LOCUS       NM_001081314            1348 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus C2 calcium-dependent domain containing 4B (C2cd4b),
            mRNA.
ACCESSION   NM_001081314 XM_891872
VERSION     NM_001081314.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1348)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1348)
  AUTHORS   Mousavy Gharavy,S.N., Owen,B.M., Millership,S.J., Chabosseau,P.,
            Pizza,G., Martinez-Sanchez,A., Tasoez,E., Georgiadou,E., Hu,M.,
            Fine,N.H.F., Jacobson,D.A., Dickerson,M.T., Idevall-Hagren,O.,
            Montoya,A., Kramer,H., Mehta,Z., Withers,D.J., Ninov,N.,
            Gadue,P.J., Cardenas-Diaz,F.L., Cruciani-Guglielmacci,C.,
            Magnan,C., Ibberson,M., Leclerc,I., Voz,M. and Rutter,G.A.
  TITLE     Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b
            gene in murine glucose homeostasis
  JOURNAL   Diabetologia 64 (4), 850-864 (2021)
   PUBMED   33492421
  REMARK    GeneRIF: Sexually dimorphic roles for the type 2
            diabetes-associated C2cd4b gene in murine glucose homeostasis.
REFERENCE   3  (bases 1 to 1348)
  AUTHORS   Mehta,Z.B., Fine,N., Pullen,T.J., Cane,M.C., Hu,M., Chabosseau,P.,
            Meur,G., Velayos-Baeza,A., Monaco,A.P., Marselli,L., Marchetti,P.
            and Rutter,G.A.
  TITLE     Changes in the expression of the type 2 diabetes-associated gene
            VPS13C in the beta-cell are associated with glucose intolerance in
            humans and mice
  JOURNAL   Am J Physiol Endocrinol Metab 311 (2), E488-E507 (2016)
   PUBMED   27329800
  REMARK    GeneRIF: The present data thus provide evidence for a limited role
            for changes in VPS13C expression in conferring altered type 2
            diabetes risk at this locus, particularly in females, and suggest
            that C2CD4A, but not C2CD4B, may also be involved.
REFERENCE   4  (bases 1 to 1348)
  AUTHORS   Omori,H., Ogaki,S., Sakano,D., Sato,M., Umeda,K., Takeda,N.,
            Nakagata,N. and Kume,S.
  TITLE     Changes in expression of C2cd4c in pancreatic endocrine cells
            during pancreatic development
  JOURNAL   FEBS Lett 590 (16), 2584-2593 (2016)
   PUBMED   27349930
REFERENCE   5  (bases 1 to 1348)
  AUTHORS   Ogaki,S., Harada,S., Shiraki,N., Kume,K. and Kume,S.
  TITLE     An expression profile analysis of ES cell-derived definitive
            endodermal cells and Pdx1-expressing cells
  JOURNAL   BMC Dev Biol 11, 13 (2011)
   PUBMED   21362171
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1348)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP769160.1, CT573422.5 and BP769161.1.
