LOCUS       NM_028331               2443 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus C1q and tumor necrosis factor related protein 6
            (C1qtnf6), transcript variant 1, mRNA.
ACCESSION   NM_028331
VERSION     NM_028331.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2443)
  AUTHORS   Yan,S., Ding,J., Wang,Z., Zhang,Y., Xu,Y., Jia,Y., Yang,J. and
            Qiu,H.
  TITLE     CTRP6 alleviates endometrial fibrosis by regulating Smad3 pathway
            in intrauterine adhesiondagger
  JOURNAL   Biol Reprod 111 (2), 322-331 (2024)
   PUBMED   38984926
  REMARK    GeneRIF: CTRP6 alleviates endometrial fibrosis by regulating Smad3
            pathway in intrauterine adhesiondagger.
REFERENCE   2  (bases 1 to 2443)
  AUTHORS   Xu,C., Sarver,D.C., Lei,X., Sahagun,A., Zhong,J., Na,C.H.,
            Rudich,A. and Wong,G.W.
  TITLE     CTRP6 promotes the macrophage inflammatory response, and its
            deficiency attenuates LPS-induced inflammation
  JOURNAL   J Biol Chem 300 (1), 105566 (2024)
   PUBMED   38103643
  REMARK    GeneRIF: CTRP6 promotes the macrophage inflammatory response, and
            its deficiency attenuates LPS-induced inflammation.
REFERENCE   3  (bases 1 to 2443)
  AUTHORS   Li,J., Xuan,R., Wu,W., Han,Y., Guo,J. and Yang,M.
  TITLE     CTRP6 suppresses neutrophil extracellular traps formation to
            ameliorate sepsis-induced lung injury through inactivation of ERK
            pathway
  JOURNAL   Allergol Immunopathol (Madr) 50 (6), 53-59 (2022)
   PUBMED   36335445
  REMARK    GeneRIF: CTRP6 suppresses neutrophil extracellular traps formation
            to ameliorate sepsis-induced lung injury through inactivation of
            ERK pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2443)
  AUTHORS   Liu,Z. and Yang,B.
  TITLE     CTRP6(C1q/Tumor Necrosis Factor (TNF)-related protein-6) alleviated
            the sevoflurane induced injury of mice central nervous system by
            promoting the expression of p-Akt (phosphorylated Akt)
  JOURNAL   Bioengineered 12 (1), 5716-5726 (2021)
   PUBMED   34516328
  REMARK    GeneRIF: CTRP6(C1q/Tumor Necrosis Factor (TNF)-related protein-6)
            alleviated the sevoflurane induced injury of mice central nervous
            system by promoting the expression of p-Akt (phosphorylated Akt).
REFERENCE   5  (bases 1 to 2443)
  AUTHORS   Lahav,R., Haim,Y., Bhandarkar,N.S., Levin,L., Chalifa-Caspi,V.,
            Sarver,D., Sahagun,A., Maixner,N., Kovesh,B., Wong,G.W. and
            Rudich,A.
  TITLE     CTRP6 rapidly responds to acute nutritional changes, regulating
            adipose tissue expansion and inflammation in mice
  JOURNAL   Am J Physiol Endocrinol Metab 321 (5), E702-E713 (2021)
   PUBMED   34632797
  REMARK    GeneRIF: CTRP6 rapidly responds to acute nutritional changes,
            regulating adipose tissue expansion and inflammation in mice.
REFERENCE   6  (bases 1 to 2443)
  AUTHORS   Wu,W.J., Mo,D.L., Zhao,C.Z., Zhao,C., Chen,Y.S., Pang,W.J. and
            Yang,G.S.
  TITLE     Knockdown of CTRP6 inhibits adipogenesis via lipogenic marker genes
            and Erk1/2 signalling pathway
  JOURNAL   Cell Biol Int 39 (5), 554-562 (2015)
   PUBMED   25639984
  REMARK    GeneRIF: Knockdown of CTRP6 can inhibit adipogenesis of 3T3-L1
            adipocytes through lipogenic marker genes and Erk1/2 signaling
            pathway.
REFERENCE   7  (bases 1 to 2443)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   8  (bases 1 to 2443)
  AUTHORS   Lee,W., Kim,M.J., Park,E.J., Choi,Y.J. and Park,S.Y.
