LOCUS       NM_027909               4334 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus C2 calcium-dependent domain containing 2-like
            (C2cd2l), transcript variant 1, mRNA.
ACCESSION   NM_027909 XM_134795
VERSION     NM_027909.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4334)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4334)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4334)
  AUTHORS   Nimitvilai,S., Uys,J.D., Woodward,J.J., Randall,P.K., Ball,L.E.,
            Williams,R.W., Jones,B.C., Lu,L., Grant,K.A. and Mulholland,P.J.
  TITLE     Orbitofrontal Neuroadaptations and Cross-Species Synaptic
            Biomarkers in Heavy-Drinking Macaques
  JOURNAL   J Neurosci 37 (13), 3646-3660 (2017)
   PUBMED   28270566
  REMARK    GeneRIF: Protein expression level differences of C2CD2L, DIRAS2,
            and PYCR2 in prefrontal neocortex of male M. fascicularis cases
            discriminates between those with heavy or light voluntary alcohol
            consumption. Results for C2CD2L were corroborated in chronic
            intermittent ethanol treated BXD strains of mice, in which the D
            allele (DBA/2) is associated with lower alcohol consumption than
            the B allele (C57BL/6J).
REFERENCE   4  (bases 1 to 4334)
  AUTHORS   Pottekat,A., Becker,S., Spencer,K.R., Yates,J.R. 3rd, Manning,G.,
            Itkin-Ansari,P. and Balch,W.E.
  TITLE     Insulin biosynthetic interaction network component, TMEM24,
            facilitates insulin reserve pool release
  JOURNAL   Cell Rep 4 (5), 921-930 (2013)
   PUBMED   24012759
  REMARK    GeneRIF: The identification of TMEM24 in the context of a
            comprehensive set of sequential insulin-binding partners provides a
            molecular description of the insulin secretory pathway in beta
            cells.
REFERENCE   5  (bases 1 to 4334)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   6  (bases 1 to 4334)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
REFERENCE   7  (bases 1 to 4334)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of TMEM24 family genes in
            silico
  JOURNAL   Int J Oncol 25 (3), 759-764 (2004)
   PUBMED   15289880
REFERENCE   8  (bases 1 to 4334)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   9  (bases 1 to 4334)
  AUTHORS   Kameya,S., Hawes,N.L., Chang,B., Heckenlively,J.R., Naggert,J.K.
            and Nishina,P.M.
  TITLE     Mfrp, a gene encoding a frizzled related protein, is mutated in the
            mouse retinal degeneration 6
  JOURNAL   Hum Mol Genet 11 (16), 1879-1886 (2002)
   PUBMED   12140190
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY202349.1, AK153804.1 and AK004920.1.
            
            [WARNING] On Aug 7, 2024 this sequence was replaced by NM_027909.3.
            
            On Feb 28, 2006 this sequence version replaced NM_027909.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153804.1, AK004920.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BY202349.1         3-31
            30-2281             AK153804.1         2-2253
            2282-3355           AK004920.1         2287-3360
            3356-4334           AK153804.1         3328-4306
FEATURES             Location/Qualifiers
     source          1..4334
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.84 cM"
