LOCUS       NM_030888               2350 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus C1q and tumor necrosis factor related protein 3
            (C1qtnf3), transcript variant 2, mRNA.
ACCESSION   NM_030888
VERSION     NM_030888.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2350)
  AUTHORS   Zhang,X., Zhang,D., Zhao,H., Qin,J., Qi,H., Zu,F., Zhou,Y. and
            Zhang,Y.
  TITLE     gCTRP3 inhibits oophorectomy-induced osteoporosis by activating the
            AMPK/SIRT1/Nrf2 signaling pathway in mice
  JOURNAL   Mol Med Rep 30 (2) (2024)
   PUBMED   38818814
  REMARK    GeneRIF: gCTRP3 inhibits oophorectomy-induced osteoporosis by
            activating the AMPK/SIRT1/Nrf2 signaling pathway in mice.
REFERENCE   2  (bases 1 to 2350)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2350)
  AUTHORS   Lin,H. and Yi,J.
  TITLE     CTRP3 regulates NF-kappaB and TGFbeta1/Smad3 pathways to alleviate
            airway inflammation and remodeling in asthmatic mice induced by OVA
  JOURNAL   Allergol Immunopathol (Madr) 51 (4), 31-39 (2023)
   PUBMED   37422777
  REMARK    GeneRIF: CTRP3 regulates NF-kappaB and TGFbeta1/Smad3 pathways to
            alleviate airway inflammation and remodeling in asthmatic mice
            induced by OVA.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2350)
  AUTHORS   Hu,H., Duan,Y., Wang,K., Fu,H., Liao,Y., Wang,T., Zhang,Z.,
            Kang,F., Zhang,B., Zhang,H., Huo,F., Yin,Y., Chen,G., Hu,H.,
            Cai,H., Tian,W. and Li,Z.
  TITLE     Dental niche cells directly contribute to tooth reconstitution and
            morphogenesis
  JOURNAL   Cell Rep 41 (10), 111737 (2022)
   PUBMED   36476878
REFERENCE   5  (bases 1 to 2350)
  AUTHORS   Song,Y., Zhang,Y., Wan,Z., Pan,J., Gao,F., Li,F., Zhou,J. and
            Chen,J.
  TITLE     CTRP3 alleviates myocardial ischemia/reperfusion injury in mice
            through activating LAMP1/JIP2/JNK pathway
  JOURNAL   Int Immunopharmacol 107, 108681 (2022)
   PUBMED   35278832
  REMARK    GeneRIF: CTRP3 alleviates myocardial ischemia/reperfusion injury in
            mice through activating LAMP1/JIP2/JNK pathway.
REFERENCE   6  (bases 1 to 2350)
  AUTHORS   Wong,G.W., Wang,J., Hug,C., Tsao,T.S. and Lodish,H.F.
  TITLE     A family of Acrp30/adiponectin structural and functional paralogs
  JOURNAL   Proc Natl Acad Sci U S A 101 (28), 10302-10307 (2004)
   PUBMED   15231994
REFERENCE   7  (bases 1 to 2350)
  AUTHORS   Takasato,M., Osafune,K., Matsumoto,Y., Kataoka,Y., Yoshida,N.,
            Meguro,H., Aburatani,H., Asashima,M. and Nishinakamura,R.
  TITLE     Identification of kidney mesenchymal genes by a combination of
            microarray analysis and Sall1-GFP knockin mice
  JOURNAL   Mech Dev 121 (6), 547-557 (2004)
   PUBMED   15172686
REFERENCE   8  (bases 1 to 2350)
  AUTHORS   Schaffler,A., Ehling,A., Neumann,E., Herfarth,H., Paul,G.,
            Tarner,I., Gay,S., Buechler,C., Scholmerich,J. and Muller-Ladner,U.
  TITLE     Role of specificity protein-1, PPARgamma, and pituitary protein
            transcription factor-1 in transcriptional regulation of the murine
            CORS-26 promoter
  JOURNAL   Biochim Biophys Acta 1678 (2-3), 150-156 (2004)
   PUBMED   15157741
  REMARK    GeneRIF: the murine CORS-26 promoter is transcriptionally regulated
            by specificity protein-1, PPARgamma, and pituitary protein
            transcription factor-1
REFERENCE   9  (bases 1 to 2350)
  AUTHORS   Schaffler,A., Ehling,A., Neumann,E., Herfarth,H., Tarner,I.,
            Gay,S., Scholmerich,J. and Muller-Ladner,U.
