LOCUS       NM_001097617            2910 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus complement component 1, s subcomponent 1 (C1s1),
            transcript variant 2, mRNA.
ACCESSION   NM_001097617 XM_003689391
VERSION     NM_001097617.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2910)
  AUTHORS   Mortensen,S.A., Sander,B., Jensen,R.K., Pedersen,J.S., Golas,M.M.,
            Jensenius,J.C., Hansen,A.G., Thiel,S. and Andersen,G.R.
  TITLE     Structure and activation of C1, the complex initiating the
            classical pathway of the complement cascade
  JOURNAL   Proc Natl Acad Sci U S A 114 (5), 986-991 (2017)
   PUBMED   28104818
REFERENCE   2  (bases 1 to 2910)
  AUTHORS   Thoren,L.A., Norgaard,G.A., Weischenfeldt,J., Waage,J.,
            Jakobsen,J.S., Damgaard,I., Bergstrom,F.C., Blom,A.M., Borup,R.,
            Bisgaard,H.C. and Porse,B.T.
  TITLE     UPF2 is a critical regulator of liver development, function and
            regeneration
  JOURNAL   PLoS One 5 (7), e11650 (2010)
   PUBMED   20657840
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2910)
  AUTHORS   Klattig,J., Sierig,R., Kruspe,D., Makki,M.S. and Englert,C.
  TITLE     WT1-mediated gene regulation in early urogenital ridge development
  JOURNAL   Sex Dev 1 (4), 238-254 (2007)
   PUBMED   18391535
REFERENCE   4  (bases 1 to 2910)
  AUTHORS   Garnier,G., Circolo,A., Xu,Y. and Volanakis,J.E.
  TITLE     Complement C1r and C1s genes are duplicated in the mouse:
            differential expression generates alternative isomorphs in the
            liver and in the male reproductive system
  JOURNAL   Biochem J 371 (Pt 2), 631-640 (2003)
   PUBMED   12513694
  REMARK    GeneRIF: C1r and this gene are duplicated in mice; differential
            expression generates alternative isomorphs in the liver and in the
            male reproductive system.
REFERENCE   5  (bases 1 to 2910)
  AUTHORS   Rossi,V., Cseh,S., Bally,I., Thielens,N.M., Jensenius,J.C. and
            Arlaud,G.J.
  TITLE     Substrate specificities of recombinant mannan-binding
            lectin-associated serine proteases-1 and -2
  JOURNAL   J Biol Chem 276 (44), 40880-40887 (2001)
   PUBMED   11527969
REFERENCE   6  (bases 1 to 2910)
  AUTHORS   Lawson,P.R. and Reid,K.B.
  TITLE     A novel PCR-based technique using expressed sequence tags and gene
            homology for murine genetic mapping: localization of the complement
            genes
  JOURNAL   Int Immunol 12 (3), 231-240 (2000)
   PUBMED   10700458
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY144429.1, AK087522.1, BC111880.1 and BB805732.1.
            
            On Mar 2, 2012 this sequence version replaced XM_003689391.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK087522.1, AK172453.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               BY144429.1         1-107
            108-1376            AK087522.1         77-1345
            1377-2234           BC111880.1         1170-2027
            2235-2467           AK087522.1         2204-2436
            2468-2906           AK087522.1         2438-2876
            2907-2910           BB805732.1         375-378
FEATURES             Location/Qualifiers
     source          1..2910
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.17 cM"
     gene            1..2910
                     /gene="C1s1"
                     /gene_synonym="C1s; C1sa"
                     /note="complement component 1, s subcomponent 1"
                     /db_xref="GeneID:50908"
                     /db_xref="MGI:MGI:1355312"
     exon            1..92
                     /gene="C1s1"
                     /gene_synonym="C1s; C1sa"
