LOCUS       NM_181344               3010 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus complement component 1, r subcomponent-like (C1rl),
            mRNA.
ACCESSION   NM_181344 XM_983874 XM_983914
VERSION     NM_181344.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3010)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3010)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 3010)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 3010)
  AUTHORS   Circolo,A., Garnier,G. and Volanakis,J.E.
  TITLE     A novel murine complement-related gene encoding a C1r-like serum
            protein
  JOURNAL   Mol Immunol 39 (14), 899-906 (2003)
   PUBMED   12686506
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK134207.1 and AK133495.1.
            
            On Nov 28, 2009 this sequence version replaced NM_181344.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133495.1, AK162497.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-210               AK134207.1         2-211
            211-3010            AK133495.1         190-2989
FEATURES             Location/Qualifiers
     source          1..3010
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.16 cM"
     gene            1..3010
                     /gene="C1rl"
                     /gene_synonym="C1r-LP; C1rl1; C1rlp"
                     /note="complement component 1, r subcomponent-like"
                     /db_xref="GeneID:232371"
                     /db_xref="MGI:MGI:2660692"
     exon            1..118
                     /gene="C1rl"
                     /gene_synonym="C1r-LP; C1rl1; C1rlp"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1487
                     /gene="C1rl"
                     /gene_synonym="C1r-LP; C1rl1; C1rlp"
                     /EC_number="3.4.21.41"
                     /note="complement component 1, r subcomponent like
                     protein; C1r-like protein; complement C1r
                     subcomponent-like protein"
                     /codon_start=1
                     /product="complement C1r subcomponent-like protein
                     precursor"
                     /protein_id="NP_851989.3"
                     /db_xref="CCDS:CCDS20520.1"
                     /db_xref="GeneID:232371"
                     /db_xref="MGI:MGI:2660692"
                     /translation="MSGFRGLVPELENSLWSSPTTSCMSKMCWWLLWGILHTCPTQAS
                     VLLAQQSPQQLTSPGYPEPYLKGQESHTDIEAPEGFAVRLTFQDFDLEPSPDCEGDSV
                     TISTGGTDATRLCGRQGSPLGNPPGHREFVSSGRSLRLTFQAHSSSKSKITHLHKGFL
                     ALYQAVAVNQPNGDTEAVTTPGAPKIQNHCQDPYYKADQTGTLSCPSSWKWKDRQDGG
                     EVPECVPVCGRPVVPLAENPNTFGSSRAKLGNFPWQAFTSIYGRGGGALLGDRWILTA
                     AHTIYPKDSIYLRRNQNVEVFLGHTDIDELLKLGNHPVRRVVVHPDYRQHESHNFNGD
                     IALLELEQRVPLGPNLLPVCLPDNETLYHSGLWGYVSGFGVEMGWLTTKLKYSKLPVA
                     PREACEAWLHQRQRTEVFSDNMFCVGEEMQVNSVCQGDSGSVYVVWDDLALRWVATGI
                     VSWGIGCGKGYGFYTKVLSYMDWIKRVIEGKD"
     exon            119..347
                     /gene="C1rl"
                     /gene_synonym="C1r-LP; C1rl1; C1rlp"
                     /inference="alignment:Splign:2.1.0"
     exon            348..537
                     /gene="C1rl"
                     /gene_synonym="C1r-LP; C1rl1; C1rlp"
                     /inference="alignment:Splign:2.1.0"
     exon            538..639
                     /gene="C1rl"
                     /gene_synonym="C1r-LP; C1rl1; C1rlp"
                     /inference="alignment:Splign:2.1.0"
     exon            640..714
                     /gene="C1rl"
                     /gene_synonym="C1r-LP; C1rl1; C1rlp"
                     /inference="alignment:Splign:2.1.0"
     exon            715..3010
                     /gene="C1rl"
                     /gene_synonym="C1r-LP; C1rl1; C1rlp"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2122
                     /gene="C1rl"
                     /gene_synonym="C1r-LP; C1rl1; C1rlp"
                     /note="major polyA site"
     regulatory      2605..2610
