LOCUS       NM_009778               5139 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus complement component 3 (C3), mRNA.
ACCESSION   NM_009778
VERSION     NM_009778.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5139)
  AUTHORS   Moldovan,G.E., Massri,N., Vegter,E.L., Pauneto-Delgado,I.N.,
            Burns,G.W., Joshi,N., Gu,B., Arora,R. and Fazleabas,A.T.
  TITLE     YAP1 and WWTR1 are required for murine pregnancy initiation
  JOURNAL   Reproduction 169 (1), e240355 (2025)
   PUBMED   39503541
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5139)
  AUTHORS   Francisco da Silva,T., Akemi Amamura,T., Cordeiro Valadao,I.,
            Carvalho Carneiro,M., Morais Freitas,V., Paula Lepique,A. and
            Isaac,L.
  TITLE     Complement system component 3 deficiency modulates the phenotypic
            profile of murine macrophages
  JOURNAL   Cell Immunol 405-406, 104886 (2024)
   PUBMED   39503081
REFERENCE   3  (bases 1 to 5139)
  AUTHORS   Song,H.J., Kim,J.E., Roh,Y.J., Seol,A., Kim,T.R., Park,K.H.,
            Park,E.S., Hong,J.T., Choi,S.I. and Hwang,D.Y.
  TITLE     Novel Role of the ALPI Gene Associated with Constipation Caused by
            Complement Component 3 Deficiency
  JOURNAL   Int J Mol Sci 25 (17), 9530 (2024)
   PUBMED   39273477
  REMARK    GeneRIF: Novel Role of the ALPI Gene Associated with Constipation
            Caused by Complement Component 3 Deficiency.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5139)
  AUTHORS   Zhu,A., Baur,C., Gotz,P., Elbs,K., Lasch,M., Faro,A.,
            Preissner,K.T. and Deindl,E.
  TITLE     The Complement System Is Essential for Arteriogenesis by Enhancing
            Sterile Inflammation as a Relevant Step in Collateral Artery Growth
  JOURNAL   Cells 13 (17), 1405 (2024)
   PUBMED   39272977
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5139)
  AUTHORS   Paglialunga,S., Fisette,A., Yan,Y., Deshaies,Y., Brouillette,J.F.,
            Pekna,M. and Cianflone,K.
  TITLE     Acylation-stimulating protein deficiency and altered adipose tissue
            in alternative complement pathway knockout mice
  JOURNAL   Am J Physiol Endocrinol Metab 294 (3), E521-E529 (2008)
   PUBMED   18160458
  REMARK    GeneRIF: reduction/deficiency in acylation stimulating protein
            (ASP) is associated with an antiadipogenic state and ASP may
            provide a target for controlling fat storage
REFERENCE   6  (bases 1 to 5139)
  AUTHORS   Sahu,A. and Lambris,J.D.
  TITLE     Structure and biology of complement protein C3, a connecting link
            between innate and acquired immunity
  JOURNAL   Immunol Rev 180, 35-48 (2001)
   PUBMED   11414361
  REMARK    Review article
REFERENCE   7  (bases 1 to 5139)
  AUTHORS   Fey,G., Domdey,H., Wiebauer,K., Whitehead,A.S. and Odink,K.
  TITLE     Structure and expression of the C3 gene
  JOURNAL   Springer Semin Immunopathol 6 (2-3), 119-147 (1983)
   PUBMED   6356427
  REMARK    Review article
REFERENCE   8  (bases 1 to 5139)
  AUTHORS   Rubinstein,P., Vienne,K. and Hoecker,G.F.
  TITLE     The location of the C3 and GLO (glyoxalase 1) loci of the IXth
            linkage group in mice
  JOURNAL   J Immunol 122 (6), 2584-2589 (1979)
   PUBMED   448134
REFERENCE   9  (bases 1 to 5139)
  AUTHORS   Natsuume-Sakai,S., Amano,S., Hayakawa,J.I. and Takahashi,M.
  TITLE     Preparation of an alloantiserum to murine C3 and demonstration of
            multiple alleles
  JOURNAL   J Immunol 121 (5), 2025-2029 (1978)
   PUBMED   101594
REFERENCE   10 (bases 1 to 5139)
  AUTHORS   Da Silva,F.P., Hoecker,G.F., Day,N.K., Vienne,K. and Rubinstein,P.
  TITLE     Murine complement component 3: genetic variation and linkage to H-2
  JOURNAL   Proc Natl Acad Sci U S A 75 (2), 963-965 (1978)
   PUBMED   273258
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CT025692.15.