  TITLE     C1qTNF-related protein-6 mediates fatty acid oxidation via the
            activation of the AMP-activated protein kinase
  JOURNAL   FEBS Lett 584 (5), 968-972 (2010)
   PUBMED   20102710
  REMARK    GeneRIF: CTRP6 plays a role in fatty acid metabolism via the
            AMPK-ACC pathway. The globular domain of CTRP6 mediates the
            phosphorylation and activation of the 5'-AMP-activated protein
            kinase (AMPK) in skeletal muscle cells.
            Erratum:[FEBS Lett. 2010 Jun 3;584(11):2491]
REFERENCE   9  (bases 1 to 2443)
  AUTHORS   Wong,G.W., Krawczyk,S.A., Kitidis-Mitrokostas,C., Revett,T.,
            Gimeno,R. and Lodish,H.F.
  TITLE     Molecular, biochemical and functional characterizations of C1q/TNF
            family members: adipose-tissue-selective expression patterns,
            regulation by PPAR-gamma agonist, cysteine-mediated
            oligomerizations, combinatorial associations and metabolic
            functions
  JOURNAL   Biochem J 416 (2), 161-177 (2008)
   PUBMED   18783346
REFERENCE   10 (bases 1 to 2443)
  AUTHORS   Wong,G.W., Wang,J., Hug,C., Tsao,T.S. and Lodish,H.F.
  TITLE     A family of Acrp30/adiponectin structural and functional paralogs
  JOURNAL   Proc Natl Acad Sci U S A 101 (28), 10302-10307 (2004)
   PUBMED   15231994
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590144.10, DQ002399.1, AK012868.1 and AI853798.1.
            
            On Feb 18, 2011 this sequence version replaced NM_028331.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC071187.1, AK051058.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AL590144.10        48458-48491
            35-1688             DQ002399.1         1-1654
            1689-2426           AK012868.1         1465-2202
            2427-2443           AI853798.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..2443
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.55 cM"
     gene            1..2443
                     /gene="C1qtnf6"
                     /gene_synonym="2810036M19Rik; Adiq; CTRP6"
                     /note="C1q and tumor necrosis factor related protein 6"
                     /db_xref="GeneID:72709"
                     /db_xref="MGI:MGI:1919959"
     exon            1..134
                     /gene="C1qtnf6"
                     /gene_synonym="2810036M19Rik; Adiq; CTRP6"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..923
                     /gene="C1qtnf6"
                     /gene_synonym="2810036M19Rik; Adiq; CTRP6"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; complement C1q tumor necrosis factor-related
                     protein 6; adiponectin q"
                     /codon_start=1
                     /product="complement C1q tumor necrosis factor-related
                     protein 6 isoform 1 precursor"
                     /protein_id="NP_082607.3"
                     /db_xref="CCDS:CCDS37134.1"
                     /db_xref="GeneID:72709"
                     /db_xref="MGI:MGI:1919959"
                     /translation="MRVIMGIASLGFLWAVFLLPLVFGVPTEETTFGESVASHLPKGC
                     RRCCDPEDLMSSDDTVQAPVSPYVLPEVRPYINITILKGDKGDRGPTGTPGKPGKNGT
                     RGDRGSQGVKGDKGQAGSPGSSCQTHYSAFSVGRKTGLHSSENFLSLLFDRVFVNTDG
                     HFDMATGSFVAPLRGLYFFSLNVHSWNYKETYVHIVHNEQAVVILYAQPSERSIMQSQ
                     SVMLPLVPGDRVWVRLFKRERENGIYSDDVDTYITFSGHLIKAEDN"
     exon            135..375
                     /gene="C1qtnf6"
                     /gene_synonym="2810036M19Rik; Adiq; CTRP6"
                     /inference="alignment:Splign:2.1.0"
     exon            376..2428
