LOCUS       NM_001204129            4393 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus C1q and tumor necrosis factor related protein 1
            (C1qtnf1), transcript variant 1, mRNA.
ACCESSION   NM_001204129
VERSION     NM_001204129.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4393)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4393)
  AUTHORS   Sonn,S.K., Seo,S., Yang,J., Oh,K.S., Chen,H., Chan,D.C., Rhee,K.,
            Lee,K.S., Yang,Y. and Oh,G.T.
  TITLE     ER-associated CTRP1 regulates mitochondrial fission via interaction
            with DRP1
  JOURNAL   Exp Mol Med 53 (11), 1769-1780 (2021)
   PUBMED   34837016
  REMARK    GeneRIF: ER-associated CTRP1 regulates mitochondrial fission via
            interaction with DRP1.
REFERENCE   3  (bases 1 to 4393)
  AUTHORS   Xiang,C., Frietze,K.K., Bi,Y., Li,Y., Dal Pozzo,V., Pal,S.,
            Alexander,N., Baubet,V., D'Acunto,V., Mason,C.E., Davuluri,R.V. and
            Dahmane,N.
  TITLE     RP58 Represses Transcriptional Programs Linked to Nonneuronal Cell
            Identity and Glioblastoma Subtypes in Developing Neurons
  JOURNAL   Mol Cell Biol 41 (7), e0052620 (2021)
   PUBMED   33903225
REFERENCE   4  (bases 1 to 4393)
  AUTHORS   Gu,Y., Hu,X., Ge,P.B., Chen,Y., Wu,S. and Zhang,X.W.
  TITLE     CTRP1 Aggravates Cardiac Dysfunction Post Myocardial Infarction by
            Modulating TLR4 in Macrophages
  JOURNAL   Front Immunol 12, 635267 (2021)
   PUBMED   34025643
  REMARK    GeneRIF: CTRP1 Aggravates Cardiac Dysfunction Post Myocardial
            Infarction by Modulating TLR4 in Macrophages.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4393)
  AUTHORS   Rodriguez,S., Little,H.C., Daneshpajouhnejad,P., Fenaroli,P.,
            Tan,S.Y., Sarver,D.C., Delannoy,M., Talbot,C.C. Jr., Jandu,S.,
            Berkowitz,D.E., Pluznick,J.L., Rosenberg,A.Z. and Wong,G.W.
  TITLE     Aging and chronic high-fat feeding negatively affect kidney size,
            function, and gene expression in CTRP1-deficient mice
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 320 (1), R19-R35 (2021)
   PUBMED   33085906
  REMARK    GeneRIF: Aging and chronic high-fat feeding negatively affect
            kidney size, function, and gene expression in CTRP1-deficient mice.
REFERENCE   6  (bases 1 to 4393)
  AUTHORS   Peterson,J.M., Aja,S., Wei,Z. and Wong,G.W.
  TITLE     CTRP1 protein enhances fatty acid oxidation via AMP-activated
            protein kinase (AMPK) activation and acetyl-CoA carboxylase (ACC)
            inhibition
  JOURNAL   J Biol Chem 287 (2), 1576-1587 (2012)
   PUBMED   22086915
  REMARK    GeneRIF: CTRP1 is a novel regulator of fatty acid metabolism.
REFERENCE   7  (bases 1 to 4393)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   8  (bases 1 to 4393)
  AUTHORS   Wong,G.W., Krawczyk,S.A., Kitidis-Mitrokostas,C., Revett,T.,
            Gimeno,R. and Lodish,H.F.
  TITLE     Molecular, biochemical and functional characterizations of C1q/TNF
            family members: adipose-tissue-selective expression patterns,
            regulation by PPAR-gamma agonist, cysteine-mediated
            oligomerizations, combinatorial associations and metabolic
            functions
  JOURNAL   Biochem J 416 (2), 161-177 (2008)
   PUBMED   18783346
REFERENCE   9  (bases 1 to 4393)
  AUTHORS   Schmidt,T., Fischer,S., Tsikolia,N., Navarrete Santos,A.,
            Rohrbach,S., Ramin,N., Thieme,R. and Fischer,B.
