LOCUS       NM_001362115            4490 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus C2 calcium-dependent domain containing 5 (C2cd5),
            transcript variant 7, mRNA.
ACCESSION   NM_001362115 XM_006507003
VERSION     NM_001362115.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4490)
  AUTHORS   Gavini,C.K., Cook,T.M., Rademacher,D.J. and Mansuy-Aubert,V.
  TITLE     Hypothalamic C2-domain protein involved in MC4R trafficking and
            control of energy balance
  JOURNAL   Metabolism 102, 153990 (2020)
   PUBMED   31666192
  REMARK    GeneRIF: Hypothalamic C2CD5 is involved in MC4R endocytosis and
            regulate bodyweight homeostasis. This suggests that C2CD5
            represents a new protein regulated by metabolic cues and involved
            in metabolic receptor endocytosis. C2CD5 represents a new target
            and pathway that could be targeted in Obesity.
REFERENCE   2  (bases 1 to 4490)
  AUTHORS   Zhou,Q.L., Song,Y., Huang,C.H., Huang,J.Y., Gong,Z., Liao,Z.,
            Sharma,A.G., Greene,L., Deng,J.Z., Rigor,M.C., Xie,X., Qi,S.,
            Ayala,J.E. and Jiang,Z.Y.
  TITLE     Membrane Trafficking Protein CDP138 Regulates Fat Browning and
            Insulin Sensitivity through Controlling Catecholamine Release
  JOURNAL   Mol Cell Biol 38 (8), e00153-17 (2018)
   PUBMED   29378832
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4490)
  AUTHORS   Xie,X., Gong,Z., Mansuy-Aubert,V., Zhou,Q.L., Tatulian,S.A.,
            Sehrt,D., Gnad,F., Brill,L.M., Motamedchaboki,K., Chen,Y.,
            Czech,M.P., Mann,M., Kruger,M. and Jiang,Z.Y.
  TITLE     C2 domain-containing phosphoprotein CDP138 regulates GLUT4
            insertion into the plasma membrane
  JOURNAL   Cell Metab 14 (3), 378-389 (2011)
   PUBMED   21907143
REFERENCE   4  (bases 1 to 4490)
  AUTHORS   McCormick,J.A., Mutig,K., Nelson,J.H., Saritas,T., Hoorn,E.J.,
            Yang,C.L., Rogers,S., Curry,J., Delpire,E., Bachmann,S. and
            Ellison,D.H.
  TITLE     A SPAK isoform switch modulates renal salt transport and blood
            pressure
  JOURNAL   Cell Metab 14 (3), 352-364 (2011)
   PUBMED   21907141
REFERENCE   5  (bases 1 to 4490)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   6  (bases 1 to 4490)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   7  (bases 1 to 4490)
  AUTHORS   Collins,M.O., Yu,L., Coba,M.P., Husi,H., Campuzano,I.,
            Blackstock,W.P., Choudhary,J.S. and Grant,S.G.
  TITLE     Proteomic analysis of in vivo phosphorylated synaptic proteins
  JOURNAL   J Biol Chem 280 (7), 5972-5982 (2005)
   PUBMED   15572359
REFERENCE   8  (bases 1 to 4490)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 4490)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127354.4 and AC122797.3.
