LOCUS       NM_173864               2662 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus complement component 1, s subcomponent 2 (C1s2), mRNA.
ACCESSION   NM_173864
VERSION     NM_173864.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2662)
  AUTHORS   Mortensen,S.A., Sander,B., Jensen,R.K., Pedersen,J.S., Golas,M.M.,
            Jensenius,J.C., Hansen,A.G., Thiel,S. and Andersen,G.R.
  TITLE     Structure and activation of C1, the complex initiating the
            classical pathway of the complement cascade
  JOURNAL   Proc Natl Acad Sci U S A 114 (5), 986-991 (2017)
   PUBMED   28104818
REFERENCE   2  (bases 1 to 2662)
  AUTHORS   Garnier,G., Circolo,A., Xu,Y. and Volanakis,J.E.
  TITLE     Complement C1r and C1s genes are duplicated in the mouse:
            differential expression generates alternative isomorphs in the
            liver and in the male reproductive system
  JOURNAL   Biochem J 371 (Pt 2), 631-640 (2003)
   PUBMED   12513694
REFERENCE   3  (bases 1 to 2662)
  AUTHORS   Rossi,V., Cseh,S., Bally,I., Thielens,N.M., Jensenius,J.C. and
            Arlaud,G.J.
  TITLE     Substrate specificities of recombinant mannan-binding
            lectin-associated serine proteases-1 and -2
  JOURNAL   J Biol Chem 276 (44), 40880-40887 (2001)
   PUBMED   11527969
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF459020.1.
            
            On Jun 3, 2003 this sequence version replaced NM_173864.1.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is supported by available conservation data:
            the update is conserved in mouse, rat, dog, horse, cow and pig, but
            not in primates and supported by homologous and paralogous C1s-A
            proteins. Furthermore, the use of an alternative upstream start
            codon does not diminish the prediction of the signal peptide per
            SignalP 3.0.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF459020.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2662              AF459020.1         1-2662
FEATURES             Location/Qualifiers
     source          1..2662
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.17 cM"
     gene            1..2662
                     /gene="C1s2"
                     /gene_synonym="C1sb; EG317677; Gm5077"
                     /note="complement component 1, s subcomponent 2"
                     /db_xref="GeneID:317677"
                     /db_xref="MGI:MGI:3644269"
     exon            1..59
                     /gene="C1s2"
                     /gene_synonym="C1sb; EG317677; Gm5077"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..2121
                     /gene="C1s2"
                     /gene_synonym="C1sb; EG317677; Gm5077"
                     /EC_number="3.4.21.42"
                     /note="complement component 1, s-B subcomponent;
                     complement C1s-B subcomponent; complement component C1SB;
                     C1 esterase; complement component 1 subcomponent s-B;
                     complement C1s-1 subcomponent"
                     /codon_start=1
                     /product="complement C1s-1 subcomponent precursor"
                     /protein_id="NP_776289.2"
                     /db_xref="CCDS:CCDS20522.2"
                     /db_xref="GeneID:317677"
                     /db_xref="MGI:MGI:3644269"
                     /translation="MGKSPGMWYLVLFSLLASFSAEPTMHGEILSPNYPQAYPNDVVK
                     SWDIEVPEGFGIHLYFTHVDIEPSESCAYDSVQIISGGIEEGRLCGQRTSKSPNSPII
                     EEFQFPYNKLQVVFTSDFSIEEQFTGFAAYYTAIDVNECTDFTDVPCSHFCNNFIGGY
                     FCSCPPEYFLHDDMRNCGVNCSGDVFTALIGEISSPNYPNPYPENSRCEYQIQLQEGF
                     QVVVTMQREDFDVEPADSEGNCPDSLTFAAKNQQFGPYCGDGFPGPLTIRTQSNTLGI
                     VFQTDLMGQKKGWKLRYHGDPISCPKESTANSNWEPDKAKYVFKDVVKITCVDGFEVV
                     EGHVSSTSYYSTCQSDGQWSNSGLKCQPVYCGIPDPIANGKVEEPENSVFGTVIHYTC
                     EEPYYYMEHEEGGEYRCAANGRWVNDQLGIELPRCIPVCGVPTEPFQVQQKIFGGQPA
                     KIENFPWQVFFNHPTAGGALINEYWVLTAAHVVEKNSDPSMYAGITALRLADLENAQR
                     LYTKRVIIHPGWKEDDDLNPRTNFDNDIALVQLKDPVKMGPKFSPICLPGTSSEYNLS
                     PGDMGLISGWGRTEKRLHVINLRGAKVPVTSLETCKQVKEENPTARPEDYVITDNMIC
                     AGEKGVDSCKGDSGGAFAFQVPNVKAPKFYVAGLVSWGKKCGAYGVYTKVKNYVDWIL
                     KTMQENSGPRKD"
     exon            60..267
                     /gene="C1s2"
                     /gene_synonym="C1sb; EG317677; Gm5077"
                     /inference="alignment:Splign:2.1.0"
     exon            268..445
                     /gene="C1s2"
                     /gene_synonym="C1sb; EG317677; Gm5077"
                     /inference="alignment:Splign:2.1.0"
