LOCUS       NM_001017985            7812 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Mus musculus C2 calcium-dependent domain containing 3 (C2cd3),
            mRNA.
ACCESSION   NM_001017985 XM_204259 XM_898118 XM_898129 XM_898144 XM_898154
            XM_898162 XM_898171 XM_898180 XM_898190 XM_898198 XM_898211
            XM_898219 XM_906365 XM_919792 XM_919798 XM_919811 XM_919824
            XM_919836 XM_919846 XM_919852 XM_919861 XM_919867 XM_919873
            XM_919879 XM_919890 XM_919906
VERSION     NM_001017985.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7812)
  AUTHORS   Brooks,E.C., Han,S.J.Y., Bonatto Paese,C.L., Lewis,A.A.,
            Aarnio-Peterson,M. and Brugmann,S.A.
  TITLE     The ciliary protein C2cd3 is required for mandibular
            musculoskeletal tissue patterning
  JOURNAL   Differentiation 138, 100782 (2024)
   PUBMED   38810379
  REMARK    GeneRIF: The ciliary protein C2cd3 is required for mandibular
            musculoskeletal tissue patterning.
REFERENCE   2  (bases 1 to 7812)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 7812)
  AUTHORS   Chang,C.F., Brown,K.M., Yang,Y. and Brugmann,S.A.
  TITLE     Centriolar Protein C2cd3 Is Required for Craniofacial Development
  JOURNAL   Front Cell Dev Biol 9, 647391 (2021)
   PUBMED   34211969
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7812)
  AUTHORS   Thauvin-Robinet,C., Lee,J.S., Lopez,E., Herranz-Perez,V., Shida,T.,
            Franco,B., Jego,L., Ye,F., Pasquier,L., Loget,P., Gigot,N.,
            Aral,B., Lopes,C.A., St-Onge,J., Bruel,A.L., Thevenon,J.,
            Gonzalez-Granero,S., Alby,C., Munnich,A., Vekemans,M., Huet,F.,
            Fry,A.M., Saunier,S., Riviere,J.B., Attie-Bitach,T.,
            Garcia-Verdugo,J.M., Faivre,L., Megarbane,A. and Nachury,M.V.
  TITLE     The oral-facial-digital syndrome gene C2CD3 encodes a positive
            regulator of centriole elongation
  JOURNAL   Nat Genet 46 (8), 905-911 (2014)
   PUBMED   24997988
REFERENCE   5  (bases 1 to 7812)
  AUTHORS   Ye,X., Zeng,H., Ning,G., Reiter,J.F. and Liu,A.
  TITLE     C2cd3 is critical for centriolar distal appendage assembly and
            ciliary vesicle docking in mammals
  JOURNAL   Proc Natl Acad Sci U S A 111 (6), 2164-2169 (2014)
   PUBMED   24469809
  REMARK    GeneRIF: results suggest that C2cd3 regulates cilium biogenesis by
            promoting the assembly of centriolar distal appendages critical for
            docking ciliary vesicles and recruiting other essential ciliogenic
            proteins
REFERENCE   6  (bases 1 to 7812)
  AUTHORS   Hoover,A.N., Wynkoop,A., Zeng,H., Jia,J., Niswander,L.A. and Liu,A.
  TITLE     C2cd3 is required for cilia formation and Hedgehog signaling in
            mouse
  JOURNAL   Development 135 (24), 4049-4058 (2008)
   PUBMED   19004860
  REMARK    GeneRIF: Furthering a link between Hedgehog signaling and cilia
            function, we find that cilia formation and proteolytic processing
            of Gli3 are disrupted in C2cd3 mutants.
REFERENCE   7  (bases 1 to 7812)
  AUTHORS   Mager,J., Schultz,R.M., Brunk,B.P. and Bartolomei,M.S.
  TITLE     Identification of candidate maternal-effect genes through
            comparison of multiple microarray data sets
  JOURNAL   Mamm Genome 17 (9), 941-949 (2006)
   PUBMED   16964442
REFERENCE   8  (bases 1 to 7812)
  AUTHORS   Zohn,I.E., Anderson,K.V. and Niswander,L.
