LOCUS       NM_013484               2644 bp    mRNA    linear   ROD 05-FEB-2024
DEFINITION  Mus musculus complement C2 (C2), mRNA.
ACCESSION   NM_013484
VERSION     NM_013484.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2644)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (bases 1 to 2644)
  AUTHORS   Ramos,T.N., Darley,M.M., Weckbach,S., Stahel,P.F., Tomlinson,S. and
            Barnum,S.R.
  TITLE     The C5 convertase is not required for activation of the terminal
            complement pathway in murine experimental cerebral malaria
  JOURNAL   J Biol Chem 287 (29), 24734-24738 (2012)
   PUBMED   22689574
  REMARK    GeneRIF: Data indicate that activation of C5 in experimental
            cerebral malaria likely occurs via coagulation enzymes of the
            extrinsic protease pathway.
REFERENCE   3  (bases 1 to 2644)
  AUTHORS   Li,Q., Li,Y.X., Stahl,G.L., Thurman,J.M., He,Y. and Tong,H.H.
  TITLE     Essential role of factor B of the alternative complement pathway in
            complement activation and opsonophagocytosis during acute
            pneumococcal otitis media in mice
  JOURNAL   Infect Immun 79 (7), 2578-2585 (2011)
   PUBMED   21502587
REFERENCE   4  (bases 1 to 2644)
  AUTHORS   Tong,H.H., Li,Y.X., Stahl,G.L. and Thurman,J.M.
  TITLE     Enhanced susceptibility to acute pneumococcal otitis media in mice
            deficient in complement C1qa, factor B, and factor B/C2
  JOURNAL   Infect Immun 78 (3), 976-983 (2010)
   PUBMED   20065024
  REMARK    GeneRIF: Bacterial titers of both Streptococcus pneumoniae serotype
            6A and 14 in the middle ear lavage fluid samples from Bf/C2(-/)(-),
            Bf(-)(/)(-), and C1qa(-/)(-) mice were significantly higher than in
            samples from wild-type mice.
REFERENCE   5  (bases 1 to 2644)
  AUTHORS   Wallis,R., Mitchell,D.A., Schmid,R., Schwaeble,W.J. and Keeble,A.H.
  TITLE     Paths reunited: Initiation of the classical and lectin pathways of
            complement activation
  JOURNAL   Immunobiology 215 (1), 1-11 (2010)
   PUBMED   19783065
  REMARK    Review article
REFERENCE   6  (bases 1 to 2644)
  CONSRTM   WHO-IUIS Nomenclature Sub-Committee
  TITLE     Nomenclature for human complement component C2. WHO-IUIS
            Nomenclature Sub-Committee
  JOURNAL   Bull World Health Organ 70 (4), 527-530 (1992)
   PUBMED   1394787
REFERENCE   7  (bases 1 to 2644)
  AUTHORS   Ishikawa,N., Nonaka,M., Wetsel,R.A. and Colten,H.R.
  TITLE     Murine complement C2 and factor B genomic and cDNA cloning reveals
            different mechanisms for multiple transcripts of C2 and B
  JOURNAL   J Biol Chem 265 (31), 19040-19046 (1990)
   PUBMED   2229060
REFERENCE   8  (bases 1 to 2644)
  AUTHORS   Lafuse,W.P., Castle,L. and David,C.S.
  TITLE     Restriction fragment length polymorphism analysis of factor B and
            C2 genes in H-2 recombinant mouse strains
  JOURNAL   Immunogenetics 31 (4), 275-277 (1990)
   PUBMED   1970336
REFERENCE   9  (bases 1 to 2644)
  AUTHORS   Muller,U., Stephan,D., Philippsen,P. and Steinmetz,M.
  TITLE     Orientation and molecular map position of the complement genes in
            the mouse MHC
  JOURNAL   EMBO J 6 (2), 369-373 (1987)
   PUBMED   3034587
REFERENCE   10 (bases 1 to 2644)
  AUTHORS   Falus,A., Wakeland,E.K., McConnell,T.J., Gitlin,J., Whitehead,A.S.
            and Colten,H.R.
  TITLE     DNA polymorphism of MHC III genes in inbred and wild mouse strains
  JOURNAL   Immunogenetics 25 (5), 290-298 (1987)
   PUBMED   2883115
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK146812.1 and BY688722.1.
            
            [WARNING] On Mar 19, 2024 this sequence was replaced by
            NM_013484.3.
