LOCUS       NM_026161               1383 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus C1q and tumor necrosis factor related protein 4
            (C1qtnf4), mRNA.
ACCESSION   NM_026161
VERSION     NM_026161.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1383)
  AUTHORS   Sarver,D.C., Xu,C., Cheng,Y., Terrillion,C.E. and Wong,G.W.
  TITLE     CTRP4 ablation impairs associative learning and memory
  JOURNAL   FASEB J 35 (11), e21910 (2021)
   PUBMED   34610176
REFERENCE   2  (bases 1 to 1383)
  AUTHORS   Ye,L., Jia,G., Li,Y., Wang,Y., Chen,H., Yu,L. and Wu,D.
  TITLE     C1q/TNF-related protein 4 restores leptin sensitivity by
            downregulating NF-kappaB signaling and microglial activation
  JOURNAL   J Neuroinflammation 18 (1), 159 (2021)
   PUBMED   34275474
  REMARK    GeneRIF: C1q/TNF-related protein 4 restores leptin sensitivity by
            downregulating NF-kappaB signaling and microglial activation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1383)
  AUTHORS   Cao,L., Tan,W., Chen,W., Huang,H., He,M., Li,Q., Zhu,X. and Wang,L.
  TITLE     CTRP4 acts as an anti-inflammatory factor in macrophages and
            protects against endotoxic shock
  JOURNAL   Eur J Immunol 51 (2), 380-392 (2021)
   PUBMED   33080044
  REMARK    GeneRIF: CTRP4 acts as an anti-inflammatory factor in macrophages
            and protects against endotoxic shock.
REFERENCE   4  (bases 1 to 1383)
  AUTHORS   Sarver,D.C., Stewart,A.N., Rodriguez,S., Little,H.C., Aja,S. and
            Wong,G.W.
  TITLE     Loss of CTRP4 alters adiposity and food intake behaviors in obese
            mice
  JOURNAL   Am J Physiol Endocrinol Metab 319 (6), E1084-E1100 (2020)
   PUBMED   33017221
REFERENCE   5  (bases 1 to 1383)
  AUTHORS   Li,Y., Ye,L., Jia,G., Chen,H., Yu,L. and Wu,D.
  TITLE     C1q/TNF-related Protein 4 Induces Signal Transducer and Activator
            of Transcription 3 Pathway and Modulates Food Intake
  JOURNAL   Neuroscience 429, 1-9 (2020)
   PUBMED   31917347
  REMARK    GeneRIF: C1q/TNF-related Protein 4 Induces Signal Transducer and
            Activator of Transcription 3 Pathway and Modulates Food Intake.
REFERENCE   6  (bases 1 to 1383)
  AUTHORS   Luo,Y., Wu,X., Ma,Z., Tan,W., Wang,L., Na,D., Zhang,G., Yin,A.,
            Huang,H., Xia,D., Zhang,Y., Shi,X. and Wang,L.
  TITLE     Expression of the novel adipokine C1qTNF-related protein 4 (CTRP4)
            suppresses colitis and colitis-associated colorectal cancer in mice
  JOURNAL   Cell Mol Immunol 13 (5), 688-699 (2016)
   PUBMED   27086950
  REMARK    GeneRIF: CTRP4 plays an important role in inflammation and
            inflammation-associated colon tumorigenesis.
REFERENCE   7  (bases 1 to 1383)
  AUTHORS   Miyata,H., Castaneda,J.M., Fujihara,Y., Yu,Z., Archambeault,D.R.,
            Isotani,A., Kiyozumi,D., Kriseman,M.L., Mashiko,D., Matsumura,T.,
            Matzuk,R.M., Mori,M., Noda,T., Oji,A., Okabe,M.,
            Prunskaite-Hyyrylainen,R., Ramirez-Solis,R., Satouh,Y., Zhang,Q.,
            Ikawa,M. and Matzuk,M.M.
  TITLE     Genome engineering uncovers 54 evolutionarily conserved and
            testis-enriched genes that are not required for male fertility in
            mice
  JOURNAL   Proc Natl Acad Sci U S A 113 (28), 7704-7710 (2016)
   PUBMED   27357688
REFERENCE   8  (bases 1 to 1383)
  AUTHORS   Byerly,M.S., Petersen,P.S., Ramamurthy,S., Seldin,M.M., Lei,X.,
            Provost,E., Wei,Z., Ronnett,G.V. and Wong,G.W.
  TITLE     C1q/TNF-related protein 4 (CTRP4) is a unique secreted protein with
            two tandem C1q domains that functions in the hypothalamus to
            modulate food intake and body weight
  JOURNAL   J Biol Chem 289 (7), 4055-4069 (2014)
   PUBMED   24366864
  REMARK    GeneRIF: These results establish CTRP4 as a novel
            nutrient-responsive central regulator of food intake and energy
            balance.
REFERENCE   9  (bases 1 to 1383)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 1383)
  AUTHORS   Wong,G.W., Wang,J., Hug,C., Tsao,T.S. and Lodish,H.F.
  TITLE     A family of Acrp30/adiponectin structural and functional paralogs
  JOURNAL   Proc Natl Acad Sci U S A 101 (28), 10302-10307 (2004)
   PUBMED   15231994
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX243534.1, DQ002397.1, AK029777.1 and BF458176.1.