                     /gene="C1qtnf6"
                     /gene_synonym="2810036M19Rik; Adiq; CTRP6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2402..2407
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1qtnf6"
                     /gene_synonym="2810036M19Rik; Adiq; CTRP6"
                     /note="hexamer: AATAAA"
     polyA_site      2428
                     /gene="C1qtnf6"
                     /gene_synonym="2810036M19Rik; Adiq; CTRP6"
                     /note="major polyA site"
ORIGIN      
        1 tccatccctc cgccctccta gctcagtcgt aggcctaggg gtcgggcctg caacaagtta
       61 tcatcacaga catgggccaa ggagccagag gccgtccggg gtctgtgagt tgagcttgag
      121 gccgcaggat gagggtcatc atggggatag ccagcctggg gttcctctgg gcagtattcc
      181 tgcttcctct tgtgtttggg gtccccacag aggagactac ctttggagaa tctgtggcct
      241 cccatctccc caaaggctgt cgacgatgct gtgaccccga ggacctgatg tcctctgatg
      301 atacggtcca ggcccctgtt tccccttatg tcctgcctga agtcaggccg tacatcaaca
      361 ttactatcct aaagggtgac aaaggggaca gaggtcctac aggaacacca gggaagccag
      421 gcaagaatgg tacccgaggg gaccgtggct ctcagggtgt caaaggtgac aaggggcagg
      481 caggtagccc tggcagctcg tgccagacac attactcagc cttctctgtg ggccgcaaga
      541 ctggcttgca cagcagcgag aacttcctct cactgctgtt cgacagggtc tttgtgaaca
      601 cggatggcca ctttgacatg gccactggca gctttgtggc tcccctgcgc ggcctctact
      661 tcttcagcct caacgtacac agctggaact acaaggagac ctacgtgcac atcgtgcaca
      721 atgagcaggc agtggtgatc ctgtacgcgc agcccagcga acgcagcatc atgcagagcc
      781 agagtgtgat gctgccactg gtgccgggtg accgtgtgtg ggtgcggctc ttcaagcggg
      841 agcgggaaaa cggcatctac agtgatgacg tggacacgta catcaccttc agtggccacc
      901 tgatcaaggc agaggacaac tgagctccgc ccctctcccc cctcccccct tctcccctcc
      961 ctccccgcca ctttcacagc tgggcagctg gtggctaggg caggtcctag ggctgggtct
     1021 gctgctctcc attccttgtc tccacagtta ctgcagtctg tctccatccc tctcctctta
     1081 gcttcgtttt tctgatactt tggggcttac atatttcaga ctttgccagc ctctagagtg
     1141 gctatcctga cactccacca ctctattcat ccctggggtc tttattatct ggtagatgct
     1201 ggctttgcat ttggggtaga cccaggattc ttcatttcta gtgatttcct ccatgacatt
     1261 gacgctacag gtctgtggat cacacttgag gagttgtgct ctctctaaag tgttcccagc
     1321 attctaggga cttcaggaac actctggaat tgctccccta cccccaaact ctagcattct
     1381 ttccacatcc tctagcttcc tcctcctcct cctggccctc cctcatgcct gacctttccc
     1441 ctcctcccct tttccagcca ttgttcattt gtgcacttgt ctaatgctga gcgctcacat
     1501 ggtctcaggc cttaggaaag cccagaagtg ggtactaaga cttgagcaca tactgggtgc
     1561 tcctctagac tgggtccgcg ggcaccgtgg ttccttctcc actgcttcca tggtctgaca
     1621 ggtcccggag atgggatgat aacctttccc atgctccacg ttcttgccct gtgcccagca
     1681 ataaagcaaa tataggtata atcttagctg ggaggagacc caggagttta gatgtatctg
     1741 ggatgaaggg gcatctggga actggagcct gttctcttcc ctgatgttag aagactcctc
     1801 ctgccccctt ctttccccca gacattagcc atggtcagac catgcactag tgctctctgg
     1861 ccctcctggc tcctccaagg cccaggctca ccctgggttt atgaaggtgc ttaagcccct
     1921 gtccccctgg aggtggctcc catttcagag cttctcctgc ctgtattgcc cttgcagaca
     1981 tcgtgggcaa gtcaggcagg acagaggtgg caggtttcag cccaaagcag gtctagggac
     2041 tgaagccagt gacattcagg ttacctgggg gccttctctg agccatgctg ccaagacagg
     2101 ccctggggga ggttgtgaaa aaagcaagac ctccacgtct ttcccagggt gtgtagcctg
     2161 gtggccctcc aaccttcccc tctcccactg tagcctgccc aagcttctca ggggaaggtg
     2221 gcctccgtcc attggtgctt ctgcagatcc aaggcagggc tggccctgag agggcatctc
     2281 tggtgcttac aaccaagcga gccatggcag ggtaacagag gcaaggcccg ccatgtgctg
     2341 tgagggctgg ctctacgaaa ccaccctcag cccgactgtc cttgcctgct tggccagtgt
     2401 gaataaagat attggattct cttggcaaaa aaaaaaaaaa aaa
//
