LOCUS       NM_174847               6568 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus C2 calcium-dependent domain containing 2 (C2cd2),
            mRNA.
ACCESSION   NM_174847
VERSION     NM_174847.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6568)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6568)
  AUTHORS   Shalom-Barak,T., Zhang,X., Chu,T., Timothy Schaiff,W., Reddy,J.K.,
            Xu,J., Sadovsky,Y. and Barak,Y.
  TITLE     Placental PPARgamma regulates spatiotemporally diverse genes and a
            unique metabolic network
  JOURNAL   Dev Biol 372 (1), 143-155 (2012)
   PUBMED   22967998
REFERENCE   3  (bases 1 to 6568)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   4  (bases 1 to 6568)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   5  (bases 1 to 6568)
  AUTHORS   Davisson,M.T., Bechtel,L.J., Akeson,E.C., Fortna,A., Slavov,D. and
            Gardiner,K.
  TITLE     Evolutionary breakpoints on human chromosome 21
  JOURNAL   Genomics 78 (1-2), 99-106 (2001)
   PUBMED   11707078
REFERENCE   6  (bases 1 to 6568)
  AUTHORS   Akeson,E.C., Lambert,J.P., Narayanswami,S., Gardiner,K.,
            Bechtel,L.J. and Davisson,M.T.
  TITLE     Ts65Dn -- localization of the translocation breakpoint and trisomic
            gene content in a mouse model for Down syndrome
  JOURNAL   Cytogenet Cell Genet 93 (3-4), 270-276 (2001)
   PUBMED   11528125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK086520.1, AK080956.1, AK077731.1, AV241091.2, AK220454.1,
            CF734597.1, CB202385.1, CF616821.1, AA137897.1, BB005022.2 and
            AA024193.1.
            
            On Mar 21, 2009 this sequence version replaced NM_174847.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK086520.1, AK220454.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-567               AK086520.1         2-568
            568-2148            AK080956.1         512-2092
            2149-3012           AK077731.1         2110-2973
            3013-3517           AK080956.1         2957-3461
            3518-3928           AV241091.2         248-658
            3929-4444           AK220454.1         3898-4413
            4445-4524           CF734597.1         152-231
            4525-4556           AK220454.1         4494-4525
            4557-5312           CB202385.1         9-764
            5313-5804           CF616821.1         314-805
            5805-6018           AA137897.1         320-533
            6019-6549           BB005022.2         101-631
            6550-6568           AA024193.1         307-325
FEATURES             Location/Qualifiers
     source          1..6568
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 57.7 cM"
     gene            1..6568
                     /gene="C2cd2"
                     /gene_synonym="5730563M15; 5830404H04Rik; mKIAA4045;
                     ORF25"
                     /note="C2 calcium-dependent domain containing 2"
                     /db_xref="GeneID:207781"
                     /db_xref="MGI:MGI:1891883"
     exon            1..579
                     /gene="C2cd2"
                     /gene_synonym="5730563M15; 5830404H04Rik; mKIAA4045;
                     ORF25"
                     /inference="alignment:Splign:2.1.0"
     CDS             319..2409
