LOCUS       NM_145613               4292 bp    mRNA    linear   ROD 27-MAY-2024
DEFINITION  Mus musculus C1q and tumor necrosis factor related protein 5
            (C1qtnf5), transcript variant 1, mRNA.
ACCESSION   NM_145613
VERSION     NM_145613.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4292)
  AUTHORS   Yu,L., Liu,X., Wei,X., Ren,J., Wang,X., Wu,S. and Lan,K.
  TITLE     C1QTNF5 is a novel attachment factor that facilitates the entry of
            influenza A virus
  JOURNAL   Virol Sin 39 (2), 277-289 (2024)
   PUBMED   38246238
  REMARK    GeneRIF: C1QTNF5 is a novel attachment factor that facilitates the
            entry of influenza A virus.
REFERENCE   2  (bases 1 to 4292)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4292)
  AUTHORS   Borooah,S., Chekuri,A., Pachauri,S., Sahu,B., Vorochikhina,M.,
            Suk,J.J., Bartsch,D.U., Chavali,V.R.M., Jablonski,M.M. and
            Ayyagari,R.
  TITLE     A Novel Mouse Model for Late-Onset Retinal Degeneration (L-ORD)
            Develops RPE Abnormalities Due to the Loss of C1qtnf5/Ctrp5
  JOURNAL   Adv Exp Med Biol 1415, 335-340 (2023)
   PUBMED   37440053
  REMARK    GeneRIF: A Novel Mouse Model for Late-Onset Retinal Degeneration
            (L-ORD) Develops RPE Abnormalities Due to the Loss of
            C1qtnf5/Ctrp5.
REFERENCE   4  (bases 1 to 4292)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4292)
  AUTHORS   Won,J., Smith,R.S., Peachey,N.S., Wu,J., Hicks,W.L., Naggert,J.K.
            and Nishina,P.M.
  TITLE     Membrane frizzled-related protein is necessary for the normal
            development and maintenance of photoreceptor outer segments
  JOURNAL   Vis Neurosci 25 (4), 563-574 (2008)
   PUBMED   18764959
  REMARK    Erratum:[Vis Neurosci. 2008 Sep-Dec;25(5-6):713-6]
REFERENCE   6  (bases 1 to 4292)
  AUTHORS   Mandal,M.N., Vasireddy,V., Jablonski,M.M., Wang,X.,
            Heckenlively,J.R., Hughes,B.A., Reddy,G.B. and Ayyagari,R.
  TITLE     Spatial and temporal expression of MFRP and its interaction with
            CTRP5
  JOURNAL   Invest Ophthalmol Vis Sci 47 (12), 5514-5521 (2006)
   PUBMED   17122143
REFERENCE   7  (bases 1 to 4292)
  AUTHORS   Mandal,M.N., Vasireddy,V., Reddy,G.B., Wang,X., Moroi,S.E.,
            Pattnaik,B.R., Hughes,B.A., Heckenlively,J.R., Hitchcock,P.F.,
            Jablonski,M.M. and Ayyagari,R.
  TITLE     CTRP5 is a membrane-associated and secretory protein in the RPE and
            ciliary body and the S163R mutation of CTRP5 impairs its secretion
  JOURNAL   Invest Ophthalmol Vis Sci 47 (12), 5505-5513 (2006)
   PUBMED   17122142
  REMARK    GeneRIF: CTRP5, a secretory and membrane-associated protein, is
            localized to the lateral and apical membranes of the RPE and CB.
            Impaired secretion of the mutant protein may underlie the
            pathophysiology of long anterior zonules and late-onset retinal
            degeneration.
REFERENCE   8  (bases 1 to 4292)
  AUTHORS   Shu,X., Tulloch,B., Lennon,A., Vlachantoni,D., Zhou,X., Hayward,C.
            and Wright,A.F.
  TITLE     Disease mechanisms in late-onset retinal macular degeneration
            associated with mutation in C1QTNF5
  JOURNAL   Hum Mol Genet 15 (10), 1680-1689 (2006)
   PUBMED   16600989
  REMARK    GeneRIF: L-ORMD is due to insufficient levels of secreted C1QTNF5,
            compromised RPE cell function resulting from ER retention of the
            mutant protein or both mechanisms.
REFERENCE   9  (bases 1 to 4292)
  AUTHORS   Wong,G.W., Wang,J., Hug,C., Tsao,T.S. and Lodish,H.F.
