.1.
            
            On May 22, 2007 this sequence version replaced NM_009779.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BB665738.1, U77460.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               BB665738.1         1-154
            155-3481            U77460.1           3-3329
            3482-4299           AK080984.1         843-1660
FEATURES             Location/Qualifiers
     source          1..4299
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 57.93 cM"
     gene            1..4299
                     /gene="C3ar1"
                     /gene_synonym="AZ3B; C3AR; HNFAG09"
                     /note="complement component 3a receptor 1"
                     /db_xref="GeneID:12267"
                     /db_xref="MGI:MGI:1097680"
     exon            1..174
                     /gene="C3ar1"
                     /gene_synonym="AZ3B; C3AR; HNFAG09"
                     /inference="alignment:Splign:2.1.0"
     exon            175..4299
                     /gene="C3ar1"
                     /gene_synonym="AZ3B; C3AR; HNFAG09"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..1616
                     /gene="C3ar1"
                     /gene_synonym="AZ3B; C3AR; HNFAG09"
                     /note="C3a-R; anaphylatoxin C3a receptor"
                     /codon_start=1
                     /product="C3a anaphylatoxin chemotactic receptor"
                     /protein_id="NP_033909.1"
                     /db_xref="CCDS:CCDS20504.1"
                     /db_xref="GeneID:12267"
                     /db_xref="MGI:MGI:1097680"
                     /translation="MESFDADTNSTDLHSRPLFQPQDIASMVILGLTCLLGLLGNGLV
                     LWVAGVKMKTTVNTVWFLHLTLADFLCCLSLPFSLAHLILQGHWPYGLFLCKLIPSII
                     ILNMFASVFLLTAISLDRCLIVHKPIWCQNHRNVRTAFAICGCVWVVAFVMCVPVFVY
                     RDLFIMDNRSICRYNFDSSRSYDYWDYVYKLSLPESNSTDNSTAQLTGHMNDRSAPSS
                     VQARDYFWTVTTALQSQPFLTSPEDSFSLDSANQQPHYGGKPPNVLTAAVPSGFPVED
                     RKSNTLNADAFLSAHTELFPTASSGHLYPYDFQGDYVDQFTYDNHVPTPLMAITITRL
                     VVGFLVPFFIMVICYSLIVFRMRKTNFTKSRNKTFRVAVAVVTVFFICWTPYHLVGVL
                     LLITDPESSLGEAVMSWDHMSIALASANSCFNPFLYALLGKDFRKKARQSIKGILEAA
                     FSEELTHSTNCTQDKASSKRNNMSTDV"
     regulatory      1748..1753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C3ar1"
                     /gene_synonym="AZ3B; C3AR; HNFAG09"
                     /note="hexamer: ATTAAA"
     polyA_site      1774
                     /gene="C3ar1"
                     /gene_synonym="AZ3B; C3AR; HNFAG09"
                     /note="major polyA site"
     regulatory      1904..1909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C3ar1"
                     /gene_synonym="AZ3B; C3AR; HNFAG09"
                     /note="hexamer: AATGAA"
     polyA_site      1926
                     /gene="C3ar1"
                     /gene_synonym="AZ3B; C3AR; HNFAG09"
ORIGIN      
        1 tgtgcagtca gatagcagtc atgatcctga gttcccttta cccagggaaa agtcagtgct
       61 cagcaactcg tccaatgcac ttcactactt cattttggct ggaccagaca ggatttgttg
      121 gtggctcgca gatcatcagt cctggagcct ttggattcca tctcagtgtg cttgactgag
      181 ccatggagtc tttcgatgct gacaccaatt caactgacct acactcacgg cctctgtttc
      241 aaccccaaga cattgcctcc atggtcattc ttggtctcac ttgtctattg ggactgctag
      301 gcaatgggct ggtgctgtgg gtagctggcg taaagatgaa gacgaccgtg aacacagtct
      361 ggttcctcca tctcaccctg gccgatttcc tctgctgcct ctccttgccc ttctccttgg
      421 ctcacctgat tctccaagga cactggccct atggcttgtt cctgtgcaaa cttatcccat
      481 ccatcattat tctcaacatg tttgccagtg tcttcctgct tactgccatt agcctggacc
      541 gatgtctgat agtacataag ccaatctggt gccagaatca tcgaaacgtg agaaccgcct
      601 tcgccatctg tggatgtgtc tgggtggtag cctttgtgat gtgtgtgccc gtatttgtat
      661 accgtgatct gttcattatg gacaatcgca gtatatgtag atataatttt gattcctcca
      721 ggtcatatga ttattgggac tacgtgtaca aactaagtct accagaaagc aattctactg
      781 ataactccac tgctcagcta actggacata tgaatgacag gtcagctcct tcctctgtac
      841 aggcaaggga ttacttttgg acagttacca ctgccctcca gtcacagcca ttcctaacat
      901 ctcctgaaga ctcattctct ctagattcag caaaccaaca accccattat ggtggaaagc