  TITLE     Genomic organization, chromosomal localization and adipocytic
            expression of the murine gene for CORS-26 (collagenous
            repeat-containing sequence of 26 kDa protein)
  JOURNAL   Biochim Biophys Acta 1628 (1), 64-70 (2003)
   PUBMED   12850274
  REMARK    GeneRIF: Genomic organization, chromosomal localization and
            adipocytic expression of the murine gene for CORS-26
REFERENCE   10 (bases 1 to 2350)
  AUTHORS   Maeda,T., Abe,M., Kurisu,K., Jikko,A. and Furukawa,S.
  TITLE     Molecular cloning and characterization of a novel gene, CORS26,
            encoding a putative secretory protein and its possible involvement
            in skeletal development
  JOURNAL   J Biol Chem 276 (5), 3628-3634 (2001)
   PUBMED   11071891
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102219.11 and AK029352.1.
            
            On Feb 18, 2011 this sequence version replaced NM_030888.3.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. The
            encoded isoform (2) is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK128898.1, AK029352.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AC102219.11        53842-53865
            25-2338             AK029352.1         2-2315
            2339-2350           AC102219.11        81661-81672
FEATURES             Location/Qualifiers
     source          1..2350
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 5.38 cM"
     gene            1..2350
                     /gene="C1qtnf3"
                     /gene_synonym="2310005P21Rik; Adim; Corcs; Cors; CORS-26;
                     CORS26; CTRP3"
                     /note="C1q and tumor necrosis factor related protein 3"
                     /db_xref="GeneID:81799"
                     /db_xref="MGI:MGI:1932136"
     exon            1..206
                     /gene="C1qtnf3"
                     /gene_synonym="2310005P21Rik; Adim; Corcs; Cors; CORS-26;
                     CORS26; CTRP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..863
                     /gene="C1qtnf3"
                     /gene_synonym="2310005P21Rik; Adim; Corcs; Cors; CORS-26;
                     CORS26; CTRP3"
                     /EC_number="5.1.99.4"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; cartonectin; complement C1q tumor necrosis
                     factor-related protein 3; adiponectin m; cartducin;
                     secretory protein CORS26; collagenous repeat-containing
                     sequence 26 kDa protein"
                     /codon_start=1
                     /product="complement C1q tumor necrosis factor-related
                     protein 3 isoform 2 precursor"
                     /protein_id="NP_112150.1"
                     /db_xref="CCDS:CCDS27380.1"
                     /db_xref="GeneID:81799"
                     /db_xref="MGI:MGI:1932136"
                     /translation="MLGRQRIWWHLLPLLFLPFCLCQDEYMESPQAGGLPPDCSKCCH
                     GDYGFRGYQGPPGPPGPPGIPGNHGNNGNNGATGHEGAKGEKGDKGDLGPRGERGQHG
                     PKGEKGYPGVPPELQIAFMASLATHFSNQNSGIIFSSVETNIGNFFDVMTGRFGAPVS
                     GVYFFTFSMMKHEDVEEVYVYLMHNGNTVFSMYSYETKGKSDTSSNHAVLKLAKGDEV
                     WLRMGNGALHGDHQRFSTFAGFLLFETK"
     exon            207..318
                     /gene="C1qtnf3"
                     /gene_synonym="2310005P21Rik; Adim; Corcs; Cors; CORS-26;
                     CORS26; CTRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            319..473
                     /gene="C1qtnf3"
                     /gene_synonym="2310005P21Rik; Adim; Corcs; Cors; CORS-26;
                     CORS26; CTRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            474..603
                     /gene="C1qtnf3"
                     /gene_synonym="2310005P21Rik; Adim; Corcs; Cors; CORS-26;
                     CORS26; CTRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            604..703
                     /gene="C1qtnf3"
                     /gene_synonym="2310005P21Rik; Adim; Corcs; Cors; CORS-26;
                     CORS26; CTRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            704..2350
                     /gene="C1qtnf3"