                     /gene="C2cd2"
                     /gene_synonym="5730563M15; 5830404H04Rik; mKIAA4045;
                     ORF25"
                     /codon_start=1
                     /product="C2 domain-containing protein 2"
                     /protein_id="NP_777272.2"
                     /db_xref="CCDS:CCDS28361.1"
                     /db_xref="GeneID:207781"
                     /db_xref="MGI:MGI:1891883"
                     /translation="MGSWLSEVQWLFLVSLFVAALGTVGLYLAQWALAKARPPPRRRA
                     EPDELRRRESDTLLSWILTRDSWGNQWQAAWVTALNYEAEKRGGPLRLSFQKDPRPQS
                     LQLTVEKVSSVVKSTQEKVVICHVVGETLQFLVSAGPASATGSECQLYDVHLSPFHLK
                     VEFHMEEKREDIQIRWSFTHVPETAIKIQPQAPGEKQALGVNMLSEALEDLFKHLVNA
                     ASPSVFLSTKPTQVKEAQSLQCPSSTAQEPCPPKPPRAHELKLQVKNIRVSLINHPGA
                     SGLSHVCVAQLNDPEQRFISTLVRNTTDLSWEEEFTFELNAKSKELVLQISQDGCSSE
                     GLLGIATIHLDLFRKQPNGPQTFRLISGTEPDSLVLGSVTAEFSYVEPGELKSWPAPP
                     PVSAAKIEKDRTVMPCGTVVTTVTAVKTKPRFDTGRATPLNSESPVRTPVTVKVIEKD
                     ISVQAISCHSAPVSKTFSSSDTELLVLNGSDPVAEVAIRQLSESSKLKLKSPRKKSTI
                     IISGISKTSLSQDHNAALMLDYAASMDSTNQGDATSALCHPEATEASATTPPEENEPA
                     QTLPALKPRENDLDSWELEKESPVASWSGPALQEPDGDELSESSLSTSELGAMKKHKG
                     GLLRKGAKLFFRRRHQQKDPGLSQSHNDLVFLQQPEGRQKKGATLGRLLNRKLLTRHR
                     GKHTMNGVPREPCI"
     exon            580..678
                     /gene="C2cd2"
                     /gene_synonym="5730563M15; 5830404H04Rik; mKIAA4045;
                     ORF25"
                     /inference="alignment:Splign:2.1.0"
     exon            679..798
                     /gene="C2cd2"
                     /gene_synonym="5730563M15; 5830404H04Rik; mKIAA4045;
                     ORF25"
                     /inference="alignment:Splign:2.1.0"
     exon            799..903
                     /gene="C2cd2"
                     /gene_synonym="5730563M15; 5830404H04Rik; mKIAA4045;
                     ORF25"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1026
                     /gene="C2cd2"
                     /gene_synonym="5730563M15; 5830404H04Rik; mKIAA4045;
                     ORF25"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1150
                     /gene="C2cd2"
                     /gene_synonym="5730563M15; 5830404H04Rik; mKIAA4045;
                     ORF25"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1256
                     /gene="C2cd2"
                     /gene_synonym="5730563M15; 5830404H04Rik; mKIAA4045;
                     ORF25"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1321
                     /gene="C2cd2"
                     /gene_synonym="5730563M15; 5830404H04Rik; mKIAA4045;
                     ORF25"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1446
                     /gene="C2cd2"
                     /gene_synonym="5730563M15; 5830404H04Rik; mKIAA4045;
                     ORF25"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1621
                     /gene="C2cd2"
                     /gene_synonym="5730563M15; 5830404H04Rik; mKIAA4045;
                     ORF25"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1735
                     /gene="C2cd2"