                     /inference="alignment:Splign:2.1.0"
     exon            93..248
                     /gene="C1s1"
                     /gene_synonym="C1s; C1sa"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..2310
                     /gene="C1s1"
                     /gene_synonym="C1s; C1sa"
                     /EC_number="3.4.21.42"
                     /note="complement C1s-A subcomponent; serine protease;
                     complement component C1SA; C1 esterase; complement
                     component 1 subcomponent s-A; complement C1s-1
                     subcomponent"
                     /codon_start=1
                     /product="complement C1s-1 subcomponent precursor"
                     /protein_id="NP_001091086.1"
                     /db_xref="CCDS:CCDS51907.1"
                     /db_xref="GeneID:50908"
                     /db_xref="MGI:MGI:1355312"
                     /translation="MGKSPGMWCLVLFSLLASFSAEPTMHGEILSPNYPQAYPNDVVK
                     SWDIEVPEGFGIHLYFTHVDIEPSESCAYDSVQIISGDIEEGRLCGQRTSKSPNSPII
                     EEFQFPYNKLQVVFTSDFSNEERFTGFAAYYTAIDINECTDFTDVPCSHFCNNFIGGY
                     FCSCPPEYFLHDDMRNCGVNCSGDVFTALIGEISSPNYPNPYPENSRCEYQIQLQEGF
                     QVVVTMQREDFDVEPADSEGNCPDSLTFASKNQQFGPYCGNGFPGPLTIRTQSNTLGI
                     VFQTDLMGQKKGWKLRYHGDPISCAKKITANSTWQPDKAKYVFKDVVKITCVDGFEVV
                     EGHVSSTSYYSTCQSDGQWSNSGLKCQPVYCGIPDPIANGKVEEPENSVFGTVVHYTC
                     EEPYYYMEHEEGGEYRCAANGRWVNDQLGIELPRCIPACGVPTEPFQVHQRIFGGQPA
                     KIENFPWQVFFNHPRASGALINEYWVLTAAHVLEKISDPLMYVGTMSVRTTLLENAQR
                     LYSKRVFIHPSWKKEDDPNTRTNFDNDIALVQLKDPVKMGPKVSPICLPGTSSEYNVS
                     PGDMGLISGWGSTEKKVFVINLRGAKVPVTSLETCKQVKEENPTVRPEDYVFTDNMIC
                     AGEKGVDSCHGDSGGAFAFQVPNVTVPKFYVAGLVSWGKRCGTYGVYTKVKNYVDWIL
                     KTMQENSGPRKD"
     exon            249..456
                     /gene="C1s1"
                     /gene_synonym="C1s; C1sa"
                     /inference="alignment:Splign:2.1.0"
     exon            457..634
                     /gene="C1s1"
                     /gene_synonym="C1s; C1sa"
                     /inference="alignment:Splign:2.1.0"
     exon            635..760
                     /gene="C1s1"
                     /gene_synonym="C1s; C1sa"
                     /inference="alignment:Splign:2.1.0"
     exon            761..960
                     /gene="C1s1"
                     /gene_synonym="C1s; C1sa"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1114
                     /gene="C1s1"
                     /gene_synonym="C1s; C1sa"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1230
                     /gene="C1s1"
                     /gene_synonym="C1s; C1sa"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1309
                     /gene="C1s1"
                     /gene_synonym="C1s; C1sa"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1438
                     /gene="C1s1"
                     /gene_synonym="C1s; C1sa"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1513
                     /gene="C1s1"
                     /gene_synonym="C1s; C1sa"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..2910
                     /gene="C1s1"
                     /gene_synonym="C1s; C1sa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2888..2893
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1s1"
                     /gene_synonym="C1s; C1sa"
                     /note="hexamer: AGTAAA"
     polyA_site      2905
                     /gene="C1s1"
                     /gene_synonym="C1s; C1sa"
                     /note="major polyA site"
ORIGIN      