            
            On May 22, 2007 this sequence version replaced NM_026161.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CX243534.1, AK002948.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               CX243534.1         1-223
            224-1040            DQ002397.1         1-817
            1041-1342           AK029777.1         216-517
            1343-1383           BF458176.1         1-41                c
FEATURES             Location/Qualifiers
     source          1..1383
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 50.43 cM"
     gene            1..1383
                     /gene="C1qtnf4"
                     /gene_synonym="0710001E10Rik; 9430004J15Rik; Adin; CTRP4"
                     /note="C1q and tumor necrosis factor related protein 4"
                     /db_xref="GeneID:67445"
                     /db_xref="MGI:MGI:1914695"
     exon            1..218
                     /gene="C1qtnf4"
                     /gene_synonym="0710001E10Rik; 9430004J15Rik; Adin; CTRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            219..1365
                     /gene="C1qtnf4"
                     /gene_synonym="0710001E10Rik; 9430004J15Rik; Adin; CTRP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..1204
                     /gene="C1qtnf4"
                     /gene_synonym="0710001E10Rik; 9430004J15Rik; Adin; CTRP4"
                     /note="complement C1q tumor necrosis factor-related
                     protein 4; adiponectin n; C1q/TNF-related protein 4"
                     /codon_start=1
                     /product="complement C1q tumor necrosis factor-related
                     protein 4 precursor"
                     /protein_id="NP_080437.2"
                     /db_xref="CCDS:CCDS16417.2"
                     /db_xref="GeneID:67445"
                     /db_xref="MGI:MGI:1914695"
                     /translation="MLLLLLGFLGPAACWALGPAGPGSSELRSAFSAARTTPLEGTSE
                     MAVTFDKVYVNIGGDFDAATGRFRCRVPGAYFFSFTAGKAPHKSLSVMLVRNRDEVQA
                     LAFDEQRRPGARRAASQSAMLQLDYGDTVWLRLHGAPQYALGAPGATFSGYLVYADAD
                     ADAPARGPAAPEPRSAFSAARTRSLVGSDAAPGPRHRPLAFDTELVNIGGDFDAAAGV
                     FRCRLPGAYFFSFTLGKLPRKTLSVKLMKNRDEVQAMIYDDGASRRREMQSQSVMLPL
                     RRGDAVWLLSHDHDGYGAYSNHGKYITFSGFLVYPDLAAAGPPALKPPEL"
     regulatory      1322..1327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1qtnf4"
                     /gene_synonym="0710001E10Rik; 9430004J15Rik; Adin; CTRP4"
                     /note="hexamer: AATAAA"
     polyA_site      1362
                     /gene="C1qtnf4"
                     /gene_synonym="0710001E10Rik; 9430004J15Rik; Adin; CTRP4"
                     /note="major polyA site"
ORIGIN      
        1 cctgctcccc gcccttgcgt ttctccgctt cagcttctgc tgtccttccc acttgctcac
       61 gcctcccttg ccggggtccc cactcgtcgc cggctaaacc cccgccaccc ctggaggccc
      121 ggtcaagccg cagcgcgggc gaccagtgtg tagcccggcg tcctcaccga gcaggatagc
      181 cggctgggac cgaagccgac ccgcccgcca ccagccaggt gccatgctgc tgctcttgct
      241 gggcttccta ggcccggcgg cctgctgggc actgggcccg gctggccctg gctcctcgga
      301 gctgcggtca gccttctcgg cggctcgcac caccccgctg gagggcacgt cggagatggc
      361 ggtgaccttc gacaaggtgt acgtgaacat cgggggtgac ttcgacgcag ccaccgggcg
      421 gttccgctgt cgcgtgccgg gcgcctactt cttctccttc acggccggca aggccccgca
      481 caagagcctg tcggtgatgc tggtgcgcaa ccgcgacgag gtgcaggcgc tggctttcga
      541 cgagcagcga cggccaggcg cgcggcgcgc ggccagccag agcgccatgc tgcagctcga
      601 ctacggcgac acggtgtggc tgcggctgca cggcgctccg cagtacgcgc tcggcgcgcc
      661 gggcgccacc ttcagcggct acctggtgta cgcggacgcc gacgccgacg cgcctgcgcg
      721 cggccccgcg gccccggagc cgcgctcggc cttctccgcg gcgcgcacgc gcagcctggt
      781 gggctcggac gccgcccccg gcccgcgcca ccggccgttg gccttcgaca ccgagctggt
      841 aaacataggt ggcgacttcg acgcggcggc cggcgtgttc cgctgccgcc tgccgggagc
      901 ctatttcttc tccttcacgc tgggcaagct gccgcgcaag acgctgtcgg tgaagctgat
      961 gaagaaccgc gacgaggtgc aggccatgat ttacgacgac ggcgcttcga ggcgccgtga
     1021 gatgcagagt cagagcgtga tgctgccgct gcggcgcggc gacgccgtct ggctacttag
     1081 ccacgatcac gatggctatg gcgcctacag caaccacggc aagtacatca ctttctcagg
     1141 cttcctggtg taccctgacc tcgccgccgc cggcccgccg gccctcaagc ccccagagct
     1201 ctgagcctct gcttggagga gcccgggaga gccgtggggc atgcatgccg agccgggacc
     1261 gcggcccgaa cgccccaccg gtccgagcat gactgcctgc tcagcacgcc tggactctgc
     1321 caataaagtg gggctgcctg tcagccttat ggtcctgccc tgtgtaaaaa aaaaaaaaaa
     1381 aaa
//