  TITLE     Expression of adipokines in preimplantation rabbit and mice embryos
  JOURNAL   Histochem Cell Biol 129 (6), 817-825 (2008)
   PUBMED   18330590
REFERENCE   10 (bases 1 to 4393)
  AUTHORS   Wong,G.W., Wang,J., Hug,C., Tsao,T.S. and Lodish,H.F.
  TITLE     A family of Acrp30/adiponectin structural and functional paralogs
  JOURNAL   Proc Natl Acad Sci U S A 101 (28), 10302-10307 (2004)
   PUBMED   15231994
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591075.11, AK005484.1 and BM934297.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005484.1, BC049894.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AL591075.11        14251-14292
            43-2474             AK005484.1         2-2433
            2475-2575           BM934297.1         426-526
            2576-4393           AL591075.11        35759-37576
FEATURES             Location/Qualifiers
     source          1..4393
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 83.17 cM"
     gene            1..4393
                     /gene="C1qtnf1"
                     /gene_synonym="1600017K21Rik; Adip; CTRP1; Zsig37"
                     /note="C1q and tumor necrosis factor related protein 1"
                     /db_xref="GeneID:56745"
                     /db_xref="MGI:MGI:1919254"
     exon            1..112
                     /gene="C1qtnf1"
                     /gene_synonym="1600017K21Rik; Adip; CTRP1; Zsig37"
                     /inference="alignment:Splign:2.1.0"
     exon            113..271
                     /gene="C1qtnf1"
                     /gene_synonym="1600017K21Rik; Adip; CTRP1; Zsig37"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..962
                     /gene="C1qtnf1"
                     /gene_synonym="1600017K21Rik; Adip; CTRP1; Zsig37"
                     /note="putative secreted protein ZSIG37; complement C1q
                     tumor necrosis factor-related protein 1; adiponectin p"
                     /codon_start=1
                     /product="complement C1q tumor necrosis factor-related
                     protein 1 precursor"
                     /protein_id="NP_001191058.1"
                     /db_xref="CCDS:CCDS25703.1"
                     /db_xref="GeneID:56745"
                     /db_xref="MGI:MGI:1919254"
                     /translation="MGSCAQGFMLGCCLLLAITWGPILSLVPRVQEEQQEWEETEELP
                     SPLDPVTRPEETREKYSPRQGEDLPTSRCYRCCDPSTPVYQTIPPPQINITILKGEKG
                     DRGDRGLQGKYGKIGSTGPRGHVGPKGQKGSIGAPGNHCKSQYAAFSVGRKKALHSND
                     YFQPVVFDTEFVNLYKHFNMFTGKFYCYVPGIYFFSLNVHTWNQKETYLHIMKNEEEV
                     VILYAQVSDRSIMQSQSLMMELREEDEVWVRLFKGERENAIFSDEFDTYITFSGYLVK
                     PASEP"
     exon            272..411
                     /gene="C1qtnf1"
                     /gene_synonym="1600017K21Rik; Adip; CTRP1; Zsig37"
                     /inference="alignment:Splign:2.1.0"
     exon            412..4393
                     /gene="C1qtnf1"
                     /gene_synonym="1600017K21Rik; Adip; CTRP1; Zsig37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2547..2552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1qtnf1"