            
            On Mar 21, 2015 this sequence version replaced NM_009778.2.
            
            Summary: This gene encodes complement protein C3 which plays a
            central role in the classical, alternative and lectin activation
            pathways of the complement system. The encoded preproprotein
            undergoes a multi-step processing to generate various functional
            peptides. Mice deficient in the encoded protein fail to clear
            bacteria from the blood stream upon infection, display diminished
            airway hyperresponsiveness and lung eosinophilia upon
            allergen-induced pulmonary allergy, and develop severe lung injury
            after deposition of IgG immune complexes. Deficiency of the homolog
            of the encoded protein in humans was found to be associated with
            increased susceptibility to infections, age-related macular
            degeneration, and atypical hemolytic uremic syndrome. [provided by
            RefSeq, Mar 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043338.1, K02782.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               CT025692.15        111161-111341       c
            182-371             CT025692.15        109898-110087       c
            372-537             CT025692.15        109371-109536       c
            538-608             CT025692.15        109202-109272       c
            609-703             CT025692.15        108421-108515       c
            704-786             CT025692.15        108240-108322       c
            787-877             CT025692.15        108058-108148       c
            878-980             CT025692.15        107849-107951       c
            981-1107            CT025692.15        107492-107618       c
            1108-1223           CT025692.15        107268-107383       c
            1224-1370           CT025692.15        107036-107182       c
            1371-1580           CT025692.15        106326-106535       c
            1581-1787           CT025692.15        105994-106200       c
            1788-1943           CT025692.15        105401-105556       c
            1944-2073           CT025692.15        105094-105223       c
            2074-2145           CT025692.15        104528-104599       c
            2146-2346           CT025692.15        104178-104378       c
            2347-2455           CT025692.15        103299-103407       c
            2456-2541           CT025692.15        102745-102830       c
            2542-2684           CT025692.15        102003-102145       c
            2685-2897           CT025692.15        101664-101876       c
            2898-2964           CT025692.15        100471-100537       c
            2965-3051           CT025692.15        100290-100376       c
            3052-3255           CT025692.15        98934-99137         c
            3256-3331           CT025692.15        98319-98394         c
            3332-3491           CT025692.15        97881-98040         c
            3492-3590           CT025692.15        96971-97069         c
            3591-3747           CT025692.15        95810-95966         c
            3748-3911           CT025692.15        94777-94940         c
            3912-4070           CT025692.15        93370-93528         c
            4071-4130           CT025692.15        92794-92853         c
            4131-4221           CT025692.15        92616-92706         c
            4222-4273           CT025692.15        92444-92495         c
            4274-4361           CT025692.15        90737-90824         c
            4362-4451           CT025692.15        90539-90628         c
            4452-4557           CT025692.15        89395-89500         c
            4558-4647           CT025692.15        88861-88950         c
            4648-4731           CT025692.15        88502-88585         c
            4732-4815           CT025692.15        87672-87755         c
            4816-4951           CT025692.15        87456-87591         c
            4952-5139           CT025692.15        87172-87359         c
FEATURES             Location/Qualifiers
     source          1..5139