  TITLE     Using genomewide mutagenesis screens to identify the genes required
            for neural tube closure in the mouse
  JOURNAL   Birth Defects Res A Clin Mol Teratol 73 (9), 583-590 (2005)
   PUBMED   15971254
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122269.4, AC151839.2 and AC117215.3.
            
            On Aug 14, 2018 this sequence version replaced NM_001017985.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660825.122357.1,
                                           SRR10223971.7919.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               AC122269.4         150661-150924
            265-534             AC122269.4         152692-152961
            535-692             AC122269.4         158396-158553
            693-916             AC151839.2         142243-142466       c
            917-1164            AC151839.2         141365-141612       c
            1165-1297           AC151839.2         137245-137377       c
            1298-1387           AC151839.2         136701-136790       c
            1388-1535           AC117215.3         189689-189836       c
            1536-1684           AC117215.3         183398-183546       c
            1685-1894           AC117215.3         182433-182642       c
            1895-2007           AC117215.3         181675-181787       c
            2008-2126           AC117215.3         179054-179172       c
            2127-2249           AC117215.3         176056-176178       c
            2250-2741           AC117215.3         172964-173455       c
            2742-2893           AC117215.3         170909-171060       c
            2894-3140           AC117215.3         169607-169853       c
            3141-3321           AC117215.3         166809-166989       c
            3322-3505           AC117215.3         164581-164764       c
            3506-3678           AC117215.3         163355-163527       c
            3679-3802           AC117215.3         162208-162331       c
            3803-4071           AC117215.3         159186-159454       c
            4072-4161           AC117215.3         158678-158767       c
            4162-4764           AC117215.3         156931-157533       c
            4765-5103           AC117215.3         153408-153746       c
            5104-5242           AC117215.3         149193-149331       c
            5243-5307           AC117215.3         148408-148472       c
            5308-5513           AC117215.3         145942-146147       c
            5514-5647           AC117215.3         145064-145197       c
            5648-5809           AC117215.3         140631-140792       c
            5810-6030           AC117215.3         137715-137935       c
            6031-6919           AC117215.3         134013-134901       c
            6920-7031           AC117215.3         129616-129727       c
            7032-7812           AC117215.3         119345-120125       c
FEATURES             Location/Qualifiers
     source          1..7812
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.35 cM"
     gene            1..7812
                     /gene="C2cd3"
                     /note="C2 calcium-dependent domain containing 3"
                     /db_xref="GeneID:277939"