                     /gene_synonym="1600017K21Rik; Adip; CTRP1; Zsig37"
                     /note="hexamer: ATTAAA"
     polyA_site      2575
                     /gene="C1qtnf1"
                     /gene_synonym="1600017K21Rik; Adip; CTRP1; Zsig37"
                     /note="major polyA site"
     regulatory      4372..4377
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1qtnf1"
                     /gene_synonym="1600017K21Rik; Adip; CTRP1; Zsig37"
                     /note="hexamer: AATAAA"
     polyA_site      4391
                     /gene="C1qtnf1"
                     /gene_synonym="1600017K21Rik; Adip; CTRP1; Zsig37"
                     /note="major polyA site"
ORIGIN      
        1 tcctgaccta gcctagaagg ctcagcccct gggagatgct ctaagagacg cctccccgag
       61 agccctgaga ggctggagga tttcattgca cagccggctc agctggaagg aggaagatgg
      121 gctcctgtgc acagggattc atgctgggat gctgcctgct gctggccatc acctggggcc
      181 ccatcctgag ccttgtgcca cgagttcagg aggaacaaca ggagtgggaa gagacagagg
      241 agctgccatc tcctctggat cctgtgacaa ggcctgaaga aacacgagag aagtatagcc
      301 ctcgccaggg tgaggacctc cccacttctc ggtgctaccg atgctgtgac cccagcacac
      361 ctgtatacca gacaattcct ccaccccaga tcaacatcac catcctgaaa ggcgagaaag
      421 gtgaccgagg ggatcgaggc ctccagggga agtacggcaa aataggttct acaggtccca
      481 ggggccatgt tggccccaaa gggcagaagg gatccattgg agcccctggg aaccactgca
      541 agagccagta cgcagccttc tccgtgggcc ggaagaaggc tttgcacagc aacgactact
      601 tccagcccgt ggtcttcgac acggagtttg tgaacctcta caaacacttc aatatgttca
      661 ctgggaagtt ctactgctat gtgccgggca tctacttctt cagcctcaac gtgcacactt
      721 ggaaccagaa ggagacgtac ctgcacatca tgaagaacga ggaggaggtg gtgatcctgt
      781 atgcgcaggt gagcgaccgc agcatcatgc agagtcagag cctgatgatg gagctgcggg
      841 aggaggatga ggtctgggtg cgtctcttca agggcgagcg tgagaacgcc attttcagtg
      901 acgagttcga cacctacatc accttcagtg gctacctggt caagccagcc tctgagccct
      961 agtggacact cctgtggagc ttttgtggac tgctgacctc cttgcctggc accctgacct
     1021 atccctgcat tctacagaca ctggagtcct gccccgggct gaccccattt tctctctgct
     1081 ccatcctggc ttccttggcc ttggcttcca aagttttggc ttttgacaag atgcccttgg
     1141 ccactgggaa tcccaaagga cggtgcgatc ccagatctgg ctgctactct aagcagagag
     1201 ctgccggcag atgaaatcat tgggcgggga gcctgtgagg atattggggg gcctccagct
     1261 ccttctgtgt acacagcctt agacgaccct gtgctgtgtt gtcccgtggc cacagggtgt
     1321 tccagagcac agcccctgtg tgttcccatt cctggacaca agtaagcaaa tatcatgggt
     1381 ttcttaggaa cgaagtcaag cagaaaagag aaagaaaggt ggtgttagtt ttggctttcc
     1441 agccagctgg agggagggat ggggagagag agagagcgag agctatttgt attggggaaa
     1501 ctgaggcata ggaaaaacat gaatggcaac agagtagctg cagtttgtgg gtttggaaac
     1561 cacatctgac ttaactctag atcacatatg agctttcctg gggacagcag gactgacctc
     1621 cgagctctgt tgacatgcta tagccttgcc caggggctgg tcaatctttc tgagccacac
     1681 tagtaaaagg gttgggggag aacagcaagt gccccctgtg gttggctctg ggctggtggc
     1741 agcatcctgc ttgccccaac tcacaggatc ctgacagcag ctgggaacct cagggactcc
     1801 tgcagctttc tctgtaagaa ataaagctcc tactatgtcc cagtacctct ctgctctgct
     1861 ccacttcccc agtcactctg gaccccaggg tgggagggct ctcttgcctg ttgggacatc
