LOCUS       NM_001113356            2166 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus complement component 1, r subcomponent B (C1rb), mRNA.
ACCESSION   NM_001113356 XM_001002804 XM_001480171
VERSION     NM_001113356.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2166)
  AUTHORS   Mortensen,S.A., Sander,B., Jensen,R.K., Pedersen,J.S., Golas,M.M.,
            Jensenius,J.C., Hansen,A.G., Thiel,S. and Andersen,G.R.
  TITLE     Structure and activation of C1, the complex initiating the
            classical pathway of the complement cascade
  JOURNAL   Proc Natl Acad Sci U S A 114 (5), 986-991 (2017)
   PUBMED   28104818
REFERENCE   2  (bases 1 to 2166)
  AUTHORS   Byun,S.J., Jeon,I.S., Lee,H. and Kim,T.Y.
  TITLE     IFN-gamma upregulates expression of the mouse complement C1rA gene
            in keratinocytes via IFN-regulatory factor-1
  JOURNAL   J Invest Dermatol 127 (5), 1187-1196 (2007)
   PUBMED   17159910
REFERENCE   3  (bases 1 to 2166)
  AUTHORS   Garnier,G., Circolo,A., Xu,Y. and Volanakis,J.E.
  TITLE     Complement C1r and C1s genes are duplicated in the mouse:
            differential expression generates alternative isomorphs in the
            liver and in the male reproductive system
  JOURNAL   Biochem J 371 (Pt 2), 631-640 (2003)
   PUBMED   12513694
REFERENCE   4  (bases 1 to 2166)
  AUTHORS   Rossi,V., Cseh,S., Bally,I., Thielens,N.M., Jensenius,J.C. and
            Arlaud,G.J.
  TITLE     Substrate specificities of recombinant mannan-binding
            lectin-associated serine proteases-1 and -2
  JOURNAL   J Biol Chem 276 (44), 40880-40887 (2001)
   PUBMED   11527969
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF459018.1.
            
            On or before Jan 10, 2008 this sequence version replaced
            XM_001480171.1, XM_001002804.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF459018.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2166
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.17 cM"
     gene            1..2166
                     /gene="C1rb"
                     /gene_synonym="667277; Gm8551; mC1rB"
                     /note="complement component 1, r subcomponent B"
                     /db_xref="GeneID:667277"
                     /db_xref="MGI:MGI:3779804"
     exon            1..29
                     /gene="C1rb"
                     /gene_synonym="667277; Gm8551; mC1rB"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..2148
                     /gene="C1rb"
                     /gene_synonym="667277; Gm8551; mC1rB"
                     /EC_number="3.4.21.41"
                     /note="complement C1r-B subcomponent; complement component
                     C1rb; complement component 1, r-B subcomponent; complement
                     component 1 subcomponent r-B"
                     /codon_start=1
                     /product="complement C1r-B subcomponent precursor"
                     /protein_id="NP_001106827.1"
                     /db_xref="CCDS:CCDS71834.1"
                     /db_xref="GeneID:667277"
                     /db_xref="MGI:MGI:3779804"
                     /translation="MWLFALLVTLFYGVEGSIYLPQKLYGEVTSPLYPKPYPSDLETT
                     TVITVPMGYRVKLVFWQFDVEPSEGCLYDYVKISADKQTLGRFCGQLDSPLGNPPGSK
                     EFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQAVDLDECASQPNSVEEGLQPRC
                     QHLCHNYVGGYFCSCHPGYELQKDGQSCQAECSSELYTEPSGYVSSLEYPQPYPPDLR
                     CNYSIRVERGLTVHLKFLDPFEIDDHQQVHCPYDQLQIYANGKNLGEFCGKQRPPDLD
                     TSSNAVDLLFFTDESGDSRGWKLHYTTETIKCPQPKALDEFTIIQDPQPQYQFRDYFT
                     VTCKQGYQLMEGNQALLSFTAVCQHDGTWHRAMPRCKIKNCGQPQSLSNGDFRYITTK
                     GVTTYEASIQYHCHEPYYKMLTRAGSSESMRGIYTCTAQGIWKNEEEGEKMPRCLPVC
                     GKPVNPVTQKERIIGGQPARPGNFPWQAFTTIYGPGGGALLGDRWILTAAHTIYPKYP
                     NKGKNTNPRTLVFLGHTNMEQIQKLGHHPVRRVIIHPDYRQEEPDNFEGDIALLELEN
                     SVTLGPELLPICLPDNETFYGQGLMGYVSGFGTTGNRIPFHLRFVRLPVADREACQRW
                     LWTKKDTSPFSQNMFCSGDPAVQQDACQGDSGGVFAVRDRNRDIWVATGIVSWGIGCG
                     EGYGFYTKVLNYVDWIKKEMGDEN"
     exon            30..255
                     /gene="C1rb"
                     /gene_synonym="667277; Gm8551; mC1rB"
