LOCUS       NM_023143               2762 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus complement component 1, r subcomponent A (C1ra), mRNA.
ACCESSION   NM_023143 XM_917663
VERSION     NM_023143.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2762)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2762)
  AUTHORS   Xavier,S., Sahu,R.K., Bontha,S.V., Mass,V., Taylor,R.P.,
            Megyesi,J., Thielens,N.M. and Portilla,D.
  TITLE     Complement C1r serine protease contributes to kidney fibrosis
  JOURNAL   Am J Physiol Renal Physiol 317 (5), F1293-F1304 (2019)
   PUBMED   31509012
  REMARK    Erratum:[Am J Physiol Renal Physiol. 2020 Jan 1;318(1):F283. doi:
            10.1152/ajprenal.zh2-8924-corr.2020.. PMID: 31916861]
REFERENCE   3  (bases 1 to 2762)
  AUTHORS   Mortensen,S.A., Sander,B., Jensen,R.K., Pedersen,J.S., Golas,M.M.,
            Jensenius,J.C., Hansen,A.G., Thiel,S. and Andersen,G.R.
  TITLE     Structure and activation of C1, the complex initiating the
            classical pathway of the complement cascade
  JOURNAL   Proc Natl Acad Sci U S A 114 (5), 986-991 (2017)
   PUBMED   28104818
REFERENCE   4  (bases 1 to 2762)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 2762)
  AUTHORS   Boyle,M.P., Bernard,A., Thompson,C.L., Ng,L., Boe,A., Mortrud,M.,
            Hawrylycz,M.J., Jones,A.R., Hevner,R.F. and Lein,E.S.
  TITLE     Cell-type-specific consequences of Reelin deficiency in the mouse
            neocortex, hippocampus, and amygdala
  JOURNAL   J Comp Neurol 519 (11), 2061-2089 (2011)
   PUBMED   21491433
REFERENCE   6  (bases 1 to 2762)
  AUTHORS   Byun,S.J., Jeon,I.S., Lee,H. and Kim,T.Y.
  TITLE     IFN-gamma upregulates expression of the mouse complement C1rA gene
            in keratinocytes via IFN-regulatory factor-1
  JOURNAL   J Invest Dermatol 127 (5), 1187-1196 (2007)
   PUBMED   17159910
  REMARK    GeneRIF: We conclude that IFN-gamma stimulates mC1rA gene
            expression via IRF-1 in mouse keratinocytes.
REFERENCE   7  (bases 1 to 2762)
  AUTHORS   Garnier,G., Circolo,A., Xu,Y. and Volanakis,J.E.
  TITLE     Complement C1r and C1s genes are duplicated in the mouse:
            differential expression generates alternative isomorphs in the
            liver and in the male reproductive system
  JOURNAL   Biochem J 371 (Pt 2), 631-640 (2003)
   PUBMED   12513694
  REMARK    GeneRIF: This and C1s genes are duplicated in mice; differential
            expression generates alternative isomorphs in the liver and in the
            male reproductive system.
REFERENCE   8  (bases 1 to 2762)
  AUTHORS   Rossi,V., Cseh,S., Bally,I., Thielens,N.M., Jensenius,J.C. and
            Arlaud,G.J.
  TITLE     Substrate specificities of recombinant mannan-binding
            lectin-associated serine proteases-1 and -2
  JOURNAL   J Biol Chem 276 (44), 40880-40887 (2001)
   PUBMED   11527969
REFERENCE   9  (bases 1 to 2762)
  AUTHORS   Byun,S.J., Bahk,Y.Y., Ryoo,Z.Y., Kim,K.E., Hwang,H.Y., Lee,J.W.,
            Yi,J.Y. and Kim,T.Y.
  TITLE     Identification of cDNA encoding a serine protease homologous to
            human complement C1r precursor from grafted mouse skin
  JOURNAL   J Invest Dermatol 116 (3), 374-379 (2001)
   PUBMED   11231310
REFERENCE   10 (bases 1 to 2762)
  AUTHORS   Lawson,P.R. and Reid,K.B.
  TITLE     A novel PCR-based technique using expressed sequence tags and gene
            homology for murine genetic mapping: localization of the complement
            genes
  JOURNAL   Int Immunol 12 (3), 231-240 (2000)
   PUBMED   10700458
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY014972.1, AF148216.1, AI119268.1 and AK019687.1.