                     /db_xref="MGI:MGI:2142166"
     exon            1..264
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..7181
                     /gene="C2cd3"
                     /note="protein hearty"
                     /codon_start=1
                     /product="C2 domain-containing protein 3"
                     /protein_id="NP_001017985.2"
                     /db_xref="CCDS:CCDS57568.1"
                     /db_xref="GeneID:277939"
                     /db_xref="MGI:MGI:2142166"
                     /translation="MKQRKGQGPGGGRGRKKRGLSDISPSTSLPPLVEGQLRCFLKLT
                     INKVVWKIAKPPTSVLVRVRWWGETSDGTLFCPRDALQTEPKAVRTTTRYGIRCGPKQ
                     FTSYLTDMAVLVLEVITKFDHLPVGRVQISGLAQLSPTHQINGFFTIVSPASKKLGEL
                     QVSLALEPLSETYDSYKPLPATEVTKNVLLSERELRENTESSNTQSMIPSRSCRGPAI
                     KIDGKELAGHSSRSTTPRGKDHLYFAENSDAVKGSLCGLQQHLNQGTNVETITLRGKA
                     PQKQLSLLNSSEFQPQISTVAKSHSDSCILSSNTPPAKDLLSALLEQGNKLRNAMLIS
                     AMNSNPDTSMLLDKVPPPMTEAIPRSSALNSSENHFKGHSADHLLPLADTGAIQLLLG
                     SAELSQGHFWNGLGSPPDSPTPGSDEYCSSDLNDPQYDQSLLENLFYTVPKSDVGTSE
                     LPSEDDGVEPSRTMNQSKASGRSKVVESKEQKQKRAAVKKSRNPIDQQELSRTPGHTP
                     AMSLSVDRLALLGRVHSVRIIVETMGVPPDSPHMTPSRKNFAGKPPKPTAAKKRTFFV
                     EYHFPVGFSKSGLGKTALITEVVRLASSKITDGVVKFQQRFVCPVEFGGPMIEHWWDS
                     NLIFQIYAKKTPQKKPEVIGSASLPLRAVIQSELLSFSSQLPVQQENGLSSLGPLKVT
                     MELVLGHKDFTGISAKLSSSTQPAPVSAATSSDTILPETGQDTACTRNPQSSNKIHEE
                     TTKKTQNLVLPDQESANSVASNSSIFMAVPSCNLVHQINGSNKESGLLLHVLLMVPDG
                     KDFVFGEREKQPSCNVYLNCKLFSTEEVTRSVVSWGTAQPVFNFSQVIPVSLTSKCLE
                     RLKNNVMIIETWNKVRSPGQDKLLGLVKLPLHQFYMSFKDPKISRLLLDARYPVVAVD
                     SYMPVIDVFSGHQNGSLRVFLAMGSSAQIMMLQRLKNEEGTLPPFSPRPAHFLDQPPV
                     ASVAMPEKQGTRLMEHHFEFCVAMVKGLMPLQATVWGEADCYVQYYFPFQDSQPSVLQ
                     GPDFLENGITLKPFRTSTTLCVPDPVFNSEHHHSLLLPTDVPVQRLLLSAFSSQGLVP
                     GGGVQFEVWCRYYYPNVRDQMVAKGTLPLSRVCAMVTMQYREDVGMQSFNLPLTSRLE
                     HSKELKNQSSGFLDVGLRYRRSPRTAEGILAARAVSISVHIIRACGLQAAAKALAEQE
                     PALQFSATVGVNASVTAHLSFLPKGEQRQTRPVACSFCPEFSHHIEFPCNLVTQHCSG
                     EACFLAELLEFAEIIFAIYHENTKSVSDITSIQSCKDYLLGIVKVPTKDLLVKRSGIT
                     GWYPVILPEDKGLPQDLDLMQKIVGGLELSVSFAHPGDRERVLEAAELLGWSFESIPK
                     DLVKKEEEVPATVTISTPRLWLPIHCVLLAGHMNIHKNTYCYLRYKLYNQEAFWTPLR
                     KPKESTNKNQVLITFKASKRAEVTRSQSLLWYFREEKLEIQVWRAYGNDNLERPHQTD
                     SWIGSAYVDLSRLGEKSPRTLTISGVYPLFGRNASDLSGAALRIHVLLSPLSPHTEPA
                     RELDSMDCSSHSESEQHPRKSDALQLSPPHVLQTSPTSTQVHGNSAAAQVCPAQEGPP
                     ELAGTFAVSILVERAMHLSLKGSPLTDRKVSVPSCCVSFATATELSPVYTHVVENTDS
                     PIWGFHQQARLSKELLLDPHQTLVFKVWHKGDEERVVGFASVDLSPLLSGFQFICGWY
                     NITDFSGECQGQIKVAISPMESLMHLKEERQARRGIDTPGALIPLFSALSFPASAGCD
                     AFPRPIARHVEGQLAHTSPKEDGLSSPARNGAIRSQAARHEEHVQNIRRFHESLQHGE
                     AVLTSDEKLTTAPSSSHTSILTSLRKNLSELDEIQKYFSQKLSKPFLPFSSQSSPAVS
                     QSQESQRDPVAAGTGRQDPENQCILEKSNHLVSQVSSLISDLQTLTRGSQAALTSQQA
                     RSRSRAVTTIPDAQGTEAAGEGSTTLEEPLAGAIEASTDSLPPPVEEPSKGGGMLHES
