LOCUS       NM_026600               7029 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Mus musculus C2 calcium dependent domain containing 6 (C2cd6),
            transcript variant 1, mRNA.
ACCESSION   NM_026600
VERSION     NM_026600.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7029)
  AUTHORS   Hwang,J.Y., Wang,H., Lu,Y., Ikawa,M. and Chung,J.J.
  TITLE     C2cd6-encoded CatSpertau targets sperm calcium channel to Ca2+
            signaling domains in the flagellar membrane
  JOURNAL   Cell Rep 38 (3), 110226 (2022)
   PUBMED   34998468
REFERENCE   2  (bases 1 to 7029)
  AUTHORS   Yang,F., Gracia Gervasi,M., Orta,G., Tourzani,D.A., De la
            Vega-Beltran,J.L., Ruthel,G., Darszon,A., Visconti,P.E. and
            Wang,P.J.
  TITLE     C2CD6 regulates targeting and organization of the CatSper calcium
            channel complex in sperm flagella
  JOURNAL   Development 149 (2) (2022)
   PUBMED   34919125
  REMARK    GeneRIF: C2CD6 regulates targeting and organization of the CatSper
            calcium channel complex in sperm flagella.
            GeneRIF: C2CD6 associates with the CatSper calcium-selective core
            forming subunits. Deficiency of C2CD6 depletes the CatSper
            nanodomains from the flagellum and results in male sterility.
            C2CD6-deficient sperm are defective in hyperactivation and fail to
            fertilize oocytes both in vitro and in vivo. CatSper currents are
            present but at a significantly lower level in C2CD6-deficient
            sperm.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133162.4 and AC169382.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849381, SAMN00849383
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 5' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-396               AC133162.4         99890-100285        c
            397-483             AC133162.4         83275-83361         c
            484-535             AC133162.4         82063-82114         c
            536-681             AC133162.4         80389-80534         c
            682-807             AC133162.4         75109-75234         c
            808-852             AC133162.4         74075-74119         c
            853-921             AC133162.4         73169-73237         c
            922-1001            AC133162.4         71542-71621         c
            1002-1136           AC133162.4         67788-67922         c
            1137-1242           AC133162.4         65964-66069         c
            1243-1306           AC133162.4         64048-64111         c
            1307-1344           AC133162.4         57888-57925         c
            1345-1632           AC133162.4         56390-56677         c
            1633-1669           AC133162.4         28271-28307         c
            1670-1731           AC133162.4         24142-24203         c
            1732-1794           AC133162.4         18026-18088         c
            1795-1869           AC133162.4         15461-15535         c
            1870-6543           AC133162.4         8533-13206          c
            6544-7029           AC169382.2         35844-36329         c
FEATURES             Location/Qualifiers
     source          1..7029
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 29.2 cM"
     gene            1..7029
                     /gene="C2cd6"
                     /gene_synonym="1700052H20Rik; 4930408G06Rik; Als2cr11;
                     Als2cr11b; C2cd6b; Gm33589"