     gene            1..4334
                     /gene="C2cd2l"
                     /gene_synonym="1300006O23Rik; Tmem24"
                     /note="C2 calcium-dependent domain containing 2-like"
                     /db_xref="GeneID:71764"
                     /db_xref="MGI:MGI:1919014"
     exon            1..748
                     /gene="C2cd2l"
                     /gene_synonym="1300006O23Rik; Tmem24"
                     /inference="alignment:Splign:2.1.0"
     CDS             395..2515
                     /gene="C2cd2l"
                     /gene_synonym="1300006O23Rik; Tmem24"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane protein 24; C2 domain-containing protein
                     2-like; phospholipid transfer protein C2CD2L"
                     /codon_start=1
                     /product="phospholipid transfer protein C2CD2L isoform 1"
                     /protein_id="NP_082185.2"
                     /db_xref="CCDS:CCDS23103.1"
                     /db_xref="GeneID:71764"
                     /db_xref="MGI:MGI:1919014"
                     /translation="MDPDWGQRDVGWAALLVLFAASLITVLGWMLQYARGLWLSRADG
                     GRDSRPASAAEPGGSLRELGVWRSLLRLRATRTSTPEEAGVRGLLASLFAFKSFRENW
                     QRAWVRALNEQACRDGSSIQIAFEEIPQLPPRASISHVTCVDQSERTMVLHCQLSAEE
                     VRFPISVTQQSPAAVSMETYHVTLTLPPTQLEVSLEEIPDEGLLVSWAFTDRPELSLK
                     VLPKLQTRERDEEQPELSTVEELIKDAIVSTQPAMMVNLRACSAPGGLVPSEKPPTMS
                     QAQPSIPRPTRLFLRQLRASHLGSELGGTEELCCAAELDNPMQQKWTKPMRAGPEVEW
                     TEDLALDLGPQSRELTLKVLRSSSCGDAELLGQATLPVGSPSRPMSRRQVCPLTPGPG
                     KSLSPAATVTAELHYEQGSPRNLGTPTSSTPRPSITPTKKIELDRTIMPDGTVVTTVT
                     TVQSRPRVDGKLDSPSRSPSKVEVTEKMTTVLSESSGPSNASHSSSRESHLSNGLDPV
                     AETAIRQLTEPSGRAAKKTPTKRSTLIISGVSKVPIAQDELALSLGYAASLEASMQDD
                     AGTSGGPSSPPSDPSATSPGPVDALSSPTSVQEADETTRSDISERPSVDDVESETGST
                     GALETRSLKDHKVSFLRSGTKLIFRRRPRQKEAGLSQSHDDLSNTTATPSVRKKAGSF
                     SRRLIKRFSFKSKPKANGNPSPQL"
     exon            749..844
                     /gene="C2cd2l"
                     /gene_synonym="1300006O23Rik; Tmem24"
                     /inference="alignment:Splign:2.1.0"
     exon            845..964
                     /gene="C2cd2l"
                     /gene_synonym="1300006O23Rik; Tmem24"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1075
                     /gene="C2cd2l"
                     /gene_synonym="1300006O23Rik; Tmem24"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1192
                     /gene="C2cd2l"
                     /gene_synonym="1300006O23Rik; Tmem24"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1304
                     /gene="C2cd2l"
                     /gene_synonym="1300006O23Rik; Tmem24"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1413
                     /gene="C2cd2l"
                     /gene_synonym="1300006O23Rik; Tmem24"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1478
                     /gene="C2cd2l"
                     /gene_synonym="1300006O23Rik; Tmem24"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1606
                     /gene="C2cd2l"
                     /gene_synonym="1300006O23Rik; Tmem24"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1781