                     LEQTMPITRVQSIDDTEVGPDYSDEDYEEDIIEPRTLNEITTVTDRTSPWSSFMSDMS
                     EVLSPQPTEVQREGPSCPPEPFPREELKVKSSPQKAVSPQPAQGSPSQSGVCEGGAYK
                     IEVEDLASAKPQPVPSLTFSEAQEGSDSVGWRASQINQVRKPMPEMLAESEAFSSEFS
                     DSSESFETFPLHLPSQSKREDYKDSPAVRQKQVPTGSEVSTRQTLLLPEPVVVPNFFL
                     PPQQLEASLRMISHSPGLPPAATTDQDKSEATRGALAQRPCRPRPYSIPPNLPEEETR
                     RIARIFSSQYSKKTEET"
     exon            265..534
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     exon            535..692
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     exon            693..916
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1164
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1297
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1387
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1535
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1684
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1894
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2007
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2126
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2249
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2741
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     exon            2742..2893
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     exon            2894..3140
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     exon            3141..3321
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     exon            3322..3505
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     exon            3506..3678
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     exon            3679..3802
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     exon            3803..4071
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     exon            4072..4161
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     exon            4162..4764
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     exon            4765..5103
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     exon            5104..5242
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     exon            5243..5307
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     exon            5308..5513
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     exon            5514..5647
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     exon            5648..5809
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     exon            5810..6030
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     exon            6031..6919
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     exon            6920..7031
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     exon            7032..7812
                     /gene="C2cd3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7785..7790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C2cd3"
                     /note="hexamer: AATAAA"
     polyA_site      7805
                     /gene="C2cd3"
                     /note="major polyA site"
ORIGIN      
        1 gtagtccatt tgcaggggct ctaattggcg ccttcttttg gcaccgcttt ccgggaactg