            
            On Oct 6, 2007 this sequence version replaced NM_013484.1.
            
            Summary: This gene encodes component C2 of the classical pathway of
            the complement system. The encoded protein undergoes proteolytic
            processing mediated by component C1 resulting in C2a and C2b
            fragments. C2a fragment, in turn, selectively cleaves components C3
            and C5 of the complement system. Mice lacking the encoded protein
            are found to be more susceptible to bacterial infections. Mutations
            in the human homolog of this gene are associated with disorders
            such as systemic lupus erythematosus, Henoch-Schonlein purpura, or
            polymyositis. [provided by RefSeq, Mar 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146812.1, BC011086.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2638              AK146812.1         2-2639
            2639-2644           BY688722.1         522-527
FEATURES             Location/Qualifiers
     source          1..2644
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.41 cM"
     gene            1..2644
                     /gene="C2"
                     /note="complement C2"
                     /db_xref="GeneID:12263"
                     /db_xref="MGI:MGI:88226"
     exon            1..151
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..2388
                     /gene="C2"
                     /EC_number="3.4.21.43"
                     /note="MHC complement component C2; complement factor C2;
                     classical-complement pathway C3/C5 convertase; complement
                     component 2 (within H-2S)"
                     /codon_start=1
                     /product="complement C2 preproprotein"
                     /protein_id="NP_038512.2"
                     /db_xref="CCDS:CCDS28664.1"
                     /db_xref="GeneID:12263"
                     /db_xref="MGI:MGI:88226"
                     /translation="MAPLLALFYLLQLGPGLAALFCNQNVNITGGNFTLSHGWAPGSL
                     LIYSCPLGRYPSPAWRKCQSNGQWLTPRSSSHHTLRSSRMVKAVCKPVRCLAPSSFEN
                     GIYFPRLVSYPVGSNVSFECEQDFTLRGSPVRYCRPNGLWDGETAVCDNGASHCPNPG
                     ISVGTARTGLNFDLGDKVRYRCSSSNMVLTGSAERECQSNGVWSGSEPICRQPYSYDF
                     PEDVASALDTSLTNLLGATNPTQNLLTKSLGRKIIIQRSGHLNLYLLLDASQSVTEKD
                     FDIFKKSAELMVERIFSFEVNVSVAIITFASQPKTIMSILSERSQDVTEVITSLDSAS
                     YKDHENATGTNTYEVLIRVYSMMQSQMDRLGMETSAWKEIRHTIILLTDGKSNMGDSP
                     KKAVTRIRELLSIEQNRDDYLDIYAIGVGKLDVDWKELNELGSKKDGERHAFILQDAK
                     ALQQIFEHMLDVSKLTDTICGVGNMSANASDQERTPWQVTFKPKSKETCQGSLISDQW
                     VLTAAHCFHDIQMEDHHLWRVNVGDPTSQHGKEFLVEDVIIAPGFNVHAKRKQGISEF
                     YADDIALLKLSRKVKMSTHARPICLPCTVGANMALRRSPGSTCKDHETELLSQQKVPA
                     HFVALNGNRLNINLRTGPEWTRCIQAVSQNKNIFPSLTNVSEVVTDQFLCSGMEEEDD
                     NPCKGESGGAVFLGRRYRFFQVGLVSWGLFDPCHGSSNKNLRKKPPRGVLPRDFHISL
                     FRLQPWLRQHLDGVLDFLPL"
     exon            152..376
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     exon            377..562
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     exon            563..739
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     exon            740..841
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     exon            842..975
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1114
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1255
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1345
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1486
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1581
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1699
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1865