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.72 cM"
     gene            1..5139
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /note="complement component 3"
                     /db_xref="GeneID:12266"
                     /db_xref="MGI:MGI:88227"
     exon            1..181
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..5093
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /EC_number="3.4.21.43"
                     /note="complement C3; complement component 3d; complement
                     factor 3; acylation stimulating protein"
                     /codon_start=1
                     /product="complement C3 preproprotein"
                     /protein_id="NP_033908.2"
                     /db_xref="CCDS:CCDS37670.1"
                     /db_xref="GeneID:12266"
                     /db_xref="MGI:MGI:88227"
                     /translation="MGPASGSQLLVLLLLLASSPLALGIPMYSIITPNVLRLESEETI
                     VLEAHDAQGDIPVTVTVQDFLKRQVLTSEKTVLTGASGHLRSVSIKIPASKEFNSDKE
                     GHKYVTVVANFGETVVEKAVMVSFQSGYLFIQTDKTIYTPGSTVLYRIFTVDNNLLPV
                     GKTVVILIETPDGIPVKRDILSSNNQHGILPLSWNIPELVNMGQWKIRAFYEHAPKQI
                     FSAEFEVKEYVLPSFEVRVEPTETFYYIDDPNGLEVSIIAKFLYGKNVDGTAFVIFGV
                     QDGDKKISLAHSLTRVVIEDGVGDAVLTRKVLMEGVRPSNADALVGKSLYVSVTVILH
                     SGSDMVEAERSGIPIVTSPYQIHFTKTPKFFKPAMPFDLMVFVTNPDGSPASKVLVVT
                     QGSNAKALTQDDGVAKLSINTPNSRQPLTITVRTKKDTLPESRQATKTMEAHPYSTMH
                     NSNNYLHLSVSRMELKPGDNLNVNFHLRTDPGHEAKIRYYTYLVMNKGKLLKAGRQVR
                     EPGQDLVVLSLPITPEFIPSFRLVAYYTLIGASGQREVVADSVWVDVKDSCIGTLVVK
                     GDPRDNHLAPGQQTTLRIEGNQGARVGLVAVDKGVFVLNKKNKLTQSKIWDVVEKADI
                     GCTPGSGKNYAGVFMDAGLAFKTSQGLQTEQRADLECTKPAARRRRSVQLMERRMDKA
                     GQYTDKGLRKCCEDGMRDIPMRYSCQRRARLITQGENCIKAFIDCCNHITKLREQHRR
                     DHVLGLARSELEEDIIPEEDIISRSHFPQSWLWTIEELKEPEKNGISTKVMNIFLKDS
                     ITTWEILAVSLSDKKGICVADPYEIRVMQDFFIDLRLPYSVVRNEQVEIRAVLFNYRE
                     QEELKVRVELLHNPAFCSMATAKNRYFQTIKIPPKSSVAVPYVIVPLKIGQQEVEVKA
                     AVFNHFISDGVKKTLKVVPEGMRINKTVAIHTLDPEKLGQGGVQKVDVPAADLSDQVP
                     DTDSETRIILQGSPVVQMAEDAVDGERLKHLIVTPAGCGEQNMIGMTPTVIAVHYLDQ
                     TEQWEKFGIEKRQEALELIKKGYTQQLAFKQPSSAYAAFNNRPPSTWLTAYVVKVFSL
                     AANLIAIDSHVLCGAVKWLILEKQKPDGVFQEDGPVIHQEMIGGFRNAKEADVSLTAF
                     VLIALQEARDICEGQVNSLPGSINKAGEYIEASYMNLQRPYTVAIAGYALALMNKLEE
                     PYLGKFLNTAKDRNRWEEPDQQLYNVEATSYALLALLLLKDFDSVPPVVRWLNEQRYY
                     GGGYGSTQATFMVFQALAQYQTDVPDHKDLNMDVSFHLPSRSSATTFRLLWENGNLLR
                     SEETKQNEAFSLTAKGKGRGTLSVVAVYHAKLKSKVTCKKFDLRVSIRPAPETAKKPE
                     EAKNTMFLEICTKYLGDVDATMSILDISMMTGFAPDTKDLELLASGVDRYISKYEMNK
                     AFSNKNTLIIYLEKISHTEEDCLTFKVHQYFNVGLIQPGSVKVYSYYNLEESCTRFYH
                     PEKDDGMLSKLCHSEMCRCAEENCFMQQSQEKINLNVRLDKACEPGVDYVYKTELTNI
                     ELLDDFDEYTMTIQQVIKSGSDEVQAGQQRKFISHIKCRNALKLQKGKKYLMWGLSSD
                     LWGEKPNTSYIIGKDTWVEHWPEAEECQDQKYQKQCEELGAFTESMVVYGCPN"
     exon            182..371
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            372..537
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            538..608
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            609..703
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            704..786
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            787..877
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            878..980
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1107
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1223
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1370
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1580
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1787
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1943
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2073
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2145
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2346
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2455