       61 ttggtgaaag agtgtttctt cctgcgtccc aggcttccca gcggcgcccg ttgccgggga
      121 acgcaggcgc cgtgggaagg gatggcggga gcgtacagct taggagctgg cacctgcgtt
      181 gaatttgtga cgaagggccc aggctcggga tgaaacaacg gaaaggccaa gggcctgggg
      241 gcggccgtgg gcgcaaaaag agaggtttga gtgacatttc accgtctaca agcctgccac
      301 ctctggttga agggcagtta cgctgctttc tcaaactcac tattaataag gttgtatgga
      361 agattgcgaa gcctcctact tctgtacttg tccgagtaag gtggtgggga gaaacatccg
      421 atggaaccct cttttgtccc agagatgcat tacagactga gccaaaagct gtgagaacaa
      481 ctacccgtta cgggattcgc tgtggtccaa agcagtttac ctcgtatctg acagatatgg
      541 ctgtgctggt gttggaagta atcaccaagt ttgatcatct tcctgttggc agagttcaga
      601 tcagtggact tgcccagctg tctccaaccc atcagatcaa tgggtttttt accattgttt
      661 caccagcatc gaagaaactt ggagaacttc aggtctcgct tgccctggag cctctgtcag
      721 aaacttatga cagctacaaa cctcttcctg ccactgaagt gacaaaaaat gtgcttttat
      781 ctgagcgaga actcagagag aatactgaat ccagcaacac ccagtctatg atcccgtcaa
      841 ggtcttgtag gggacctgcc atcaaaattg atgggaaaga attagcaggc cacagcagca
      901 ggtcaaccac gccaagggga aaggaccact tgtactttgc agagaactcc gatgcagtaa
      961 agggttcttt gtgtggacta cagcagcacc ttaatcaagg gacgaatgta gagactataa
     1021 ctctgagggg caaagcccca cagaagcagc tgtccctcct gaacagctct gagtttcagc
     1081 cacaaattag tacagtcgcc aagagtcaca gtgactcatg catcctgtct tcaaacaccc
     1141 cccctgcaaa ggaccttctt tcagctctgt tagaacaagg caataagctg cggaatgcca
     1201 tgttgatttc tgcaatgaac tccaacccag atactagtat gctgcttgac aaagtccctc
     1261 ctcctatgac agaagctatt cccagatcgt cagcactgaa ctcatctgag aatcacttta
     1321 aaggccacag tgcagaccac cttctcccct tggcggacac cggagctata cagctgctgt
     1381 tgggcagtgc tgaattgtcc caaggtcatt tctggaatgg attaggctct cctccagatt
     1441 ccccgactcc tgggagtgat gagtactgca gcagtgacct gaatgatcct cagtatgacc
     1501 agagtctgct ggagaacttg ttttacacag tgcctaaatc tgatgtcggc accagtgagc
     1561 tccccagtga agatgatgga gtggaacctt ctagaacaat gaaccagtcc aaagcctctg
     1621 gcagatctaa ggttgtagag tcaaaagagc agaagcagaa gagggcagct gtcaagaaaa
     1681 gcagaaaccc aattgaccag caagagctct caagaactcc aggacatacc ccagcgatgt
     1741 cactaagtgt ggatagactg gctcttctgg gtagagtaca ttcggtcaga atcatcgttg
     1801 aaaccatggg agtccctcca gatagtcccc atatgacacc aagcaggaag aactttgccg
     1861 ggaaaccacc aaagccaaca gcagcaaaaa agcgcacttt ctttgtggag tatcactttc
     1921 ctgtgggctt ttccaaaagt ggactgggaa agacagcttt gatcactgag gttgttagac
     1981 ttgcctccag taaaatcacc gatggagtgg tgaaattcca gcagcgattt gtgtgtccag
     2041 tagagtttgg tggcccgatg atagagcact ggtgggattc taacctcatc ttccaaattt
     2101 atgcaaagaa aaccccacag aaaaagccag aagtcattgg atctgcatct ctccctttgc
     2161 gagctgtcat tcagtcagag ctgctttctt tcagtagcca gcttccagtg caacaggaaa
     2221 atggtctgtc ttcacttggc cccctaaagg tcaccatgga gcttgtttta ggccacaagg
     2281 atttcactgg aatcagtgct aagttaagta gcagcaccca acctgctcca gtttctgctg
     2341 ctacaagttc agatacgata ctaccagaga caggccagga taccgcctgt accagaaatc
     2401 cacagagctc aaataaaatt cacgaggaaa ccacaaagaa aacacagaat ttagtgctcc
     2461 ccgaccaaga gtcagcaaac tctgtagcct caaactcttc aatcttcatg gctgtgccat
     2521 cttgcaattt agtccatcaa ataaatggct caaacaaaga aagcggtttg ctgttacatg
     2581 tgctgttgat ggtgccagat gggaaagatt ttgtttttgg agaacgggag aaacaaccat