     1921 agttcccctt cctccttctt ggtgaattaa ccatggaagg accagggctc ggatttgggt
     1981 tcccaaactg cccttcacca tccctagtgc cctgcttcct tcccagttca gcatcctgtc
     2041 tgggaacttg atactttaac ctgctagagc ggatgagtct gatagacctg cccagccctg
     2101 acacagccct agtcagctta tggacacgtg agagggactt cctttgagac ccagagctgg
     2161 ggtagagcta taaaaatcta cctattcccg ggtcaacccc aagtggtaga agaggacaca
     2221 ggctatcccg cccctagctc agactcaggg aaggcctcag gcctgattct ctgattgcag
     2281 agagcctgtg ttctttcccc atctcacccc gtgttgatcc ccagggcctg ggccactgga
     2341 tatctgcttt gtgccaacta ggccttgctt gctgcttcct ggtggccctt ggttaggatc
     2401 cctctctttt ccttctggag ctcaatgtac gtatatgcca cctccgaagg ggcttctgct
     2461 ggtcagactc tccaagccac ttccatgggt gtgcctacag cagaggctgc tgcctcctgt
     2521 gctctaccct gctctttcca gaaaacatta aacttgccat ggcgattcac agcaagctgg
     2581 cgttttttgg tctgctcatt ggatagagtg ctccttcttc cctcctcccc atctagagtg
     2641 ctccttcttc ccttttcccc atctaaagtg ctccttcttc tgtccttccc atctagagtg
     2701 ctccttccca tctagagtgc tccttccttc tccaaaccta gagtgctcct tcttccctcc
     2761 tccccatcta gagtgctcct tcttcccttt tccccatcta gagtgctcct tcttctgtcc
     2821 tccccatcta gagtgctcct acctcctccc catctagagt gctccttctt cccttttctc
     2881 caactagagt gctccttctt ccctcctcca catctagatg ctccttcttc ccttttcccc
     2941 atctagagtg ttccttcttc tgtcctcccc atctaaagtg ctccttcctt ctccaaactt
     3001 agagtgctcc ttcttccctc ctccccatct agaatgctcc ttcttctctt ttccccatct
     3061 agagtgctcc ttcttctgtc ctccccatct agagtgctcc tttccatcta gagtgttcct
     3121 tcctcctccc catctagagt gctccttctt ccctcctccc cgtctagcac ccacccttct
     3181 gcttattaat ccaatggagt cctcaacttt atactcaggg acctgccggg gctctaattg
     3241 tcgcatttct accaaggaca cgaggaactc ctgatatgga gtatctagag ctgcccagtg
     3301 tgtgtggtca ggcctggaga ctcccaggag gtagaggctt gttcttctgc actggagtgt
     3361 gaccaacaga gcaggtatcc cctggcctgg cctgaagcct gagctgaatg accatcctgg
     3421 ggctgtgtgt gtcaaaaagg cccagaaacc aggtagcggc acacagacaa atctcttctc
     3481 atagttctgg gagtcagagt tcaaaatcca gctgtgagca aggcagtgct catagcactg
     3541 gctgggagac gctgcttcct gctgcctgca tctccagaca tgccttgcct ggagggaggg
     3601 atcatatctc ttcagccttc ctgtcctgac tccacatgac ctcctttcaa ggacacttgg
     3661 aactgcattc agggtctcct taaatccagg actcactctt tccagattca acacaagcac
     3721 atcggctaga gatctgtgaa tggacacact gacaggtgcc agaggccaag gtgtgtgtgt
     3781 ctctactggg gatcgcaatg aagcttgctg tgacaactca tgggtttgga cacctaacag
     3841 tctctctttg tctctgtggt gaagagacat tacttctttt cattactggc caagaggtcg
     3901 gtagccacac gttcctttcc acctaccagc agttggcttg gaagctggaa ccagcagctt
     3961 ggcaaacagc tggccttgtg cctttgcctc agccttggga tgggaccaaa atgcagcagg
     4021 tggacacagg gcccagaggc cttgcagttg cctggatgtg gcccagggct tttcccaaac
     4081 ggacctaaaa tgaatgcacc agcctcactc aagggccact ggctgcctgc cctcctgtcc
     4141 tgtggcacgt gtacactcga cccacagctg gcccggtcac catggagaaa aaggtgccca
     4201 agtgatcccc atgacagatc tcatgtaggc caggctgatc ttaaactcac tctatggtaa
     4261 acctgacctt gaactcctga tcctcctgac tccacgtcct gaatgctggg attacaggtg
     4321 tgccccaata tgcctgacct ttttaaatgt tagcatagat taattataga taataaagag
     4381 tttccttatg aca
//