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..2541
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..2684
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..2897
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..2964
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3051
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            3052..3255
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            3256..3331
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            3332..3491
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            3492..3590
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            3591..3747
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            3748..3911
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            3912..4070
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            4071..4130
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            4131..4221
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            4222..4273
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            4274..4361
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            4362..4451
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            4452..4557
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            4558..4647
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            4648..4731
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            4732..4815
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            4816..4951
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            4952..5139
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5111..5116
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /note="hexamer: AATAAA"
     polyA_site      5137
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /note="major polyA site"
ORIGIN      
        1 agagaggaga gccatataaa gagccagcgg ctacagcccc agctcgcctc tgcccacccc
       61 tgccccttac cccttcattc cttccacctt tttccttcac tatgggacca gcttcagggt
      121 cccagctact agtgctactg ctgctgttgg ccagctcccc attagctctg gggatcccca
      181 tgtattccat cattactccc aatgtcctac ggctggagag cgaagagacc atcgtactgg
      241 aggcccacga tgctcagggt gacatcccag tcacagtcac tgtgcaagac ttcctaaaga
      301 ggcaagtgct gaccagtgag aagacagtgt tgacaggagc cagtggacat ctgagaagcg
      361 tctccatcaa gattccagcc agtaaggaat tcaactcaga taaggagggg cacaagtacg
      421 tgacagtggt ggcaaacttc ggggaaacgg tggtggagaa agcagtgatg gtaagcttcc
      481 agagtgggta cctcttcatc cagacagaca agaccatcta cacccctggc tccactgtct
      541 tatatcggat cttcactgtg gacaacaacc tactgcccgt gggcaagaca gtcgtcatcc
      601 tcattgagac ccccgatggc attcctgtca agagagacat tctgtcttcc aacaaccaac
      661 acggcatctt gcctttgtct tggaacattc ctgaactggt caacatgggg cagtggaaga
      721 tccgagcctt ttacgaacat gcgccgaagc agatcttctc cgcagagttt gaggtgaagg
      781 aatacgtgct gcccagtttt gaggtccggg tggagcccac agagacattt tattacatcg
      841 atgacccaaa tggcctggaa gtttccatca tagccaagtt cctgtacggg aaaaacgtgg
      901 acgggacagc cttcgtgatt tttggggtcc aggatggcga taagaagatt tctctggccc
      961 actccctcac gcgcgtagtg attgaggatg gtgtggggga tgcagtgctg acccggaagg
     1021 tgctgatgga gggggtacgg ccttccaacg ccgacgccct ggtggggaag tccctgtatg
     1081 tctccgtcac tgtcatcctg cactcaggta gtgacatggt agaggcagag cgcagtggga
     1141 tcccgattgt cacttccccg taccagatcc acttcaccaa gacacccaaa ttcttcaagc
     1201 cagccatgcc ctttgacctc atggtgttcg tgaccaaccc cgatggctct ccggccagca
     1261 aagtgctggt ggtcactcag ggatctaatg caaaggctct cacccaagat gatggcgtgg
     1321 ccaagctaag catcaacaca cccaacagcc gccaacccct gaccatcaca gtccgcacca
     1381 agaaggacac tctcccagaa tcacggcagg ccaccaagac aatggaggcc catccctaca
     1441 gcactatgca caactccaac aactacctac acttgtcagt gtcacgaatg gagctcaagc
     1501 cgggggacaa cctcaatgtc aacttccacc tgcgcacaga cccaggccat gaggccaaga
     1561 tccgatacta cacctacctg gttatgaaca aggggaagct cctgaaggca ggccgccagg
     1621 ttcgggagcc tggccaggac ctggtggtct tgtccctgcc catcactcca gagtttattc
     1681 cttcatttcg cctggtggct tactacaccc tgattggagc tagtggccag agggaggtgg
     1741 tggctgactc tgtgtgggtg gatgtgaagg attcctgtat tggcacgctg gtggtgaagg
