LOCUS       NM_026125               1339 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus C1q and tumor necrosis factor related 12 (C1qtnf12),
            mRNA.
ACCESSION   NM_026125
VERSION     NM_026125.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1339)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1339)
  AUTHORS   Fang,L., Ohashi,K., Hayakawa,S., Ogawa,H., Otaka,N., Kawanishi,H.,
            Takikawa,T., Ozaki,Y., Takahara,K., Tatsumi,M., Takefuji,M.,
            Shimizu,Y., Bando,Y.K., Fujishima,Y., Maeda,N., Shimomura,I.,
            Murohara,T. and Ouchi,N.
  TITLE     Adipolin protects against renal injury via PPARalpha-dependent
            reduction of inflammasome activation
  JOURNAL   iScience 26 (5), 106591 (2023)
   PUBMED   37250342
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1339)
  AUTHORS   Weiss,A.C., Blank,E., Bohnenpoll,T., Kleppa,M.J., Rivera-Reyes,R.,
            Taketo,M.M., Trowe,M.O. and Kispert,A.
  TITLE     Permissive ureter specification by TBX18-mediated repression of
            metanephric gene expression
  JOURNAL   Development 150 (6) (2023)
   PUBMED   36960826
REFERENCE   4  (bases 1 to 1339)
  AUTHORS   Liao,B. and Tian,X.
  TITLE     CTRP12 alleviates cardiomyocyte ischemia-reperfusion injury via
            regulation of KLF15
  JOURNAL   Mol Med Rep 26 (1) (2022)
   PUBMED   35656890
  REMARK    GeneRIF: CTRP12 alleviates cardiomyocyte ischemiareperfusion injury
            via regulation of KLF15.
REFERENCE   5  (bases 1 to 1339)
  AUTHORS   Jin,A.P., Zhang,Q.R., Yang,C.L., Ye,S., Cheng,H.J. and Zheng,Y.Y.
  TITLE     Up-regulation of CTRP12 ameliorates hypoxia/re-oxygenation-induced
            cardiomyocyte injury by inhibiting apoptosis, oxidative stress, and
            inflammation via the enhancement of Nrf2 signaling
  JOURNAL   Hum Exp Toxicol 40 (12), 2087-2098 (2021)
   PUBMED   34085554
  REMARK    GeneRIF: Up-regulation of CTRP12 ameliorates
            hypoxia/re-oxygenation-induced cardiomyocyte injury by inhibiting
            apoptosis, oxidative stress, and inflammation via the enhancement
            of Nrf2 signaling.
REFERENCE   6  (bases 1 to 1339)
  AUTHORS   Conde,J., Scotece,M., Lopez,V., Gomez,R., Lago,F., Pino,J.,
            Gomez-Reino,J.J. and Gualillo,O.
  TITLE     Expression and modulation of adipolin/C1qdc2: a novel adipokine in
            human and murine ATDC-5 chondrocyte cell line
  JOURNAL   Ann Rheum Dis 72 (1), 140-142 (2013)
   PUBMED   22736092
  REMARK    GeneRIF: The aim of this study was to demonstrate adipolin
            expression in human and murine chondrocytes and to elucidate the
            intracellular mechanism involved in adipolin basal expression
REFERENCE   7  (bases 1 to 1339)
  AUTHORS   Wei,Z., Peterson,J.M., Lei,X., Cebotaru,L., Wolfgang,M.J.,
            Baldeviano,G.C. and Wong,G.W.
  TITLE     C1q/TNF-related protein-12 (CTRP12), a novel adipokine that
            improves insulin sensitivity and glycemic control in mouse models
            of obesity and diabetes
  JOURNAL   J Biol Chem 287 (13), 10301-10315 (2012)
   PUBMED   22275362
  REMARK    GeneRIF: CTRP12 as a novel metabolic regulator linking adipose
            tissue to whole body glucose homeostasis through insulin-dependent
            and independent mechanisms.
REFERENCE   8  (bases 1 to 1339)
  AUTHORS   Enomoto,T., Ohashi,K., Shibata,R., Higuchi,A., Maruyama,S.,
            Izumiya,Y., Walsh,K., Murohara,T. and Ouchi,N.