                     /note="C2 calcium dependent domain containing 6"
                     /db_xref="GeneID:73463"
                     /db_xref="MGI:MGI:1920713"
     exon            1..396
                     /gene="C2cd6"
                     /gene_synonym="1700052H20Rik; 4930408G06Rik; Als2cr11;
                     Als2cr11b; C2cd6b; Gm33589"
                     /inference="alignment:Splign:2.1.0"
     exon            397..483
                     /gene="C2cd6"
                     /gene_synonym="1700052H20Rik; 4930408G06Rik; Als2cr11;
                     Als2cr11b; C2cd6b; Gm33589"
                     /inference="alignment:Splign:2.1.0"
     exon            484..535
                     /gene="C2cd6"
                     /gene_synonym="1700052H20Rik; 4930408G06Rik; Als2cr11;
                     Als2cr11b; C2cd6b; Gm33589"
                     /inference="alignment:Splign:2.1.0"
     exon            536..681
                     /gene="C2cd6"
                     /gene_synonym="1700052H20Rik; 4930408G06Rik; Als2cr11;
                     Als2cr11b; C2cd6b; Gm33589"
                     /inference="alignment:Splign:2.1.0"
     exon            682..807
                     /gene="C2cd6"
                     /gene_synonym="1700052H20Rik; 4930408G06Rik; Als2cr11;
                     Als2cr11b; C2cd6b; Gm33589"
                     /inference="alignment:Splign:2.1.0"
     exon            808..852
                     /gene="C2cd6"
                     /gene_synonym="1700052H20Rik; 4930408G06Rik; Als2cr11;
                     Als2cr11b; C2cd6b; Gm33589"
                     /inference="alignment:Splign:2.1.0"
     exon            853..921
                     /gene="C2cd6"
                     /gene_synonym="1700052H20Rik; 4930408G06Rik; Als2cr11;
                     Als2cr11b; C2cd6b; Gm33589"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1001
                     /gene="C2cd6"
                     /gene_synonym="1700052H20Rik; 4930408G06Rik; Als2cr11;
                     Als2cr11b; C2cd6b; Gm33589"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1136
                     /gene="C2cd6"
                     /gene_synonym="1700052H20Rik; 4930408G06Rik; Als2cr11;
                     Als2cr11b; C2cd6b; Gm33589"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1242
                     /gene="C2cd6"
                     /gene_synonym="1700052H20Rik; 4930408G06Rik; Als2cr11;
                     Als2cr11b; C2cd6b; Gm33589"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1306
                     /gene="C2cd6"
                     /gene_synonym="1700052H20Rik; 4930408G06Rik; Als2cr11;
                     Als2cr11b; C2cd6b; Gm33589"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1344
                     /gene="C2cd6"
                     /gene_synonym="1700052H20Rik; 4930408G06Rik; Als2cr11;
                     Als2cr11b; C2cd6b; Gm33589"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1632
                     /gene="C2cd6"
                     /gene_synonym="1700052H20Rik; 4930408G06Rik; Als2cr11;
                     Als2cr11b; C2cd6b; Gm33589"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1669
                     /gene="C2cd6"
                     /gene_synonym="1700052H20Rik; 4930408G06Rik; Als2cr11;
                     Als2cr11b; C2cd6b; Gm33589"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1731
                     /gene="C2cd6"