     1801 gtgacccaag agataaccat ctcgcacctg ggcaacaaac gacactcagg attgaaggaa
     1861 accagggggc ccgagtgggg ctagtggctg tggacaaggg agtgtttgtg ctgaacaaga
     1921 agaacaaact cacacagagc aagatctggg atgtggtaga gaaggcagac attggctgca
     1981 ccccaggcag tgggaagaac tatgctggtg tcttcatgga tgcaggcctg gccttcaaga
     2041 caagccaagg actgcagact gaacagagag cagatcttga gtgcaccaag ccagcagccc
     2101 gccgccgtcg ctcagtacag ttgatggaaa gaaggatgga caaagctggt cagtacactg
     2161 acaagggtct tcggaagtgt tgtgaggatg gtatgcggga tatccctatg agatacagct
     2221 gccagcgccg ggcacgcctc atcacccagg gcgagaactg cataaaggcc ttcatagact
     2281 gctgcaacca catcaccaag ctgcgtgaac aacacagaag agaccacgtg ctgggcctgg
     2341 ccaggagtga attggaggaa gacataattc cagaagaaga tattatctct agaagccact
     2401 tcccacagag ctggttgtgg accatagaag agttgaaaga accagagaaa aatggaatct
     2461 ctacgaaggt catgaacatc tttctcaaag attccatcac cacctgggag attctggcag
     2521 tgagcttgtc agacaagaaa gggatctgtg tggcagaccc ctatgagatc agagtgatgc
     2581 aggacttctt cattgacctg cggctgccct actctgtagt gcgcaacgaa caggtggaga
     2641 tcagagctgt gctcttcaac taccgtgaac aggaggaact taaggtgagg gtggaactgt
     2701 tgcataatcc agccttctgc agcatggcca ccgccaagaa tcgctacttc cagaccatca
     2761 aaatccctcc caagtcctcg gtggctgtac cgtatgtcat tgtccccttg aagatcggcc
     2821 aacaagaggt ggaggtcaag gctgctgtct tcaatcactt catcagtgat ggtgtcaaga
     2881 agacactgaa ggtcgtgcca gaaggaatga gaatcaacaa aactgtggcc atccatacac
     2941 tggacccaga gaagctcggt caagggggag tgcagaaggt ggatgtgcct gccgcagacc
     3001 ttagcgacca agtgccagac acagactctg agaccagaat tatcctgcaa gggagcccgg
     3061 tggttcagat ggctgaagat gctgtggacg gggagcggct gaaacacctg atcgtgaccc
     3121 ccgcaggctg tggggaacag aacatgattg gcatgacacc aacagtcatt gcggtacact
     3181 acctggacca gaccgaacag tgggagaagt tcggcataga gaagaggcaa gaggccctgg
     3241 agctcatcaa gaaagggtac acccagcagc tggccttcaa acagcccagc tctgcctatg
     3301 ctgccttcaa caaccggccc cccagcacct ggctgacagc ctacgtggtc aaggtcttct
     3361 ctctagctgc caacctcatc gccatcgact ctcacgtcct gtgtggggct gttaaatggt
     3421 tgattctgga gaaacagaag ccggatggtg tctttcagga ggatgggccc gtgattcacc
     3481 aagaaatgat tggtggcttc cggaacgcca aggaggcaga tgtgtcactc acagccttcg
     3541 tcctcatcgc actgcaggaa gccagggaca tctgtgaggg gcaggtcaat agccttcctg
     3601 ggagcatcaa caaggcaggg gagtatattg aagccagtta catgaacctg cagagaccat
     3661 acacagtggc cattgctggg tatgccctgg ccctgatgaa caaactggag gaaccttacc
     3721 tcggcaagtt tctgaacaca gccaaagatc ggaaccgctg ggaggagcct gaccagcagc
     3781 tctacaacgt agaggccaca tcctacgccc tcctggccct gctgctgctg aaagactttg
     3841 actctgtgcc ccctgtagtg cgctggctca atgagcaaag atactacgga ggcggctatg
     3901 gctccaccca ggctaccttc atggtattcc aagccttggc ccaatatcaa acagatgtcc
     3961 ctgaccataa ggacttgaac atggatgtgt ccttccacct ccccagccgt agctctgcaa
     4021 ccacgtttcg cctgctctgg gaaaatggca acctcctgcg atcggaagag accaagcaaa
     4081 atgaggcctt ctctctaaca gccaaaggaa aaggccgagg cacattgtcg gtggtggcag
     4141 tgtatcatgc caaactcaaa agcaaagtca cctgcaagaa gtttgacctc agggtcagca
     4201 taagaccagc ccctgagaca gccaagaagc ccgaggaagc caagaatacc atgttccttg
     4261 aaatctgcac caagtacttg ggagatgtgg acgccactat gtccatcctg gacatctcca
     4321 tgatgactgg ctttgctcca gacacaaagg acctggaact gctggcctct ggagtagata
     4381 gatacatctc caagtacgag atgaacaaag ccttctccaa caagaacacc ctcatcatct
     4441 acctagaaaa gatttcacac accgaagaag actgcctgac cttcaaagtt caccagtact
     4501 ttaatgtggg acttatccag cccgggtcgg tcaaggtcta ctcctattac aacctcgagg
     4561 aatcatgcac ccggttctat catccagaga aggacgatgg gatgctcagc aagctgtgcc
     4621 acagtgaaat gtgccggtgt gctgaagaga actgcttcat gcaacagtca caggagaaga
     4681 tcaacctgaa tgtccggcta gacaaggctt gtgagcccgg agtcgactat gtgtacaaga
     4741 ccgagctaac caacatagag ctgttggatg attttgatga gtacaccatg accatccagc
     4801 aggtcatcaa gtcaggctca gatgaggtgc aggcagggca gcaacgcaag ttcatcagcc
     4861 acatcaagtg cagaaacgcc ctgaagctgc agaaagggaa gaagtacctc atgtggggcc
     4921 tctcctctga cctctgggga gaaaagccca acaccagcta catcattggg aaggacacgt
     4981 gggtggagca ctggcctgag gcagaagaat gccaggatca gaagtaccag aaacagtgcg
     5041 aagaacttgg ggcattcaca gaatctatgg tggtttatgg ttgtcccaac tgactacagc
     5101 ccagccctct aataaagctt cagttgtatt tcacccatc
//