            
            On Apr 6, 2018 this sequence version replaced XM_006507003.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660825.38090.1,
                                           SRR9219383.107066.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               AC127354.4         121711-121930       c
            221-339             AC127354.4         121456-121574       c
            340-426             AC122797.3         115-201
            427-598             AC122797.3         7466-7637
            599-694             AC122797.3         9372-9467
            695-850             AC122797.3         10776-10931
            851-1049            AC122797.3         12339-12537
            1050-1201           AC122797.3         18106-18257
            1202-1287           AC122797.3         23659-23744
            1288-1396           AC122797.3         28939-29047
            1397-1511           AC122797.3         40561-40675
            1512-1607           AC122797.3         43662-43757
            1608-1799           AC122797.3         49257-49448
            1800-1986           AC122797.3         51791-51977
            1987-2151           AC122797.3         54401-54565
            2152-2292           AC122797.3         55638-55778
            2293-2356           AC122797.3         59175-59238
            2357-2418           AC122797.3         59494-59555
            2419-2517           AC122797.3         59924-60022
            2518-2607           AC122797.3         60589-60678
            2608-2695           AC122797.3         61140-61227
            2696-2782           AC122797.3         61554-61640
            2783-2833           AC122797.3         70426-70476
            2834-2935           AC122797.3         71371-71472
            2936-3126           AC122797.3         72727-72917
            3127-3273           AC122797.3         77452-77598
            3274-4490           AC122797.3         78664-79880
FEATURES             Location/Qualifiers
     source          1..4490
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 75.13 cM"
     gene            1..4490
                     /gene="C2cd5"
                     /gene_synonym="5730419I09Rik; C030008B15Rik; CDP138"
                     /note="C2 calcium-dependent domain containing 5"
                     /db_xref="GeneID:74741"
                     /db_xref="MGI:MGI:1921991"
     exon            1..220
                     /gene="C2cd5"
                     /gene_synonym="5730419I09Rik; C030008B15Rik; CDP138"
                     /inference="alignment:Splign:2.1.0"
     exon            221..339
                     /gene="C2cd5"
                     /gene_synonym="5730419I09Rik; C030008B15Rik; CDP138"
                     /inference="alignment:Splign:2.1.0"
     exon            340..426
                     /gene="C2cd5"
                     /gene_synonym="5730419I09Rik; C030008B15Rik; CDP138"
                     /inference="alignment:Splign:2.1.0"
     exon            427..598
                     /gene="C2cd5"
                     /gene_synonym="5730419I09Rik; C030008B15Rik; CDP138"
                     /inference="alignment:Splign:2.1.0"
     exon            599..694
                     /gene="C2cd5"
                     /gene_synonym="5730419I09Rik; C030008B15Rik; CDP138"
                     /inference="alignment:Splign:2.1.0"
     exon            695..850
                     /gene="C2cd5"
                     /gene_synonym="5730419I09Rik; C030008B15Rik; CDP138"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1049
                     /gene="C2cd5"
                     /gene_synonym="5730419I09Rik; C030008B15Rik; CDP138"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1201
                     /gene="C2cd5"
                     /gene_synonym="5730419I09Rik; C030008B15Rik; CDP138"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1287
                     /gene="C2cd5"
                     /gene_synonym="5730419I09Rik; C030008B15Rik; CDP138"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1396
                     /gene="C2cd5"
                     /gene_synonym="5730419I09Rik; C030008B15Rik; CDP138"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1511
                     /gene="C2cd5"
                     /gene_synonym="5730419I09Rik; C030008B15Rik; CDP138"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1607
                     /gene="C2cd5"