     exon            446..571
                     /gene="C1s2"
                     /gene_synonym="C1sb; EG317677; Gm5077"
                     /inference="alignment:Splign:2.1.0"
     exon            572..771
                     /gene="C1s2"
                     /gene_synonym="C1sb; EG317677; Gm5077"
                     /inference="alignment:Splign:2.1.0"
     exon            772..925
                     /gene="C1s2"
                     /gene_synonym="C1sb; EG317677; Gm5077"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1041
                     /gene="C1s2"
                     /gene_synonym="C1sb; EG317677; Gm5077"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1120
                     /gene="C1s2"
                     /gene_synonym="C1sb; EG317677; Gm5077"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1249
                     /gene="C1s2"
                     /gene_synonym="C1sb; EG317677; Gm5077"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1324
                     /gene="C1s2"
                     /gene_synonym="C1sb; EG317677; Gm5077"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..2662
                     /gene="C1s2"
                     /gene_synonym="C1sb; EG317677; Gm5077"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgccctttac ttccaaaatc agagagccag agagccatgg gcaaatcgcc agggatgtgg
       61 tatttggtcc tgttttctct tttggcatca ttttctgctg agcccaccat gcatggggag
      121 atcctgtccc ctaactatcc ccaggcgtac cccaatgacg tcgtgaaatc ttgggacatt
      181 gaagtcccag aggggtttgg gattcacctt tactttaccc atgtggacat agagccgtca
      241 gagagctgtg catacgactc agtgcagata atctcaggag gcatcgagga agggagactc
      301 tgtggtcaga ggaccagcaa gagccccaac tcccccatta tagaagagtt tcagttccca
      361 tacaataaac ttcaggtggt ctttacctca gacttctcca tcgaagaaca gtttaccggc
      421 tttgcagcat actacactgc catagacgta aacgaatgca cagattttac agatgtcccc
      481 tgtagccact tctgcaataa cttcattggt ggatacttct gctcctgtcc cccagaatac
      541 ttcctccatg atgacatgag gaattgtgga gtcaactgta gtggagatgt gttcactgcc
      601 ctgattgggg agatctcaag tcccaattat cccaatccat acccggagaa ctcaaggtgt
      661 gaataccaga ttcaactgca ggagggcttc caagtggtgg tgacgatgca gagagaagat
      721 tttgatgtgg agcccgctga ctcagagggg aactgccctg acagtttaac ttttgctgca
      781 aaaaaccaac agtttggtcc ttactgtggc gatgggtttc ctggaccgct aactattaga
      841 acccagagca atactctcgg cattgtcttt caaactgatc taatggggca aaaaaagggt
      901 tggaagcttc gttaccatgg agatcccatc tcctgtccta aagaaagcac tgccaattct
      961 aattgggagc ccgataaggc aaaatacgtg tttaaagatg tggtgaagat aacctgtgtg
     1021 gacggatttg aagttgtgga gggacatgtt agctctactt catactattc cacttgtcaa
     1081 agcgatggac agtggagcaa ctccggtcta aaatgtcaac ctgtgtattg tggaattcca
     1141 gatcccattg cgaatggtaa agttgaagag ccagagaata gtgtgtttgg tactgtcatt
     1201 cactatacgt gtgaagagcc atattactac atggaacatg aagaaggtgg ggagtatcga
     1261 tgtgctgcaa atgggagatg ggtaaatgac cagctgggta ttgagcttcc aagatgtatt
     1321 ccagtctgtg gagtacccac cgagcccttt caagtgcagc agaagatatt cggaggacaa
     1381 cctgcaaaga ttgaaaattt tccctggcaa gtcttcttta atcaccccac agctggtggg
     1441 gctcttatta atgagtactg ggtgctgacg gccgctcacg ttgtggagaa aaactccgac
     1501 ccttcaatgt atgccgggat cacggctttg agactggctg acttggaaaa tgcccagagg
     1561 ctctacacca agcgtgtgat tattcatccc ggctggaagg aagacgatga cctaaaccca
     1621 cggacaaatt ttgacaatga cattgccctg gtccagctga aagaccctgt gaaaatggga
     1681 cccaagtttt cccccatctg cctaccaggc acctcctcag agtacaacct ctcaccgggt
     1741 gacatggggc tgatctcagg gtggggcaga acagaaaaga gactccatgt tatcaacctc
     1801 agaggggcaa aggtaccggt aacctcttta gaaacctgca aacaggtgaa agaagagaac
     1861 cccacagcaa ggccagagga ctatgttatc actgacaaca tgatctgtgc tggtgagaag
     1921 ggtgttgaca gctgtaaagg ggacagtgga ggggcttttg ctttccaggt ccccaatgtc
     1981 aaggccccaa aattctatgt agctgggttg gtgtcttggg gaaaaaagtg tggggcctat
     2041 ggggtctaca caaaggtaaa gaattatgtg gactggatcc tgaaaactat gcaggagaat
     2101 agtgggccca ggaaggacta atccataggg cgacaactcc cctccagggc atagcaagct
     2161 cactgttctc agatcctatg gtggtcccct tatttcacaa caatggagag aagatgtggg
     2221 agtatggtta atgctgaact tgattgtcaa aaagtctgca tggaggcaga gttgatcact
     2281 gagctgtgtt ggttattcag ttactattgc taacaacatg gcagagaccc ttctatcttg
     2341 cgctattcca cagggatatc ttatccgatc ttccctcatt taacctgctt gaaattcctg
     2401 aataacttgc agcaaagcat gcttccaacc tggttctggt tgtatggaga gccacgaagg
     2461 agagagaggg agatttgggg gcatagcatc atggaattca ggcatcaaca gcatggaact
     2521 ctgcatctct aacaagatgc agacagggaa cacagccttt ttttctttct agtgagactt
     2581 actgaatact cggaatttag aaatgactac cttaattttt ctctgtgagt tgcttcaata
     2641 tgtttcctag aaatcaattt tc
//