                     /gene_synonym="1700052H20Rik; 4930408G06Rik; Als2cr11;
                     Als2cr11b; C2cd6b; Gm33589"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1794
                     /gene="C2cd6"
                     /gene_synonym="1700052H20Rik; 4930408G06Rik; Als2cr11;
                     Als2cr11b; C2cd6b; Gm33589"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1869
                     /gene="C2cd6"
                     /gene_synonym="1700052H20Rik; 4930408G06Rik; Als2cr11;
                     Als2cr11b; C2cd6b; Gm33589"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..6543
                     /gene="C2cd6"
                     /gene_synonym="1700052H20Rik; 4930408G06Rik; Als2cr11;
                     Als2cr11b; C2cd6b; Gm33589"
                     /inference="alignment:Splign:2.1.0"
     exon            6544..7029
                     /gene="C2cd6"
                     /gene_synonym="1700052H20Rik; 4930408G06Rik; Als2cr11;
                     Als2cr11b; C2cd6b; Gm33589"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7011..7016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C2cd6"
                     /gene_synonym="1700052H20Rik; 4930408G06Rik; Als2cr11;
                     Als2cr11b; C2cd6b; Gm33589"
                     /note="hexamer: AATAAA"
     polyA_site      7029
                     /gene="C2cd6"
                     /gene_synonym="1700052H20Rik; 4930408G06Rik; Als2cr11;
                     Als2cr11b; C2cd6b; Gm33589"
                     /note="major polyA site"
ORIGIN      
        1 agtggcagat agggccctga agagaatgca gcaatggagt tgcctcctcc gggaaaccgg
       61 agggtttcca tcaataaccc tcaagagaca tctggcaggg ttcctaccac ctcagccggg
      121 tttcccaccc agtcatctaa gatctccttg aagcgctcca cctacgccta caggccttcc
      181 atgatgagca accgcagctc aggaggccag tccctgctgc cgagctccat tctccagaag
      241 acctccctca accctccagg ttctctgcag agcaaaccat ccaacctctc ttcagtccac
      301 tatgctgatg aagaaggcaa gccactcacg gacaagaaca aggacaaaga caagggcagg
      361 ggcaagggta aaggcacagg aactcggctg ctgaccatgc taaggaaaac tcttcaaggg
      421 tctcagagtg atgaaatggc aatagcaaat cagacaccga acttgatacc atttggagac
      481 gtggtgggct gtctggcgat tcacataaag agctgtagac agttttctca gaggttcctt
      541 ggccaacagc gttttaatct gttcatgcgt gtctccataa acaacattgt gaaatgtaca
      601 aaaattcgtc acttgaaagc tgttaataat gaaaagaacc ttgtacttag gtttggcgag
      661 atgaagtact tttctgtaca ggttcccaga cgtcaagatg atgagcggaa ttttatttac
      721 ttggaactaa tgcatgatgg aggcgatcca gaaagccccc ctattccctt aggcggtgca
      781 gaatcacatc tttatgaagt aatacagaaa ggctgcttta ctgaagtaat gcacttgatg
      841 cataaaaact ccagtatctg cagggtggaa gtggaattta tgttctccta tggaaacttt
      901 ggctatggat tttcacatca gttaaaacct cttcagaaag ccattgagcc atctatgttt
      961 atgaatattg cacctcctcc agagagaaca gaccctgtca caaatgttat tactccgcaa
     1021 cgagtagaat acccggcatt cttatcccct gaatttaatg ttagcattgg ggttcctgaa
     1081 gccagccatg caactgtggt gcaacttgag aaactccgtg agaagccccg ggaaaggttg
     1141 gaaagaatga aagaggagta taaaaatatg agtacatgga tagaaaaagc tgattattta
     1201 agaaacctta ttaatccaaa aatgacaaaa agggataata agggaagtag tataccaagt
     1261 gaatcaaatt ctagtgcatt agaagagctt gaaaggacaa catacgatat tcatcacaga
     1321 aaatatgaag ctatttcaaa tgagtatggt gataaggaag gccgggtcat accagtttta
     1381 aaggtgttgg accaaaatta ttcagaggta tttttaccta aaagtagtga ctccacaccg
     1441 ctggaagatg ttctcctgcc ccccattcac agcctgcaga tagtagaaga gaatgaaatg
     1501 ccacatttac cgaagacctc tgagccagaa gacaggccac atgaagagag gaaaagtata