                     /gene_synonym="5730419I09Rik; C030008B15Rik; CDP138"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1799
                     /gene="C2cd5"
                     /gene_synonym="5730419I09Rik; C030008B15Rik; CDP138"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1986
                     /gene="C2cd5"
                     /gene_synonym="5730419I09Rik; C030008B15Rik; CDP138"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2151
                     /gene="C2cd5"
                     /gene_synonym="5730419I09Rik; C030008B15Rik; CDP138"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2292
                     /gene="C2cd5"
                     /gene_synonym="5730419I09Rik; C030008B15Rik; CDP138"
                     /inference="alignment:Splign:2.1.0"
     exon            2293..2356
                     /gene="C2cd5"
                     /gene_synonym="5730419I09Rik; C030008B15Rik; CDP138"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2418
                     /gene="C2cd5"
                     /gene_synonym="5730419I09Rik; C030008B15Rik; CDP138"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2517
                     /gene="C2cd5"
                     /gene_synonym="5730419I09Rik; C030008B15Rik; CDP138"
                     /inference="alignment:Splign:2.1.0"
     exon            2518..2607
                     /gene="C2cd5"
                     /gene_synonym="5730419I09Rik; C030008B15Rik; CDP138"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..2695
                     /gene="C2cd5"
                     /gene_synonym="5730419I09Rik; C030008B15Rik; CDP138"
                     /inference="alignment:Splign:2.1.0"
     exon            2696..2782
                     /gene="C2cd5"
                     /gene_synonym="5730419I09Rik; C030008B15Rik; CDP138"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..2833
                     /gene="C2cd5"
                     /gene_synonym="5730419I09Rik; C030008B15Rik; CDP138"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..2935
                     /gene="C2cd5"
                     /gene_synonym="5730419I09Rik; C030008B15Rik; CDP138"
                     /inference="alignment:Splign:2.1.0"
     exon            2936..3126
                     /gene="C2cd5"
                     /gene_synonym="5730419I09Rik; C030008B15Rik; CDP138"
                     /inference="alignment:Splign:2.1.0"
     exon            3127..3273
                     /gene="C2cd5"
                     /gene_synonym="5730419I09Rik; C030008B15Rik; CDP138"
                     /inference="alignment:Splign:2.1.0"
     exon            3274..4490
                     /gene="C2cd5"
                     /gene_synonym="5730419I09Rik; C030008B15Rik; CDP138"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4462..4467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C2cd5"
                     /gene_synonym="5730419I09Rik; C030008B15Rik; CDP138"
                     /note="hexamer: AATAAA"
     polyA_site      4483
                     /gene="C2cd5"
                     /gene_synonym="5730419I09Rik; C030008B15Rik; CDP138"
                     /note="major polyA site"
ORIGIN      
        1 agatcgatcg ctcccgcccc tcgagccgcc atttttggaa ggtgggagga gaaaggtggg
       61 tgggcgcggt gcctgctttg cgggatgctg actggacttg gcggctctct gcagcacgtc
      121 aggggtaggg cagcacggct ggccggcgcc cttcctccgg ctgcttctcc ggaatgaggc
      181 ctcggtggcc gcgcgggacg actcggttcc tgctcagagc gaatcctagg agaggccgaa
      241 gccgccgtga tgccggggaa gctgaaggtg aaaattgtgg ccggtcgcca tttgccggtg
      301 atggaccgtg ccagtgacct gacggatgcc ttcgtggagg taaaatttgg taatacaacc
      361 tttaagacag atgtgtatct caagtcactg aatcctcagt ggaactcgga gtggtttaaa
      421 tttgaggtgg acgatgaaga tttacaggat gagcctctgc agatcacagt tcttgaccac
      481 gatacttaca gtgcaaacga tgctattggc aaggtgtaca ttgacatcga ccctttactg
      541 tacagtgaag ctgccacagt catctcaggc tggttcccaa tttatgacac catacatggt
      601 atccgcggag aaatcaatgt tgtggttaaa gtagacctct tcaatgattc aaacaggttc
      661 agacagtctt catgtggagt taaattcttt tgcacaacat ctattccaaa gtgctacaga
      721 gctgtggtaa tccacggatt tgtagaagaa cttgtggtca atgaggatcc cgagtatcag
      781 tggattgatc ggatccgcac cccaagggca tcgaatgaag ccaggcagag actcatctcc
      841 ttgatgtcag gtgaattaca gagaaagatt ggcttgaaag tcctcgagat gagagggaat
      901 gcagttgttg ggtacttgca gtgctttgat ctggagggcg agtctgggtt agtggtccga