                     /gene_synonym="5730563M15; 5830404H04Rik; mKIAA4045;
                     ORF25"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1863
                     /gene="C2cd2"
                     /gene_synonym="5730563M15; 5830404H04Rik; mKIAA4045;
                     ORF25"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..2188
                     /gene="C2cd2"
                     /gene_synonym="5730563M15; 5830404H04Rik; mKIAA4045;
                     ORF25"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..6556
                     /gene="C2cd2"
                     /gene_synonym="5730563M15; 5830404H04Rik; mKIAA4045;
                     ORF25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2998..3003
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C2cd2"
                     /gene_synonym="5730563M15; 5830404H04Rik; mKIAA4045;
                     ORF25"
                     /note="hexamer: ATTAAA"
     polyA_site      3015
                     /gene="C2cd2"
                     /gene_synonym="5730563M15; 5830404H04Rik; mKIAA4045;
                     ORF25"
                     /note="major polyA site"
     regulatory      6525..6530
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C2cd2"
                     /gene_synonym="5730563M15; 5830404H04Rik; mKIAA4045;
                     ORF25"
                     /note="hexamer: AATAAA"
     polyA_site      6551
                     /gene="C2cd2"
                     /gene_synonym="5730563M15; 5830404H04Rik; mKIAA4045;
                     ORF25"
                     /note="major polyA site"
ORIGIN      
        1 ctcctgcggt tactacgggc cgcgggcggg acaacccggg cggcaagctg ggaagaagag
       61 cctttgcctt gcacttccca accgcgcgtg gggagcagct tcctctgtcc cgcgtttggc
      121 tcccaggcgc gcagcgctca atttggttcg cttaccggtc ctcgccgccc tccccgctgc
      181 cttggcctcc caggccccgg accctgtgcc cctgcgtacc ggcggatgtc ctgagtcgcc
      241 acccgccagc tccgcgcgcc ctgcggccac ggctgctggg ggaagtcggg gcgcgctcgc
      301 cgggtatgcg ccgtcagcat gggctcgtgg ctcagcgagg tgcagtggct cttcctggtg
      361 tcgctcttcg tcgcggccct gggcaccgtg ggcctgtact tggcgcagtg ggcgctggcc
      421 aaggcgcgac ccccgccccg gcggcgggcg gagccggatg agctaaggcg ccgggagtcg
      481 gacacactcc tttcctggat actgacacgg gatagctggg ggaaccagtg gcaggcggct
      541 tgggtgaccg ccctgaacta tgaggccgaa aagagagggg gtccactgcg tctctctttc
      601 cagaaggacc cacggccaca atccttgcag ctgacagttg agaaggtatc cagtgtagtc
      661 aagtcaaccc aggagaaggt ggtgatctgt catgtggtgg gtgagaccct tcagttcttg
      721 gtcagtgcag ggcctgcctc tgccacaggc tcggagtgcc agctgtatga tgtccatctt
      781 tccccatttc atttaaaggt agaattccac atggaagaga agagagagga catacaaatc
      841 aggtggtctt tcacccacgt cccagaaaca gccatcaaga tccagcccca ggccccaggg
      901 gagaagcagg cgctcggggt aaacatgctt tctgaagccc ttgaggatct tttcaagcac
      961 ctagttaatg ctgcctctcc atctgttttt ctgagcacca aacccacgca ggtcaaagaa
     1021 gctcagagtc tacagtgccc ttcctccact gctcaggaac cctgccctcc caaacctcca
     1081 agggctcatg aactaaaatt gcaggtgaag aatatcagag tttccctgat aaaccaccct
     1141 ggtgcttcag gccttagcca tgtgtgcgtg gctcagctga acgatcctga acagagattc
     1201 atcagcaccc tagtgagaaa cactactgac ctcagttggg aggaggaatt cacctttgaa
     1261 ctgaacgcca aatccaagga gctggtcctg cagatctcac aggatgggtg ctcctcagaa