                     /gene_synonym="2310005P21Rik; Adim; Corcs; Cors; CORS-26;
                     CORS26; CTRP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1860..1865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1qtnf3"
                     /gene_synonym="2310005P21Rik; Adim; Corcs; Cors; CORS-26;
                     CORS26; CTRP3"
                     /note="hexamer: AGTAAA"
     polyA_site      1891
                     /gene="C1qtnf3"
                     /gene_synonym="2310005P21Rik; Adim; Corcs; Cors; CORS-26;
                     CORS26; CTRP3"
                     /note="major polyA site"
     regulatory      1913..1918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1qtnf3"
                     /gene_synonym="2310005P21Rik; Adim; Corcs; Cors; CORS-26;
                     CORS26; CTRP3"
                     /note="hexamer: AATAAA"
     polyA_site      1940
                     /gene="C1qtnf3"
                     /gene_synonym="2310005P21Rik; Adim; Corcs; Cors; CORS-26;
                     CORS26; CTRP3"
                     /note="major polyA site"
     polyA_site      2321
                     /gene="C1qtnf3"
                     /gene_synonym="2310005P21Rik; Adim; Corcs; Cors; CORS-26;
                     CORS26; CTRP3"
ORIGIN      
        1 accacacagc cggctgcagc tctcatctcc aaacctggca tttgcctgag gcgaccacgg
       61 tacctccagc ccctgtcaag cttccctgcg agactcttgt cgatttgccg atttgccgag
      121 ccatgctcgg gaggcagcgc atctggtggc acctgctgcc tttgcttttc ctcccatttt
      181 gcctgtgtca agatgaatac atggagtctc cacaagctgg aggactgccc ccagactgca
      241 gcaagtgttg ccatggagat tatggatttc gtggttacca agggccccct ggacctccag
      301 gtcctcctgg cattccagga aaccatggaa acaatgggaa caatggagct actggccatg
      361 aaggggccaa aggtgagaaa ggagacaaag gcgacctagg ccctcgagga gaacgggggc
      421 agcatggccc caaaggagag aaaggctacc caggggtgcc accagaactg cagattgcat
      481 tcatggcttc tctagcaact cacttcagca atcagaacag tggcattatc ttcagcagtg
      541 ttgagaccaa cattggaaac ttcttcgatg tcatgactgg gagatttggg gcccccgtat
      601 caggtgtgta tttcttcacc ttcagcatga tgaagcatga ggacgtagag gaagtgtatg
      661 tgtaccttat gcacaacggc aacacagtct tcagcatgta cagctatgaa acaaagggaa
      721 aatcagatac atccagcaac catgcagtgc tgaagttggc caaaggagat gaagtctggc
      781 taagaatggg caacggtgcc ctccacgggg accaccagcg cttctccacc ttcgcaggct
      841 ttctgctctt tgaaactaag tgacaaggaa gacaggatat ctccactttg ggggcaattt
      901 atagctgagc tagggttgtt aggatatgaa ggatgttgaa gtcgggggtt ctttatggag
      961 catttaagtg ttgcattggt cacactgcta ctcattctaa tggcatacca ataatgttgg
     1021 atgcttcagg ggctcactgc tactcattct aatggcatac caataatgtt ggatgcttca
     1081 ggggctcact gctactcatt ctaatggcat accaataatg ttggatgctt caggggctaa
     1141 gaatagacca caaggtaatc tttccagatg accttgggaa atactcagca ttttcatcac
     1201 tcttctctac atgtctaaag ggattgccac ctgatacagg ctggaaaaaa agcactcacc
     1261 tcaaaggatg catttgcata gagttttggt gctctgttta aatgtaatat tggctttcga
     1321 gtcaaccaag ttttcagctc attgttcata atatttcaga gactagcctg attatgatgg
     1381 ggcaaaaata agcccactta ctagactcta cataggaaaa acacttctga agtctaaact
     1441 gggaaatagc atttggttta gtgggtttta ttcttatact cattaataaa atacatttag
     1501 tcatttcagg taaccttcag atagggcaat tatttacaat gctcacaaat aattggctcc
     1561 tcttttaaaa caaacaaaca accccatgta gataatattg agttctactg gcttagactt
     1621 gcagatataa acttttctcc catctggctt gccacatctt ctctttgcca ttgcattcct
     1681 ggggctgtgg tagagctctc ttgactctgt acaacaagct gaggtaagat gaggctgata
     1741 tagtacagaa gttatcacat tttttttaat ttgggaatta tacccaaatt tttatataca
     1801 ccgtgttata ttgaatggtc tgtaaactta attaaataca ggcagacaaa tggatgcaaa
     1861 gtaaagtgta ttccatttat gagatccata acaacatgtc ttaaatgttt tcaataaaaa
     1921 tgatattatt ttctctatta tcatacttga ctaatgttca caaatcaact ttaatatgcc
     1981 acagtgttat agaaggtgct agatggtttt tgcctagctt tccccatccc agaatctata
     2041 aagaaaaagg attaaatttg ccaccaaaac accattatgc tacctgctat aagttgacac
     2101 agatagtaac ataatttggg ggctggagaa gcggttctgc ggttaagaac actggctgtt
     2161 tcccagagga ctgacttttg ctgcccagcg ttcacgtgtc accttacagc catcttgccc
     2221 tcagatacaa caccctcttc tggcctctgc aggcaccagg catgcctaca ctgcacagac
     2281 acacatgcag gcaaaaaact cgtaccaatt acaaaataaa atttaaaaat ttaaagcttc
     2341 ttacttattt
//
