LOCUS       NM_183175               1903 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus C1q and tumor necrosis factor related protein 9
            (C1qtnf9), mRNA.
ACCESSION   NM_183175
VERSION     NM_183175.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1903)
  AUTHORS   Guan,H., Wang,L., Geng,Z., Duan,B., Gao,Y., Liang,Z., Zheng,X.,
            Shi,T. and Guo,F.
  TITLE     CTRP9 Promotes Brown Adipose Tissue Lipolysis in Mice Fed a
            High-Fat Diet
  JOURNAL   Front Biosci (Landmark Ed) 29 (6), 236 (2024)
   PUBMED   38940054
  REMARK    GeneRIF: CTRP9 Promotes Brown Adipose Tissue Lipolysis in Mice Fed
            a High-Fat Diet.
REFERENCE   2  (bases 1 to 1903)
  AUTHORS   Hu,Q., Qu,W., Zhang,T., Feng,J., Dong,X., Nie,R., Chen,J., Wang,X.,
            Peng,C. and Ke,X.
  TITLE     C1q/Tumor Necrosis Factor-Related Protein-9 Is a Novel
            Vasculoprotective Cytokine That Restores High Glucose-Suppressed
            Endothelial Progenitor Cell Functions by Activating the Endothelial
            Nitric Oxide Synthase
  JOURNAL   J Am Heart Assoc 13 (4), e030054 (2024)
   PUBMED   38348774
  REMARK    GeneRIF: C1q/Tumor Necrosis Factor-Related Protein-9 Is a Novel
            Vasculoprotective Cytokine That Restores High Glucose-Suppressed
            Endothelial Progenitor Cell Functions by Activating the Endothelial
            Nitric Oxide Synthase.
REFERENCE   3  (bases 1 to 1903)
  AUTHORS   Yang,X. and Niu,Y.
  TITLE     CTRP 9 mitigates the apoptosis and unfolded protein response of
            OGD/R-induced retinal ganglion cells by regulating the AMPK pathway
  JOURNAL   Pol J Pathol 75 (1), 40-53 (2024)
   PUBMED   38741428
  REMARK    GeneRIF: CTRP 9 mitigates the apoptosis and unfolded protein
            response of OGD/R-induced retinal ganglion cells by regulating the
            AMPK pathway.
REFERENCE   4  (bases 1 to 1903)
  AUTHORS   Wang,X., Ma,X., Zeng,Y., Xu,L. and Zhang,M.
  TITLE     Hypermethylation of the CTRP9 promoter region promotes Hcy induced
            VSMC lipid deposition and foam cell formation via negatively
            regulating ER stress
  JOURNAL   Sci Rep 13 (1), 19438 (2023)
   PUBMED   37945738
  REMARK    GeneRIF: Hypermethylation of the CTRP9 promoter region promotes Hcy
            induced VSMC lipid deposition and foam cell formation via
            negatively regulating ER stress.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1903)
  AUTHORS   Haustein,R., Trogisch,F.A., Keles,M., Hille,S., Fuhrmann,M.,
            Weinzierl,N., Hemanna,S., Thackeray,J., Dou,Y., Zwadlo,C.,
            Froese,N., Cordero,J., Bengel,F., Muller,O.J., Bauersachs,J.,
            Dobreva,G. and Heineke,J.
  TITLE     C1q and Tumor Necrosis Factor Related Protein 9 Protects from
            Diabetic Cardiomyopathy by Alleviating Cardiac Insulin Resistance
            and Inflammation
  JOURNAL   Cells 12 (3), 443 (2023)
   PUBMED   36766785
  REMARK    GeneRIF: C1q and Tumor Necrosis Factor Related Protein 9 Protects
            from Diabetic Cardiomyopathy by Alleviating Cardiac Insulin
            Resistance and Inflammation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1903)
  AUTHORS   Kambara,T., Ohashi,K., Shibata,R., Ogura,Y., Maruyama,S.,
            Enomoto,T., Uemura,Y., Shimizu,Y., Yuasa,D., Matsuo,K., Miyabe,M.,
            Kataoka,Y., Murohara,T. and Ouchi,N.
  TITLE     CTRP9 protein protects against myocardial injury following
            ischemia-reperfusion through AMP-activated protein kinase
            (AMPK)-dependent mechanism
  JOURNAL   J Biol Chem 287 (23), 18965-18973 (2012)
   PUBMED   22514273
  REMARK    GeneRIF: CTRP9 protects against acute cardiac injury following
            ischemia-reperfusion via an AMPK-dependent mechanism.