      961 ctcctaatgt cctcacagcc gccgtaccca gcgggtttcc tgttgaagat cgtaaatcca
     1021 atacactgaa cgctgacgct tttctctctg ctcacacaga acttttccct actgcttcta
     1081 gtggtcattt atacccctat gatttccagg gggattatgt tgaccaattc acgtatgaca
     1141 atcatgtgcc gacaccgctg atggcaataa ccatcacaag gctggtggtg ggcttcctgg
     1201 tgccgttttt catcatggta atttgttaca gcctcatcgt cttcagaatg cgaaaaacca
     1261 acttcaccaa gtctcggaac aaaacctttc gggtggctgt ggctgtggtc actgtctttt
     1321 ttatctgctg gactccatac catcttgtcg gagtcctgct attgattact gatccagaaa
     1381 gttccttggg ggaagctgtg atgtcctggg accacatgtc cattgcttta gcatctgcca
     1441 atagttgctt caaccctttc ctgtatgccc tcttggggaa agactttagg aagaaagcaa
     1501 gacagtctat aaagggcatt ctggaagcag ccttcagcga agagctcacg cactctacca
     1561 actgtaccca agacaaagcc tcttcaaaaa gaaacaatat gagtacagat gtgtgaagat
     1621 gtggccctgg gaacctaagc agagttctca ggtgaacagt gatggatgac atgtgagcag
     1681 gacactttag acaatttggc gactctcaga gaaaggtctc ttattgacat cagcatcatt
     1741 tgaaaacatt aaagatgcaa aatttcaagc cccatcccag atgtgttgac tcagaatctc
     1801 tggcccatgg gaccagtgtt ttaacaggcc ttcttgtttc catcagtgtt aagttttacc
     1861 tcatttggct tagtctattc ccatccctga ctacaccatg tgcaatgaat aactttttca
     1921 tctgttttca gtattctttt tttttcctta gcatcatcta aacttctagt ttgcatggaa
     1981 ggctgctctt attgttctga atggaagata ttcatttatt gtacagtttt gtggtggtga
     2041 caagtgattt ttaagtgggg aaagagacac agtaagaaaa gatctatgaa agcagggagt
     2101 gttgagttag agtttgacag aacacagtgc caaatgccac ccactaaaag caacctgaga
     2161 taattccagt gttcatgtga gcaagtgagc acagatacac ataaacactt tcctactcct
     2221 ggagtgtttt agaagttgta gcttggagct ctctcttccc tgtgtattct gcttgttcat
     2281 agagccatct atgttccatt tctttttgtt tgttggtttg gcttcttgtg ttggttggtt
     2341 ggttggttgg ttggttggtt ggttggttgg ttgcttggtt ggttggttgg ttggttggtt
     2401 ggttgcttgg ttgcttggtt tactgttttt tcaagacagt agccctggct gtcctgaaac
     2461 tcattctgta gaccaaactg gcctgaaact cagagatcag tgtgcctctg cctccaagga
     2521 gtcttcttaa ggtcttgaat tcctttctgt tttccacaca gggccttgcc atctcctgct
     2581 gggattaggc gtgtgcaggt gtgcagtacg tacctggccc catcgtcttc ggctttttac
     2641 attagacttt gtatctcaca tagaataaaa caatatccta atgggatgat gggtggaact
     2701 tcaggatcaa tgcatgcttc aacagcaata tcaaaagatt ttaaacatga gtctaggtat
     2761 cttacatgac aaaagtgtca ggcacactct cttttttttc ttttcttttc ttttcttttt
     2821 ttttttttca aattaatgtt tgcctggacc atgctaatat aaagtactgt atgcagccaa
     2881 ttttaaagga actaattaaa aatgaaataa aaaagggtgg tttctccagt gcccagtagt
     2941 tcccatctct ccctactttg caagaattgt agctgttcct tctgatattt accatggtgt
     3001 gcctaaaaca cctcttatgc tgctgatctt tgtagacagg aagaaaaggc tgtcttgatt
     3061 ttgatttact ttacctacat tttcatccag caccccagtg ttgactggta tcacacatta
     3121 atctgttcgt gatcattttt ctcttccctt tgttgtcggg ttttgcttgc cttcgtgcca
     3181 tcatctcagt gtagcacaca caatctagct tcagactccc aggtctcttg ttatagtaac
     3241 cagatgagca ccaccaccat ccccaccccc agctgaccac acaattttcc tgtcaataca
     3301 tttcaatagc atacagcttt tctctgtcct ctcatttttc atgctgacat atattaattg
     3361 tacatattaa taaggttcca cgtggctgat ccatccatgc acacaacatt cacactttca
     3421 cccccagcct cttctttatc attattctac ttactgattg actttaaaaa aaaaaaaaaa
     3481 agtctgaaga atctcatgct ggccttaaaa tcactatgca accaaaaatg agtttgaaat
     3541 tcaaatcctc ctgcctccca tgggctgtga ttataggcat ggaacactat gcccactctt
     3601 atgtggtact gggactcaaa accagggctt catgcatagt cgttaagcat cctaccaact
     3661 aaactactct gcacccgccc cccagcctgc tcaggttgac atttctggcc ctcatatatg
     3721 agactatgtg atacgtatgt gtccattcac atccattctg ttaaaaccag tatttcactc
     3781 attgttatgg ctgaataaca ctgcactgtg tatgtgcatg cacacgcatg tgtgtacatg
     3841 tgtatgtgca cgtgtgtgta gtaagtgcca ttatccaccc aactaccaac caatgcctaa
     3901 gcagattcta tatcttagct attatacata gtactacact caacctttag tttaaaaaaa
     3961 gaaaaccagc agctcccata ataatctatt atgtggatac tttccatgtg ttaaatcact
     4021 agaaagtcaa gcttgtttgt acagataggt atgtctaaga tgaacgagtt aatctacaaa
     4081 gacggaagat ggaatgtagt ttagtcttgt gatacattat ttattcagtt gtcaagagaa
     4141 gggccttagg ctacaactgt tgtatgaaca attatgtgga aatttcaaat cactaaaaga
     4201 tcttgtttac tacgaggtaa ttctgggcat aagactgcag ttctgccttt ccagtatgag
     4261 cggtttacat attccctatg aataaatgct tttatctac
//