  TITLE     A family of Acrp30/adiponectin structural and functional paralogs
  JOURNAL   Proc Natl Acad Sci U S A 101 (28), 10302-10307 (2004)
   PUBMED   15231994
REFERENCE   10 (bases 1 to 4292)
  AUTHORS   Kameya,S., Hawes,N.L., Chang,B., Heckenlively,J.R., Naggert,J.K.
            and Nishina,P.M.
  TITLE     Mfrp, a gene encoding a frizzled related protein, is mutated in the
            mouse retinal degeneration 6
  JOURNAL   Hum Mol Genet 11 (16), 1879-1886 (2002)
   PUBMED   12140190
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK053629.1 and AF469650.1.
            
            On Jun 15, 2010 this sequence version replaced NM_145613.3.
            
            Summary: The protein encoded by this gene is a member of the
            C1q/tumor necrosis factor superfamily. This family member is a
            secretory protein that functions in eye development. Mutations in
            this gene are thought to underlie the pathophysiology of late-onset
            retinal degeneration (L-ORD) and early-onset long anterior zonules
            (LAZ). Bicistronic transcripts composed of the coding sequences for
            this gene (C1qtnf5) and the membrane-type frizzled-related protein
            gene (Mfrp) have been identified, and the resulting products can
            interact with each other. Co-transcription of C1qtnf5 and Mfrp has
            been observed in both human and mouse. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, Jun 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. This variant is a bicistronic transcript that can
            encode the C1qtnf5 and Mfrp products; the C1qtnf5 protein is
            represented in this RefSeq. Variants 1-5 encode the same C1qtnf5
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF469650.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            bicistronic transcript :: PMID: 12140190
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AK053629.1         2-73
            73-2737             AF469650.1         1-2665
            2738-4270           AK053629.1         2722-4254
            4271-4292           AF469650.1         4199-4220
FEATURES             Location/Qualifiers
     source          1..4292
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.62 cM"
     gene            1..4292
                     /gene="C1qtnf5"
                     /gene_synonym="Adie; Ctrp5; Mfrp"
                     /note="C1q and tumor necrosis factor related protein 5"
                     /db_xref="GeneID:235312"
                     /db_xref="MGI:MGI:2385958"
     exon            1..177
                     /gene="C1qtnf5"
                     /gene_synonym="Adie; Ctrp5; Mfrp"
                     /inference="alignment:Splign:2.1.0"
     exon            178..280
                     /gene="C1qtnf5"
                     /gene_synonym="Adie; Ctrp5; Mfrp"
                     /inference="alignment:Splign:2.1.0"
     exon            281..394
                     /gene="C1qtnf5"
                     /gene_synonym="Adie; Ctrp5; Mfrp"
                     /inference="alignment:Splign:2.1.0"
     exon            395..568
                     /gene="C1qtnf5"
                     /gene_synonym="Adie; Ctrp5; Mfrp"
                     /inference="alignment:Splign:2.1.0"
     exon            569..782
                     /gene="C1qtnf5"
                     /gene_synonym="Adie; Ctrp5; Mfrp"
                     /inference="alignment:Splign:2.1.0"
     exon            783..913
                     /gene="C1qtnf5"
                     /gene_synonym="Adie; Ctrp5; Mfrp"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1039
                     /gene="C1qtnf5"
                     /gene_synonym="Adie; Ctrp5; Mfrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1116
                     /gene="C1qtnf5"
