LOCUS       NM_026979               1359 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus C1q and tumor necrosis factor related protein 2
            (C1qtnf2), mRNA.
ACCESSION   NM_026979 XM_126141
VERSION     NM_026979.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1359)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1359)
  AUTHORS   Ye,M., Wu,Q.H., Yang,K. and Luo,Y.
  TITLE     C1q/TNF-related protein-2 improved angiogenesis to protect
            myocardial function during ischaemia-reperfusion
  JOURNAL   Diab Vasc Dis Res 19 (6), 14791641221137355 (2022)
   PUBMED   36409464
  REMARK    GeneRIF: C1q/TNF-related protein-2 improved angiogenesis to protect
            myocardial function during ischaemiareperfusion.
REFERENCE   3  (bases 1 to 1359)
  AUTHORS   Lei,X. and Wong,G.W.
  TITLE     C1q/TNF-related protein 2 (CTRP2) deletion promotes adipose tissue
            lipolysis and hepatic triglyceride secretion
  JOURNAL   J Biol Chem 294 (43), 15638-15649 (2019)
   PUBMED   31439668
  REMARK    GeneRIF: CTRP2 regulates lipid metabolism in adipose tissue and
            liver.
REFERENCE   4  (bases 1 to 1359)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   5  (bases 1 to 1359)
  AUTHORS   Peterson,J.M., Seldin,M.M., Tan,S.Y. and Wong,G.W.
  TITLE     CTRP2 overexpression improves insulin and lipid tolerance in
            diet-induced obese mice
  JOURNAL   PLoS One 9 (2), e88535 (2014)
   PUBMED   24586339
  REMARK    GeneRIF: CTRP2 overexpression improves insulin and lipid tolerance
            in diet-induced obese mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1359)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 1359)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   8  (bases 1 to 1359)
  AUTHORS   Wong,G.W., Krawczyk,S.A., Kitidis-Mitrokostas,C., Revett,T.,
            Gimeno,R. and Lodish,H.F.
  TITLE     Molecular, biochemical and functional characterizations of C1q/TNF
            family members: adipose-tissue-selective expression patterns,
            regulation by PPAR-gamma agonist, cysteine-mediated
            oligomerizations, combinatorial associations and metabolic
            functions
  JOURNAL   Biochem J 416 (2), 161-177 (2008)
   PUBMED   18783346
REFERENCE   9  (bases 1 to 1359)
  AUTHORS   Schmidt,T., Fischer,S., Tsikolia,N., Navarrete Santos,A.,
            Rohrbach,S., Ramin,N., Thieme,R. and Fischer,B.
  TITLE     Expression of adipokines in preimplantation rabbit and mice embryos
  JOURNAL   Histochem Cell Biol 129 (6), 817-825 (2008)
   PUBMED   18330590
REFERENCE   10 (bases 1 to 1359)
  AUTHORS   Wong,G.W., Wang,J., Hug,C., Tsao,T.S. and Lodish,H.F.
  TITLE     A family of Acrp30/adiponectin structural and functional paralogs
  JOURNAL   Proc Natl Acad Sci U S A 101 (28), 10302-10307 (2004)
   PUBMED   15231994
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL670472.7.
            
            On Jan 24, 2023 this sequence version replaced NM_026979.5.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007683.1, ERR3835353.211090.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AL670472.7         161631-161727       c
            98-171              AL670472.7         155049-155122       c
            172-424             AL670472.7         149945-150197       c
            425-1359            AL670472.7         144360-145294       c
FEATURES             Location/Qualifiers
     source          1..1359
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 25.72 cM"
     gene            1..1359
                     /gene="C1qtnf2"
                     /gene_synonym="1810033K05Rik; Adih; CTRP2"
                     /note="C1q and tumor necrosis factor related protein 2"
                     /db_xref="GeneID:69183"
                     /db_xref="MGI:MGI:1916433"
     exon            1..97
                     /gene="C1qtnf2"
                     /gene_synonym="1810033K05Rik; Adih; CTRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            98..171
                     /gene="C1qtnf2"
                     /gene_synonym="1810033K05Rik; Adih; CTRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            172..424
                     /gene="C1qtnf2"
                     /gene_synonym="1810033K05Rik; Adih; CTRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            425..1359
                     /gene="C1qtnf2"
                     /gene_synonym="1810033K05Rik; Adih; CTRP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1185..1190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1qtnf2"
                     /gene_synonym="1810033K05Rik; Adih; CTRP2"
                     /note="hexamer: ATTAAA"
     polyA_site      1211
                     /gene="C1qtnf2"
                     /gene_synonym="1810033K05Rik; Adih; CTRP2"
                     /note="major polyA site"
     regulatory      1334..1339
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1qtnf2"
                     /gene_synonym="1810033K05Rik; Adih; CTRP2"
                     /note="hexamer: AATAAA"
     polyA_site      1359
                     /gene="C1qtnf2"
                     /gene_synonym="1810033K05Rik; Adih; CTRP2"
ORIGIN      
        1 atgcctgggg ccggcatctc tggctgctgc aggcaggact gaacaccacc ggagcagcga
       61 cgtcggatgg ccctggatgt ggctcggtgc acagaagcaa gaagacttga tgaagccttt
      121 cttcccaacc cattcccaga aagaacaact tagatgacaa tttttaaaaa ggtgacaacc
      181 atgatctcct gggtactctt ggcctgtgcc cttccgtgtg ctgctgaccc aatgcttggt
      241 gcctttgctc gcagggactt ccagaagggg ggtcctcaac tagtttgcag cctgcctggt
      301 ccccaaggcc cacctggccc tccaggagca ccaggatcct caggagtggt gggaagaatg
      361 ggtttccctg ggaaagacgg ccaagatggc caggacggag accgggggga cagtggagaa
      421 gaaggtccac ctggcaggac aggcaaccgt ggaaaacaag gaccaaaggg caaagctggg
      481 gccattggca gagctggccc tcgaggaccc aagggggtca gtggtacccc cgggaagcat
      541 ggcacaccgg gcaagaaggg acctaagggc aaaaaagggg agcctggcct cccaggcccc
      601 tgcagctgcg gcagtagccg agccaagtcg gccttttccg tggcggtaac caagagctac
      661 ccacgcgagc gactgcctat caagtttgac aagattctga tgaacgaggg tggccactac
      721 aacgcgtcca gtggcaagtt cgtctgcagc gtgccgggga tctattactt tacctatgac
      781 attacgctgg ccaacaaaca cctggccatc ggcctggtgc acaatggtca gtaccgcatt
      841 cggacttttg atgccaacac gggcaaccac gacgtggcct cgggctccac catcctagct
      901 ctcaaggagg gtgatgaagt ctggctgcag atcttctact cagagcagaa tggcctcttc
      961 tacgaccctt actggaccga cagcctgttc accggcttcc tcatctacgc tgaccaagga
     1021 gaccccaacg aggtatagac aagccggggt tgagccttga ggtagggact aagagtctgc
     1081 gtgggtgcct ggaggaagat ccctcgactg gggctgtgga ctgacaatct tgggatcttt
     1141 tattcccagg caggcctcct ctattgctgc ttaaaaaaga aatcattaaa tccaagctat
     1201 tgattcatct atttctctgt ccatcaccaa tggtcttagt atctgttgag taaccagcac
     1261 tgggctatac tccatgaggt acatacacca gtgggaagac agagtgccta tcctcccgga
     1321 aatacaattc acaaataaag agcaaattat ataaatggc
//