                     /gene="C2cd2l"
                     /gene_synonym="1300006O23Rik; Tmem24"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1883
                     /gene="C2cd2l"
                     /gene_synonym="1300006O23Rik; Tmem24"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2017
                     /gene="C2cd2l"
                     /gene_synonym="1300006O23Rik; Tmem24"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2303
                     /gene="C2cd2l"
                     /gene_synonym="1300006O23Rik; Tmem24"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..4334
                     /gene="C2cd2l"
                     /gene_synonym="1300006O23Rik; Tmem24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3335..3340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C2cd2l"
                     /gene_synonym="1300006O23Rik; Tmem24"
                     /note="hexamer: ATTAAA"
     polyA_site      3356
                     /gene="C2cd2l"
                     /gene_synonym="1300006O23Rik; Tmem24"
                     /note="major polyA site"
ORIGIN      
        1 ggtgttgtca gtgtcagttc tgcgcacgca gccctcccgg agccggtgcc ggcccgcgag
       61 ccccggtatc tctgcaggct ggtccctgcc cgggtccggc ggggccccac gccgtgggag
      121 gaatcgggtg atagctggaa cctagctggg gtcacaccgc cggtgttagg gatccagatc
      181 tctggctacg gagacagagc tcgagcgtcg cgaccccgga ggacctcttc tccatccgtg
      241 gcacccactg gtcctggaat ctcggcggcg ccggagagcc ccggagcccg cgcgctcagc
      301 cccgggggag ctcgcccacg ccccacggtc catccgggcc atgctccccc ggggcagcgg
      361 ctgaacccga gccgggaccc gagcccgcgg gagcatggat ccggactggg ggcagcggga
      421 tgtgggctgg gcggccctgc tggttctctt cgccgcctcg ctgatcacgg tattgggctg
      481 gatgctgcag tatgcccggg gtttgtggct gtcgcgagcc gatgggggcc gagactcccg
      541 acctgcctca gctgctgagc ccgggggttc actgcgcgag ctgggtgtgt ggcgttcgct
      601 gctgcgtttg cgggcgaccc ggaccagcac ccccgaggaa gccggcgtac ggggcctcct
      661 ggcttcgctc tttgccttca agtctttccg ggagaactgg caacgggctt gggtgcgagc
      721 cttgaatgag caggcctgca gggacgggag ctccatccaa atcgcctttg aagagatacc
      781 ccaactccca ccaagagcca gcatcagtca tgtgacctgc gttgaccaat cagagcgcac
      841 catggtgctg cattgccagc tctctgctga ggaggtgcgc ttccccatct ctgtgaccca
      901 gcagtccccc gctgccgtct ccatggagac ctaccacgtc actctgacac tgccaccaac
      961 acagttggaa gtcagcctgg aggaaatccc tgatgagggg ctcctggtgt cctgggcctt
     1021 cactgaccgc ccagaactca gcctaaaggt gcttcccaag ttgcagacta gggagagaga
     1081 tgaggaacaa ccagagctct caacagttga ggaactgatc aaggacgcta tagtcagcac
     1141 tcagcccgcc atgatggtca acctcagggc ctgctctgcc ccaggaggcc tggtacccag
     1201 tgagaagcca cccacgatgt cccaggccca gccatccatc cccagaccta cccgattatt
     1261 cttacggcag cttcgagcat ctcacctggg aagtgagcta ggaggtactg aggaactgtg
     1321 ctgtgccgct gagcttgaca accccatgca acaaaagtgg accaaaccca tgagggcggg
     1381 ccccgaggtg gaatggaccg aggacctagc tctggatctg ggtccccaga gccgggagct
     1441 gaccctcaaa gtgctccgga gcagcagctg tggagatgct gaactccttg gccaagccac
     1501 actgcctgtg ggctcaccct ctagaccgat gtcacgaaga caggtgtgcc cactgactcc
     1561 agggcccggg aaatccctga gcccggcagc caccgtgaca gcggagctac attatgagca
     1621 gggttcccct cggaatctgg gcacgcccac ctcctccacc cctcgcccca gcatcacacc
     1681 caccaagaag attgagttgg accggaccat catgcccgac ggcacagtcg tcaccactgt