     1321 ggtctgttgg ggatagcaac cattcacctg gacctattta ggaagcagcc taatggccca
     1381 cagaccttca gactgatcag tgggacagag cctgacagct tggtgttggg ctcagtcact
     1441 gcagagtttt cttacgtaga acctggggag ctgaaatcct ggccagctcc tccccctgtt
     1501 tctgctgcaa agatagaaaa ggaccgtacg gtgatgccat gtgggactgt ggtcaccact
     1561 gtcactgctg tgaagaccaa acctcggttt gacactggga gggcaacccc actgaactca
     1621 gagtcccctg tgaggacacc cgtcacagtg aaggtcattg agaaggacat ctctgtccag
     1681 gccatttctt gccacagcgc ccccgtcagc aagacattct cctcttcaga cacggaactg
     1741 ttggtgctga atggctcaga ccctgtggct gaagtcgcca ttcggcaact cagcgagtcc
     1801 tcaaagctga aactcaagtc cccacggaag aaaagcacca tcataatttc agggatctcc
     1861 aagacctcac tatctcagga ccacaatgct gccctcatgc tggactacgc agcttctatg
     1921 gacagcacca accagggaga tgccacgtct gctttgtgcc atccagaggc cactgaagcc
     1981 tctgctacta ccccacctga agaaaatgag ccagcccaga ccctacctgc cctcaagcct
     2041 agagaaaatg atctagattc ctgggaactg gagaaggagt ctccagtagc atcatggagc
     2101 ggaccagcct tgcaggagcc tgacggtgat gaactatccg agagctccct gagtacttca
     2161 gagctaggag ctatgaagaa gcataaagga ggactcctaa ggaaaggtgc caagctcttc
     2221 ttccgccggc gacaccaaca gaaagacccg ggcttgagcc agtcacataa tgacctggta
     2281 ttcctgcagc agccagaggg gaggcagaag aagggggcga ccctcggccg gctcctgaac
     2341 agaaagctgc ttaccaggca cagaggcaaa cacactatga atggagtacc cagagagccc
     2401 tgcatatagc ccaagtcacc ccctgtcctc acagctggag gatggggaac agaaaggtct
     2461 ccaccagaac agcaggaacc agtaccacca gatgcctgct tgtctatctt ggttgttttt
     2521 cccaataatc ttgtctttga aaggaacaaa acaatctgtg tgtatggcta ggaagcttcc
     2581 cctgagagga ctgataacac agtccagttt gctaccagat actccgtgtc tggctccagc
     2641 ttcaccaagc catcaaagct ctgaggggga acataaagag agagacttgc atctttgaag
     2701 ccatgtgtga tctgatggac tatggatggt aggcaggaga gatcctagtc cacctccttc
     2761 ttcctctctc ctgaaggact gactattgga gtttgtgtct ggaccttgtc aggagggaga
     2821 ggtgtccctc tgggctgttg ctatgagcag gatgggctac ctcacctaac ttgtttagaa
     2881 ttaaaacgtg cacctgggcc aggggatata ggcaggaatt ttgacccatg ggaaaaaaat
     2941 aggaaaagat gtgctttgac aagtgtgagg tattcacctt tgatattagc catagaaatt
     3001 aaaaatgtat gcaaatacta agtgtgttct atgcagattg tgccaggaac ttccagattt
     3061 actctagtct tcttgcaagt ggaggtgtag aaattcagat atgtttcttt gtttcttatg
     3121 tctggggctc tgttttttcc cacagtgcag acagtatgct gagctcaaat atgctgaggc
     3181 tgctatcagg agcagtgaat gacagcttat aggatatgac acacatatat atatatatat
     3241 atatatatat atatttcttg ccaaatatag ctaacaacca aaacaatgaa cttttagggc
     3301 aactgaggaa attactctgt atctcaggtg ccagttagtc ttaggtgtag aagttctaat
     3361 aacaatgggc caaacttgca ggaattcttc ttatgggatc ttcagaattt tactgtgaac
     3421 agagacttct ggtcacattt tagggtattc tggttttggt ttactgtggg aaaattataa
     3481 agttggcacc tggcttcagt gtccccacat aaagtccgta agatgctgtc ctaatctgta
     3541 tgcctggcat tgtgggttca ctgagtctca gaaccctcca gagacattgc gttgggttag
     3601 ggtgtccatt ttcctactat agcagtggaa aggctgacag taaaacctgt gtgctcgtca
     3661 ctgacatgca atcaggaagc tccctctggc atcttctgta cattagaaat atgcatttca
     3721 ggggcaaagt cactgttgac caaaaatgtc tacgatagcc aacattatag gaaaattttt
     3781 tttatatttt gttttagcaa gaaagatttg taaactacat ttagaaatcc ttccttccta
     3841 tctatctatc tatctatcta tctatctatc tatctatcta tctattcttt tcctcagttc
     3901 ttgggattaa acctgtatct ttgtgcacac tagacaagtc cttgtccact gaactgacta