REFERENCE   7  (bases 1 to 1903)
  AUTHORS   Zheng,Q., Yuan,Y., Yi,W., Lau,W.B., Wang,Y., Wang,X., Sun,Y.,
            Lopez,B.L., Christopher,T.A., Peterson,J.M., Wong,G.W., Yu,S.,
            Yi,D. and Ma,X.L.
  TITLE     C1q/TNF-related proteins, a family of novel adipokines, induce
            vascular relaxation through the adiponectin
            receptor-1/AMPK/eNOS/nitric oxide signaling pathway
  JOURNAL   Arterioscler Thromb Vasc Biol 31 (11), 2616-2623 (2011)
   PUBMED   21836066
  REMARK    GeneRIF: We have provided the first evidence that CTRP9 is a novel
            vasorelaxative adipocytokine that may exert vasculoprotective
            effects via the adiponectin receptor 1/AMPK/eNOS dependent/NO
            mediated signaling pathway.
REFERENCE   8  (bases 1 to 1903)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   9  (bases 1 to 1903)
  AUTHORS   Wong,G.W., Krawczyk,S.A., Kitidis-Mitrokostas,C., Ge,G.,
            Spooner,E., Hug,C., Gimeno,R. and Lodish,H.F.
  TITLE     Identification and characterization of CTRP9, a novel secreted
            glycoprotein, from adipose tissue that reduces serum glucose in
            mice and forms heterotrimers with adiponectin
  JOURNAL   FASEB J 23 (1), 241-258 (2009)
   PUBMED   18787108
  REMARK    GeneRIF: A novel and highly conserved paralog of adiponectin
            designated as C1q/TNF-related protein (CTRP) 9 is characterized.
REFERENCE   10 (bases 1 to 1903)
  AUTHORS   Wong,G.W., Krawczyk,S.A., Kitidis-Mitrokostas,C., Revett,T.,
            Gimeno,R. and Lodish,H.F.
  TITLE     Molecular, biochemical and functional characterizations of C1q/TNF
            family members: adipose-tissue-selective expression patterns,
            regulation by PPAR-gamma agonist, cysteine-mediated
            oligomerizations, combinatorial associations and metabolic
            functions
  JOURNAL   Biochem J 416 (2), 161-177 (2008)
   PUBMED   18783346
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DQ002401.1, AC151835.4 and AW125201.1.
            
            On Feb 17, 2011 this sequence version replaced NM_183175.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ002401.1, BC115632.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               DQ002401.1         1-188
            189-189             AC151835.4         107986-107986       c
            190-1900            DQ002401.1         190-1900
            1901-1903           AW125201.1         17-19               c
FEATURES             Location/Qualifiers
     source          1..1903
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 31.93 cM"
     gene            1..1903
                     /gene="C1qtnf9"
                     /gene_synonym="9130217G22Rik; Adif1; Ciqtnf9; CTRP9"
                     /note="C1q and tumor necrosis factor related protein 9"
                     /db_xref="GeneID:239126"
                     /db_xref="MGI:MGI:3045252"
     exon            1..35
                     /gene="C1qtnf9"
                     /gene_synonym="9130217G22Rik; Adif1; Ciqtnf9; CTRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            36..222
                     /gene="C1qtnf9"
                     /gene_synonym="9130217G22Rik; Adif1; Ciqtnf9; CTRP9"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1058
                     /gene="C1qtnf9"
                     /gene_synonym="9130217G22Rik; Adif1; Ciqtnf9; CTRP9"
                     /note="complement C1q tumor necrosis factor-related
                     protein 9; complement C1q and tumor necrosis
                     factor-related protein 9; adiponectin f1"
                     /codon_start=1
                     /product="complement C1q and tumor necrosis factor-related
                     protein 9 precursor"
                     /protein_id="NP_898998.2"
                     /db_xref="CCDS:CCDS27178.1"
                     /db_xref="GeneID:239126"
                     /db_xref="MGI:MGI:3045252"
