LOCUS       NM_207233               2070 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus complement component 1, q subcomponent-like 2 (C1ql2),
            mRNA.
ACCESSION   NM_207233 XM_129437
VERSION     NM_207233.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2070)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2070)
  AUTHORS   Dietrich,S., Company,C., Song,K., Lowenstein,E.D., Riedel,L.,
            Birchmeier,C., Gargiulo,G. and Zampieri,N.
  TITLE     Molecular identity of proprioceptor subtypes innervating different
            muscle groups in mice
  JOURNAL   Nat Commun 13 (1), 6867 (2022)
   PUBMED   36369193
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2070)
  AUTHORS   Roy,D.S., Zhang,Y., Aida,T., Shen,C., Skaggs,K.M., Hou,Y.,
            Fleishman,M., Mosto,O., Weninger,A. and Feng,G.
  TITLE     Anterior thalamic circuits crucial for working memory
  JOURNAL   Proc Natl Acad Sci U S A 119 (20), e2118712119 (2022)
   PUBMED   35537049
REFERENCE   4  (bases 1 to 2070)
  AUTHORS   Roy,D.S., Zhang,Y., Aida,T., Choi,S., Chen,Q., Hou,Y., Lea,N.E.,
            Skaggs,K.M., Quay,J.C., Liew,M., Maisano,H., Le,V., Jones,C.,
            Xu,J., Kong,D., Sullivan,H.A., Saunders,A., McCarroll,S.A.,
            Wickersham,I.R. and Feng,G.
  TITLE     Anterior thalamic dysfunction underlies cognitive deficits in a
            subset of neuropsychiatric disease models
  JOURNAL   Neuron 109 (16), 2590-2603 (2021)
   PUBMED   34197733
REFERENCE   5  (bases 1 to 2070)
  AUTHORS   Guo,Q. and Li,J.Y.H.
  TITLE     Defining developmental diversification of diencephalon neurons
            through single cell gene expression profiling
  JOURNAL   Development 146 (12) (2019)
   PUBMED   30872278
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2070)
  AUTHORS   Wei,Z., Seldin,M.M., Natarajan,N., Djemal,D.C., Peterson,J.M. and
            Wong,G.W.
  TITLE     C1q/tumor necrosis factor-related protein 11 (CTRP11), a novel
            adipose stroma-derived regulator of adipogenesis
  JOURNAL   J Biol Chem 288 (15), 10214-10229 (2013)
   PUBMED   23449976
REFERENCE   7  (bases 1 to 2070)
  AUTHORS   Bolliger,M.F., Martinelli,D.C. and Sudhof,T.C.
  TITLE     The cell-adhesion G protein-coupled receptor BAI3 is a
            high-affinity receptor for C1q-like proteins
  JOURNAL   Proc Natl Acad Sci U S A 108 (6), 2534-2539 (2011)
   PUBMED   21262840
REFERENCE   8  (bases 1 to 2070)
  AUTHORS   Iijima,T., Miura,E., Watanabe,M. and Yuzaki,M.
  TITLE     Distinct expression of C1q-like family mRNAs in mouse brain and
            biochemical characterization of their encoded proteins
  JOURNAL   Eur J Neurosci 31 (9), 1606-1615 (2010)
   PUBMED   20525073
REFERENCE   9  (bases 1 to 2070)
  AUTHORS   Shimono,C., Manabe,R., Yamada,T., Fukuda,S., Kawai,J., Furutani,Y.,
            Tsutsui,K., Ikenaka,K., Hayashizaki,Y. and Sekiguchi,K.
  TITLE     Identification and characterization of nCLP2, a novel C1q family
            protein expressed in the central nervous system
  JOURNAL   J Biochem 147 (4), 565-579 (2010)
   PUBMED   19996152
  REMARK    GeneRIF: characterization of nCLP2: cDNA sequencing, amino acid
            sequence, sequence alignment/homology with isoproteins, tissue
            localization (primarily retina & hippocampus [mossy fibers]),
            trimer structure/disulfide bridges, signal sequence suggests
            secretion
REFERENCE   10 (bases 1 to 2070)
  AUTHORS   Wong,G.W., Krawczyk,S.A., Kitidis-Mitrokostas,C., Revett,T.,
            Gimeno,R. and Lodish,H.F.
  TITLE     Molecular, biochemical and functional characterizations of C1q/TNF
            family members: adipose-tissue-selective expression patterns,
            regulation by PPAR-gamma agonist, cysteine-mediated
            oligomerizations, combinatorial associations and metabolic
            functions
  JOURNAL   Biochem J 416 (2), 161-177 (2008)
   PUBMED   18783346
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC040774.1.