                     /inference="alignment:Splign:2.1.0"
     exon            256..448
                     /gene="C1rb"
                     /gene_synonym="667277; Gm8551; mC1rB"
                     /inference="alignment:Splign:2.1.0"
     exon            449..595
                     /gene="C1rb"
                     /gene_synonym="667277; Gm8551; mC1rB"
                     /inference="alignment:Splign:2.1.0"
     exon            596..792
                     /gene="C1rb"
                     /gene_synonym="667277; Gm8551; mC1rB"
                     /inference="alignment:Splign:2.1.0"
     exon            793..940
                     /gene="C1rb"
                     /gene_synonym="667277; Gm8551; mC1rB"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1062
                     /gene="C1rb"
                     /gene_synonym="667277; Gm8551; mC1rB"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1141
                     /gene="C1rb"
                     /gene_synonym="667277; Gm8551; mC1rB"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1297
                     /gene="C1rb"
                     /gene_synonym="667277; Gm8551; mC1rB"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1372
                     /gene="C1rb"
                     /gene_synonym="667277; Gm8551; mC1rB"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..2166
                     /gene="C1rb"
                     /gene_synonym="667277; Gm8551; mC1rB"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacccaaaa caaactggcc ttgagacatg tggctctttg ccctcctggt gaccctgttc
       61 tatggggtgg aaggctccat ctacctccct cagaagctct atggagaggt gacctcccct
      121 ctgtatccca agccttaccc cagtgacttg gagacaacca ctgtgatcac tgtccccatg
      181 gggtacaggg tgaagctggt cttctggcag tttgacgtgg agccttctga aggctgcctc
      241 tatgactatg ttaagatttc tgctgataag caaacactgg ggaggttctg tgggcagctg
      301 gattctcccc tgggcaaccc cccaggaagc aaggaattca tgtcccaagg aaacaagatg
      361 ctgctgacct tccacacaga cttctccaat gaggagaatg ggaccatcat gttctacaag
      421 ggcttcctgg cctactacca ggctgtagac cttgatgaat gtgcatcgca gcccaactca
      481 gtggaagagg gtttgcagcc ccgatgccaa catctgtgtc acaactatgt tggaggctac
      541 ttctgttcct gccatcctgg ctatgagctt cagaaagatg ggcaatcctg ccaggctgag
      601 tgcagcagtg agctctacac agagccctca ggctatgtct ccagccttga ataccctcag
      661 ccctatccac cggatctacg ctgcaactac agcatccggg tggagagggg cctcactgtg
      721 cacctcaagt tcctggatcc ttttgaaatt gatgaccacc agcaagtgca ctgcccctat
      781 gaccagctcc agatctacgc taatgggaag aacttgggtg aattctgtgg aaagcaaagg
      841 cctccagacc ttgacaccag cagcaatgca gtggatctgc tgttcttcac agatgagtca
      901 ggggacagcc gaggctggaa gctgcactac accactgaaa ccatcaagtg cccccagccc
      961 aaggctctgg atgagttcac catcatccag gatccacagc ctcagtacca gttccgggat
     1021 tacttcactg tcacctgcaa gcaaggctac cagctcatgg agggaaatca ggcgctactg
     1081 tccttcacag ctgtttgcca gcatgatggc acgtggcatc gtgccatgcc caggtgcaag
     1141 atcaagaact gtgggcagcc ccaaagcctg tctaatgggg acttccgcta catcaccaca
     1201 aaaggtgtga ccacctatga agccagtatc cagtatcact gccatgaacc atattacaag
     1261 atgctgacca gagctggcag cagcgagtcc atgcgaggga tatatacctg cacagcccaa
     1321 ggcatttgga agaatgaaga ggaaggagag aaaatgcccc ggtgtctgcc agtgtgtggg
     1381 aaacctgtca accctgtgac acagaaggag cgcatcattg gagggcagcc agccaggccc
     1441 ggcaacttcc cctggcaggc cttcaccact atctatgggc cagggggtgg ggccctgctt
     1501 ggagaccgct ggatcctcac agcagcccac accatctacc ccaagtatcc caacaaagga
     1561 aaaaacacca accccagaac gcttgttttc ctgggccaca caaacatgga acagatccaa
     1621 aaactgggac atcacccagt ccgtagggtc atcatacacc cagactaccg ccaagaagaa
     1681 cctgacaatt ttgaaggaga cattgctcta ctggagctgg aaaacagtgt cacactgggc
     1741 cccgaactcc tccccatctg tctcccagac aatgagacct tctatggcca aggcctcatg
     1801 ggttatgtca gcggattcgg gacaacagga aataggatac ctttccatct caggtttgtc
     1861 agactgcctg tagctgatcg agaggcatgc cagagatggc tctggacaaa aaaggatact
     1921 tctccatttt ctcaaaatat gttctgttct ggggacccag ctgtacagca agacgcctgc
     1981 cagggggaca gtgggggtgt ttttgcagtc agggacagaa atcgtgatat ctgggtggct
     2041 acgggcatcg tatcctgggg cattgggtgt ggtgagggat atggcttcta caccaaggta
     2101 ctgaattatg ttgactggat caagaaagag atgggagacg aaaactgaac ccagtgttca
     2161 ctgggt
//