                     /gene_synonym="Adie; Ctrp5; Mfrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1265
                     /gene="C1qtnf5"
                     /gene_synonym="Adie; Ctrp5; Mfrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1414
                     /gene="C1qtnf5"
                     /gene_synonym="Adie; Ctrp5; Mfrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1525
                     /gene="C1qtnf5"
                     /gene_synonym="Adie; Ctrp5; Mfrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1653
                     /gene="C1qtnf5"
                     /gene_synonym="Adie; Ctrp5; Mfrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..3382
                     /gene="C1qtnf5"
                     /gene_synonym="Adie; Ctrp5; Mfrp"
                     /inference="alignment:Splign:2.1.0"
     CDS             3169..3900
                     /gene="C1qtnf5"
                     /gene_synonym="Adie; Ctrp5; Mfrp"
                     /note="complement C1q tumor necrosis factor-related
                     protein 5; Membrane frizzled-related protein; adiponectin
                     e"
                     /codon_start=1
                     /product="complement C1q tumor necrosis factor-related
                     protein 5 precursor"
                     /protein_id="NP_663588.2"
                     /db_xref="CCDS:CCDS52777.1"
                     /db_xref="GeneID:235312"
                     /db_xref="MGI:MGI:2385958"
                     /translation="MRPLLALLLLGLVSGSPPLDDNKIPSLCPGQPGLPGTPGHHGSQ
                     GLPGRDGRDGRDGAPGAPGEKGEGGRPGLPGPRGEPGPRGEAGPMGAIGPAGECSVPP
                     RSAFSAKRSESRVPPPADTPLPFDRVLLNEQGHYDPTTGKFTCQVPGVYYFAVHATVY
                     RASLQFDLVKNGQSIASFFQYFGGWPKPASLSGGAMVRLEPEDQVWVQVGVGDYIGIY
                     ASIKTDSTFSGFLVYSDWHSSPVFA"
     exon            3383..4275
                     /gene="C1qtnf5"
                     /gene_synonym="Adie; Ctrp5; Mfrp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4255..4260
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1qtnf5"
                     /gene_synonym="Adie; Ctrp5; Mfrp"
                     /note="hexamer: AATAAA"
     polyA_site      4275
                     /gene="C1qtnf5"
                     /gene_synonym="Adie; Ctrp5; Mfrp"
                     /note="major polyA site"
ORIGIN      
        1 gacagccttg tccctcaaga gcaaaggccg cctctttgat tggtggcttg tgaccaggga
       61 gtggaccctc ggaggtcttg agctatcagg ggacctccag aaagccatgc cgagtcttaa
      121 accatgaagg actatgacga cgtcatcctc cgtccagagg cgagtgagtt gagcaagaca
      181 gagttctgta atcctgcttt cgacccggaa gcagggccat cctgccctcc accagcgtta
      241 cagagggatg tcggcagccg gctccaagcc ccctggcatg cccagcgtct ccgggggcta
      301 cagcccgact gccacttctc ctggttctgt attctgcttc tcagtggcct gctgctcctg
      361 ctgctggggc tactggtggc tgtcatcctg gctcagttgc aggctacatc cctccccagg
      421 actaccaaga acccactgct cacccgaggc ctcaccccca tgggtgtcat tcccagcacc
      481 acccctaaca ccaccaccac caccaccact accaccccag caaggacagg gcagcaggag
      541 gcagccatga gccctacaca ccagaccacc tgtggaggcc tccttcctgg tcccagtggt
      601 ttcttcagca gccctaacta cccagacctc tacccacccc tcagccactg tgtctggcat
      661 atccaggtag ccgcgggcca gacaatacag ctcaagattc aagccctcag catagagagt
      721 atgctcacct gtctttttga tcgcttggaa attatctcag agcctacagg ccctctcctc
      781 agggtgtgtg gtaaaacacc tcctgccaca ttaaacacca ataccagcca cctccgtgtg
      841 tccttcgtct ctgataacga tgtggaaggg tctggtttcc aggcctggta ccaagcagtg
      901 gcccctggac attggagctg tgcccataat gagttccact gtgaccttct cctctgcctg
      961 aagcgtgact ctgtatgtga cggtattacc gagtgtgccg atggcagtga cgaggccaac
     1021 tgcagtgcca agacgttggg gtgtggaggg aacctgactg ggctctatgg cgtattctct
     1081 accccaaact atccacagca ctaccctcac caacagcttt gcacctggta catcgaagtg
     1141 cctgtgggat acgggataag actggagttc cacaacttca gtctggaagc acaggctgag