            
            On Aug 30, 2004 this sequence version replaced XM_129437.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040774.1, AK144471.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2070
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 52.68 cM"
     gene            1..2070
                     /gene="C1ql2"
                     /gene_synonym="Adii; CTRP10"
                     /note="complement component 1, q subcomponent-like 2"
                     /db_xref="GeneID:226359"
                     /db_xref="MGI:MGI:3032521"
     exon            1..1219
                     /gene="C1ql2"
                     /gene_synonym="Adii; CTRP10"
                     /inference="alignment:Splign:2.1.0"
     CDS             536..1399
                     /gene="C1ql2"
                     /gene_synonym="Adii; CTRP10"
                     /note="complement C1q-like protein 2; C1qTNF10; C1q and
                     tumor necrosis factor-related protein 10; C1q/TNF-related
                     protein 10; adiponectin i"
                     /codon_start=1
                     /product="complement C1q-like protein 2 precursor"
                     /protein_id="NP_997116.1"
                     /db_xref="CCDS:CCDS15233.1"
                     /db_xref="GeneID:226359"
                     /db_xref="MGI:MGI:3032521"
                     /translation="MALGLLIAVPLLLQAAPPGAAHYEMLGTCRMICDPYSVAPAGGP
                     AGAKAPPPGPSTAALEVMQDLSANPPPPFIQGPKGDPGRPGKPGPRGPPGEPGPPGPR
                     GPPGEKGDSGRPGLPGLQLTTSAAGGVGVVSGGTGGGGDTEGEVTSALSAAFSGPKIA
                     FYVGLKSPHEGYEVLKFDDVVTNLGNHYDPTTGKFSCQVRGIYFFTYHILMRGGDGTS
                     MWADLCKNGQVRASAIAQDADQNYDYASNSVVLHLDSGDEVYVKLDGGKAHGGNNNKY
                     STFSGFLLYPD"
     exon            1220..1999
                     /gene="C1ql2"
                     /gene_synonym="Adii; CTRP10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1981..1986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1ql2"
                     /gene_synonym="Adii; CTRP10"
                     /note="hexamer: ATTAAA"
     polyA_site      1999
                     /gene="C1ql2"
                     /gene_synonym="Adii; CTRP10"
                     /note="major polyA site"
ORIGIN      
        1 atcttacgtt agggtagctg ggtaccccct ccgcccggga accagctagt agagggagaa
       61 cagagcagag cgtgcggcag agccgatccc gcgtcccgcc gaaccctgcc aagccccgcc
      121 aatcccagca gagcaggaac cagcgcagct gagccaacac cggacgccgc actgagaccc
      181 agcattcccc agccgccact acccggtccc cgccggggtg ccgggctcgt cctgtgagcc
      241 cctcgtcatg cgtgtcgggc tcttcgactc tccagatcag ttccagagcg gtggcctcag
      301 gagcccaggt ccggatacct ctcgttgaaa tagttgggtg gctaagagag gggtctccac
      361 gtcggggacg cggaggggac ctgcggagtt ggcgtccgaa cgcatagagc ggggccaccc
      421 gcgccgctcc accattacct ccccaggcgg caaggaggag ctggtggcgg tcgcctcccg
      481 gctgtggcag cggcggcggc gcgcctgctt ggcggccgtc ggcgtgctct tggccatggc
      541 actggggctg ctgatcgcgg tgcctctgct gctgcaggcg gcgccccccg gagcggctca
      601 ctacgagatg ctgggcacct gccgcatgat ctgtgaccca tacagcgtcg ctcccgcagg
      661 gggacccgcg ggcgccaagg ctccaccgcc gggacccagt accgctgccc tggaagttat
      721 gcaggacctc agcgccaacc ccccgcctcc gtttatccag ggaccaaagg gtgatccggg
      781 gcgaccaggc aagccagggc ctcggggtcc tcctggagag ccagggcctc ctgggcccag
      841 gggtcccccg ggagagaaag gagactcggg gaggccaggg ctacccggac tgcagttgac
      901 aaccagcgcg gccggtggcg ttggagtggt gagtggcgga accgggggcg gtggcgacac
      961 ggagggagaa gtgaccagtg cgctgagcgc cgccttcagc ggtcccaaga tcgccttcta
     1021 cgtgggactc aagagccccc acgaaggcta cgaggtgctc aagttcgacg acgtggtcac
     1081 caatcttggc aatcactacg accccactac aggcaagttc agctgccagg tgcggggcat
     1141 ctacttcttc acgtaccaca ttctcatgcg tggcggcgac ggaaccagca tgtgggcgga
     1201 tctctgcaag aacgggcagg tgcgagccag cgccatagcc caggacgcgg accagaatta
     1261 cgactacgcc agcaacagcg tggtactgca cctggattca ggcgatgaag tctacgtgaa
     1321 gctggacggc gggaaggctc acggcggcaa caataacaag tacagcacgt tctcgggctt
     1381 cctcctgtat ccggattagg ggcctagagg gcgcgcgcga ggccgggtgg cttcaggcca
     1441 ccccatcccc atcgggcgcg cgcgggctct ttggtgaatg tcactctgcg gcttcatgac
     1501 acttcctgac atctccgttg gaaaagacac atccctgctc tcctacttgt cctgcctcag
     1561 gcctcagtgt gtctaggatt cactacgctg cggggaggct gtgtccccgg tcccagtgcc
     1621 catcctgggg agggagaggg aacattcaag tggggagctg ggcgagaatc ccagctctgg
     1681 cggggttagt tgcggggcag cccagacttg agaaagctga ttggactaga caggcggccc
     1741 tagggagttt gaggtctccc agcttgcctc ttccttccag tgtcccccgg ttaagggctg
     1801 caagactcac aaggaagaaa gaccctggtg accgctactc tctcggacct ccctttttgt
     1861 gacccgaaat gcctgtgcag tttttcctat ccatcagcca aaaatccacc cctagcagaa
     1921 ttccaacaaa cagaaagttc accttgtcat gcacactctc catatcctcc tctgccatgc
     1981 attaaattat gtttttagaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2041 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
