LOCUS       NM_001163143            1352 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus C2 calcium-dependent domain containing 4A (C2cd4a),
            mRNA.
ACCESSION   NM_001163143 XM_001004247 XM_001004252 XM_146937
VERSION     NM_001163143.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1352)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1352)
  AUTHORS   Mousavy Gharavy,S.N., Owen,B.M., Millership,S.J., Chabosseau,P.,
            Pizza,G., Martinez-Sanchez,A., Tasoez,E., Georgiadou,E., Hu,M.,
            Fine,N.H.F., Jacobson,D.A., Dickerson,M.T., Idevall-Hagren,O.,
            Montoya,A., Kramer,H., Mehta,Z., Withers,D.J., Ninov,N.,
            Gadue,P.J., Cardenas-Diaz,F.L., Cruciani-Guglielmacci,C.,
            Magnan,C., Ibberson,M., Leclerc,I., Voz,M. and Rutter,G.A.
  TITLE     Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b
            gene in murine glucose homeostasis
  JOURNAL   Diabetologia 64 (4), 850-864 (2021)
   PUBMED   33492421
REFERENCE   3  (bases 1 to 1352)
  AUTHORS   Kuo,T., Kraakman,M.J., Damle,M., Gill,R., Lazar,M.A. and Accili,D.
  TITLE     Identification of C2CD4A as a human diabetes susceptibility gene
            with a role in beta cell insulin secretion
  JOURNAL   Proc Natl Acad Sci U S A 116 (40), 20033-20042 (2019)
   PUBMED   31527256
REFERENCE   4  (bases 1 to 1352)
  AUTHORS   Mehta,Z.B., Fine,N., Pullen,T.J., Cane,M.C., Hu,M., Chabosseau,P.,
            Meur,G., Velayos-Baeza,A., Monaco,A.P., Marselli,L., Marchetti,P.
            and Rutter,G.A.
  TITLE     Changes in the expression of the type 2 diabetes-associated gene
            VPS13C in the beta-cell are associated with glucose intolerance in
            humans and mice
  JOURNAL   Am J Physiol Endocrinol Metab 311 (2), E488-E507 (2016)
   PUBMED   27329800
  REMARK    GeneRIF: The present data thus provide evidence for a limited role
            for changes in VPS13C expression in conferring altered type 2
            diabetes risk at this locus, particularly in females, and suggest
            that C2CD4A, but not C2CD4B, may also be involved.
REFERENCE   5  (bases 1 to 1352)
  AUTHORS   Omori,H., Ogaki,S., Sakano,D., Sato,M., Umeda,K., Takeda,N.,
            Nakagata,N. and Kume,S.
  TITLE     Changes in expression of C2cd4c in pancreatic endocrine cells
            during pancreatic development
  JOURNAL   FEBS Lett 590 (16), 2584-2593 (2016)
   PUBMED   27349930
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156799.2.
            
            On or before Jul 10, 2009 this sequence version replaced
            XM_001004252.1, XM_001004247.1, XM_146937.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CJ090429.1, SRR7345562.1627516.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AC156799.2         168727-168807
            82-1352             AC156799.2         169255-170525
FEATURES             Location/Qualifiers
     source          1..1352
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 36.77 cM"
     gene            1..1352
                     /gene="C2cd4a"
                     /gene_synonym="EG244911; Fam148a"
                     /note="C2 calcium-dependent domain containing 4A"
                     /db_xref="GeneID:244911"
                     /db_xref="MGI:MGI:3645763"
     exon            1..81
                     /gene="C2cd4a"
                     /gene_synonym="EG244911; Fam148a"
                     /inference="alignment:Splign:2.1.0"
     exon            82..1352
                     /gene="C2cd4a"
                     /gene_synonym="EG244911; Fam148a"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..1129
                     /gene="C2cd4a"
                     /gene_synonym="EG244911; Fam148a"
                     /note="family with sequence similarity 148, member A"
                     /codon_start=1
                     /product="C2 calcium-dependent domain-containing protein
                     4A"
                     /protein_id="NP_001156615.1"
                     /db_xref="CCDS:CCDS52850.1"
                     /db_xref="GeneID:244911"
                     /db_xref="MGI:MGI:3645763"
                     /translation="MWCLERLLRDRDGFLPGRVHRSKARSSAACANVLTPDRIPEFFI
                     PPRLEPSTAWAALREAWAADTEADDGAGRTDWDPRSQAALSLPHLPRARTAYGFCALL
                     ESPHTRRKESLFLGHPGVPVRRPGLRHRTHTYASPRRVPDAPRPAPGDPDAARVPTPT
                     PAPSRRRLLRSPGKLLSRALRAPRRLASARPPCRGDEHERAASCAPPVPSSPDPERLQ
                     AEASVALGRGGCTLRLAAEYCPRSACLRLRLLRAEGPAAALEPRALGCRLSLVLRPSG
                     QQRASVVRRSRKAALDQDCCFDRLPEEQLRRLAVRIKAESKGRRLGQGELLLGSLLLL
                     "
ORIGIN      
        1 atcaggaatc aactctgccg cgctcttttg aatttctccg cgtttctccg ggttggaaaa
       61 ccatctgact ctgaatacca ggcagcctgg aacaggatca cagggttcag acactagcgg
      121 ccagatgtgg tgtctggagc ggctcttgcg ggaccgagat gggtttctcc cggggcgcgt
      181 ccaccgctcc aaagctcgct catccgctgc gtgcgcaaac gtgctcactc cagaccgcat
      241 cccagagttc ttcatcccgc cgaggctgga acctagcacg gcctgggctg cgctgcgcga
      301 agcctgggct gcagacacgg aggccgacga cggcgcgggc cgcacagact gggacccgcg
      361 ctcccaggct gcgctctcgc tgccgcacct accccgcgcg cgcaccgctt acggcttctg
      421 cgcgctgctc gagagcccgc acacgcgccg aaaggagtcg ctcttcctcg gccacccagg
      481 tgtcccggtc cgccggcctg ggcttcgcca ccgcacgcac acctacgcga gcccccgccg
      541 agtcccggac gctccgcgcc ctgccccggg cgacccagac gctgcccggg tcccgacgcc
      601 cactcctgct cccagcagac gccgcctcct acgctccccg ggcaagctgc tgagccgcgc
      661 acttcgagcc cctcgacgtc tggccagcgc gcgccccccg tgccgcggcg acgagcacga
      721 gcgcgccgcc tcctgcgcgc ccccggtccc cagcagcccg gatcccgagc gcctgcaagc
      781 tgaagccagc gtggctctgg gccgcggggg ttgcacgctg cgcctggcgg ccgaatactg
      841 tccgcgcagc gcctgcctcc gcctccgcct gctgcgcgct gagggcccgg ccgccgcgct
      901 ggaaccccgc gccctgggct gccgcctcag cctggtgctg aggccgtcgg gccagcagcg
      961 tgccagtgtg gtccgccgca gccgcaaggc cgccctggac caggactgct gctttgaccg
     1021 gctcccggag gagcagctgc gccgcctggc cgtgcgcatc aaggcggaga gcaagggacg
     1081 gcggctgggc cagggcgagc tgctgctggg ctctctgcta ctgctatgag cgcggcttcc
     1141 ctggagccct ggacacctaa ggtcgcttgg ccatgagatg cacagagact cttggcccag
     1201 agacacttgt agcctcctct tggtcctgga acacttgcag cttcttggcc ctgagacact
     1261 cttaggtttt ggtcctggca cactctcagc ctcttggctc ttggacaatg actgacagcc
     1321 atttgtacaa aataaacatg tgttcatttt tc
//