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1942
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2034
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2164
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2214
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2644
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2619..2624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C2"
     polyA_site      2639
                     /gene="C2"
                     /note="putative"
ORIGIN      
        1 actcccctct agcgagcgag cgagcgagcg ctgtcttttc cgatctcggg gaagtcagat
       61 gacttttcct ctcccctagc tctccgttct actgtcctgg agaccatggc ccctctgctg
      121 gctctcttct acctgctgca gctgggccca ggcctggctg ctctcttctg caaccagaat
      181 gtcaatatca ccggtggtaa tttcaccctc agccatggct gggcccctgg gagcctcctc
      241 atctactcct gccccctggg caggtacccg tccccagcct ggaggaaatg tcagagcaac
      301 ggacagtggc tgacaccaag gtctagctca catcacaccc tgcgatcctc tcggatggtt
      361 aaagcagtct gcaaaccggt tcgatgccta gctccttcat cctttgaaaa tggcatctat
      421 ttccctcggc tggtgtccta ccctgtgggt agcaacgtga gctttgagtg tgagcaagac
      481 ttcaccttgc ggggctcacc tgtgcggtac tgtcgcccca acggcctgtg ggatggagag
      541 acggctgtgt gtgacaatgg ggctagccac tgccccaacc ctggcatctc agtgggcaca
      601 gctcggacag gcttgaactt tgaccttggg gacaaggtca ggtaccgctg ctcctcctca
      661 aatatggtat tgactggctc tgcagagcgg gagtgtcaga gcaatggagt gtggagtggg
      721 tcggaaccca tttgccgaca gccttactct tacgacttcc ctgaggatgt agcatctgcc
      781 ctagacacct ccctcaccaa cctgcttgga gccaccaatc ccacccagaa ccttctgaca
      841 aaaagtttgg gccgtaagat cataatccag cgctcgggtc acctgaacct ctatttgctg
      901 cttgatgctt ctcagagtgt gacagaaaaa gactttgaca tcttcaagaa gagtgccgaa
      961 ctcatggtgg agaggatctt cagctttgag gtaaatgtca gcgtagctat catcaccttt
     1021 gcctctcagc ccaaaaccat catgtcgatc ctgagtgaga gatcccagga tgtgacggag
     1081 gtgatcacca gtctggactc tgccagctac aaagatcacg aaaatgccac tggcactaac
     1141 acttatgagg ttctcatccg cgtttactcc atgatgcaaa gccagatgga tcgcctgggc
     1201 atggagacct ctgcctggaa ggaaatccgt cacaccatca tccttctgac tgacggaaag
     1261 tccaacatgg gtgactctcc caagaaagca gtcaccagaa tcagagagct cctgagcatc
     1321 gaacagaaca gagatgacta cctggacatc tatgctattg gggtgggcaa gctggatgtg
     1381 gactggaaag aactgaatga gctgggttcc aagaaggatg gcgagaggca tgccttcatc
     1441 ttgcaggatg caaaggcctt gcaacagatc tttgagcaca tgttggatgt ctctaagctc
     1501 acagatacca tctgtggggt ggggaacatg tccgccaatg cctctgacca ggagaggaca
     1561 ccttggcaag tcacctttaa gcccaagagc aaggaaactt gccagggatc actcatctct
     1621 gatcagtggg tgctgacagc agctcactgc ttccatgaca ttcagatgga ggaccaccac
     1681 ctgtggaggg tcaatgtagg tgatcccacc tctcagcatg gcaaagaatt tcttgtggag
     1741 gacgtgataa ttgccccagg gtttaatgtc catgcaaagc ggaagcaggg catctcagag
     1801 ttctatgctg atgacattgc cttgctgaag ctatctcgga aagtgaaaat gtccacccat
     1861 gccagaccca tctgccttcc ttgcactgtg ggagccaaca tggctctgcg gagatcccca
     1921 ggtagtacct gtaaagatca tgagacagaa cttctgtcac agcagaaagt tcctgcacat
     1981 tttgtagctt tgaatgggaa cagactcaac atcaacctca ggacaggacc tgagtggaca
     2041 aggtgtatcc aggctgtctc ccaaaacaaa aacatcttcc ccagcttgac aaacgttagc
     2101 gaggtggtga cagaccagtt cctatgcagt gggatggagg aggaagatga caatccttgc
     2161 aaaggagaat ctgggggagc cgttttcctt ggacggagat acaggttctt ccaggtgggc
     2221 ctggtgagtt ggggtctttt tgacccttgt catggttcct ccaacaaaaa cttgcgcaag
     2281 aaacctccac gtggtgttct gccaagggac ttccacatta gtcttttccg cctgcagccc
     2341 tggctgaggc agcacctgga tggtgtcctg gactttctgc cactttaaca tggtcactga
     2401 ctcctttatt agtctgaact tcctgtctaa tacctctgag cgttctcact cctggataca
     2461 taaatcttgg gccccgggag cccagagaca gtggcaaaag ctagggaatc cccaggattg
     2521 tgccgggacc tctgtgccac ctgtgaagca agtctctctc tagtgtggat gacccgtgct
     2581 ccttttgctt tcacacggaa tttcccagtt atgtaattaa taaaaatcaa tgatttccac
     2641 atcc
//