     2641 catgcaatgt ttatttgaat tgcaagcttt tcagcacaga agaagtcacc agatctgtcg
     2701 tctcgtgggg cacagcacag cctgtcttta atttttctca ggtgatccct gtctctctga
     2761 cttccaaatg cctggagaga cttaagaaca atgtgatgat aattgaaact tggaacaagg
     2821 tgcggagccc aggacaggac aagctgctcg ggctggtgaa actgccactc catcagtttt
     2881 acatgtcatt caaagacccc aagatttctc gcctgctgct tgatgccagg tacccagttg
     2941 ttgctgttga cagctatatg cctgtgattg atgtgttctc gggccaccaa aatgggagtc
     3001 ttcgagtctt tttagccatg ggttcttcag ctcagataat gatgctgcaa agattaaaga
     3061 atgaagaagg aacactccct cccttcagtc ctaggccagc ccatttcctg gaccagccac
     3121 ctgtagcatc tgttgctatg ccagaaaaac aaggaacccg gttgatggag caccactttg
     3181 agttctgtgt ggcgatggtt aaagggctca tgccccttca ggcaacagtc tggggagaag
     3241 cagattgcta cgtccagtac tactttccat ttcaagactc ccaacccagt gtgctccaag
     3301 gacccgactt ccttgaaaat ggaattactc tgaagccctt tagaacttca accacactgt
     3361 gtgtcccaga tcccgtcttt aatagtgaac accatcactc tctcctgttg ccgactgacg
     3421 ttccagtgca aaggctcctg ctgagtgcct tctcctccca ggggctggtg cctggaggag
     3481 gcgtccagtt tgaagtctgg tgcagatact attatcctaa cgtaagggac cagatggttg
     3541 ccaaaggaac cttgccatta tcaagggtct gtgccatggt aaccatgcag taccgtgaag
     3601 atgtgggaat gcagagcttt aatctcccat taacctccag acttgagcac agcaaagaat
     3661 taaagaacca gtcatcaggt ttcctggatg tgggtttgag gtaccggcgt agcccaagaa
     3721 cagcagaggg aattcttgct gcccgagctg tctccatctc agtccatatt atcagagcct
     3781 gtggtcttca ggcagcagcc aaggcgttgg ctgagcagga acccgcttta cagtttagcg
     3841 ccaccgttgg agtcaatgct tctgtcaccg cccatctctc atttctgccc aagggggagc
     3901 agcgccaaac ccgccctgtg gcctgctcct tctgccctga gttctcccac cacattgagt
     3961 tcccgtgtaa cctggtgact cagcactgta gtggagaagc ctgcttcctg gcagagctgt
     4021 tggagtttgc agaaattatt tttgctatct atcatgaaaa taccaaatca gtcagtgata
     4081 taaccagtat ccagtcgtgc aaggattatc tgcttggaat agtaaaggtt ccaacgaaag
     4141 atctgctggt caaaagatct gggatcacag gatggtatcc tgtcatttta ccagaagaca
     4201 aaggcctgcc tcaggacctg gacttgatgc agaagattgt aggaggcttg gagctttctg
     4261 tttccttcgc acatccggga gatagagaga gggtactgga agctgctgag ctgctgggct
     4321 ggagctttga gagcatccca aaggatcttg tcaagaaaga agaagaggtg ccagccactg
     4381 tcaccatctc taccccaagg ctctggcttc ctatccactg tgtgctgctt gctggtcata
     4441 tgaacattca taagaataca tattgctacc ttcgctacaa gctgtacaat caagaagcct
     4501 tttggactcc tctcaggaaa cctaaggagt ctacaaacaa aaaccaggtc ctgattactt
     4561 tcaaggcatc caaaagagca gaagtcacta ggagccagtc cctgctttgg tacttcaggg
     4621 aagagaagtt agagatccaa gtgtggcgag cctatggcaa cgacaattta gagaggccac
     4681 accagactga cagctggatt ggctcagcct atgtagacct gtccagactt ggggaaaaat
     4741 ctccaaggac actgactatc agtggggtgt atcccctgtt tggaagaaat gcttccgacc
     4801 tctctggagc tgctctgcgc attcatgtgc ttctttcccc gctttcccca cacactgaac
     4861 ctgctcggga gctggactcc atggactgca gcagccacag tgagtctgag cagcacccca
     4921 gaaagagcga tgcgctccag ctctctccac cccatgtgct ccagacgtct cccacctcca
     4981 cccaggtcca cggcaacagt gctgcagccc aagtgtgccc cgcccaggag ggccctcctg
     5041 agttggctgg gacttttgca gtcagcatcc tggtagagag agccatgcat ctgagcttga
     5101 aagggagccc cttgacagac cggaaagtat ctgtacccag ttgctgtgta tcctttgcca
     5161 cagccactga gctgtctcct gtctacactc acgtggttga aaacacggat tcccccatct