     1201 tgcaagtttg actacgtgga agtgtacgag gccagcaacc tgggaacctt cagcttcctg
     1261 ggcaggttct gtggagcaga gccaccactc aacgttgtct cctcgatgca ccagctggct
     1321 gtaatcttca agacggatct tggtatcagc agcgggggct ttctagccac ctaccaggcc
     1381 atcaatacta cagagagtgg gtgtccctgg gcagagttct gccagagcgg aggatatagg
     1441 gatctgcaat ggatgtgtga cttatggaaa gactgtgcaa atgacagcaa cgacaactgc
     1501 agcagccact tgtccccaca accagacctg acctgtgaac ctgtccaggt ggagatgtgc
     1561 cttggactaa gctacaatac cacggccttt cctaacatct gggtgggcct ggccacgcag
     1621 acagaggtga cagacatcct ccgaggctac aagagtctga caagtctacc ctgctaccag
     1681 actttccaga ggttcctctg tggactgctt gtgcctcgat gcacctcact gggcactatc
     1741 ctaccccctt gtcgttccgt ctgccaggcg gcggagcagc agtgccagtc tagcctggca
     1801 ttattgggca ccccctggcc tttcaactgc aacaggctgc ccgtggcagc tagcctggaa
     1861 gcttgctccc agccctgacc tgaagccagc ccccaccctc tgtctgccca tcctcctcta
     1921 cctatgtggg tgggtgggtg ggtgggtggg tgggcagggc aggcagtgct gtggagccgg
     1981 ggcaaggagc aaccagaagc taggagtcag ggcagaaaac aagggcaagg gtggcctgga
     2041 taagggattc tgcgcatcct ccctggtgct tctcagaaag gaaaaggacc agagttccaa
     2101 ttctgatcct gcccaggaca accaggacca tctttcctcc accttccctg agctcttatt
     2161 taccaagaca gccctagaca gtggccaggc cccacgctgt gccattggac agcctagcag
     2221 acttcctatc caagtctctg accctgattc cgtgtctcgg tcttctgcct tctccctttc
     2281 catttaagtt cactgtcatc tgaccttcaa tctttttcat ttaatcaaca aaactgtttt
     2341 gagtgacaat ctaagcctgg aggtccaact ggctctctgt ttctgaaatt cttcaccctg
     2401 ggccccctac taatccagtt ctccacccct gccccacccc caccacgggt tttgatcttg
     2461 gactccatca ttatcccatt ccttcctccc tccctccctc cagctcctgg gaactggagt
     2521 cccaagtgtc tgcctcacag ttcggcctct tggtgatgca ggctctactc tctcctcctc
     2581 ctcctttctc cacaccccct acatccccac aattttggcc ggccgccggg cgacaccacg
     2641 agttatttcc ctgctatttc ccagccctgg agttcttggc ctctgaacaa ctggtttcct
     2701 ctaggagtct gggaggagcg ctgtgaagcc agcaaggagc aaccagaagc taggagtcag
     2761 tcagcaagga caggggctgc ctggtagggg taggagtggg agcagggcca gcaggaaggt
     2821 ctgaggaagc cattcaaagc ttgcagctgg gagtgctggg gagccgggag gggtgagttt
     2881 ggcagaggag gagggtaagt gggggagggg actgtgggaa agcctgggcg ccagctaggg
     2941 ggatggagaa gggcttgtct ctcctttcct tgttcccagt tcttggtttg gggcacccca
     3001 tcacacagtg ctcaacccca aaggcatgtt tgtagggcgg ggacctactg ggttccacct
     3061 gggtggggcg cgaggttggt cctaagattc tgggttccaa ctctggtcct gcccagccta
     3121 cagactacaa gagaggttcc tggagtctga gcctccgggg tcaccaccat gaggccactt
     3181 cttgcccttc tgcttctggg tctggtgtca ggctctcctc ctctggacga caacaagatc
     3241 cccagcctgt gtcccgggca gcccggcctt ccaggcacac caggtcacca tggcagccaa
     3301 ggcctgcctg gccgtgacgg ccgtgatggc cgcgacggtg cacccggagc tccgggagag
     3361 aaaggcgagg gcgggagacc gggactacct ggcccacgtg gggagcccgg gccgcgtgga
     3421 gaggcagggc ccatgggggc tatcgggcct gcgggggagt gctcggtacc cccacgatca
     3481 gccttcagtg ccaagcgatc cgagagccgg gtacctccgc cagccgacac acccctacct
     3541 ttcgaccgtg tgctgctaaa tgagcagggc cattacgacc ccactactgg caagttcacc
     3601 tgccaagtgc ctggcgtcta ctactttgct gtgcacgcca ctgtctaccg ggccagcttg
     3661 cagtttgatc ttgtcaaaaa cgggcagtcc atcgcctctt tcttccagta ttttgggggg
     3721 tggcccaagc cagcctcgct ctcagggggt gcgatggtaa ggctagaacc tgaggaccag
     3781 gtgtgggtgc aggtgggcgt gggtgattac attggcatct atgccagcat caagacagac
     3841 agtaccttct ctggatttct cgtctattct gactggcaca gctccccagt cttcgcttaa
     3901 aacacagtga acccggagct ggcacttgct cctcagtgga gggtgtgaca ctaacccgcg
     3961 cagcgcatac caggagggct ggccccctgg aatattgtga atgacttagg aagagaggga
     4021 gccacttcca gtcccactgc tggcaatgaa tggagacagg ctgtctgagg tcaagacagc
     4081 gtggagcagt ggctgggttt ctgcccagga ctttagaatg cagtaggctg gcagctgtgg
     4141 gtcctggccc aggactccaa ggtgggatgc tccattccta gtcctgtgtc ccctctaggt
     4201 ccctgactcc atctctgctg ctcccagggc aggccttttt ctcagaggtc acttaataaa
     4261 cctaaaatcc tcccaaaaaa aaaaaaaaaa aa
//