        1 aaaggccact ccctctggag ctgcaggggc ttaactgcat gaccagaggc aggagaggag
       61 gctggcccac ttgttcccat cagctcctga aggtgacact gagccctggg tggtccctca
      121 ctaccaaagc aagcacctgt atttgtcaga taaagacagc caggactgct gactgccctt
      181 tacctccaaa atcagagagc cagagagcca gagagccaga gagccatggg caaatcgcca
      241 gggatgtggt gtttggtcct gttttctctt ttggcatcat tttctgctga gcccaccatg
      301 catggggaga tcctgtcccc taattatccc caggcgtacc ccaatgacgt cgtgaaatct
      361 tgggacattg aagtcccaga ggggtttggg attcaccttt actttaccca tgtggacata
      421 gagccgtcag agagctgtgc atacgactca gtgcagataa tctcaggaga catcgaggaa
      481 gggagactct gtggccagag gaccagcaag agccccaact cccccattat agaagagttt
      541 cagttcccat acaataaact tcaggtggtc tttacctcag acttctccaa cgaagaacgg
      601 tttacgggct ttgcagcata ctacactgcc atagacataa atgaatgcac agattttaca
      661 gatgtcccct gtagccactt ctgcaataac ttcattggtg gatacttctg ctcctgtccc
      721 ccagaatact tcctccacga tgacatgagg aattgtggag tcaactgtag tggagatgtg
      781 ttcactgccc tgattgggga gatctcaagt cccaattatc ccaatccata cccggagaac
      841 tcaaggtgtg aataccagat tcagctgcag gagggcttcc aagtggtggt gacgatgcag
      901 agagaagatt ttgatgtgga gcccgctgac tcagagggga actgccctga cagtttaact
      961 tttgcttcaa aaaaccaaca gtttggtcct tactgtggta atgggttccc tggaccgcta
     1021 actattagaa cccagagcaa tactctcggc attgtctttc aaactgacct aatggggcaa
     1081 aagaagggtt ggaagcttcg ttaccatgga gatcccatct cctgtgccaa aaaaatcact
     1141 gccaattcta cttggcagcc cgataaggca aaatacgtgt ttaaagatgt ggtgaagata
     1201 acctgtgtgg acggatttga agttgtggag ggacatgtta gctctacttc atactattcc
     1261 acttgtcaaa gcgatggaca gtggagcaac tccggtctaa aatgtcaacc tgtgtattgt
     1321 ggaattccag atcccattgc gaatggtaaa gttgaagagc cagagaatag tgtgtttggt
     1381 actgttgttc actacacgtg tgaagagcca tattactaca tggaacatga agaaggtggg
     1441 gagtatcgat gtgctgcaaa tgggagatgg gtaaatgacc agctgggtat tgagcttcca
     1501 agatgtattc cagcctgtgg agtacccacc gagccctttc aagtgcatca gaggatattt
     1561 ggaggacaac ctgcaaagat tgaaaatttt ccctggcaag tcttctttaa tcaccccaga
     1621 gctagtgggg ctcttattaa tgagtactgg gtgctgacgg ctgctcacgt tttggagaaa
     1681 atctccgacc ctttaatgta tgtcgggacc atgtctgtga ggacaactct cttggaaaat
     1741 gcccagagac tctacagtaa acgtgtcttt attcatccca gctggaagaa agaagatgac
     1801 ccaaacacac ggacaaattt tgacaatgac attgccctgg tgcagctgaa agaccctgtg
     1861 aaaatgggac ccaaagtctc ccccatctgc ctaccaggca cctcctcaga gtacaacgtc
     1921 tcaccgggtg acatggggct gatctcaggg tggggcagta cagaaaagaa agtctttgtt
     1981 atcaacctca gaggggcaaa ggtaccagta acctctttag aaacctgcaa acaggtgaaa
     2041 gaggagaacc ccactgtaag gcctgaggac tatgttttca ctgacaacat gatctgtgct
     2101 ggcgagaaag gtgttgacag ctgtcacggg gacagcggcg gggcttttgc tttccaggtc
     2161 cccaatgtca cggtccccaa attctatgta gctggcttgg tgtcttgggg gaaaaggtgt
     2221 gggacttatg gggtctacac aaaggtaaag aattacgtgg actggatcct gaaaactatg
     2281 caggagaata gtgggcccag gaaggactaa tccgtagggc gacaactccc ctcaagggca
     2341 tagcaagctc actgttctca gatcctatgg tggtcccctt atttcacaac gatggagaga
     2401 agatgtggga gtatggttaa tgctgaactt gattgtcaaa gagtctgcat ggaggcaggg
     2461 ttgatcactg agccgtgttg gttattcagt tactattgct aacaacatgg cagaaaccct
     2521 tctatcttgc gctattccac agggatatct tatccgatct tccctcattt aacctgcttg
     2581 aaattcctga ataatttaca gcaaagcatg cttccaacct ggttctggct gtatggagag
     2641 ccacgaaggg agagagggag atttgggggc atagcatcat ggaattcagg catcaacagc
     2701 atggaactct gcatctctaa caagatgcag acagggaaca cagcctttta ttctttctag
     2761 tgagacttac cgaatactca gaagttagaa atgactacct tagtttttct ctgtgagttg
     2821 cttcaatata tttcctagaa attaattttc ttgtaatcct cctttgtatc atacagtgta
     2881 atgacttagt aaaatagaaa ttgaacattg
//