     5221 ggggttttca ccagcaggca aggctttcaa aagagctgct tctggaccca catcaaaccc
     5281 tggtcttcaa agtgtggcat aaaggagatg aagagagggt ggttggcttt gcctcggtgg
     5341 acctctcccc actactgtct ggctttcagt ttatctgtgg ctggtacaat attacagact
     5401 tcagtggaga gtgccaaggg caaatcaaag ttgctatttc acctatggag agcctgatgc
     5461 acctaaaaga agaaagacaa gcaagacgtg ggatagatac tccaggagca ctgattccat
     5521 tgtttagcgc cctttccttc cctgcctctg ctggatgcga tgcattccct aggcccattg
     5581 caaggcacgt cgaaggccag cttgctcaca catctccaaa ggaggacggt ctctcctctc
     5641 ctgcaagaaa tggtgccatc agaagccagg ccgcacgcca tgaagagcat gtgcagaaca
     5701 tccgccgctt tcacgagtcc ctgcagcacg gggaggcagt cctgacaagt gatgagaagc
     5761 tgaccacagc gccttcgtcc tcccacacct ccatcctgac ttctctcagg aagaatctga
     5821 gtgagctaga tgagatccag aagtacttca gccagaagct cagcaagccc ttcctgccct
     5881 tctcctctca gagctcgcct gctgtctcac agagccagga gagccagagg gaccctgtgg
     5941 ctgcaggaac cggccgccag gaccccgaga accagtgcat cctggagaag tccaatcacc
     6001 tggtgtcgca agtcagctcc ttgatctcag atctgcagac tctcaccaga ggttcacaag
     6061 cagctttgac ttctcagcaa gccaggagta gaagcagagc agtcaccacc atcccagatg
     6121 ctcagggcac cgaagctgct ggagaaggaa gcaccacact ggaggagcct ttggcaggag
     6181 ctatagaggc gagcacagat tccctgcctc cccctgttga agagccttcc aagggaggag
     6241 ggatgctcca tgagtcgctg gagcagacga tgcccatcac gagggtgcag agcatcgatg
     6301 acacggaggt gggcccagac tacagtgatg aagactatga ggaagacatt attgagccca
     6361 ggaccctaaa tgaaataacc acagtgacag acagaaccag cccctggtcc agtttcatgt
     6421 cagacatgag tgaggtcctt agccctcagc ccactgaggt acaaagggaa ggcccctcat
     6481 gtcccccaga acctttcccc agagaggagc tgaaggtcaa aagtagcccg caaaaggcag
     6541 tcagccccca gcctgcacag ggctccccta gccaaagtgg tgtttgtgag ggtggagcct
     6601 ataagatcga ggttgaagac cttgcctcag ccaagcctca gcctgtccca agcctaacat
     6661 tctcagaagc ccaagagggc agcgattctg ttggatggcg tgcatcacag ataaatcagg
     6721 tcaggaagcc catgccagag atgctggctg agagtgaggc tttctccagt gagttcagtg
     6781 actcttctga aagctttgag acgtttcctc tacacctacc ctcccaaagc aaaagagaag
     6841 actacaagga ctcccctgct gtgaggcaga agcaggtacc aactggatca gaggtgtcca
     6901 caaggcagac gctccttctc ccagaacctg ttgtggtgcc caacttcttt ttgcctcccc
     6961 aacaactgga ggcctctctc cgcatgatct cacactctcc aggtttgcca ccagcagcca
     7021 caactgacca ggacaagagt gaagccacca ggggagccct tgcccagagg ccttgtcgcc
     7081 ccagacctta ctccatccct cccaaccttc ctgaggaaga gactcgcagg attgcacgga
     7141 tattttcttc ccagtattcc aaaaagactg aggaaacctg agggacgtgg ctaccagcca
     7201 gcctctcagc tctgtaaagc ttgcaagaga caacaggcct gtttccctca gcatcctcag
     7261 gccactagca tcaccctatt ccatgggtat cttgagacct aatcagctaa gaccagagga
     7321 gtgtcccaaa ccacctagca gctgcctacc aggacctcag cttccttctg taatgaggtg
     7381 actgctggaa gtgagactca agcacccaag tgtcccaccc atcttctgac tgtggggcct
     7441 aaggaggcct ctctgagcag agaaaccagt gtccttgaca cagcctactg ctgaccagag
     7501 cccaccttct gcttaaatag gacaggctat ttttgccata aatattggaa gaaacatgga
     7561 ataagtatgt acatagctga gaaaattcca gagccctgtc cagcttgttt gtttgggaat
     7621 gaggtatttt atagatataa attattttta tgatgtatta atcaatagaa caggggaatt
     7681 gcctccttta aaactgtatt cggttgtctg aaatttaacc atgtttttaa cataatgttt
     7741 gtttctactc agctctgaaa ttcattgctc ttgcctttgt ttttaataaa agtctggcat
     7801 ttgtatttgt gt
//