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1rl"
                     /gene_synonym="C1r-LP; C1rl1; C1rlp"
                     /note="hexamer: AATAAA"
     polyA_site      2632
                     /gene="C1rl"
                     /gene_synonym="C1r-LP; C1rl1; C1rlp"
ORIGIN      
        1 actccctggc ctgagccaag cactctagcc agttccagat gtcagggttc agaggcctgg
       61 tcccagagct ggagaacagc ctatggagtt ctcccaccac aagctgcatg agcaagatgt
      121 gctggtggct cctttgggga atcctccata cttgccccac acaggcctct gtgcttttgg
      181 cccagcagtc accacagcaa ctgacatccc ctggataccc agagccatat ctcaaaggcc
      241 aggagagcca cactgacatc gaggctccag aggggtttgc tgtgaggctg accttccagg
      301 actttgatct ggagccatcc ccagactgtg aaggcgactc tgtcacaatt tcaactggag
      361 gaacagatgc aacccggctg tgtgggcggc aaggttcccc tctggggaac cctcctggtc
      421 acagggagtt tgtatcttct ggtaggagcc tgcggctgac cttccaggca cactcgtcct
      481 ccaagagcaa aatcacacac ctccacaaag gtttcctggc tctctaccaa gctgtagctg
      541 tgaaccaacc caatggggac accgaggctg tcaccacacc cggagctccc aagattcaga
      601 accactgcca agatccttat tataaggcag accagacagg gacacttagc tgcccatcct
      661 cgtggaagtg gaaggacaga caggatggag gagaggttcc tgaatgcgtg ccagtctgtg
      721 gaagaccagt cgtccccctt gctgagaacc caaacacttt tggttcttcc cgagctaaac
      781 tgggcaactt cccctggcaa gccttcacca gcatctatgg tcgtgggggt ggagccctgc
      841 tgggtgacag atggatcctg acggctgccc ataccatcta ccccaaggat agcatctatc
      901 tcagaaggaa ccagaatgtg gaagtgtttc tgggtcacac agacatagac gagctactga
      961 aactcgggaa ccatcctgtc cgtagggtcg tggttcaccc agactaccgc caacatgagt
     1021 cccacaactt caatggagat attgctctcc tggaacttga gcagagagtc cctctggggc
     1081 ccaatctcct cccagtctgt ctgccggaca acgagaccct ctaccacagc ggcctgtggg
     1141 gttacgtcag tgggtttggt gtggagatgg gctggttaac aacaaagttg aaatactcaa
     1201 aactgcctgt agctcccagg gaggcctgtg aagcctggct ccaccagagg cagcgaactg
     1261 aggtgttttc tgacaatatg ttctgtgttg gggaagagat gcaggtgaac agtgtctgcc
     1321 agggagacag cggcagcgtc tatgtggtgt gggacgatct tgctctccgc tgggtggcca
     1381 caggcattgt atcctggggc atcgggtgtg gcaaggggta cggcttctac accaaagtgc
     1441 tcagctacat ggattggatt aagagggtga ttgaaggtaa agactgaccc cagggggccc
     1501 gaggagtggc cagccagtgc tgtggaggtc cctgctaaga acgggcagga gtgaggatcc
     1561 acttgaaacc gggagacccc atttaagtca ctggttcagc agggcagtgg tggcacaagt
     1621 ctttaatccc agcacttggg aggcagagac aggtggattt ctgagttcca ggtcagcctg
     1681 gtctacagat tgagttccag gacaggtagg gctacacaga gaaaccctgt atcaaaaact
     1741 aaacaaaaaa aaaaaaaaaa aaagtcactg attcagcaac ccactgccaa gagaaagccc
     1801 cgcctcccca gaccacgctg tcccaaatca gaaacagaac cttctgctct cctgggtttt
     1861 ataccaagca acctttgctc agaatgtctt tttgtttgtt caaggcagga tttcactctg
     1921 tagccaggct ggccttgaac tcacggcaat gctcccgctt cagcctccca aacactggga
     1981 ttacaagcgt gtacacctgc atcatcacca tgtgtgtctt tttttaattc cccgacctca
     2041 gctatggacg gtttcttctg tatttactca tggtctcttg tgtttctgaa atattctgaa
     2101 aacccttaca atgagcttca aatatgcctc ctgtcccagc ttctccagac aatcgtggca
     2161 atactcgatt ccattttaca tctactgtaa gccaggagca tcgcctgttg tctcatccag
     2221 tcctccctcc ctgttggcag agggtgtgtt ttctgtcatt catgcctcac aaagaggaaa
     2281 cggaagctcc cacagatccc gtggcttgtg gaagttccaa agctggttct ccactgaggc
     2341 ttcattcatc ccagcatgtt tgcccagcat gctctgtctc cgggattcct cccagttgcc
     2401 ccgcagacct gcctgagcac ccatttcacc ttccgggctc caccactgta cagactccat
     2461 ccctgggaag gcctgtttct atgaagattg taccaccagc tctcactttc ctgctggccc
     2521 tcatcaccca gggcattgcg agcctgagaa gatgaactct ttaatttgta gggaagattt
     2581 ggagtgattt atactaaaag acaaaataaa acacacgagt tcagtgataa tagaaaatga
     2641 ataccataaa agagagggga gaaaaggaag ggggttagtg ttgagatgaa cgtgctctaa
     2701 agtcaaaggt taaatttatc tttgaaataa cagcagcatc caagctaagc cataatacac
     2761 actaaaatcc cagccacgcg ggaggctgag gcagaaggat cataagttca aggccagctt
     2821 tgatctcatt tcaaagttaa caaaaaatta aaacatagta gtggtgcctt atgcctttag
     2881 tcctagcact gcgggaagtt caaggccagc ctggtctaca aagtcagttc caggatagcc
     2941 agggctacac agggaaaccc tgtcttaaaa accaataaat aaacaaataa attaataaat
     3001 agttggcagg
//