                     /translation="MRIWWLLLVMGACTRSVFSQDTCRQGHSGIPGNPGHNGLPGRDG
                     RDGAKGDKGDAGEPGHPGGPGKDGIRGEKGEPGADGRVEAKGIKGDPGSRGSPGKHGP
                     KGSIGPTGEQGLPGETGPQGQKGDKGEVGPTGPEGLMGSTGPLGPKGLPGPMGPIGKP
                     GPRGEAGPMGPQGEPGVRGMRGWKGDRGEKGKVGEAPLVPKSAFTVGLTVISKFPPPD
                     APIKFDKILYNELNHYNVATGKFTCHVAGVYYFTYHITVFSRNVQVSLVKNGVKVLHT
                     KDSYMSSEDQASGGIVQELKLGDEVWMQVTGGERFNGLFADEDDDTTFTGFLLFSSS"
     exon            223..285
                     /gene="C1qtnf9"
                     /gene_synonym="9130217G22Rik; Adif1; Ciqtnf9; CTRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            286..1903
                     /gene="C1qtnf9"
                     /gene_synonym="9130217G22Rik; Adif1; Ciqtnf9; CTRP9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1301..1306
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1qtnf9"
                     /gene_synonym="9130217G22Rik; Adif1; Ciqtnf9; CTRP9"
                     /note="hexamer: AACAAA"
     polyA_site      1325
                     /gene="C1qtnf9"
                     /gene_synonym="9130217G22Rik; Adif1; Ciqtnf9; CTRP9"
     regulatory      1884..1889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1qtnf9"
                     /gene_synonym="9130217G22Rik; Adif1; Ciqtnf9; CTRP9"
                     /note="hexamer: AGTAAA"
     polyA_site      1903
                     /gene="C1qtnf9"
                     /gene_synonym="9130217G22Rik; Adif1; Ciqtnf9; CTRP9"
                     /note="major polyA site"
ORIGIN      
        1 agtgccagga tccagcctgc aactcctggg ctcagttgag accctgtggt ctgaccatga
       61 ggatttggtg gcttctgctg gttatgggtg catgcacgag aagtgtattc tcccaggaca
      121 cctgccggca agggcactcc ggcatccctg ggaatccagg tcacaatggc ctacctggaa
      181 gagatggacg agatggtgcc aagggtgaca aaggagacgc aggagaacca ggacatcctg
      241 gtggtccagg aaaggatgga attcgtgggg agaaaggaga accaggagca gatggaagag
      301 ttgaagcaaa aggcatcaaa ggtgatccag gctccagagg atctccgggg aaacatggcc
      361 caaagggatc cattggtcct acaggagagc aagggctgcc aggagagact ggccctcagg
      421 ggcagaaggg ggataaaggc gaagtgggcc ccactggacc cgaaggacta atgggcagta
      481 ctggtccttt gggtcccaag ggcttacctg gcccgatggg ccccatcggc aaaccaggtc
      541 ccaggggaga agctggaccc atgggccccc agggggagcc aggagtcaga ggaatgagag
      601 gctggaaagg cgatcgagga gagaagggga aagttggtga ggctcccctt gtgcccaaga
      661 gtgctttcac tgtgggactc acggtgatca gtaagttccc tcccccagat gcacccatta
      721 aattcgataa gatcctatac aatgaactga accactacaa tgtagcgacg gggaagttca
      781 cctgccacgt ggcaggtgtc tattacttta cctaccatat cactgtgttc tccaggaatg
      841 tgcaggtatc tttggtcaaa aacggggtaa aagtcctgca caccaaggac agttacatga
      901 gctctgagga ccaggcgtct ggtggcattg tgcaggagct gaaactcggg gacgaagtgt
      961 ggatgcaggt gacaggagga gagaggttca atggcttatt tgcagacgag gatgacgata
     1021 ccacgttcac gggcttcctg ctgttcagca gctcttgaca caaggactct gcacgtgggc
     1081 ctcacagagg gctctctctg ctggtgaacg tggtgcctac agaactcgct tggggagggt
     1141 gggatgtgac tgcatccatt cctcagatta tcgcatccat cctacaatgt atacctggga
     1201 agttagtcct acagatgccg tcatttgaac acatgaatga acactaagag ccaccagcaa
     1261 tgtatcagtg tcccctgaag gcttcccctc catgtcactg aacaaagact gagtccagat
     1321 ttgaattctc tagttcgtga atcctgtgtt ccccactaca ccccgcacca cccccatctg
     1381 tttgctgtat gagtctgaat ccgaatctgc ttgaagactg tcttgtgaat ctgtccttgt
     1441 ccccaacaaa gggttttgct ctctctttta ttgagcagta caaaaaaaca acacacggag
     1501 aaagggatga gggatgcttc atagacatct ttaacagagt cttacactga gtccaagtgt
     1561 tcccaattca cccagataac aacaaacaaa caccattaaa tggggtgggg gaggggaaag
     1621 gaaaggagac ggggtgggga ggaagagagg agagactaga tctgtcatgg gcttttgaag
     1681 cctcaagggc ctctctcagt gacatgtctc ctctaacaag gccacgccta gtccttccca
     1741 aacagtttca ctaactggaa cattcaaaca tatgagccta gggggcacca tcctctctct
     1801 ccgcattcaa accaccccag taatgcaagg ggtactttca tcacaatgca ctgccacagt
     1861 tgcatgtgtg tcacttgtta aagagtaaaa gaataagcag tga
//