  TITLE     Adipolin/C1qdc2/CTRP12 protein functions as an adipokine that
            improves glucose metabolism
  JOURNAL   J Biol Chem 286 (40), 34552-34558 (2011)
   PUBMED   21849507
  REMARK    GeneRIF: Adipolin/C1qdc2/CTRP12 protein functions as an adipokine
            that improves glucose metabolism
REFERENCE   9  (bases 1 to 1339)
  AUTHORS   Karner,C.M., Das,A., Ma,Z., Self,M., Chen,C., Lum,L., Oliver,G. and
            Carroll,T.J.
  TITLE     Canonical Wnt9b signaling balances progenitor cell expansion and
            differentiation during kidney development
  JOURNAL   Development 138 (7), 1247-1257 (2011)
   PUBMED   21350016
REFERENCE   10 (bases 1 to 1339)
  AUTHORS   Bachmanov,A.A., Li,X., Reed,D.R., Ohmen,J.D., Li,S., Chen,Z.,
            Tordoff,M.G., de Jong,P.J., Wu,C., West,D.B., Chatterjee,A.,
            Ross,D.A. and Beauchamp,G.K.
  TITLE     Positional cloning of the mouse saccharin preference (Sac) locus
  JOURNAL   Chem Senses 26 (7), 925-933 (2001)
   PUBMED   11555487
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627204.7, AK004116.1 and CO043709.1.
            
            On Oct 4, 2011 this sequence version replaced NM_026125.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004116.1, AK002876.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AL627204.7         37952-37957
            7-869               AK004116.1         2-864
            870-1339            CO043709.1         1-470               c
FEATURES             Location/Qualifiers
     source          1..1339
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 87.66 cM"
     gene            1..1339
                     /gene="C1qtnf12"
                     /gene_synonym="1110035L05Rik; alipolin; C1qdc2; CTRP12;
                     Fam132a"
                     /note="C1q and tumor necrosis factor related 12"
                     /db_xref="GeneID:67389"
                     /db_xref="MGI:MGI:1914639"
     exon            1..426
                     /gene="C1qtnf12"
                     /gene_synonym="1110035L05Rik; alipolin; C1qdc2; CTRP12;
                     Fam132a"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..1194
                     /gene="C1qtnf12"
                     /gene_synonym="1110035L05Rik; alipolin; C1qdc2; CTRP12;
                     Fam132a"
                     /note="C1q domain containing 2; adipolin; protein FAM132A;
                     adipose-derived insulin-sensitizing factor; complement C1q
                     tumor necrosis factor-related protein 12; family with
                     sequence similarity 132, member A"
                     /codon_start=1
                     /product="adipolin precursor"
                     /protein_id="NP_080401.1"
                     /db_xref="CCDS:CCDS19052.1"
                     /db_xref="GeneID:67389"
                     /db_xref="MGI:MGI:1914639"
                     /translation="MWAWGWAAAALLWLQTAGAGARQELKKSRQLFARVDSPNITTSN
                     REGFPGSVKPPEASGPELSDAHMTWLNFVRRPDDGSSRKRCRGRDKKSRGLSGLPGPP
                     GPPGPPGPPGSPGVGVTPEALLQEFQEILKEATELRFSGLPDTLLPQEPSQRLVVEAF
                     YCRLKGPVLVDKKTLVELQGFQAPTTQGAFLRGSGLSLSLGRFTAPVSAIFQFSASLH
                     VDHSELQGRGRLRTRDMVRVLICIESLCHRHTSLEAVSGLESNSRVFTVQVQGLLHLQ
                     SGQYVSVFVDNSSGAVLTIQNTSSFSGMLLGT"
     exon            427..543
                     /gene="C1qtnf12"
                     /gene_synonym="1110035L05Rik; alipolin; C1qdc2; CTRP12;
                     Fam132a"