      961 gccataggaa cggcgtgcac tctggataaa ctgagcagcc cagcagcgtt ccttcctgca
     1021 tgcagctccc catccagaga actgaaggag attcccttca atgaggatcc caaccccaat
     1081 actcactcat caggaccctc aacccctctg aaaaaccaaa cttattcctt ttcaccttcc
     1141 aagtcctaca gtcggcagtc ctcttcttct gacacagatt tgagtttgac acccaagact
     1201 ggaatgggca gtgggagtgc tggaaaagaa ggggggccct ttaaagccct tttacggcaa
     1261 cagacgcagt cggcgttgga acagcgggag ttcccgttcc tcaccctgac ggccttcccc
     1321 cctggacttc ttgtgcacgt cggtggcgtt gtcagtgcac gctctgtgaa gcttttagat
     1381 cggatccaca accctgatga accagaaact cgagatgcat ggtgggcaga aatcagacaa
     1441 gagataaagt cacatgctaa agccttaggc tgccatgctg tagtgggcta cagcgagtca
     1501 accagcatct gtgaagaagt ctgtatttta tcagcgtctg gcacggcagc tgtgctgaac
     1561 cctcggtttc tgcaggaagg cactgtggag ggctgtttgg aacaaaggat tgaagagaat
     1621 ttaccggtgg gctgcggatt ctgccatata ccatatgatg aactgaacat gccgtttccc
     1681 gctcatctca catattgcta taactgcagg aagcaaaaag tccctgatgt tctcttcaca
     1741 actatcgatc tgcccacaga cgcagtggtt gttggtaaag gttgtcttat tcaggcaagg
     1801 ttatgtcgat taaaaaagaa agcacaggca gaagccaatg ccacagctat cagtaatctc
     1861 ttgccgttta tggaatatga agtacacact caactgatga acaagctcaa actcaaagga
     1921 atgaatgctt tgtttggact gagaattcag atcacagtgg gcgagaccat gctgatgggc
     1981 ttagcgtcgg ccacaggagt ctacttagca gccttaccca cacccggtgg aatccagatc
     2041 gctgggaaga cccctaatga tggctcctat gaacagcaca tctcccacat gcagaagaga
     2101 ataaacgaca ccattgcaaa aaacaaagag ctgtatgaga tcaccccccc ggaggtgtct
     2161 gaggagatga taggatcccc catcccagaa cccagacagc gctccagact tctaagatca
     2221 cagtcggaaa gttctgatga agttacagag ttagatcttt cacacgggaa aaaggatgct
     2281 tttgttttag agatcgatga caccgatgcc atggaagatg tgcactccct ccttactgac
     2341 gccccgcccc cttcaggttt ttatagttgt aatacagaaa ttatgcctgg cataaataac
     2401 tggacatcag aaatacagat gttcacgtca gtaagagtgg tcagactaag tagcctcaac
     2461 ttgactaacc aagctctcaa taagaacttc aacggcctat gtgagaactt gctcaagagc
     2521 ctgtatttca aacttcggtc catgaccccc tgctgcctct gccatgtgaa ctttacagtg
     2581 tctctgcctg aagatgagtt aatccaggtc acagtcacag cagttgcaat aacttttgat
     2641 aaaaaccagg ccttacagac cacaaaaccc cacgttgaaa agtcactaca aagagcctcc
     2701 acagataacg aagaactgct gcagttccca ctggagctct gctcagactc actgcctcct
     2761 catcctttcc cagcagctaa agaacacctg gagagtgcga actctaactc aggtatacca
     2821 gctgcacaga gagcaacgtc agttgattac agttcctttg cagacagatg cagcagctgg
     2881 atagagctca ttagactgaa agctcagacc ataaggcgcg gatcaattaa gacaactgtg
     2941 actgttgaaa aagcaagtgc catgggtgat ggaaatttcc ggaatcgctc tgctccacct
     3001 tgtgcaagtc ccacagttgg ggttgttaag atgacgccgc tttctttcat ccctggagca
     3061 aagataacca agtacctcgg catcattaac atgtttttca ttcgggaaac cacttctctc
     3121 cgcgaggaag gcggagtcag tggttttctc cacgctttca ttgctgaagt gtttgccatg
     3181 gtccgagctc acgtggcagc gctgggcggg aatgctgttg tgtcctacat catgaagcag
     3241 tgtgtcttca tggagaaccc cagtaagaac caggcacagt gtctcataaa tgtcagtggg
     3301 gacgcggtgg tgtttgttcg tgactccgac ttagaggtca tgtcatctca gcagcctgct
     3361 gccaactgcc agccctcatg taccggagaa gttacaactt gaagacagcg gctcaactgg
     3421 ctcaaccgag tgaaattcat gtgtctccat tgtgtgtcac cctcttctca gcccagaggc
     3481 ccggcgtggg gtggggtact gaggagcagg gatgcggctg gatagcttgt gtgcacatct
     3541 gggagagttg agaatttctg atcttgacat tttgtttgtc cagtctacac agacaggccc
     3601 catggattct ggtaccttca gttatgggag ttatttgtaa tttgtgttga tttttaataa
     3661 aagtataatt aaaaatgaaa tggaaagctt atcaagagtc tagggtagga agctcctgtg
     3721 gctttgaaaa ccaagcagga atccaattgc taatgagtcc atagctgatt tgtaaatgga
     3781 ggaaacttgt gtgtattttc agagaatgac tgcagctttc tcagtgtctt ctgcttgaag
     3841 tgaggacttt gttagctgga tgggtgatgt gtttgttagc tggatgggta gtgtgttaga
     3901 ccatctttta aaggaaggtt tacggtgtgg gtctgtagaa ttgcctgagt gctctcagga
     3961 acttctcaga ggtgtccgca cccaggagcg gaggatgcct caggactggc tgtcctcatg
     4021 gaggagggag ggggcacctc acgactggcc gttgcttcat atttaattgt ctagaagagg
     4081 cttggctcca acaggggaga gactgctgtg gaatgtattt aagtagtgaa aatacagttg
     4141 acctaggaag aacaggattg ttttctaatg atatattgca ctcaataatc ttagggattg
     4201 gtgaggtaca ctgttggtat agaaggtgga aaggagactt gaatatgctg tgaagtgttg
     4261 aatgtatgta ttaagtctta cctatgccaa gtacccacta ctaatgagat agcaaattcc
     4321 tcctttgccc aataaaatgt ccttataaaa cataggattt tattctctca aaacagcaaa
     4381 ttaccctaaa gatgaaaagt cattttaatg ctacacaggt gtcaatattt ttctgtattt
     4441 tgtttataat tttatttttt aaataaaaag tttataaaca acacattcct
//