            
            On Jan 9, 2008 this sequence version replaced NM_023143.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC093528.1, AF148216.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                BY014972.1         2-49
            49-480              AF148216.1         37-468
            481-481             AI119268.1         457-457
            482-2413            AF148216.1         470-2401
            2414-2762           AK019687.1         252-600
FEATURES             Location/Qualifiers
     source          1..2762
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.16 cM"
     gene            1..2762
                     /gene="C1ra"
                     /gene_synonym="C1r; mC1rA"
                     /note="complement component 1, r subcomponent A"
                     /db_xref="GeneID:50909"
                     /db_xref="MGI:MGI:1355313"
     exon            1..180
                     /gene="C1ra"
                     /gene_synonym="C1r; mC1rA"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..2302
                     /gene="C1ra"
                     /gene_synonym="C1r; mC1rA"
                     /EC_number="3.4.21.41"
                     /note="complement C1r-A subcomponent; complement component
                     1, r-A subcomponent; complement component 1 subcomponent
                     r-A"
                     /codon_start=1
                     /product="complement C1r-A subcomponent precursor"
                     /protein_id="NP_075632.3"
                     /db_xref="CCDS:CCDS20521.1"
                     /db_xref="GeneID:50909"
                     /db_xref="MGI:MGI:1355313"
                     /translation="MWLFALLVTLFYGVEGSIYLPQKLYGEVTSPLYPKPYPSDLETT
                     TVITVPMGYRVKLVFWQFDVEPSEGCFYDYVKISADKQTLGRFCGQLDSPLGNPPGSK
                     EFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQAVDLDECASQPNSVEEGLQPRC
                     QHLCHNYVGGYFCSCHPGYELQKDGQSCQAECSSELYTEPSGYVSSLEYPQPYPPDLR
                     CNYSIRVERGLTVHLKFLDPFEIDDHQQVHCPYDQLQIYANGKNLGEFCGKQRPPDLD
                     TSSNAVDLLFFTDESGDSRGWKLHYTTETIKCPQPKALDEFTIIQDPQPQYQFRDYFI
                     VTCKQGYQLMEGNQALLSFTAVCQNDGTWHRAMPRCKIKNCGQPQSLSNGDFRYITTK
                     GVTTYEASIQYHCHEPYYKMLTRAGSSESMRGIYTCTAQGIWKNEEEGEKMPRCLPVC
                     GKPVNPVTQKERIIRGQPARPGNFPWQAFTTTHGRGGGALLGDRWILTAAHTIYPKHH
                     NKENDNANPKMLVFLGHTNVEQIKKLGHHPVRRVIIHPDYRQDEPNNFEGDIALLELE
                     NSVTLGPELLPICLPDNETFYGQGLMGYVSGFGITEDKLAFDLRFVRLPVADSEACQR
                     WLQTKKDTSPFSQNMFCSGDPAVQQDACQGDSGGVFAVRDRNRDIWVATGIVSWGIGC
                     GEGYGFYTKVLNYVDWIKKEMGDEN"
     exon            181..406
                     /gene="C1ra"
                     /gene_synonym="C1r; mC1rA"
                     /inference="alignment:Splign:2.1.0"
     exon            407..599
                     /gene="C1ra"
                     /gene_synonym="C1r; mC1rA"
                     /inference="alignment:Splign:2.1.0"
     exon            600..746
                     /gene="C1ra"
                     /gene_synonym="C1r; mC1rA"
                     /inference="alignment:Splign:2.1.0"
     exon            747..943
                     /gene="C1ra"
                     /gene_synonym="C1r; mC1rA"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1091
                     /gene="C1ra"
                     /gene_synonym="C1r; mC1rA"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1213
                     /gene="C1ra"
                     /gene_synonym="C1r; mC1rA"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1292
                     /gene="C1ra"
                     /gene_synonym="C1r; mC1rA"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1448
                     /gene="C1ra"
                     /gene_synonym="C1r; mC1rA"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1523
                     /gene="C1ra"
                     /gene_synonym="C1r; mC1rA"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..2762