     3961 tttccctggc cctcttttca cgtttggtca tcataattgt caggatttta ctgctgtgaa
     4021 cagacaccat gaccaagaca actcttataa aggacaaact ttaattgagg ctggcttaca
     4081 agttcagagg ttcagtccat tatcatcaag gcggggcatg gcagcatcca ggcaggcatg
     4141 gcactggagg agctgagggt tctacctctc tttcagaagt cagctaggaa aaggctggct
     4201 cttttgcact ggcagagctt caaaacccac acccacagtg atgtactttc tccaaccagg
     4261 ccacacctcc aaatagtgcc actccctggt tcaagcatat acaaacctcc acaatcatca
     4321 tcatcatcat aattattgtc attatcaagc taaggtttta ctgagttgtt gcttgggctg
     4381 ccctgtaatt cattctgtaa cccagacata tcttgaaact ctgattctcc tgcctttgtc
     4441 tctcaagtta cagtgaatac aggcctgagc cactgggccc ggagaacttt actttcaaat
     4501 aaacatttga aaattcttca tgggtatggt ggtacaggcc tgtgatccta gcacttagaa
     4561 gatggagaga ggagaatggt agcttccacc tcaacctggg ctacatgaga cccccttctc
     4621 aaaacaaaca acaaaaatag aagaaaaaga actgcaaagt tctagaatga tccatcaata
     4681 ataagttggt tcccaaagcc aggaatcccc acaacttttg ggggatagaa gtgattttaa
     4741 tgctgtgctc tactcgaagc attgctactc catgcagtct gcagaattgt gatccgtacc
     4801 tgtcaattcc cagagactac aggtgccagg aattctgatt ctgatggtgc attttcagtg
     4861 tgggacacag tagctgtcat ccaacatact gggggccaga agtgtttcag gcttcttttg
     4921 gatctggggc tatcttgata agactttacc atctgagcat cccttcatcc caaaatataa
     4981 aaatttcaga aacatgaaac tctttgaaca ctgtgatgca tacagtgttt tgggttttag
     5041 acttttgggt tagggatgct caacctatgc aggttttatt ggtttgggca tttaggttaa
     5101 gtctagtcaa gtgtgaaggt atcagaattt taggttatac ttttagcaag aacaaaaaag
     5161 aacaaatgat ttttagccat tctagcccac aaatgactct gtgagcatcc tgctcctggc
     5221 ttcccaacca catctaagac ctgcttcctt tagggtctcc attgagtagc ctttgccagt
     5281 tgtgaatacc atcacagcag agtgtacaga gatgggggac acaaagagga caagcctgag
     5341 aaaatgggcc ttcctcagac tataaaatcc cttctccaag ctgtttatcc acttctgttt
     5401 ctttgtagtg tagggtaatt atgttgaaat gaacaccatt aagattatgt aacaggtgcc
     5461 aacagcacaa ctgcttaagc caactctgtc cattgatctt gactacattc tttggtggct
     5521 tcagtttctg tcttaagatt ttggcagagt gctagtttta aagcagtttt tcatgaacac
     5581 taatccatgt gtctgtgaat ctggaagcag aactcaggtt ggctggagtt ggccacattt
     5641 cccctgtcct tcatgcagtg actgaataga gctgtttgtg tgatgttgat gtagcaataa
     5701 caaaactagg gctcttttgc tctgattgaa aacacactat gaacaatagg atttagacaa
     5761 agcactttat tttacatttt agtttaggtt taaaactagc cctgcttcct agctgtggat
     5821 acttggccat ttattgctaa ccagttccaa attagatttt tgcttggatt ttccctgacc
     5881 acatttacag aaatttttct tatgcagaca gggaaagatt aatttacatt gctgccaccc
     5941 aaagtggtgt tttctttggt taataagctc agggctgtca atcttgaact ttcaaagttc
     6001 aagttgatgg atggtagaag gtaaaatttg tctgtctcag aaacaagtgt gggcactgac
     6061 tgacaaccag gcacagaaac aggtgtgggt cctgagacaa gcaggcactg tctccactat
     6121 cccaacaggt aaaaagactt gaggaccaaa gcacctgcac agggacagag acactgttca
     6181 aaccagcagt gcaagctcct atcacctctg gctctttaca taaaatgtcc atgttctgtg
     6241 tataaataag ttgtgggatc accaagctgc ctggatcact tggctgaggg tggaatgaag
     6301 atgtgattat ccatcgggct ggaagctgtg gctttctgcc ctctgtcacg ccagtctcta
     6361 tgtcagaggg gataaaagta aaagcttccc aggtgtgtgg cgaacctgaa gctggtgtgt
     6421 ggggactggc atctgtggaa atgattgtat ttgttatgaa agacatgggt ggcacaggat
     6481 gccgtgcagt gagacgtggc tggaacttca ttgatctctc gagaaataaa tgtacccacg
     6541 gaagacttta agccgaaaaa aaaaaaaa
//
