LOCUS       NM_001135172            1652 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus C1q and tumor necrosis factor related protein 7
            (C1qtnf7), transcript variant 1, mRNA.
ACCESSION   NM_001135172
VERSION     NM_001135172.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1652)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1652)
  AUTHORS   Petersen,P.S., Lei,X., Wolf,R.M., Rodriguez,S., Tan,S.Y.,
            Little,H.C., Schweitzer,M.A., Magnuson,T.H., Steele,K.E. and
            Wong,G.W.
  TITLE     CTRP7 deletion attenuates obesity-linked glucose intolerance,
            adipose tissue inflammation, and hepatic stress
  JOURNAL   Am J Physiol Endocrinol Metab 312 (4), E309-E325 (2017)
   PUBMED   28223291
  REMARK    GeneRIF: In obese male mice consuming a high-fat diet, CTRP7
            deficiency attenuated insulin resistance and enhanced glucose
            tolerance, independent of body weight, metabolic rate, and physical
            activity level. Improved glucose metabolism in CTRP7-deficient mice
            was associated with reduced adipose tissue inflammation, as well as
            decreased liver fibrosis and cellular oxidative and endoplasmic
            reticulum stress.
REFERENCE   3  (bases 1 to 1652)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 1652)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 1652)
  AUTHORS   Wong,G.W., Krawczyk,S.A., Kitidis-Mitrokostas,C., Revett,T.,
            Gimeno,R. and Lodish,H.F.
  TITLE     Molecular, biochemical and functional characterizations of C1q/TNF
            family members: adipose-tissue-selective expression patterns,
            regulation by PPAR-gamma agonist, cysteine-mediated
            oligomerizations, combinatorial associations and metabolic
            functions
  JOURNAL   Biochem J 416 (2), 161-177 (2008)
   PUBMED   18783346
REFERENCE   6  (bases 1 to 1652)
  AUTHORS   Schmidt,T., Fischer,S., Tsikolia,N., Navarrete Santos,A.,
            Rohrbach,S., Ramin,N., Thieme,R. and Fischer,B.
  TITLE     Expression of adipokines in preimplantation rabbit and mice embryos
  JOURNAL   Histochem Cell Biol 129 (6), 817-825 (2008)
   PUBMED   18330590
REFERENCE   7  (bases 1 to 1652)
  AUTHORS   Wong,G.W., Wang,J., Hug,C., Tsao,T.S. and Lodish,H.F.
  TITLE     A family of Acrp30/adiponectin structural and functional paralogs
  JOURNAL   Proc Natl Acad Sci U S A 101 (28), 10302-10307 (2004)
   PUBMED   15231994
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK017441.1, BC090967.1 and BC038308.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090967.1, AK017441.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AK017441.1         13-31
            20-1422             BC090967.1         1-1403
            1423-1652           BC038308.1         1066-1295
FEATURES             Location/Qualifiers
     source          1..1652
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 23.78 cM"
     gene            1..1652
                     /gene="C1qtnf7"
                     /gene_synonym="5530401N20Rik; 8430425G24Rik; Adig; Ctrp7"
                     /note="C1q and tumor necrosis factor related protein 7"
                     /db_xref="GeneID:109323"
                     /db_xref="MGI:MGI:1925911"
     exon            1..418
                     /gene="C1qtnf7"
                     /gene_synonym="5530401N20Rik; 8430425G24Rik; Adig; Ctrp7"
                     /inference="alignment:Splign:2.1.0"
     CDS             406..1296
                     /gene="C1qtnf7"
                     /gene_synonym="5530401N20Rik; 8430425G24Rik; Adig; Ctrp7"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; C1q and tumor necrosis factor related protein