            
            On Sep 12, 2009 this sequence version replaced NM_001081314.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039571.1, BP769160.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-620               BP769160.1         26-645
            621-1095            CT573422.5         3025-3499           c
            1096-1348           BP769161.1         1-253               c
FEATURES             Location/Qualifiers
     source          1..1348
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 36.72 cM"
     gene            1..1348
                     /gene="C2cd4b"
                     /gene_synonym="3300001A09Rik; Fam148b"
                     /note="C2 calcium-dependent domain containing 4B"
                     /db_xref="GeneID:75697"
                     /db_xref="MGI:MGI:1922947"
     exon            1..80
                     /gene="C2cd4b"
                     /gene_synonym="3300001A09Rik; Fam148b"
                     /inference="alignment:Splign:2.1.0"
     exon            81..1330
                     /gene="C2cd4b"
                     /gene_synonym="3300001A09Rik; Fam148b"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1143
                     /gene="C2cd4b"
                     /gene_synonym="3300001A09Rik; Fam148b"
                     /note="family with sequence similarity 148, member B"
                     /codon_start=1
                     /product="C2 calcium-dependent domain-containing protein
                     4B"
                     /protein_id="NP_001074783.1"
                     /db_xref="CCDS:CCDS40675.1"
                     /db_xref="GeneID:75697"
                     /db_xref="MGI:MGI:1922947"
                     /translation="MKLLGRLRSSTPEPAFSNVLTPGRIPEFCIPPRLQVPGALESPL
                     PAAALPWRCAAEPDLWPRIPDDREDSDEDCAGRTDWDPRSQAALSLPHLPRARTVYGF
                     CALLESPHTRRKESLFLGHPGTPRLGLCHRAHTYASPRRASDSELGAPRDLDKTPPAA
                     PVPRMRRLLRAPDGLLSRALRAPRGRASARPAPRGDEHERAASCAPPVPSSPDPERLQ
                     AEASVALGRGGCTLRLAAEYCPRSACLRLRLLRAEGPAAALEPRALGCRLSLVLRPSG
                     QQRASVVRRSRKAALDQDCCFDRLPEEQLRRLAVRIKAESKGRGLERGRPLGQGELLL
                     GSLLLL"
     regulatory      1301..1306
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C2cd4b"
                     /gene_synonym="3300001A09Rik; Fam148b"
                     /note="hexamer: AATAAA"
     polyA_site      1327
                     /gene="C2cd4b"
                     /gene_synonym="3300001A09Rik; Fam148b"
                     /note="major polyA site"
ORIGIN      
        1 gtggagccct agctgtgaac tacacgtcac ctgcttcgtt cctgcgacta gtcggaccca
       61 gcgagactga agaagaaaag acgctcgtgt atccgccacg ctcgggcata agctagaagg
      121 atgaagcttc tcggtcgact tcgctcctcc actcctgagc ctgccttctc caacgtgctc
      181 accccgggcc gcatcccaga gttctgcatc cccccgcggc tgcaggtccc cggcgctctc
      241 gaatcaccgc ttcccgctgc cgcactgcct tggcgctgcg cggccgaacc ggacctgtgg
      301 ccgcgcatcc ctgacgaccg cgaagacagt gacgaagact gcgcgggtcg caccgactgg
      361 gacccgcgct cccaggctgc gctctcgctg ccgcacctgc cccgcgcgcg caccgtttac
      421 ggcttctgcg cgctgctcga gagcccgcac acgcgccgga aggagtcgct cttcctcggc
      481 caccccggca cccccaggct gggactttgc caccgtgcgc acacctacgc gagtccgcgc
      541 cgagcatcgg actctgagct cggcgccccg cgcgacctgg acaaaacccc accagccgct
      601 ccagtgcccc gtatgcgccg cctcctccgc gcccccgatg gtctgttgag ccgcgcgctg
      661 cgggctcccc gcggccgggc cagcgcgcgc cccgcgcccc gcggcgacga gcacgagcgc
      721 gccgcttcct gcgcgccccc ggtccccagc agcccggatc ccgagcgcct gcaagctgaa
      781 gccagcgtgg ctctgggccg cgggggttgc acgctgcgcc tggcggccga gtactgtccg
      841 cgcagcgcct gcctccgcct ccgcctgctg cgcgctgagg gcccggccgc cgcgctggag
      901 ccccgcgccc tgggctgccg cctcagcctg gtgctgaggc cgtcgggcca gcagcgcgcc
      961 agtgtggtcc gccgcagccg caaggccgcc ctggaccagg actgctgctt cgatcggctc
     1021 ccggaggagc agctgcgccg cctggccgtg cgcatcaagg cggagagcaa gggccgcggg
     1081 ctggagcgcg gacgaccgct gggccagggc gagctgctgc tgggctctct gctactgcta
     1141 tgagcgcggc ttccctggtg ctctggacat ttaaggttga gtcgccttga gatgcacaga
     1201 gactcttggc cctcagatac tcaaggcctc ttgacagtgg cttatccccg ggacacacac
     1261 aacagccttt tggctctggt gcactttccc ttttgtacaa aataaaagtt atttattttt
     1321 ctatctataa aaaaaaaaaa aaaaaaaa
//