                     /inference="alignment:Splign:2.1.0"
     exon            544..664
                     /gene="C1qtnf12"
                     /gene_synonym="1110035L05Rik; alipolin; C1qdc2; CTRP12;
                     Fam132a"
                     /inference="alignment:Splign:2.1.0"
     exon            665..816
                     /gene="C1qtnf12"
                     /gene_synonym="1110035L05Rik; alipolin; C1qdc2; CTRP12;
                     Fam132a"
                     /inference="alignment:Splign:2.1.0"
     exon            817..925
                     /gene="C1qtnf12"
                     /gene_synonym="1110035L05Rik; alipolin; C1qdc2; CTRP12;
                     Fam132a"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1016
                     /gene="C1qtnf12"
                     /gene_synonym="1110035L05Rik; alipolin; C1qdc2; CTRP12;
                     Fam132a"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1095
                     /gene="C1qtnf12"
                     /gene_synonym="1110035L05Rik; alipolin; C1qdc2; CTRP12;
                     Fam132a"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1321
                     /gene="C1qtnf12"
                     /gene_synonym="1110035L05Rik; alipolin; C1qdc2; CTRP12;
                     Fam132a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1293..1298
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1qtnf12"
                     /gene_synonym="1110035L05Rik; alipolin; C1qdc2; CTRP12;
                     Fam132a"
                     /note="hexamer: AATAAA"
     polyA_site      1318
                     /gene="C1qtnf12"
                     /gene_synonym="1110035L05Rik; alipolin; C1qdc2; CTRP12;
                     Fam132a"
                     /note="major polyA site"
ORIGIN      
        1 cccaatgagt cctccccttg gagcctggga ggcctaggga gaaagtagtt ctctttcggt
       61 ggcagggttg ctgtcgaggg caccgagcag gaggataggt cgacagagac gaggagttct
      121 ggctcctcct gcagacatgc accagcggct gctgggctcg tccctgggcc tcgcccccgc
      181 gcgggggctc tgaatgcctg ccgccgcccc catgagagca ccggcctggg ctcccgcccc
      241 taagcctctg ctcgcggaga ctgagccatg tgggcctggg gctgggccgc tgcagcgctc
      301 ctctggctac agactgcagg agccggggcc cggcaggagc tcaagaagtc tcggcagctg
      361 tttgcgcgtg tggattcccc caatattacc acgtccaacc gtgagggatt cccaggctcc
      421 gtcaagcccc cggaagcctc tggacctgag ctctcagatg cccacatgac gtggttgaac
      481 tttgtccgac ggccagatga tgggtcctct agaaaacggt gtcgtggccg ggacaagaag
      541 tcgcgaggcc tctcaggtct cccagggccc ccaggacctc ctggccctcc tggtccccct
      601 ggctcccctg gtgtgggcgt taccccagag gccttactgc aggaatttca ggagatactg
      661 aaagaggcca cagaacttcg attctcaggg ctaccagaca cattgttacc ccaggaaccc
      721 agccaacggc tggtggttga ggccttctac tgccgtttga aaggccctgt gctggtggac
      781 aagaagactc tggtggaact gcaaggattc caagctccta ctactcaggg cgccttcctg
      841 cggggatctg gcctgagcct gtccttgggc cgattcacag ccccagtctc tgccatcttc
      901 cagttttctg ccagcctgca cgtggaccac agtgaactgc agggcagagg ccggttgcgt
      961 acccgggata tggtccgtgt tctcatctgt attgagtcct tgtgtcatcg tcatacgtcc
     1021 ctggaggctg tatcaggtct ggagagcaac agcagggtct tcacagtgca ggttcagggg
     1081 ctgctgcatc tacagtctgg acagtatgtc tctgtgttcg tggacaacag ttctggggca
     1141 gtcctcacca tccagaacac ttccagcttc tcgggaatgc ttttgggtac ctagcggagc
     1201 tgaagaaacg attgtggatt gaggaaccaa caccttgctt cttagaggag ctgaaaagga
     1261 ctactcactc cccttttaat agttttcata gcaataaaga actccaaact tcttcatcgc
     1321 taaaaaaaaa aaaaaaaaa
//