     1741 cactaccgtc cagtcccgcc cccgtgtaga tggcaaacta gactccccct cccgctcccc
     1801 gtccaaggtg gaggtgactg agaagatgac aaccgtgctg agtgagagca gcggccccag
     1861 caatgcctcc cacagcagca gccgggagag ccacctttcc aatggcttgg atccagtagc
     1921 agagacagcc attcgccagc tgactgagcc cagtgggcgg gcagccaaga agacacccac
     1981 caagaggagc acgctcatca tctctggtgt ttccaaggtg cccatcgccc aggacgagtt
     2041 ggctctctcc ttgggttacg cggcatctct ggaagcctcg atgcaagatg atgcaggaac
     2101 cagtggtggt ccttcgtcac ctccctcaga cccctcagcc acatccccag gacctgttga
     2161 tgccctctcc agtcccacaa gtgtccagga ggcagatgag acaacacgtt cagacatctc
     2221 tgagaggccg tctgtggatg atgttgagtc agaaacaggg tccactggtg ccctggagac
     2281 cagaagcctc aaggatcaca aagtgagttt cctgcgcagt ggcacaaagc tcatcttccg
     2341 ccggaggccc cgacagaagg aagctggtct gagccagtca cacgatgacc tgtccaacac
     2401 gacggccaca cctagcgtcc ggaagaaggc tggcagcttt tcccgtcgcc ttatcaagcg
     2461 tttttccttc aaatccaaac ccaaggccaa tggcaaccct agcccccagc tctgaaagcc
     2521 cccgagctag gagagatcaa gagttctctt agtctgtccc ccacatcccc ttctgtaccc
     2581 cttcctggat ccccactgct ggggccagga aagccctcgg gttataggga gccccagcac
     2641 actgggctgt ggggtgagcg ggaagggtgt ctgacatggg aggcatctgg gaggcaacag
     2701 ttgttgcgtg agcgtagagg agagtttggc agctgagagt caggggcaag ctctgtcttg
     2761 ggcgtgtgga cactcatcag aagcctctgc tggtactgcc gccagagggg agcccagagt
     2821 actctctcat cagcaggtcc ttctccctta tttattctcg tttctattta tatgtgtggt
     2881 ctagaaccct tggcaaacag atgatagagg gcatctctcc caggtgaccc ttttctgtcc
     2941 caggagggta aggcaattcc caggacgggt ttctacccct cccttgggag tcctctctta
     3001 gaccagcacc aatgtctgcc ttcagaagac attggcagat cacaggaagc cgggctaggg
     3061 cccgggatgg ggggcaggca ctccccacct ccctacctcc cacatcgctc cttgtctctc
     3121 cttccccttt attaccattt tgtacttgat gccttctcca tgagcagtgg ctcagttgga
     3181 aggagggagc caggaagctg ggaggaagcc ttccctagag agccagcttt aggagtttta
     3241 aagacagtac gatcatagag caaggttgca cctctgtatg ttgggagatg atgatgtcca
     3301 ttgctgtgtg atggcctgga atttaattta tttaattaaa atcaaattgg agtttataaa
     3361 cgggagtggc tggttatcct ttgaaaagca aacaggccta aaggctgtgg tgttgataga
     3421 gtgggcaggc gggctcactg actatgacct aggcagtcag gtggcacagg tgcccttgaa
     3481 cacagataca agtagagagg tttgagtgat gatactctga aaagtcaagt tgctgcaaag
     3541 aagccacccc tcccccacag gctgttcttt ctgggctgta acacgattta gagtgtggac
     3601 tctgaggctg cactgttctg acctgagacc cagctccact gacctttgtg acctttgtta
     3661 cctttgtgac cgtggacaaa tatggggcct cagttgtttt ggtttgtttt tgatccagag
     3721 cctcacctat gttgtcctag ctggcttaga actccttaag tagaccaggt tggccttgaa
     3781 ctcagagata gcctggtttc ttcctcctga gtgctaggac accacacctg gttgtgtact
     3841 cagttttttt cttctgtcaa atgggggcta gggactgggg atgtagctca aaggtagagt
     3901 tctgccttag catacccaaa gccctggggt ttgtctctag caatatttca tagagaggat
     3961 gaagccaggt gtggtggcta acacaaacct ttaatttcag tacctgggaa ctctgtgagt
     4021 ttcaggctag tcaggactat atagtgagac cctgtccaaa acaaacaaac aaacaaaagc
     4081 actattccta acataggtga gttttagata cctacagata tgtctctgtt tcctgtcctt
     4141 tgggatatta cacaggattg aaccaggtaa gctgctatag gaggttaggc aaaatgcagg
     4201 accaataggc aggaaactaa gtgtgccacc aatatctcta tctggcccaa gctgctactc
     4261 tttctggact ccagtttctt cacctctaaa ataaatgaaa gtggcctggg ataatcaggt
     4321 catttctgaa ctcc
//