                     /gene="C1ra"
                     /gene_synonym="C1r; mC1rA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2421..2426
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1ra"
                     /gene_synonym="C1r; mC1rA"
                     /note="hexamer: AATAAA"
     polyA_site      2446
                     /gene="C1ra"
                     /gene_synonym="C1r; mC1rA"
                     /note="major polyA site"
ORIGIN      
        1 agattttttt tgctgtttat gcaaatgctt cattccctga aacattcctc cgggaatggt
       61 caccccctcc actgccacaa tccttccctc ccctgtatgc ctactccctc cttcaactta
      121 cagtgcctga agactctgtc aggagagctg aggacccaaa acaaactggc cttgagacat
      181 gtggctcttt gccctcctgg tgaccctgtt ctatggggtg gaaggctcca tttacctccc
      241 tcagaagctc tatggagagg tgacctcccc tctgtatccc aagccttacc ccagtgactt
      301 ggagacaacc actgtgatca ctgtccccat ggggtacagg gtgaagctgg tcttctggca
      361 gtttgacgtg gagccttctg aaggctgctt ctatgactat gttaagattt ctgctgataa
      421 gcaaacactg gggaggttct gtgggcagct ggattctccc ctgggcaacc ccccaggaag
      481 caaggaattc atgtcccaag gaaacaagat gctgctgacc ttccacacag acttctccaa
      541 tgaggagaat gggaccatca tgttctacaa gggcttcctg gcctactacc aggctgtaga
      601 ccttgatgaa tgtgcatcgc agcccaactc agtggaagag ggtttgcagc cccgatgcca
      661 acatctgtgt cacaactatg ttggaggcta cttctgttcc tgccatcctg gctatgagct
      721 tcagaaagat gggcaatcct gccaggctga gtgcagcagt gagctctaca cagagccctc
      781 aggctatgtc tccagccttg aataccctca gccctatcca ccggatctac gctgcaacta
      841 cagcatccgg gtggagaggg gcctcactgt gcacctcaag ttcctggatc cttttgaaat
      901 tgatgaccac cagcaagtgc actgccccta tgaccagctc cagatctacg ctaatgggaa
      961 gaacttgggt gaattctgtg gaaagcaaag gcctccagac cttgacacca gcagcaatgc
     1021 agtggatctg ctgttcttca cagatgagtc aggggacagc cgaggctgga agctgcacta
     1081 caccactgaa accatcaagt gcccccagcc caaggctctg gatgagttca ccatcatcca
     1141 ggatccgcag cctcagtacc agttccggga ttacttcatt gtcacctgca agcaaggcta
     1201 ccagctcatg gagggaaatc aggcgctact ctccttcaca gctgtttgcc agaatgatgg
     1261 cacatggcat cgtgccatgc ccaggtgcaa gatcaagaac tgtgggcagc cccaaagcct
     1321 gtctaatggg gacttccgct acatcaccac aaaaggcgtg accacctatg aagccagtat
     1381 ccagtatcac tgccatgaac catattacaa gatgctgacc agagctggca gcagcgagtc
     1441 catgcgaggg atatatacct gcacagccca aggcatttgg aagaatgaag aggaaggaga
     1501 gaaaatgccc cggtgtctgc cagtgtgtgg gaaacctgtc aaccctgtga cacagaagga
     1561 gcgcatcatc agagggcagc cagccaggcc cggcaacttc ccctggcagg ccttcaccac
     1621 tacccacggg cgagggggtg gggccctgct tggagaccgc tggatcctca cagcagccca
     1681 caccatctac cccaagcatc acaacaagga aaacgacaat gccaacccca aaatgcttgt
     1741 tttcctgggc cacacaaatg tggaacagat caaaaaactg ggacatcacc cagtccgtag
     1801 ggtcatcata cacccagact accgccaaga tgaacctaac aattttgaag gagacattgc
     1861 tctactggag ctggaaaaca gtgtcacact gggccccgaa ctcctcccca tctgtctccc
     1921 agacaatgag accttctatg gccaaggcct catgggttat gtcagcggat tcgggataac
     1981 agaagataag ttagctttcg atctcaggtt cgtcagactg cctgtagctg acagtgaggc
     2041 atgccagaga tggctccaga caaaaaagga tacttctcca ttttctcaaa atatgttctg
     2101 ttctggggac ccagctgtac agcaagacgc ctgccaaggg gacagtgggg gtgtttttgc
     2161 agtcagggac agaaatcgtg atatttgggt ggctacgggc atcgtatcct ggggcattgg
     2221 gtgtggtgag ggatatggct tctacaccaa ggtactgaat tatgttgact ggatcaagaa
     2281 agagatggga gacgaaaact gaacccagtg ttcactgggt cagaatccag ggtatagtgt
     2341 attaaaaaaa atgtatctga ccaattgttg ataagcacta tgattctcat ataaaaatca
     2401 aagatgcaga acgtgtatag aataaactct cttttctgta atcccatcaa cgttatggta
     2461 ttttgttgtg ttttcaatat agtttgattg tgtggcccag tgtggagagc cgcaataaca
     2521 tttaccatca taagatggca ctggctcctc agtgccttat gccacctaaa caaagaacaa
     2581 gctatatgcg catgtgctag gagcaaaagc ccgccaaaag tcactagtcc accctggggc
     2641 ttgggagatc gtgggtggag caaccagtca tagttaggca cgtcacacca gagggtattt
     2701 aagcaacacg tttctgagcc tttttgcctt tctcgtcaag atgtaataaa gggtagccat
     2761 gg
//