                     5; complement C1q tumor necrosis factor-related protein 7;
                     adiponectin g"
                     /codon_start=1
                     /product="complement C1q tumor necrosis factor-related
                     protein 7 isoform a precursor"
                     /protein_id="NP_001128644.1"
                     /db_xref="CCDS:CCDS51488.1"
                     /db_xref="GeneID:109323"
                     /db_xref="MGI:MGI:1925911"
                     /translation="MPRKEPKMIVLLYVTSLAICASGQPRANQAKGESYSPRYICSIP
                     GLPGPPGPPGANGSPGPHGRIGLPGRDGRDGRKGEKGEKGTAGLKGKTGPLGLAGEKG
                     DQGETGKKGPIGPEGEKGEVGPAGPPGPKGDRGDQGDPGLPGVCRCGSIVLKSAFSVG
                     ITTSYPEERLPIIFNKVLFNEGEHYNPATGKFICAFPGIYYFSYDITLANKHLAIGLV
                     HNGQYRIRTFDANTGNHDVASGSTVIYLQPEDEVWLEIFFNDQNGLFSDPGWADSLFS
                     GFLLYVDTDYLDSISEDDEL"
     exon            419..664
                     /gene="C1qtnf7"
                     /gene_synonym="5530401N20Rik; 8430425G24Rik; Adig; Ctrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            665..1631
                     /gene="C1qtnf7"
                     /gene_synonym="5530401N20Rik; 8430425G24Rik; Adig; Ctrp7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1610..1615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1qtnf7"
                     /gene_synonym="5530401N20Rik; 8430425G24Rik; Adig; Ctrp7"
                     /note="hexamer: ATTAAA"
     polyA_site      1631
                     /gene="C1qtnf7"
                     /gene_synonym="5530401N20Rik; 8430425G24Rik; Adig; Ctrp7"
                     /note="major polyA site"
ORIGIN      
        1 agatacccga gacccttgct tcacatctgc ctccgtctgg ggtttgcaga agaaccttgc
       61 ccactcctcc tcattcctaa cgagtgtata tagtaaactc tttgaaatgt gagtattatg
      121 ggaaggatcg cagttgcttt aaattataga agttggcaag tgcctgggag aaggagtggg
      181 aggttgttta aactgagaaa gacggttgca gaacttcgta cgacagcatg agctcgcgct
      241 ccgcacacat cctttatttt tcttcaagac acttctctgc attgttgtgg agcagcttgg
      301 gtaataacca tatttctgct ctgaatagtt tttaatggtt tctaaattca tgggagtgtc
      361 aaagcaagga agtctcatgt ttgggaagga catctgaacc cagcaatgcc caggaaagag
      421 cccaagatga ttgtcctgct ctacgtgacg agtcttgcca tctgtgcaag tggacaacct
      481 cgggccaatc aggctaaggg agagagctac tctccaaggt acatctgcag catccctgga
      541 ttacctgggc ccccaggtcc tcctggagca aatggctccc ctggacccca tggtcgcatt
      601 ggccttcctg gaagggatgg tagagatggc agaaaaggag agaaggggga aaagggcact
      661 gcaggtctaa aaggtaaaac tggacccctg ggccttgctg gtgagaaagg agaccaagga
      721 gaaactggaa agaaaggacc cataggacca gagggtgaga aaggagaagt cggtccagct
      781 gggcctcctg ggccaaaggg agacagagga gatcaagggg acccagggct gcctggagtg
      841 tgcaggtgtg gaagcattgt gctcaaatct gccttttcag ttggcatcac aaccagctac
      901 ccagaagaaa gactacccat catatttaac aaagtcctct tcaatgaggg ggagcattac
      961 aaccctgcaa cggggaagtt catttgcgct ttcccaggga tctattactt ttcttatgac
     1021 atcacgttgg ccaataagca cctagcaatc gggctggtgc acaatgggca gtaccggata
     1081 aggacctttg atgccaacac agggaaccat gatgtggcgt cggggtccac agtcatctac
     1141 ctgcagccag aagatgaggt ctggctggag atcttcttca atgaccagaa cggcctcttc
     1201 tcagatccag gctgggcaga cagcttgttc tctgggtttc tcctctatgt cgatacagat
     1261 tacctggatt ctatatcaga ggatgatgag ctgtgatcca gaccactaca ggcctgaatg
     1321 ttgcaaacat gagtaccaca gtggctgaca ctctaatctg gagtgctgga aggtggagca
     1381 agtgatacgg ggattcagaa aacgtttttt acagacgact ctggctgagt tatcaaaata
     1441 agacaaacca ccaactagct gaaatcacaa caaaacgaat ggcatacaat aacctcagac
     1501 atggaccccc taaagtaatg atcctaaata ttgaagcaaa ttaaagcaaa tgatgttaac
     1561 aaatttgaat gcccttggca atacaaccag ctggaaatga cactgcctca ttaaatattc
     1621 ataaaacccc aaaaaaaaaa aaaaaaaaaa aa
//