     1561 gtattttcat cggatgaaga actaatgccc aaacatccaa gcattttaaa aataagctca
     1621 tctcaacaag agaataggcg taaaatggaa aaatcgccac atttttcaga tgtgttaata
     1681 atacctgata aacccttcga agatttaaac acaaataaga aagggagacc tcccatcgag
     1741 ttaaggaaat cttgggaaag acatcctact gacgttgcct gtagtctccg aaaggtggct
     1801 tttgcacaaa aagactacac cataccagtt tgcaaagcag aaactacaga attcaaaccc
     1861 aaacatcagt ttcagaaact cagcaagagt ggtcttgatc cttttctaag aaacataaac
     1921 agcaaaatgt cattcagaaa gaagaaagat catgatgatg gatacagaaa tctaagcacg
     1981 tcaagtgcag agattttaga gcatgaagat caagatcctc cttacccagg acattcaggg
     2041 tctgcaggat ctgatgcaac atgggctgaa aaccctagcc ctgtcacagt ccagatggta
     2101 aacagggaca gcttgcctcc tgacctgata acagccacaa tagtgatttc agacaggaag
     2161 aataagctgt cgcttgatag tgttttcaac tcagcaaaca gtttaaatac aaagagtatc
     2221 tttgcaagtg ataatcctgt tgtcagccta acaaagcttt cagattctga taataaactg
     2281 ataactgatt ctagttttaa tacaacaaag ccttcaaata ggaggctgtc taaggactcg
     2341 aatttcaata caacaaagcc ttcagatagg aagctgtcta gtgaccctag ttccaataca
     2401 acaaagcctt cagatactaa actgtttagt gatcctagta gcaataaatt gtcccaaggt
     2461 cctagtagca atgcatcaca gctttcaggt tctaatagat tatcccataa tcctagtatc
     2521 aatggaaata aatcttcata tacttcagat cttaataagg tatcccgaga tcctagtatc
     2581 gtctcaacaa tatcttcaga tcctaacaag ttatcccgtg atcctagctt cgttttagca
     2641 aagtcttcag atcctaacaa gttgtcccat tatcctagta tcatttcagc aaagtcttca
     2701 gatcccaaca agttgtccca tgatcctagc ttcgtttcag caaggtcttc agatcctaac
     2761 aagctgtccc atgatcctag catcatttca gcaaggtctt cagatcctat caagttatct
     2821 cgtgatccta gcttcgtttc agcaaggtct tcagatccta acaagctgtc ccatgatcct
     2881 agtatcattt cagcaaggtc ttcagatcct aacaagttat cccgtgatcc tagcatcaat
     2941 tcaacaaagc tttcagatcc tagtaagttg agtcgtgatc ctagtatctt ctcaacaaag
     3001 tcttcagatc ctaataagtt ataccgtgtt cctagcatca tttcagggat gtcttccaat
     3061 cctaagttat cccgtgatcc tagcatcatt tcaggaatgt cttccgatcc taagttatcc
     3121 cgtgatccta gcatcatttc agcaaagtct tcagatccta acaagttatc ccatgatcct
     3181 agtatcattt caggaatgtc ttcaaatcct aataagttat cccatgatcc tagcatcatt
     3241 tcaatgaagc tttcagatat gagtaagttg agccgtgagt ctagtatcaa tgcaagtaag
     3301 tcttcagata ctaatcagtt gtcatatgat cccaatatca tttcagcaaa gtctttagat
     3361 agtaacaata gttcggcaag tagcagtcct actgtcaatt cagatactac taccaacgca
     3421 gcggaacctt caggtactaa gaacatgctg gatcctgttg tctccacaat agactcttca
     3481 gataaacaga gtaagttaga atggctccca aatgtccaag gagcatcatc agtgactgaa
     3541 aatataaaca cacatcgctc ctcaaactcg gtaaatttta catctgatat tgacatttta
     3601 aaacagtcaa tagtactcaa atcaatttta agtaaaaatc tgcaagacct ttcagatgag
     3661 ttgttttcta aatcagaact ctacacaaat gatgaaggct attctccacc tccaagtgtg
     3721 cacagcaggc catctgatag cacagatgac agagtgttgg gaaaagtcca agatctaaac
     3781 agctggcgtt catcaaaaga ccttctaaat tcccaggttc ttttaagtcc tgtagttaaa
     3841 aatagccctc aagatttact cccagaaggt gaaccaggaa aatcttcaga catagaagac
     3901 tatgtctctg aaaaactctt agaggctgct ggaagaaatt ttccaatgaa cagaaagagt
     3961 agtttcaaga aaaaacattt agtaagtgaa gaatctagct ctgaacatgt tttaagtggt
     4021 agcatatatg agtacgttat caagcaaata ttcactgcac ccatattctc acaactggga
     4081 ataggaataa agagctcaag tgaggcccgg atggactcac aaaatcagtt gctgacacct
     4141 tgggagagaa gtgtaacttc acacattatc aactatgaag aaaaggacag tgacgttaac
     4201 ttgtcacagt ccaaatcgat cataagccaa ataatacagt cctttcctgt aaatactctg
     4261 ttagaatctg gggtaatcaa agtgatagaa cttgataaag aacatcagaa ctctttgttg
     4321 gactcacaga caacctcttc cacagagcag tattctgata gtagaagcca aataaaactt
     4381 ctttccaggc agaatacatc tagcatcaac cccctagact cttctgtgag tggagctgaa
     4441 tatacagaag actgccaaag tatatccaca caagagtcaa aatatccagt acgagataca
     4501 aagtcagact caccaaatga tacagaggag atggagctag actctaactt agaaagttct
     4561 agtagctcac tagataaagt taaagacacc gacacagcaa agttaaaaaa catcctaaaa
     4621 aatatcttca gtattttctt caaatacaat cagtctgaaa gaagacaaca accagaaaaa
     4681 gactcagaaa gtctaattaa acattcttca tcaagtggtt cagaacactt agaaaaaact
     4741 caagagaatt ttaacaaagc agacaaaaaa gtagacagga aacccatttt gaatccaaag
     4801 ctgcgtatgt ttctagagaa actctcggag acagaagtaa aaaatttgaa gtctgagtta
     4861 agtaaacaca ttcagcatta ccttgttgaa agacttacag agtcaggcca catcaccaag
     4921 gaggacttac caacaatcta tcacaagctc tatctaatga atgagaaagt cgagttaaaa
     4981 gagcaaactc cctttcagga gaaatactca gaaactgtaa aagaaatcat gtcttttgta
     5041 aacaacttta accatcattt catagataaa catctagaaa caaagcttag aggttttcta
     5101 agtgaaattc tccaaaatta tttcctgaag aatctttcag tgagcaactt attcaatgag
     5161 acagacgcta tggctctcca tgccagcatg tcccctgtaa gaagtaagag tgagctagga
     5221 caagacattg cagatgggaa ttttggttca agccttaaaa taaacatgca ataccctgta
     5281 accaaatctc tacaacatta tcttcaggat ttatcagaaa atgaattatt aagtctaaaa
     5341 actgatttga gcaaatacct ccaggtcctc tttatagaaa aactttataa gtcaggactg
     5401 gtgtcagaaa ggcagctaaa ggggatcagc caggaaatta tctcactcca ttccccttcc
     5461 ataccattaa aacacataaa aacaaattta ccttttagaa atgaaagtta ctttatgagg
     5521 gaggattcag aagagcaaat gaaatattta aaaaatggcc aaaatgcagc tttacacgtg
     5581 ctgcttaaag ataaatgcgg agaaacagaa ctgtccagga agaaagaaag ggaaagttct
     5641 ttctcacaaa ttttaaaaga aaacctacca gcaatatggg aacagaaaaa tatttatacc
     5701 agggaagaag aaacactgaa tttaatacaa atgcaatctt tcctcaacaa aaataaccag
     5761 gcaaatccac taactaggtc accagaaaga ccttcagaca tatcacttaa gaaacagaag
     5821 aaagatcatg gtttcatgca gtttactcaa gtagaaggtt ctgtctacaa aacagagatt
     5881 caagatccat atagttggga tagtagatca aaaacaattc aatcaaaacc ttgcttagaa
     5941 aagacattga aaatgaagct acttgacaag agggaaaaca ataactttta taaattgact
     6001 gcacaggaaa aacttgatac cgaattttca tcttatctca agctccctaa ctgcaaaata
     6061 ccaaaagaaa aggaacccat aagcaggctc tccttcccta catggaagac taacaccttc
     6121 attcatgtca agccagagat cggggagcaa tcgaaattag accactatta tcagagactg
     6181 aaaggaaata ataataacaa taaaaaacac ttggttacat ttgcacaatt caaaaatgaa
     6241 atggaaactc tttatagaaa cccatatgaa gcttgcaatg aaaaacgtgc caagatctct
     6301 gaatcacagt catttaaata taaagaaaag gagaaaagct caagaccatt cttcttccca
     6361 gaagtattga agagagaaaa cacgaaatcc aaaagaaaag aaagagacca cgccaccaaa
     6421 ccaaagaagt catttcacaa gatagttagg ttactaccag ccacactgcc cactacaaga
     6481 cctcatctcc ggaagtctgc gccaaggaat ttacttcact ggactgcaag gagaactata
     6541 catgattgtt tggatagatt cgacgattta cacgcaccca cagttaaatg tcctaaaaaa
     6601 tcaaaatcag gagcaagact tttaggcaag agtccagaag attcccataa tcaggcaaaa
     6661 cactgtgcac gaccatacac tgctccagag cctaacaaac gacgagaaag tgccgcctgg
     6721 aaatttgcaa gtcctcggat ggtttcagcg ggcttacttc acttatatgt caccccagcg
     6781 tatggaatcc gtaaagtgcg gtccaaaagg aaattaaaag aggatattga aaagcgtccg
     6841 ctcattagtg agattatcca gatgctagac aatgcagaat gatatgtaat gccaccagtc
     6901 agaatataat ttctccatta acaaaatggt ttggagatct atccttgtgt gatagaagtc
     6961 agcaactaaa tttcatcttg ttagaccatt ttgttataat taaagtgaaa aataaacatt
     7021 ctacagaaa
//
